104 results about "Motor dysfunction" patented technology

The invention discloses a wearable hand function rehabilitation robot, which is mainly used for assisting the repeated movement function rehabilitation training of the patient with hand movement function disorder which is caused by stroke, brain trauma, spinal cord injury and peripheral nerve injury in communities or families. The robot system extracts the active movement will of the patient by detecting the multi-channel surface myoelectric signals of the affected hand and obtains the state of the affected limb by combining the data which is measured by an angle and force sensor to carry out the rehabilitation training of the affected hand by pneumatic muscle contraction assistance by using the intelligent control algorithm on the basis. The rehabilitation robot has multiple degrees of freedom, which can assist the affected hand to carry out multi-joint complex movement and inosculate the multi-sensor data information fusion during the rehabilitation process to be further used for the evaluation of rehabilitation effect, and the activity and the training interest of the patient can be improved by using the rehabilitation treatment virtual environment on a computer. The invention has the advantages of simple structure, flexible movement, safety and reliability, which can not only realize the rehabilitation training of the movement function of the affected hand, but can also be in line with the physiologic structure characteristics of human hands. The invention is more comfortable to wear.

The invention relates to a mass balancing device and method for a lower limb rehabilitation training patient. The balancing device comprises a reduced gravity generating mechanism, a bracket, an electric winch, a steel wire rope, a pulley wheel, a force sensor, a suspender, a running machine and a control system. When a reduced gravity walking training is carried out, the patient wears the suspender to stand on the running machine; the suspender is connected to the steel wire rope through the pulley wheel and two ends of the steel wire rope are respectively mounted on the reduced gravity generating mechanism and the electric winch; and the size of the actual reduced gravity detected by the force sensor is fed back to the control system to realize closed-ring control. Aiming to the patient of lower limb motor dysfunction caused by central nervous system diseases including spinal injuries, brain stroke and the like, a load to lower limbs of the patient which is caused by the self-gravity of the patient and the dynamic load in the walking process can be simultaneously relieved when the reduced gravity walking training is carried out, so as to realize constant-mass gravity reduction. According to the rehabilitation conditions of the patient or the training requirements, a weight reducing device provided by the invention can conveniently adjust a gravity reducing ratio. The suspender of the weight reducing device can be moved along the gravity center of the patient in real time and is good for the rehabilitation of normal physiological gaits of the patient.

A method and device for the rehabilitation of patients that have suffered loss of motor control of an appendicular joint due to neurological damage. The method includes attempted contraction by a patient of a muscle that serves to move an affected joint coupled with the production of a perception by the patient that the joint is being moved more than it really is. The method results in dramatic non-transient improvements in motor control of the joint. The device provides an apparatus for performance of the method.

An apparatus for rehabilitation of patients with motor disorders affecting the legs and standing dysfunctions, the apparatus comprising a couple of bars moving along a closed loop representing a walking step for the patient, with each bar including a plate to affix a foot of the patient and the plate being slidably arranged in the bar, with a motor connected to the bars to move the bars along the closed loop, the apparatus also having an harness to support the patient.

The invention discloses a joint compound motion mechanical arm used for rehabilitation training of an upper limb. The mechanical arm comprises a base, an electric lifting column, a T type supporting frame, a main fixed base and an outer skeleton mechanical arm system, wherein the base is placed on the ground; the electric lifting column is fixedly connected with the base; the electric lifting column is fixedly connected with the T type supporting frame; the main fixed base is mounted on a supporting frame; the outer skeleton mechanical arm system is connected with driving motors through the main fixed base; and the driving motors are all mounted on the main fixed base. When the mechanical arm is in use, only the outer skeleton mechanical arm system moves according to a control instruction; the motors are motionless relative to the base; the mechanical arm is light, convenient and flexible, creative in structure, small in occupied space, and stable and reliable in movement; the joint compound motion mechanical arm can be used for assisting a patient with upper limb dyskinesia to finish all kinds of rehabilitation training actions; and meanwhile, the mechanical arm can be used for single-joint rehabilitation training for a shoulder joint and an elbow joint, and also can be used for compound motion rehabilitation training for multiple joints of the upper limb.

The invention discloses a multi-pose lower-limb rehabilitation robot and a use method thereof, and belongs to the field of medical apparatuses. The rehabilitation robot comprises a pedestal, a liftingmechanism and a bed body which are arranged sequentially from bottom to top; a pair of thigh training mechanisms and a pair of leg training mechanisms are symmetrically arranged on the two sides of the bed body correspondingly; the thigh training mechanisms and the leg training mechanisms are used for performing lower-limb rehabilitation training on a patient whose lower limbs have dyskinesia; the patient is subjected to lower-limb rehabilitation training by multiple modes; furthermore, the bed body and a seat cushion are overturned, so that training of three poses of sitting, lying and standing can be realized, the training mode is comprehensive and the training effect is good. By the method adopting the multi-pose lower-limb rehabilitation robot, the training effect is excellent.

