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Application of selenomethionine

A technology of selenomethionine and health products, applied in the application field of selenomethionine, can solve problems such as the research of selenium compounds, achieve significant curative effect, improve memory and cognition

Inactive Publication Date: 2017-05-10
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are many kinds of drugs for the treatment of neurodegenerative diseases, but there is no research on the effect of selenium compounds on the proliferation of neural stem cells.

Method used

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  • Application of selenomethionine
  • Application of selenomethionine
  • Application of selenomethionine

Examples

Experimental program
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Effect test

Embodiment 1

[0054] Selenomethionine (Se-Met) was added to the cell culture medium of neural stem cells (NSCs) at a concentration of 10 μM to observe its proliferation effect on neural stem cells. The effect of different concentrations of Se-Met on the viability of neural stem cells was detected by CCK-8 method; after neural stem cells were pretreated with Se-Met, the proliferation of neural stem cells was detected by 5-bromodeoxyuridine (BrdU) and DAPI immunofluorescence; The effect of Se-Met on the proliferation of neural stem cells was determined by morphological observation and analysis of the rate at which neural stem cells aggregated into neurospheres; the effect of Se-Met on the proliferation of neural stem cells was verified by Western blot (Westen Blot) detection of protein changes related to neural stem cell proliferation. Proliferation of neural stem cells.

[0055] (1) CCK-8 detects the viability of neural stem cells, and the result is: see figure 1 , the effect of selenomethi...

Embodiment 2

[0064] In the pathogenesis of some neurodegenerative diseases, the loss and apoptosis of neurons are important reasons for affecting cognition, and the nerve regeneration in the subgranular layer of the dentate gyrus of the hippocampus is inhibited, which in turn leads to obstacles in the differentiation of newborn neural stem cells into neurons , is also considered to be the main cause of cognitive impairment, so this example explores whether Se-Met can promote the differentiation of NSCs into neurons, and then repair the damaged nervous system.

[0065] After changing the culture medium of neural stem cells, adding Se-Met continuously for 14 days, the neurospheres attached to the wall began to grow neuropils around, and the number of neuropils growing around neurospheres in the Se-Met group was significantly more than that in the Se-Met group. In the control group, microtubule-associated protein (MAP2)-labeled neurons were found around the neurospheres by immunofluorescence s...

Embodiment 3

[0067] In this example, the effect of Se-Met on neural stem cells and the differentiation of neural stem cells into neurons was studied at the animal level.

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Abstract

The invention is suitable for the field of selenium-containing compounds, and provides application of selenomethionine. The application is applying the selenomethionine to preparation of a medicine / health-care product for promoting nerve regeneration. The application of the selenomethionine provided by the embodiment has the advantages that the selenomethionine is used for preparing the medicine / health-care product for promoting nerve regeneration, and the therapy effect on the nerve regeneration of animals is obvious; a certain prevention and therapy function on neurodegenerative disease or nerve system injury is realized, and significant meaning on restoration of nerve system and improvement of memory and cognition is realized.

Description

technical field [0001] The invention belongs to the field of selenium-containing compounds, and in particular relates to an application of selenomethionine. Background technique [0002] Selenium is an essential trace element for organisms, and proper supplementation of selenium has a good effect on the prevention of some major diseases. There are two forms of selenium: inorganic selenium and organic selenium. The common inorganic selenium is sodium selenite and sodium selenate, and the organic selenium is mainly selenoprotein and selenium polysaccharide. However, inorganic selenium is far superior to organic selenium in terms of cumulative toxicity and mutagenicity. Organic selenium has relatively less side effects. It can not only play the role of selenium better, but also is more significant than inorganic selenium in stimulating immune response. Therefore, it is of great significance to isolate or synthesize new selenium compounds from natural products and to study thei...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61P25/00A61P25/28
CPCA61K31/198
Inventor 宋国丽郑瑞张中豪
Owner SHENZHEN UNIV
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