1505 results about "Antibacterial drug" patented technology

The invention is intended for a treatment of severe infections using an injectable drug-delivery system comprising nanoparticles of a biodegradable polymer with incorporated antibacterial drug.

The invention discloses a blending electric spun nanometer fiber film biological compress and preparing method in medicinal biological compress technical domain, which is characterized by the following: choosing chitose or polyvinyl alcohol or water-soluble antibacterial drugs as main raw material; adopting electrostatic spinning method; producing nanometer fiber film. This product possesses the advantages of higher strength, good air perviousness and good biological compatibility.

The invention provides a double-layered bone repairing membrane material and a preparation method thereof and in particular provides a bone repairing membrane material with antibacterial and inflammation-diminishing and bone promotion functions and belongs to the field of biological materials. The material takes biodegradable aliphatic polyester with biocompatibility and natural polymers as main raw materials and is prepared by adopting an electrostatic spinning method. The material has a double-layered membrane structure and comprises an outer layer added with an antibacterial drug and an inner layer added with a bone promotion substance. The material provided by the invention has excellent biocompatibility and a controllable and long-period medicine releasing performance; meanwhile, an outer-layer membrane of the double-layered membrane structure can be used for inhibiting bacterial infection and inflammation, which are easily caused after bone defects occur, and preventing bacteria from entering defected parts; an inner-layer membrane can be used for promoting the repairing of the bone defects. The material can be used for realizing controllable in-vivo degradation according to requirements and the material does not need to be taken out by a second surgery.

The oral cavity quick dissolving and quick disintegrating freeze dried tablet for children includes at least one medicinal active component and at least one medicinal stuffing, adhesive and other supplementary material. It is loose and porous tablet in network structure and prepared through common freeze drying process. The said medicinal active component may be different children's medicines, such as antibiotic, antipyretic, analgesic, cough stopping and phlegm eliminating medicine, cold medicine, etc. Bitter or excitant medicine may be coated and water insoluble medicine is prepared intofine powder of 50 micron below size for stable dispersion in liquid. The present invention has fast disintegration, no jamming in throat, simple preparation process and low cost.

The invention relates to a method of industrial and artificial breeding of Epinephelus, which is applicable to the breeding of Epinephelus malabaricus and E.coioides. The method comprises the following steps: (1) treating a nursery pond and water; (2) preparing before breeding; (3) putting larval fishes of Epinephelus or germ cells; (4) controlling the quality of the breeding water body; and (5) feeding baits. The method is applied to conduct the industrial and artificial breeding, so that the water quality of the breeding is stable, the output for the unit water body breeding is high, the bred sizes of advanced fries are uniform, no antibacterial drugs are used, no special breeding is conducted to unicellular alga, no bottom-attaching happens in the process of breeding, and the operation is simple.

A marine-derived Bacillus velezensis (Bacillus velezensis) BMF 03 having a deposit number of CCTCC NO: 2017374 is disclosed. BMF 03 strain and its aseptic fermentation broth have inhibitory effect onplant pathogenic fungi, including apple rot fungi, grape white rot fungi, mango anthracnose fungi and so on. The aseptic fermentation broth of BMF 03 strain can be used as an active ingredient to prepare an antibacterial drug, and the bacteria is selected from the group consisting of Keratinobacteria, Bacillus subtilis and Ralstonia solanacearum. The invention also discloses a fermentation methodof aseptic fermentation broth of BMF 03. The invention adopts a plate confrontation method and an Oxford cup method to screen a new marine bacterial strain BMF-03 with strong bacteriostatic effect andwide bacteriostatic spectrum, and adopts strain morphological observation, physiological and biochemical tests and 16S rDNA sequence analysis to determine the species relationship of excellent resistant strains. At that same time, the bacteriostatic substance produce by the strain, the sporulation fermentation medium and the shake flask fermentation conditions were also study, and the promoting effect of the strain fermentation broth and the solid fermentation product on the growth of the cucumber seedling was clarified, which laid a foundation for the application of the strain.