The present invention relates to a brain-machine interface system based on face recognition specific wave N170 component, which implements sorting of facial pictures and object pictures, and comprises a picture stimulator, a cortical electric signal collector, a face recognition specific wave N170 detector, and a picture sorter. Pictures to be sorted are presented by the visual picture stimulator as visual stimulations to a user, and the cortical electric signals of the user generated in response are recorded and subjected to amplification and A / D conversion, and then processed and analyzed by the face recognition specific wave N170 detector, whereby a determination is made whether the collected cortical electric signals contain specific wave N170 component related to facial picture stimulation, and accordingly, the cortical electric signals are transformed into picture sorting control commands for identifying facial pictures and object pictures. The advantages of the present invention are: the present invention utilizes the specific cortical electric signal N170 component generated in the facial picture recognition process in response to facial picture stimulations, and employs an effective online feature extraction and sorting algorithm in the cortical electric signal analyzer; therefore, the discrimination ratio of the system is increased. The present invention provides a novel means for persons who suffer from dyskinesia but can think normally to communicate with and control the external environment.

Effective systems and methods for improving neural communication impairment of a vertebrate being and affecting motor activity of a peripheral body part including a first signal-providing component configured to provide pulsed peripheral stimulation signals at the peripheral body part, a second signal-providing component configured to provide a pulsed motor cortex stimulation signal to a motor cortex area, a substantially DC signal-providing component configured to provide direct current spinal stimulation signal at a neural spinal junction and a controller component configured to control timing of the pulsed peripheral stimulation signals and the pulsed motor cortex stimulation signal.

Disclosed are an inertial-sensor-based wearable hemiplegia rehabilitation apparatus and a strap-down attitude algorithm. The inertial-sensor-based wearable hemiplegia rehabilitation apparatus mainly comprises an upper computer and an inertia measurement system. Inertia measurement units distributed on different body parts of a patient acquire attitude angle information of the patient moving, through inertial sensors; the attitude angle information is transmitted to the upper computer through a wireless transmission module; the upper computer tracks the rehabilitation training process of the patient in real time according to the attitude angle information of different positions. The invention further provides a strap-down attitude algorithm based on plane constraint. According to the method, a restraint plane is established according to previous-moment motion attitudes of a forearm and a postbrachium during moving, the restraint plane is used to restrain acceleration information, systematic self-restrained measurement is achieved accordingly, and angle measurement is better in stability and accuracy. The inertial-sensor-based wearable hemiplegia rehabilitation apparatus and the strap-down attitude algorithm have the advantages that accurate rehabilitation motion attitudes and accurate amount of motion can be provided according to conditions of the patient with hemiplegia, degree and times of completing each set of moves are recorded for the patient, and a function of simple evaluation on hemiplegia and treatment effect for the patient with hemiplegia is provided.

The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: wherein R1, R2, R3, R4, R5, R6, n1, m, p Z1, Z2, and Z3 are as describe in the specification. The invention also relates to compounds of of formula (I) which are antagonists of the motilin receptor and are useful in the treatment of disorders associated with this receptor and with or with motility dysfunction.

The invention provides a multifunctional gait rehabilitation training device, and aims to provide a multifunctional gait rehabilitation training robot. The multifunctional gait rehabilitation training device adopts a step length adjustable, ankle gesture controllable and phalanx joint trainable multifunctional gait rehabilitation training robot structure, and comprises four main components, namely, a rack playing a supporting function, a gait movement simulating mechanism for realizing gait track, an ankle gesture adjusting mechanism for realizing ankle gesture real-time adjustment and a phalanx rehabilitation mechanism for conducting phalanx joint rehabilitation training. The multifunctional gait rehabilitation training robot can be applied to a series of lower limb rehabilitation training of gait track walking, ankle joint rehabilitation training, phalanx joint rehabilitation and the like by patients with lower limb dyskinesia.

