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Degradable composite nerve conduit and preparation method thereof

A nerve catheter and needle tube technology, applied in the field of degradable composite nerve catheter and its preparation, can solve the problems of catheter mechanical properties, flexibility, compliance, and elastic degradation rate control, which are difficult to precisely control, surrounding tissue extrusion, catheter collapse, etc. , to achieve the effects of adjustable mechanical properties and degradation properties, good biocompatibility, and improved mechanical properties

Inactive Publication Date: 2019-02-15
BEOGENE BIOTECH GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bridging and repairing nerve defects through tissue-engineered artificial nerves constructed by catheters is the most promising method. It is difficult to precisely regulate the control, which is not conducive to the regeneration of nerve axons
The existing nerve conduits have insufficient mechanical properties and are easily squeezed by surrounding tissues, causing conduit collapse; the nerve regeneration rate does not match the conduit degradation rate, causing the conduit to exist for a long time in the body and affecting the normal physiological function of the nerve; in addition, biocompatibility Poor sexuality, prone to inflammation, tissue adhesion and other problems

Method used

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  • Degradable composite nerve conduit and preparation method thereof
  • Degradable composite nerve conduit and preparation method thereof
  • Degradable composite nerve conduit and preparation method thereof

Examples

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Effect test

Embodiment 1

[0032] A degradable composite nerve guide, comprising the following materials: 1 g of polylactic acid-glycolic acid, 0.1 g of hyaluronic acid, 0.02 g of collagen, 0.3 g of silk fibroin and heparin.

[0033] The preparation method of the degradable composite nerve guide in this example is as follows: use an electronic balance to weigh 1 g of polylactic-glycolic acid (PLGA), 0.1 g of hyaluronic acid (HA), 0.02 g of collagen (COL), prepared and dried silk Sulfin (SF) 0.3g was dissolved in 10mL of hexafluoroisopropanol, and stirred for 12h with an electromagnetic stirrer to fully dissolve the raw materials to obtain a uniform and stable spinning solution. A 18# needle was used to control the spinning parameters (spinning The flow rate of the silk solution is 2mL / h, the spinning voltage is 18KV, and the distance between the needle and the receiver is 18cm), and the spinning solution is sprayed onto a rotating circular needle tube (inner diameter 3mm) to make a nerve conduit with a w...

Embodiment 2

[0039] A degradable composite nerve guide, comprising the following materials: polylactic acid-glycolic acid 6g, hyaluronic acid 1.2g, collagen 0.1g, silk fibroin 3.5g and heparin.

[0040] The preparation method of the nerve guide in this example is the same as in Example 1, and the concentration of heparin in the preparation method of this example is 1%.

Embodiment 3

[0042] A degradable composite nerve guide, comprising the following materials: 10g of polylactic acid-glycolic acid, 0.8g of hyaluronic acid, 0.3g of collagen, 2g of silk fibroin and heparin.

[0043] The preparation method of the nerve guide in this example is the same as in Example 1, and the concentration of heparin in the preparation method of this example is 0.5%.

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Abstract

The invention relates to a degradable composite nerve conduit and a preparation method thereof, and belongs to the technical field of medical biomaterials. The degradable composite nerve conduit comprises the following materials: polylactic acid-glycolic acid, hyaluronic acid, silk fibroin, collagen and heparin. With natural materials and synthetic high molecular materials as raw materials, according to an electrospinning technology, the nerve conduit adopting a composite structure and having good biocompatibility, mechanical properties and degradability is prepared; the nerve conduit adopts abiomimetic structure and can simulate an extracellular matrix, so that cell adhesion, proliferation and migration inside the conduit are facilitated and nerve regeneration is promoted.

Description

technical field [0001] The invention relates to a degradable composite nerve guide and a preparation method thereof, belonging to the technical field of medical biomaterials. Background technique [0002] Every year in China, more than 500,000 people suffer from peripheral nerve injury due to trauma. Peripheral nerve injury often causes sensory and motor dysfunction in the innervated area, affects the quality of life of patients, and brings a heavy burden to individuals and society. Short-distance nerve defects are self-healing, but long-distance peripheral nerve transection injuries remain a major clinical challenge, and the therapeutic effect is usually limited. At present, autologous nerve transplantation is the best way to treat peripheral nerve defects, but this method is limited by surgery, nerve dysfunction and local tissue adhesion. To overcome these shortcomings, biomimetic nerve guides are being developed as an alternative to autografts. [0003] With the advanc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/22A61L27/24A61L27/50A61L27/54A61L27/58
CPCA61L27/18A61L27/20A61L27/227A61L27/24A61L27/50A61L27/54A61L27/58A61L2300/236A61L2300/412A61L2300/602A61L2430/32C08L5/08C08L67/04C08L89/00
Inventor 刘玉蓝咏胡圣学冯龙宝朱麒宇
Owner BEOGENE BIOTECH GUANGZHOU
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