The invention provides a chitosan emergent hemostasis material, which is provided with at least two layers of structures: a chitosan hemostasis layer as an upper layer, and a polyacrylic acid grafting chitosan lining layer as a lower layer, wherein the chitosan hemostasis layer is of a structure of a porous microsphere, porous fiber, porous sponge, or a compound of the porous microsphere, the porous fiber and the porous sponge; and the polyacrylic acid grafting chitosan lining layer is of a structure of porous fiber, porous sponge, or a compound of the porous fiber and the porous sponge. According to the chitosan emergent hemostasis material, the polyacrylic acid grafting chitosan is used as the lining layer of the chitosan, so that powerful water suction force can be provided, seepage velocity of blood in the chitosan hemostasis material is improved, blood is further concentrated, the density of the hemostasis material is improved simultaneously, the hemostasis material is easier to sink to arrive at a bleeding point, gravity press of a bleeding part is formed, pressurization is convenient, and the hemostasis effect is improved. Meanwhile, the polyacrylic acid grafting chitosan layer also can be used as a medicine-carrying substrate, can be used for carrying antibacterial drug, acesodyne, factors for promoting tissue repair and the like, and is good for preventing and controlling infection while stopping bleeding, relieving pains, and accelerating wound tissue healing.

The invention discloses genipin cross-linked biogel as well as a preparation method and application thereof. The genipin cross-linked biogel comprises the following raw materials in percentage by weight: 0.05wt%-0.2wt% of genipin, 1wt%-10wt% of matrix and the balance of water. By carrying out crosslinking by virtue of optimized genipin concentration, the obtained biogel has the properties of low toxicity, good water-absorbing property and mechanical property and the like. The biogel can be directly used for protecting and isolating the surfaces of various wounds, bedsores and ulcers, can be used as a dressing carrier to load antibacterial drugs, paregorics, growth factors and the like, and can be applied to the treatment of wound infection, wound analgesia or promotion of wound healing and the like. According to the genipin cross-linked biogel, the matrix, a crosslinking agent and the components are all derived from natural organisms, so that the biogel is safe and non-toxic and can be widely applied to the treatment and repair of clinical acute and chronic wounds.

The invention relates to a microbe vitamin premix material and a method for preparing the same, in particular to a microbe vitamin premix material consisting of a plurality of useful microbes and vitamins and a method for preparing the same. The microbe vitamin premix material comprises bacillus, microzyme, enterococcus, vitamin A, vitamin D3, vitamin E, vitamin K3 and vitamin 12, and is the microbe vitamin premix material generally for pigs, poultries, ruminant or aquatic animals. The microbe vitamin premix material has the animal immunization health care function as well as nutrient efficacy, and can improve illness resistant capability of animals, reduce the consumption of antibacterial drugs in feed, lower the drug resistant degree of bacteria, improve the feed utilization ratio, promote health of mankind and improve the ecological environment.

The invention provides a medical titanium metal implant material and a preparation method thereof. The medical titanium metal implant material includes a titanium metal, titania nanotubes grown on the titanium metal surface in a matrix arrangement, a biodegradable superpolymer coating the end face of a titania nanotube layer in the matrix arrangement and sealing the titania nanotubes, and an anti-inflammatory antibacterial drug loaded in the titania nanotubes. The medical titanium metal implant material has the characteristics of being high in drug loading capacity and capable of making drug properties of the drug slowly released.

The invention relates to a degradable wound repair material and a preparation method thereof. The degradable wound repair material includes a matrix component and an auxiliary component, wherein the matrix component includes a protein ingredient, and the auxiliary component includes at least one of an antibacterial agent and an active factor. Specifically, the antibacterial agent is a synthetic antibacterial drug, an inorganic antibacterial agent, an organic antibacterial agent, or a natural antibacterial agent, and the active factor is at least one of the following active factors: an epidermal growth factor, an FGF vascular endothelial growth factor, a platelet-derived growth factor, a platelet activating factor, an insulin-like growth factor, a tumor necrosis factor, interleukin, colony stimulating factor-1, various bone morphogenetic proteins or transforming growth factors. By loading the antibacterial agent and active factor component on the basis of the matrix component, the degradable wound repair material provided by the invention can have biological activity on the basis of meeting degradability, can better promote wound repair, and has good anti-infection properties during use.

The invention discloses a preparing method of east Asia Tityus antibiotic peptide gene and appliance, which comprises the following steps: restructuring bacillus coli Escherichia coli DH5a / BmKAMP1, CCTCC NO: M207036; constructing east Asia Tityus ioterium cell cDNA library; choosing PCR method; sieving positive colony of scorpion antibiotic peptide gene from ioterium cDNA library; sequence-analyzing coding trait of antibiotic peptide gene; assuring amino acid sequence of the antibiotic peptide gene; adopting chemosynthesis antibiotic peptide; possessing inhibition of diverse density for Gram's bacterium. This antibiotic peptide possesses specificity and high active, which can be used as antibacterial drugs.