The invention discloses a design method of a motor imagery training man-machine interactive system based on electrooculogram and electroencephalogram. The invention provides the method aiming at dyskinesia paints, and being capable of realizing timely and effective recognition and feedback on the brain motor imagery state. According to the method, in the imagination process for the upper limb movement of the brain, a signal collecting device acquires electroencephalogram and electrooculogram signal change data of the human body completing the specific upper limb movement, the electroencephalogram and electrooculogram signal change data is stored into a personalized database to be taken as an information source, then feature extraction is carried out on the electroencephalogram signals and the electrooculogram signals, the two types of features are fused by utilizing the criterion based on an information fusion scheme, the fused features are taken as the new motor imagery features, then the new motor imagery features are identified, and thus the identification on the motor imagery state of the human body completing the specific movement is realized.

Provided are a cognitive function evaluation apparatus, a cognitive function evaluation method and system, and a program that can be implemented for non-handicapped persons and persons with severe motor impairment. The apparatus according to the present invention is an apparatus for evaluating cognitive function provided with a processing unit that analyzes and processes a brain wave caused by a plurality of stimulus events including a target and a non-target; estimates a stimulus event selected as the target from the plurality of stimulus events; determines a discrimination score or decoding accuracy; and evaluates cognitive function on the basis of a value of one or more of the discrimination score, the decoding accuracy, any of time courses, and decoding speed. With respect to two or more stimulus event groups having different levels of difficulty distinguishing between stimulus events, a discrimination score or decoding accuracy may be determined for each of the different difficulty levels, and cognitive function may be evaluated on the basis of a connection between one or more of the discrimination score, the decoding accuracy, any of time courses, and decoding speed and the difficulty levels.

The invention discloses a new external Chinese medicinal composition for treating hydrocephalus and a preparation method thereof. The Chinese medicinal composition mainly comprises the following raw material medicaments: szechuan lovage rhizome, grassleaf sweelflag rhizome, manchurian wildginger, incised notopterygium rhizome, fineleaf schizonepeta herb, divaricate saposhnikovia root, cassia twig, Chinese ligusticum rhizome, angelica dahurlica, kudzuvine root, flos chrysanthemi, baical skullcap root, ash bark, lightyellow sophora root, radix scrophulariae, red paeony root, giant knotweed rhizome, natural indigo, vietnamese sophora root, Indian buead, Chinese lobelia herb, cortex lycii radicis, rhubarb, akebia stem, oriental waterplantain rhizome, plantain seed, India madder root, cattail pollen, rosewood heart wood, peach seed, safflower, root of red-rooted salvia, common burreed rhizome, zedoary, ground beeltle, storax, borneol, camphor, toad venom, musk, benzoin, sandalwood, mint, pubescent angelica root, beautiful sweetgum fruit, radix stephaniae tetrandrae, glandularstalk St paulswort herb, cortex acanthopanax radicis, swordlike atractylodes rhizome, herba agastachis, cortex magnoliae officinalis, talc, manshurian dutchmanspipe stem, ricepaperplant pith, Japanese climbing rern spore, pyrrosia leaf, longhairy antenoron herb, prepared common monkshood daughter root, costustoot, cyperus rotunus, szechwan chinaberry fruit, pangolin scales and the like. The Chinese medicinal composition can be prepared into any external preparation used commonly according to the conventional method of Chinese medicinal preparations. The external Chinese medicinal composition can improve symptoms such as increased intracranial pressure, pain of bilateral tempus or whole skull, nausea, cephaloedema or optic atrophy, mental retardation, dyskinesia, phenomena from slow walk and disequilibrium to incapability of walking and finally ill-health in beds, dysphrenia and hypomnesis.

The invention relates to a rehabilitation system and method based on interactive virtual reality and electrical nerve stimulation. The rehabilitation system and method based on interactive virtual reality and electrical nerve stimulation are used for rehabilitation of limb dyskinesia caused by nervous system function damage, such as cerebral apoplexy, spinal nerve damage and cerebral palsy. The rehabilitation system based on interactive virtual reality and electrical nerve stimulation includes the following function devices: an interactive input device, a motion imagination device, an electrical stimulation device, a data analysis device and a system processor. The rehabilitation method based on interactive virtual reality and electrical nerve stimulation is depended on the display mode under the virtual reality application technology, combined with the interactive input device and the bioelectrical nerve stimulation device, and uses the rehabilitation kinesitherapy and the motion imagination therapy to implement the systematic rehabilitation scheme covering the whole stage of rehabilitation.

