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Medical composite alginate dressing containing antibacterial drug and preparation method thereof

A technology of alginate and antibacterial drugs, applied in medical science, bandages, absorbent pads, etc., can solve problems such as easy adhesion of new tissues, secondary trauma of wounds, and destruction of growth factors, and achieve good water vapor transmission rate and promote Effects on healing, biodegradation and biocompatibility

Inactive Publication Date: 2016-10-12
SICHUAN KUIXING MEDICAL POLYMER PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional dressings used on wounds mainly play an isolation and antibacterial role, but often lead to dryness of the wound, damage to healthy growth factors, and easy adhesion to new tissue, which will lead to secondary trauma of the wound when the dressing is removed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] prescription:

[0060] Calcium alginate 99 parts;

[0061] 1 part of gentamicin sulfate.

[0062] Preparation:

[0063] Take the calcium alginate fiber, through opening, carding, and then after passing through the cross-lapper or not, enter the acupuncture equipment for acupuncture or spunlace equipment for spunlace reinforcement; press 100U / cm 2 After spraying evenly into the aqueous solution of gentamicin sulfate (concentration: 160mg / ml), dry it at 80°C; cut and pack the obtained dressing, and then pass Co 60 The medical compound alginate dressing can be obtained by irradiation sterilization.

[0064] The prepared medical composite alginate dressing can absorb wound exudate, provide a moist healing environment for the wound, and play a role in preventing and controlling wound infection. When in use, the medical compound alginate dressing is covered on the affected area, which can be supplemented with secondary dressings such as bandages.

Embodiment 2

[0066] prescription:

[0067] 98.5 parts of calcium alginate;

[0068] 1 part of gentamicin sulfate.

[0069] Tween 20 0.5 parts

[0070] Preparation:

[0071]Get gentamicin sulfate and Tween 20 and add water to dissolve into an aqueous solution, so that the concentrations of gentamicin sulfate and Tween 20 in the solution are 160 mg / ml and 80 mg / ml respectively; take the prescription amount of calcium alginate fiber, pass Opening, carding, and then cross-laying, enter the acupuncture equipment for acupuncture reinforcement to obtain dressings; the dose of gentamicin sulfate is 100U / cm 2 And the content of Tween 20 is 0.5%, and the above aqueous solution is evenly sprayed into the dressing in the form of nano or micro droplets, and dried at 80°C. The resulting dressing was cut, packaged, and then subjected to Co 60 The medical compound alginate dressing can be obtained by irradiation sterilization.

[0072] The prepared medical composite alginate dressing can absorb woun...

Embodiment 3

[0074] prescription:

[0075] 98.5 parts of calcium alginate;

[0076] 1 part of gentamicin sulfate.

[0077] Glycerin 0.5 parts

[0078] Preparation:

[0079] Take gentamicin sulfate and glycerin and add water to dissolve it into an aqueous solution, so that the concentrations of gentamicin sulfate and glycerin in the solution are 160mg / ml and 80mg / ml respectively; take the prescribed amount of calcium alginate fiber, and through opening and combing, Then, after cross-laying, it enters the acupuncture equipment for acupuncture reinforcement to obtain a dressing; the dose of gentamicin sulfate is 100U / cm 2 and the content of glycerin is 0.5%, and the above aqueous solution is evenly sprayed into the dressing in the form of nano or micro droplets, and dried at 80°C. The resulting dressing was cut, packaged, and then subjected to Co 60 The medical compound alginate dressing can be obtained by irradiation sterilization.

[0080] The prepared medical composite alginate dress...

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Abstract

The invention discloses a medical composite alginate dressing containing antibacterial drugs and a preparation method thereof. In parts by weight, the medical composite alginate dressing comprises the following components: 50-99.9 parts of alginate and 0.05-10 parts of antibacterial drugs, The antibacterial drug is selected from gentamicin or its salt, neomycin or its salt, amikacin or its salt, fusidic acid or its salt, kanamycin or its salt, polycresol , mupirocin, sulfamethonium or its salt and clindamycin or its salt at least one. The medical composite alginate dressing of the present invention has strong ability to absorb exudate, has good water vapor transmission rate, can be biodegraded and has good biocompatibility, does not adhere to the wound and can quickly form gel after absorbing wound exudate , has strong moisturizing properties, can effectively promote wound healing, shorten wound repair time, can effectively prevent or treat sensitive bacterial infections, and can be widely used in acute and chronic wounds with exudate.

Description

technical field [0001] The invention relates to the technical field of wound dressings, in particular to a medical composite alginate dressing containing antibacterial drugs and a preparation method thereof. Background technique [0002] The skin and mucous membranes of the human body are the barriers to maintain the stability of the human body environment and prevent the invasion of microorganisms. Damage to the skin and mucous membranes caused by ulcers, trauma, burns and inflammation will cause a series of problems in the body, such as bacterial infection, increased metabolism, Excessive water and protein loss, endocrine and immune system dysfunction, etc., may be life-threatening in severe cases. Good wound care management is of great significance to wound healing. Wounds can generally be divided into mechanical or traumatic wounds, thermal wounds, chemical wounds, ulcerative wounds, and radiation wounds. Inadequate wound management may lead to local or systemic bacteri...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44
CPCA61L15/28A61L15/44A61L2300/404A61L2300/406A61L2300/412C08L5/04
Inventor 莫始奎
Owner SICHUAN KUIXING MEDICAL POLYMER PROD CO LTD
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