The invention belongs to the technical field of determination of antibacterial drug residues in water environment, and in particular relates to a method for simultaneous determination of 92 antibacterial drug residues in the water environment. The method includes an improved solid phase extraction-liquid chromatography-tandem mass spectrometry determination method, and in particular includes (1) water sample pretreatment; (2) use of solid phase extraction for enrichment of various antibacterial drugs in a water sample; and (3) liquid chromatography-tandem mass spectrometry determination method establishment. The sample is fed by one time, can simultaneously determine 92 antibacterial drugs, reduces the detection cost, and improves detection efficiency, and is suitable for the detection of antibacterial drug residues in high flux water environment.

The invention provides a method for preparing cefoxitin (I). It comprises taking 7 alpha- methoxy- 7 beta- aminocephalosporanic acid (7- MAC) as raw material, carrying out 2- thiofuran acetylation reaction, hydrolytic reaction, carbamylation reaction and getting cefoxitin (I). The invention greatly increases the prductivity for cefoxitin and its sodium salt and reduces production cost.

The invention discloses a baicalin metal complex of which the molecular formula is (C21H17O11) xM (H2O) y, wherein M in the formula is Cu (II), x is 1 and y is 2; or M is Fe (III), x is 2 and y is 0; or M is La (III) or Y (III), x is 3 and y is 0. The preparation method comprises the following steps: adding aqueous alkali into baicalin until the baicalin and alkali (sodium bicarbonate, potassium bicarbonate, sodium formate, potassium formate, sodium acetate, potassium acetate, disodium hydrogen phosphate, dipotassium hydrogen phosphate, sodium phosphate or potassium phosphate) are just completely reacted, then adding metal salt (copper salt, ferric salt, lanthanum salt or yttrium salt) for reaction to obtain the baicalin metal complex. The baicalin metal complex has obviously stronger antibacterial and antitumor activities than the baicalin, can be used for preparing antibacterial drugs and antitumor drugs, and has good development and application prospects. In the preparation method, an organic solvent is not used, a strong basic condition is not adopted, and the method is simple and feasible, is green and environment-friendly and has the advantages of low cost, high product purity and high yield.

Nanocomposite biocompatible hydrogels (NCHGs) may be synthesised as model systems for in situ cured local drug delivery devices for treatment of inter alia periodontal infections. The composite includes the following components: nanoparticles (NPs), a matrix gel, and chlorhexidine (CHX) or other antibacterial drug. The NPs were obtained by free radical initiated copolymerization of the monomers, 2-hydroxyethyl methacrylate (HEMA) and polyethyleneglycol dimethacrylate (PEGDMA), in aqueous solution. The same monomers were used to prepare crosslinked matrices by photopolymerization. NCHGs were obtained by mixing NPs, monomers, and drug in an aqueous solution then crosslinked by photopolymerization.

The invention discloses a medical composite chitosan gel containing antibacterial drugs. In parts by weight, the medical composite chitosan gel comprises the following components: 0.5 to 10 parts of chitosan polymer materials, 0.05 ~2 parts of antibacterial drug, 0~10 parts of thickener, 1~25 parts of humectant and 53~98.45 parts of purified water. The medical composite chitosan gel containing antibacterial drugs of the present invention can effectively maintain a moist environment for wound healing, promote wound healing and prevent and control wound infection. The drug combines the advantages of chitosan polymer materials such as moisture absorption, moisturizing, antibacterial, and hemostasis with the role of antibacterial drugs in preventing and controlling infection, and prepares a gel with excellent performance.

The invention provides toad peptide antibiotics separated from toad maggots and a preparation method of antibacterial drugs thereof. The preparation method comprises the following steps: taking toad maggots as raw materials; carrying out ultrafiltration and microfiltration, gel chromatography separation, ultrasonic standing wave liquid preparation chromatography and the like by adopting a solvent extraction method and an ion-exchange resin adsorption method; freeze-drying to prepare the toad peptide antibiotics; and combining the active components with appropriate excipients to prepare tablets, capsules, suppositories, ointments, enteric tablets and the like to be used for treating various diseases. The drugs prepared by the invention have the advantages of wide antibacterial range, specific drug components, controllable quality and stable performance and have industrial production values.

The invention provides a preparation method of a chitosan-based drug-loading composite antibacterial superfine fiber membrane. The preparation method comprises the following steps: S1, adding antibacterial medicine powder into an acetic acid aqueous liquid with mass fraction of 2-90%, stirring by a magnetic stirrer to fully dissolve, weighing chitosan and polyoxyethylene powder into the liquid, and stirring to obtain a spinning liquid; and S2, adding the spinning liquid into an unfolder for electrostatic spinning, putting the obtained electrostatic spinning membrane in a drier holding a 25% glutaraldehyde aqueous liquid for crosslinking for 12-36 hours, drying, and finally obtaining the chitosan-based drug-loading composite antibacterial superfine fiber membrane, wherein the diameter of the fiber is 150-600nm. The electrostatic spinning superfine fiber prepared by the invention has the characteristics of good adhesion, flexibility, good antibacterial performance, hemostasis, percolate absorption, healing and the like. By designing the compounding proportion of chitosan and antibacterial drug, the membrane can satisfy different anti-infection demands, wound nursing of different types and surgical dressing field.

