Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

1475results about How to "Strong interaction" patented technology

Separation of charged particles by a spatially and temporally varying electric field

This invention relates to a method and device for separating charged particles according to their diffusivities in a separation medium by means of a spatially and temporally varying electric potential. The method is particularly suited to sizing and separating DNA fragments, to generating DNA fragment length polymorphism patterns, and to sequencing DNA through the separation of DNA sequencing reaction products. The method takes advantage of the transport of charged particles subject to an electric potential that is cycled between an off-state (in which the potential is flat) and one or more on-states, in which the potential is preferably spatially periodic with a plurality of eccentrically shaped stationary potential wells. The potential wells are at constant spatial positions in the on-state. Differences in liquid-phase diffusivities lead to charged particle separation. A preferred embodiment of the device is microfabricated. A separation medium fills physically defined separation lanes in the device. Electrodes deposited substantially transverse to the lanes create the required electric potentials. Advantageously, injection ports allow sample loading, and special gating electrodes focus the sample prior to separation. The effects of thermal gradients are minimized by placing the device in contact with a thermal control module, preferably a plurality of Peltier-effect heat transfer devices. The small size of a microfabricated device permits rapid separation in a plurality of separation lanes.
Owner:CURAGEN CORP

EphA2 agonistic monoclonal antibodies and methods of use thereof

InactiveUS20040091486A1Altered ligand binding propertyPrevents or decreases the cells' ability to proliferateImmunoglobulins against cytokines/lymphokines/interferonsImmunoglobulins against cell receptors/antigens/surface-determinantsDrugCancer therapy
The present invention relates to methods and compositions designed for the treatment, management, or prevention of cancer, particularly, metastatic cancer. The methods of the invention comprise the administration of an effective amount of one or more antibodies that bind to and agonize EphA2, thereby increasing EphA2 phosphorylation and decreasing EphA2 levels in cells which EphA2 has been agonized. The invention also encompasses antibodies that preferentially bind an EphA2 epitope exposed on cancer cells but not non-cancer cells. The invention also provides pharmaceutical compositions comprising one or more EphA2 antibodies of the invention either alone or in combination with one or more other agents useful for cancer therapy.
Owner:MEDIMMUNE LLC +1

Man-machine interaction method and device based on emotion system, and man-machine interaction system

The invention discloses a man-machine interaction method and device based on an emotion system, and a man-machine interaction system. The method comprises following steps of collecting voice emotion parameters, expression emotion parameters and body emotion parameters; calculating to obtain a to-be-determined voice emotion according to the voice emotion parameters; selecting a voice emotion most proximate to the to-be-determined voice emotion from preset voice emotions as a voice emotion component; calculating to obtain a to-be-determined expression emotion according to the expression emotion parameters; selecting an expression emotion most proximate to the to-be-determined expression emotion from preset expression emotions as an expression emotion component; calculating to obtain a to-be-determined body emotion according to the body emotion parameters; selecting a body emotion most proximate to the to-be-determined body emotion from preset body emotions as a body emotion component; fusing the voice emotion component, the expression emotion component and the body emotion component, thus determining an emotion identification result; and outputting multi-mode feedback information specific to the emotion identification result. According to the method, the device and the system, the man-machine interaction process is more smooth and natural.
Owner:BEIJING GUANGNIAN WUXIAN SCI & TECH

Sustained delivery of drugs from biodegradable polymeric microparticles

InactiveUS20110206773A1Maximizes loading of drugPromote nerve regenerationBiocideOrganic active ingredientsOptic nerve regenerationActive agent
Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing or one or more diseases or disorders of the eye, and methods of making and using thereof, are described. The microsphere compositions release an effective amount of the one or more active agents for a period greater than 14 days in vivo, preferably greater than 60 days in vivo, more preferably up to 73 days in vivo, more preferably greater than 90 days in vivo, even more preferably over 100 days in vivo, and most preferably greater than 107 days in vivo. In a preferred embodiment, the microparticle compositions contain one or more active agents such as AG1478 to induce nerve regeneration, specifically regeneration of the optic nerve useful for managing elevated intraocular pressure (TOP) in the eye.
Owner:UNIV OF IOWA RES FOUND +1

Microwave electric field intensity meter based on cold Rydberg atom interferometer and measuring method thereof