The invention aims to provide an exoskeleton robot power-assisted control system and method based on a neural network. The exoskeleton robot power-assisted control system is applied to elbow joints and comprises a sensing detection module and a data collecting and processing module. According to the exoskeleton robot power-assisted control system based on the neural network and the method, sensorssuch as a myoelectric sensor and a bending sensor are used for data fusion through the radial basis neural network, and motion power-assisted auxiliary is carried out on the aged people and patientswith motor dysfunction to meet the requirements of daily life of the aged people and the patients with motor dysfunction. According to a control strategy, a torque estimation index based on a myoelectric signal and an energy estimation index based on the myoelectric signal are adopted to objectively and quantitatively evaluate the motion power-assisted effect.

Disclosed herein are sequences, molecules and methods used to suppress the expression of HD genes encoding for huntingtin protein in primates including Macaca mulatta and Homo sapiens. These sequences, molecules and methods aid in the study of the pathogenesis of HD and can also provide a treatment for this disease by reducing HD mRNA without causing death, locomotor impairment or cellular alterations of the Macaca mulatta and Homo sapiens.

The present invention provides compounds represented by formula (1) shown below:(wherein R1, R2, R3, R4, and R5 are each individually selected from among a hydrogen atom, methyl group, acetyl group, hydroxyl group, and alkoxy group; and X represents an alkylene group or alkenylene group); and compounds represented by formula (2) shown below:(wherein R6, R7, R8, R9, and R10 are each individually selected from among a hydrogen atom, alkyl group, acetyl group, hydroxyl group, and alkoxy group; A represents an oxygen atom or NH, and m is 0 or 1; and Y represents an alkylene group or alkenylene group, and Z represents a hydrogen atom or hydroxyl group).The compounds of the present invention are useful for preventing or treating brain dysfunctions, motor dysfunctions, or urinary dysfunctions caused by the degeneration and / or loss of the central nervous system or peripheral nervous system cells.

The invention designs and realizes electrical wheelchair control based on a brain machine interface, so as to provide another will output way or an ability of interaction with the outside environment for the disabled of motor dysfunction or other person in related need and provide assists in the aspects of life and work. The actual system can enable the user to control steering, forward, backward, speed-up, speed-down, start, stop and the like of the wheelchair only through imagination and receiving stimulation of a vehicle-mounted computer.

Huntington's Disease (HD) is an autosomal-dominant inherited progressive neurodegenerative disease from the group of CAG repeat / polyglutamine diseases and is characterized by a triad of psychiatric alterations, dementia and motor dysfunction. On a sub-cellular level, a mutation with extended CAG tri-nucleotide repeats has been identified as the cause of HD. The therapeutic effects of certain substances can be tested on neurotoxically-induced or transgenic animal models with expanded CAG-repeats. In the present invention, transgenic rats were generated and characterized for human HD. Said rat model for human HD and other diseases of the CNS carries 51 CAG repeats under the control of a rat promoter and has a slow progressive neurological phenotype, closely reflecting human HD syndrome. The comparability of the rat model in relation to human HD is characterized by neuropathological, neuroradiological and neurochemical modifications accompanied by typical behavioral symptoms.

The invention discloses a rope-driven upper limb rehabilitation training robot system based on virtual reality and a use method thereof. The rope-driven upper limb rehabilitation training robot systemcomprises a 7-DOF upper limb rehabilitation train robot body and a virtual reality rehabilitation training system, can realize shoulder joint abduction / adduction, external / internal rotation and flexion / extension, elbow flexion / extension, forearm internal / external rotation and wrist joint abduction / adduction and flexion / extension rehabilitation training of patients with upper limb motor dysfunction, can ensure the safety of rehabilitation training and improve the control accuracy of rehabilitation training robot through a method of shoulder joint movement center positioning; and the virtual reality rehabilitation training system recognizes the posture of human upper limbs through the posture sensor and Kinect binocular vision sensor installed on the rehabilitation training robot, and, as the input of virtual reality scene, improves the interest and efficiency of rehabilitation through games related to upper limb movement training.

The present invention discloses a switch control method based on human face identification specificity waves in brain waves. The method comprises the following steps: a picture exciting module presents human face and object pictures synchronously at a certain interval, and if a user wants to open a device, the user should observe the human face picture, or else observe the object picture; a brain wave signal acquiring module records brain wave signals of the user scalp and performs amplification and digital-to-analog conversion; a signal detection module detects that whether specificity waves generated by the exiting of the human face picture exist in the brain wave signals or not; a switch control module transforms the detection result into binary control signals to control the switch, and if obvious specificity wave component exist in the brain waves, the device is opened, or else the device is closed. In the present invention, a direct control channel between a human brain and an external switch device is established through acquiring and analyzing human face identification specificity wave components in the brain waves without depending on normal information transmitting channels such as peripheral nerves, muscles and the like for providing a novel method of controlling external environment for persons having normal thinking abilities but suffering from dyskinesia.

