Medicinal composition for nerve regeneration after ischemic cerebral stroke and application thereof
A technology for ischemic stroke and nerve regeneration, which is applied in the medical field, can solve the problems of non-disclosure, etc., and achieve the effect of promoting the process of nerve regeneration and the recovery of motor function
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Embodiment 1
[0012] Example 1: Preparation of N'-(2-(1H-indol-3-yl)acetyl)-2-iodobenzohydrazide
[0013] (1) Add 8.8g (50mmol) of indole acetic acid (50mmol), methanol (60mL), and concentrated sulfuric acid (3mL) to a 500ml round bottom flask, and react at 70°C for 1-3 hours. water (50mL), separate the organic phase, extract the aqueous phase with ethyl acetate (3×20mL), combine the organic phases, wash with saturated sodium bicarbonate solution and water successively, dry over anhydrous sodium sulfate, and concentrate under reduced pressure to obtain indole Crude methyl acetate.
[0014] (2) Add 9.46g (48mmol) of methyl indole acetate, ethylene glycol methyl ether (40mL), and 5mL of hydrazine hydrate into a 500ml round-bottomed flask, heat and reflux at 115°C for about 20 hours, thin-layer chromatography (TLC) After detecting the disappearance of the raw material point, stop the reaction, cool to room temperature, add water (50 mL), stand still to precipitate a white solid, obtain the cr...
Embodiment 2
[0017] Example 2: Effect test of compounds on middle cerebral artery occlusion model
[0018] 55 adult SD rats, male, healthy and clean, with a body weight of 280-320 g, 15 rats were randomly selected as the sham operation group, and the rest of the rats were used to make the middle cerebral artery occlusion model as follows: use 0.4% pentobarbital Rats were anesthetized by intraperitoneal injection of sodium 10mL / kg, fixed on the operating table in the lateral position, along the midpoint of the line connecting the right external auditory canal and the outer canthus of the right eye, incised the skin about 2 cm perpendicular to the line, and then under the operating microscope along the temporal Cut the temporal muscle and masseter muscle in sequence, and separate them to the sides to expose the zygomatic arch. Use a rongeur to remove the zygomatic arch and cut the fascia along the skull to expose the anterior temporal fossa. Use a small distractor to widen the distance betwe...
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