The invention provides a long-acting controlled-release antibacterial real silk woven type surgical suture and a preparing method thereof. The long-acting controlled-release antibacterial real silk woven type surgical suture is characterized by including heart yarn and weaving yarn that are woven, wherein the surfaces of the heart yarn and the weaving yarn are coated with antibacterial coatings; the antibacterial coatings contain macromolecular absorbing material and quinolone antibacterial drugs. As the weaving yarn contains antibacterial drugs, the long-acting controlled-release antibacterial real silk woven type surgical suture has the functions of sterilization and bacteriostasis; as the antibacterial drugs are uniformly dispersed in the macromolecular absorbing material, can be slowly released along with the swelling and degradation of the macromolecular absorbing material, so that the long-acting controlled-release antibacterial real silk woven type surgical suture has the long-acting controlled-release antibacterial effect.

The invention provides a?Penicillium griseofulvum?CPCC400528, the preservation number of which is CGMCC NO.5752. The Penicillium griseofulvum CPCC400528 can be fermented to generate an antibacterial active compound with a molecular formula of C7H6O4 and a structure shown as formula (I). The compound has a good growth inhibition effect on a variety of Gram positive pathogenic bacteria and Gram negative pathogenic bacteria. With the increase of concentration, the inhibition effect is gradually enhanced. Also, the compound has a good inhibition effect on a plurality of drug resistant strains. The Penicillium griseofulvum strain provided in the invention is easy to ferment and culture and has a high yield. The preparation process of the active compound is simple and is easy to control. The prepared compound has obvious antibacterial activity, lays the foundation for research and development of new antibacterial drugs, and has very broad market prospects.

The invention relates to a thermo-sensitive and long-acting antibacterial arginine-group hydrogel dressing and a preparation method thereof. Antibacterial drugs are distributed on the surface of and inside hydrogel. The preparation method comprises steps as follows: L-arginine and sodium bicarbonate are dissolved in distilled water, methacrylic anhydride is dropwise added at 0 DEG C, the mixture is stirred, the pH of the solution is adjusted to be 7.4, the solution is filtered and washed, and a modified arginine monomer (M-Arg) is acquired; two antibacterial drugs, namely, A and B, are combined with an N-isopropylacrylamide monomer and a modified arginine monomer with chemical grafting and drug preloading methods, thermo-sensitive and long-acting antibacterial arginine-group hydrogel is obtained and combined with a matrix, and the thermo-sensitive and long-acting antibacterial arginine-group hydrogel dressing is obtained. Raw materials have good biocompatibility, and the obtained hydrogel dressing has thermosensitivity, can resist bacteria and protein absorption, has a long-acting antibacterial function and is suitable for wound protection and treatment of burns, scalds and traumatic injuries.

The invention relates to a bursin extracting method and its application to curing disease and immunity, having important value in application in the aspects of heightening organismal immunity and acting as immunoenhancer, heightening effect of vaccine, etc., and able to heighten body fluid and cell immune functions of mammal at the same time. It can be used to prevent and cure infectious diseases and young animal diseases singly or together with other drugs such as antivirus and antibacterial drugs or immunomodulators, also be applied to animal vaccine as adjuvant or immunoenhancer to strengthen the disease-resistant ability and immunoresponse ability to peculiar antigens, thus heightening the immune effect.

The invention discloses a method for screening 62 antibacterial drugs in livestock excrement. The method specifically comprises the following steps: (1) preparing a standard working solution; (2) preprocessing a sample to be detected before analyzing; (3) drawing a substrate matching standard curve; (4) performing mass spectrometric analysis on the sample containing a certain amount of drugs in step (3) so as to obtain standard molecular ions and two characteristic ions of each drug; wherein the two characteristic ions include qualitative ions and quantitative ions; (5) performing qualitative analysis; (6) performing quantitative analysis. The screening method is precise, accurate, and high in sensitivity; the technical support is provided to detect the residues of antibiotics in a livestock farm and the surrounding environment and evaluate the potential risk and the influence of the antibiotics residual in the excrement to the environment. Therefore, the method is high in social benefit.

