Piezoelectric stent composition capable of realizing self-generating electricity stimulation as well as preparation method and application thereof
A self-generating and composite technology, applied in the field of biomedicine, can solve problems such as the mismatch between material degradation rate and tissue regeneration rate, unsatisfactory clinical application effect, inflammation and glial hyperplasia, etc., and achieve good clinical application prospects , Relieve muscle atrophy, promote nerve regeneration
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Embodiment 1-11
[0047] One, embodiment 1-11, comparative example 1-2
Embodiment 1
[0049] A piezoelectric support capable of spontaneous electrical stimulation, the preparation method of which is as follows:
[0050] A biodegradable material with a weight ratio of 80% and a piezoelectric material with a weight ratio of 20% is a piezoelectric scaffold composition capable of spontaneous electrical stimulation; the biodegradable material is preferably polycaprolactone, and the piezoelectric material is preferably Vinylidene fluoride polymer.
[0051] Dissolving polycaprolactone in a solvent of 10 times the weight of the composition, then adding vinylidene fluoride polymer and mixing thoroughly to obtain a solution of the piezoelectric stent composition capable of spontaneous electric stimulation, the solvent is preferably dichloromethane .
[0052] The above solution was poured onto a glass plate and annealed on a hot plate at 55 °C for 12 hours. The annealed copolymer was immersed in a 25°C water bath to remove solvent residues, and dried in vacuum for 12 ho...
Embodiment 2
[0056] A piezoelectric support capable of spontaneous electrical stimulation, the preparation method of which is as follows:
[0057] A biodegradable material with a weight ratio of 70% and a piezoelectric material with a weight ratio of 30% is a piezoelectric scaffold composition capable of spontaneous electrical stimulation; the biodegradable material is preferably polycaprolactone, and the piezoelectric material is preferably Vinylidene fluoride polymer.
[0058] Dissolving polycaprolactone in a solvent of 20 times the weight of the composition, then adding vinylidene fluoride polymer and mixing thoroughly to obtain a solution of the piezoelectric stent composition that can be stimulated by electricity, the solvent is preferably dichloromethane .
[0059] The above solution was poured onto a glass plate and annealed on a hot plate at 20 °C for 12 hours. The annealed copolymer was immersed in a 25°C water bath to remove solvent residues, and dried in vacuum for 12 hours to...
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