ActiveCN104880614AHigh measurement accuracyMake up for the defect that only point frequency measurement can be realizedElectrostatic field measurementsRydberg atomBeam splitting
The invention discloses a microwave electric field intensity meter based on a cold Rydberg atom interferometer and a measuring method thereof. The microwave electric field intensity meter comprises: a vacuum system, which is used for cooling and trapping atom to generate a cold atom cloud for preparing a Rydberg state and generating an interference effect so as to generate a phase difference by coherent atomic states; a laser, which is used for generating coupling light and detection light and exciting the cold atom in the vacuum system from a ground state to the Rydberg state coherently; a photoelectric detector, which is used for detecting an interference fringe generated by two beams of cold atom clouds due to coherence; and a microwave source, which is used for generating a microwave electric field. According to the invention, when the microwave electric field intensity meter is applied to the evolution process of coherent beam splitting and combination, the atom cloud in the Rydberg state interacts with a to-be-measured microwave electric field, thereby generating an alternating-current stark effect; and the to-be-measured microwave electric field intensity is associated with a phase generated by the an alternating-current stark, thereby realizing precise measurement of the microwave electric field.
Owner:清远市天之衡量子科技有限公司

Use of EphA4 and modulator of EphA4 for diagnosis, treatment and prevention of cancer

The present invention relates to methods and compositions designed for the treatment, management, or prevention of cancer, particularly, metastatic cancer. In one embodiment, the methods of the invention comprise the administration of an effective amount of one or more antibodies that bind to EphA4 and agonize EphA4. In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more antibodies that bind to EphA4 and inhibit cancer cell colony formation in soft agar or tubular network formation in three-dimensional basement membrane or extracellular matrix preparation. In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more antibodies that preferentially binds to an EphA4 epitope that is exposed on cancer cells but not non-cancer cells. In another embodiment, the methods of the invention comprise the administration of an effective amount of one or more antibodies that bind to EphA4 with a very low Koff to reduce EphA4 expression and, thereby, inhibit tumor cell growth and/or metastasis. The invention also provides pharmaceutical compositions comprising one or more EphA4 antibodies of the invention either alone or in combination with one or more other agents useful for cancer therapy.
Owner:MEDIMMUNE LLC

Dual-rotational-flow inspirator

ActiveCN103867340AStrong interactionGood atomization performanceRocket engine plantsHollow cylinderEngineering
The invention provides a dual-rotational-flow inspirator, which comprises a top cover, a nozzle, an upper bottom, a middle bottom, a gas whirlcone and an inspirator cavity, wherein the inspirator cavity is a barrel-shaped hollow cylinder; a fuel cavity is formed between the top cover and the upper bottom of the inspirator; a gas oxidizing agent cavity is formed between the upper bottom and the middle bottom of the inspirator; a water cavity is formed between the middle bottom of the inspirator and the base of the inspirator; an inner nozzle passes through mounting holes in the upper bottom, the middle bottom and the inspirator cavity and is fixedly arranged on the upper bottom via a thread; the gas whirlcone is installed on the nozzle by a thread; water nozzles are water holes evenly distributed on the circumstance on the base of the inspirator. The inspirator provided by the invention has the characteristics of simple structure, low cost, good atomization performance and stable flame.
Owner:NAT UNIV OF DEFENSE TECH

High temperature self-repairing conductive silver adhesive and preparation method thereof

The invention provides a high temperature self-repairing conductive silver adhesive. The high temperature self-repairing conductive silver adhesive is prepared from the following raw constituents by parts: 100 parts of epoxy resin, 10-30 parts of curing agent, 10-40 parts of epoxy diluent, 240-990 parts of silver pieces, 3-20 parts of coupling agent and 5-20 parts of self-repairing microcapsule; wherein the self-repairing microcapsule is composed of the following raw constituents by parts: 100 parts of epoxy resin, 8-20 parts of latent curing agent, 30-60 parts of diluents, 0.5-2.5 parts of emulsifying agent, 500-800 parts of nano silver wires, 5-16 parts of coupling agent, 60-120 parts of capsule wall material, 0.5-2 parts of antifoaming agent and 150-900 parts of deionized water. The invention also provides a preparation method of the high temperature self-repairing conductive silver adhesive. The high temperature self-repairing conductive silver adhesive has the positive effects that the repairing efficiency is high, the repairing effect is expanded on the basis of the original conductive network, crack-conductive network double repairing is realized, and the long-term using effect of the conductive adhesive is guaranteed, the cost is saved, and the reliability and service life of the conductive adhesive in high temperature working environment are improved.
Owner:CHINA ELECTRONIC TECH GRP CORP NO 38 RES INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products