Paris total saponins extract with tumor metastasis resisting action and pharmaceutical formulation thereof

Abstract

The present invention provides a paris total saponin extract for resisting tumor metastasis and a pharmaceutical preparation thereof. The pharmaceutical preparation is composed of paris total saponin extract as the active component and medicinal auxiliary materials; wherein, the weight percentage of paris total saponin extract in the total weight of the pharmaceutical preparation is 60 to 98 percent. The paris total saponin extract for resisting tumor metastasis and the pharmaceutical preparation provided by the present invention have good inhabitation on the metastasis of animal transplanted tumor cells, demonstrated in (1) significant anti-metastasis function for inbred mice and nude mice metastasis model of vaccinated mouse lung adenocarcinoma, human lung cancer, human gastric cancer, human intestinal cancer, human liver cancer and other tumor strains; (2) significant effect on relative albumen metastasis; (3) significant effect on relative gene metastasis and no obvious toxicity on major viscera. In addition, the main active component of the pharmaceutical preparation is a Chinese medicine extract, so compared with chemical drugs, the present invention has the advantage of small toxicity.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to an extract of total saponins of polyphylla with anti-tumor metastasis and a pharmaceutical preparation thereof. Background technique [0002] Malignant tumors are common and frequently-occurring diseases that seriously threaten human health. According to the report of the World Health Organization, among the more than 5 billion people in the world, about 9 million people are newly diagnosed with cancer every year, and 7 million people die due to cancer, accounting for Nearly 20% of the total fatality rate, so the development of anticancer drugs has become a major topic of new drug research in this century. At present, the drug treatment of cancer at home and abroad, especially the molecular targeted therapy, is constantly improving the treatment effect of cancer, but at the same time, it should be noted that many chemotherapeutic drugs may cause a variety of short-term and lon...

AI Technical Summary

Problems solved by technology

Modern pharmacological studies have shown that the alcohol extract and water extract of Chonglou have inhibitory effects on various tumor cells in vitro, and have obvious inhibitory effects on the growth of animal transplanted tumors S180, S37, EAC, ARS, L759, etc. But so far, it has not been found that the total saponins extract of Chonglou has anti-metastatic effect and its application in anti-metastatic drugs has been reported.