The invention relates to a preparation method for linezolid, which comprises the following steps of: carrying out condensation reaction on N-benzyloxyl hydroxyl-3-fluoro-4-morpholinyl aniline and (S)-N-[2-acetoxyl-3-chloropropyl] acetamide in a solvent and purifying to obtain linezolid, wherein a condensating agent is lithium tert-butoxide, the solvent is a mixed solvent of dimethyl formamide, methanol and dichlormethane in volume ratio of (7-9):(0.8-1.2):(75-85). The preparation method has the advantages of simple operation, shorter reaction time and high yield, and is suitable for industrial production.

The invention relates to a method for extracting high-purity hemoglobin from pig blood, and on the condition of 2 to 6 DEG C, the following operations are carried out sequentially: first, anticoagulant pig blood is used for preparing packed red blood cells; hypotonic solution is used for dissolving packed red blood cells, in which inert gas is pumped, antioxidant is added, the pH value of the solution is adjusted and protective agent and antibacterial drugs are added, and after high-speed centrifugation, crude hemoglobin solution is obtained; toluene is added into the crude hemoglobin solution which is extracted in low temperature and the hemoglobin solution in the lower layer is extracted for dialysis; after being frozen and dried the hemoglobin solution after dialysis is then dissolved into high-concentration and small-volume liquid which is then purified by a sephadex chromatography column as a sample and high-concentration hemoglobin with even molecular weight is obtained to be frozen and dried in vacuum after being filtered for removing pyrogen so as to prepare high-concentration hemoglobin dry powder with no matrix or pyrogen. The hemoglobin obtained through the method of the invention has no matrix or pyrogen, which can be further modified to produce blood substitute safely and effectively and the operation is simple; the cost is low.

The invention discloses application of a molybdenum disulfide / nanosilver composite serving as a matrix to MALDI (matrix-assisted laser desorption / ionization) time of flight mass spectrometry. Few-layer molybdenum disulfide is prepared according to an improved chemical lithium ion intercalation and exfoliation method, on the basis of which the molybdenum disulfide / nanosilver composite is prepared through in-situ reduction of silver nitrate. An analysis method taking molybdenum disulfide / nanosilver composite as an MALDI matrix is applicable to mass spectrometry of micromolecules with molecular weight smaller than 1000 and suitable for molecules of amino acids, oligopeptides, fatty acids, alkaloids, hormones, antibiotics, antibacterial drugs, anticancer drugs and the like. Matrix background interference is avoided when the method is adopted for detection of molecules with a mass-to-charge ratio (m / z) smaller than 1000. The method can be effectively applied to fields of organic and biomass spectrometry, imaging mass spectrometry, protein mass spectrometry, metabonomics, biomarker discovery, environmental analysis and the like.

The invention discloses a medical composite alginate dressing containing antibacterial drugs and a preparation method thereof. In parts by weight, the medical composite alginate dressing comprises the following components: 50-99.9 parts of alginate and 0.05-10 parts of antibacterial drugs, The antibacterial drug is selected from gentamicin or its salt, neomycin or its salt, amikacin or its salt, fusidic acid or its salt, kanamycin or its salt, polycresol , mupirocin, sulfamethonium or its salt and clindamycin or its salt at least one. The medical composite alginate dressing of the present invention has strong ability to absorb exudate, has good water vapor transmission rate, can be biodegraded and has good biocompatibility, does not adhere to the wound and can quickly form gel after absorbing wound exudate , has strong moisturizing properties, can effectively promote wound healing, shorten wound repair time, can effectively prevent or treat sensitive bacterial infections, and can be widely used in acute and chronic wounds with exudate.

The invention discloses a preparation method for a medical titanium alloy surface bio-piezoelectric composite coating. The preparation method comprises the steps that: firstly, a micro-arc oxidation technology is used for generating an inner dense and superficial porous titanium dioxide coating in situ on the surface of a titanium alloy substrate, then a hydrothermal chemistry method is adopted toreact on the titanium dioxide coating in-situ to produce a barium titanate coating, and finally holes of the surface of the polarized coating are filled, that is, a composite coating with bio-piezoelectric characteristics is formed on the surface of the medical titanium alloy. The inner layer of the coating prepared by the method is compact, has good combination with the substrate, has high stability, and can effectively prevent dissolution of harmful metal ions into body fluid; the surperficial porous barium titanate coating can generate a piezoelectric effect, promote local blood circulation, and further accelerate repair of bone; the pores are filled with substances conducive to growth of early bone tissues or antibacterial drugs, at the same time, the rough surface is conducive to cell adhesion and proliferation so that metal materials can have good biocompatibility and biological activity.