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Compositions, structures and methods for neural regeneration

A technology of nerve regeneration and composition, applied in the field of compositions for promoting nerve growth and/or regeneration, can solve problems such as no effective treatment method, and achieve the effect of inhibiting inhibitory nerve regeneration mechanism and enhancing nerve regeneration

Inactive Publication Date: 2015-08-05
CORMATRIX CARDIOVASCULAR INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Despite medical improvements in restoring nerve function in the CNS via the delivery of selective molecules that block the various nerve growth inhibitors The presence or upregulation of and / or promotion of neural growth and cell survival

Method used

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  • Compositions, structures and methods for neural regeneration
  • Compositions, structures and methods for neural regeneration
  • Compositions, structures and methods for neural regeneration

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Embodiment Construction

[0048] Before describing the present invention in detail, it should be understood that the present invention is not limited to specific exemplary devices, systems, structures or methods, as the above can of course be changed. Therefore, although many devices, systems, mechanisms, and methods similar or equivalent to those described herein can be used in the practice of the present invention, the preferred devices, systems, structures, and methods are described herein.

[0049] It should also be understood that the terms used herein are only for the purpose of describing specific embodiments of the present invention, and are not intended to be limiting.

[0050] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which the present invention belongs.

[0051] In addition, all publications, patents and patent applications cited herein (whether above or below) are incorporated herei...

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Abstract

A nerve regeneration device comprising a support structure having an outer surface and a plurality of conduits extending therethrough, the support structure comprising a first extracellular matrix (ECM) material from a mammalian tissue source, the support structure outer layer including at least a first layer comprising a first ECM composition having at least a second ECM material from a mammalian tissue source. When the nerve regeneration device is deployed proximate damaged neural tissue, the device induces modulated healing of the damaged tissue.

Description

Technical field [0001] The present invention relates to compositions and methods for promoting nerve growth and / or regeneration. More specifically, the present invention relates to extracellular matrix (ECM)-based compositions, structures, and methods for promoting nerve growth and / or regeneration. Background technique [0002] Although soft tissues (such as muscles and skin) and bones have considerable ability to recover after injury, insufficient nerve repair often limits the recovery of normal functions. In the peripheral nervous system (PNS), nerves can often regenerate on their own if the damage is small enough. [0003] Larger injuries can be effectively treated by surgery by directly reconnecting damaged nerve ends with nerve sheaths, or by using grafts obtained elsewhere in the body, where the nerve sheaths were previously adopted by axons in order to reach their destination. However, the clinical function recovery rate after nerve transplantation is usually only close t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/30A61K35/12
CPCA61L27/3675A61K35/12A61L27/3633A61K31/722A61K45/06A61L2300/414A61L27/54A61L2430/32A61L2300/64A61L27/3878A61K2300/00
Inventor 罗伯特·G·马西尼
Owner CORMATRIX CARDIOVASCULAR INC
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