The invention provides a gait rehabilitation trainer which simulates gait of human during normal walking and provides patients with lower limb movement dysfunction with oval leg-swinging gait training. The gait rehabilitation trainer comprises a mainframe, a lifting stabilization device and a pedaling machine, the mainframe mainly comprises a bottom plate and a supporting body mounted on the upperportion of the bottom plate, the lifting stabilization device is mounted on the upper portion of the supporting body, and the pedaling machine is mounted on the rear portion of the bottom plate and comprises a mounting seat, a rotating member, pedaling plates, sliding wheels and a pedaling power device; the mounting seat is fixedly mounted on the bottom plate, the rotating member is mounted on the mounting seat, one ends of the pedaling plates are connected with the rotating member while the other ends of the same are connected with the sliding wheels which contact with the bottom plate, andthe pedaling power device is used for driving the rotating member to rotate. The gait rehabilitation trainer can be combined with virtual equipment to allow the patients to see a scene in which they autonomously walk through their own two legs.

The invention discloses a multi-objective control command generation device based on myoelectricity. Body movement, sending out a command in a customized mode, of a user and corresponding specific command content are supported, each slave module comprises a myoelectricity signal collecting system and can be worn on one part of the body individually, and the multiple slave modules can be combined for use; a host module comprises a multichannel management system, an action recognition system, a user interactive system, a control command management system and a power management system. Accordingto the device, in theory, surface myoelectricity signals under different actions are converted into control commands of corresponding electronic equipment; accordingly, the multichannel management system of the host module is adaptive to any number of onboard slave modules, each independent slave module can complete acquisition of myoelectricity data, and therefore users (especially some people suffering from movement disturbance) can select the number of slave modules needing to be used and the wearing positions according to the situations of the users and control objectives, and a control command is generated by using a separate action or a combined action.

The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates:wherein R1, R2, R3, R4, R5, R6, n1, m, p Z1, Z2, and Z3 are as describe in the specification. The invention also relates to compounds of formula (I) which are antagonists of the motilin receptor and are useful in the treatment of disorders associated with this receptor and with or with motility dysfunction.

Mutations in the leucine-rich repeat kinase (LRRK2) gene cause late-onset autosomal dominant Parkinson's disease (PD) with pleiomorphic pathology. Previously, we and others found that expression of mutant LRRK2 causes neuronal degeneration in cell culture. Here we used the GAL4 / UAS system to generate transgenic Drosophila expressing either wild-type (WT1) human LRRK2 or LRRK2-G2019S, the most common mutation associated with PD. Expression of either WT1 human LRRK2 or LRRK2-G2019S in the photoreceptor cells caused retinal degeneration. Expression of WT1 LRRK2 or LRRK2-G2019S in neurons produced adult-onset selective loss of dopaminergic neurons, locomotor dysfunction, and early mortality. Expression of mutant G2019S-LRRK2 caused a more severe parkinsonism-like phenotype than expression of equivalent levels of WT1 LRRK2. Treatment with L-DOPA improved mutant LRRK2-induced locomotor impairment but did not prevent the loss of tyrosine hydroxylase (TH)-positive neurons. To our knowledge, this is the first in vivo “gain-of-function” model which recapitulates several key features of LRRK2-linked human parkinsonism. These flies may provide a useful model for studying LRRK2-linked pathogenesis and for future therapeutic screens for PD intervention.

The invention discloses an application of imatinib mesylate in preparation of drugs for resisting Parkinson's disease (PD). The application of imatinib mesylate (STI571) in preparation of drugs for treating neurodegenerative diseases belongs to the protective range of the invention, and the neurodegenerative diseases can be PD. An experiment proves that by continuous administration of the STI571, the dyskinesia induced by MPTP can be obviously improved, and the cognitive dysfunction of mice can be improved. The STI571 can obviously improve the dopaminergic neuron loss induced by the MPTP, can inhibit the rat CA1 and DG (diacylglycerol) region nerve cell apoptosis reaction induced by rotenone, can obviously inhibit the primary substantia nigra neuron apoptosis and Lewy protein expression induced by rotenone, and can inhibit the phosphorylation activation of PKC (Protein Kinase C) and Akt. The STI571 used as a specific inhibitor of c-Ab1 can resist the formation of PD, can improve the behavioral abnormity and cognitive dysfunction of PD, can be used as a new candidate drug for resisting neurodegenerative diseases such as PD and the like, and has favorable application prospects; and the clinical indications of the STI571 are greatly expanded.