67 results about "Mupirocin" patented technology

The invention discloses a soft tissue binder with effects of antibiosis and haemostasis. The soft tissue binder comprises, by weight, 65-75 parts of polymethyl methacrylate, 5-11 parts of chitin, 11-14 parts of cellulose, 4-6 parts of agar, 5-11 parts of mupirocin, 5-11 parts of ethyl acetate, 2-5 parts of defatted silkworm chrysalis powder, 5-15 parts of powder of cortex dictamni, 11-14 parts of radix sanguisorbae powder, 2-5 parts of glutamic acid, 3-5 parts of stannous octoate and 5-10 parts of sodium carboxymethylcellulose. The soft tissue binder with effects of antibiosis and haemostasis has high bonding strength and compressive strength and small irritation on organism tissue, does not contain any harmful reagents, has functions of antibiosis and haemostasis, is suitable for a surgical operation and is especially suitable for soft tissue bonding.

The invention discloses a medical composite alginate dressing containing antibacterial drugs and a preparation method thereof. In parts by weight, the medical composite alginate dressing comprises the following components: 50-99.9 parts of alginate and 0.05-10 parts of antibacterial drugs, The antibacterial drug is selected from gentamicin or its salt, neomycin or its salt, amikacin or its salt, fusidic acid or its salt, kanamycin or its salt, polycresol , mupirocin, sulfamethonium or its salt and clindamycin or its salt at least one. The medical composite alginate dressing of the present invention has strong ability to absorb exudate, has good water vapor transmission rate, can be biodegraded and has good biocompatibility, does not adhere to the wound and can quickly form gel after absorbing wound exudate , has strong moisturizing properties, can effectively promote wound healing, shorten wound repair time, can effectively prevent or treat sensitive bacterial infections, and can be widely used in acute and chronic wounds with exudate.

The present invention relates to the field of bacteriology. In particular, the present invention provides compositions (e.g., comprising a lantibiotic and mupirocin or gentamicin) and methods of treating (e.g., killing or inhibiting growth of) bacteria. For example, the present invention provides pharmaceutical compounds (e.g., comprising a lantibiotic and mupirocin or gentamicin) and methods of using the same in research, therapeutic and drug screening applications.

The present invention provides methods, compositions and diagnostic kits for the detection of Staphylococcus Aureus (SA) and antibiotic resistant forms and variants thereof, such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Staphylococcus aureus (VRSA), mupirocin-resistant Staphylococcus aureus (mupSA), and the like, in a sample population. The invention preferably involves the improvements of bacterial sampling by means of SA enrichment, followed by SA cell disruption and amplification procedures incorporating the use of multiplex assays for SA specific genes, such as mecA and coagulase negative Staphylococci (CONS) specific genes such as tufA, for SA identification and identification of its known species. This provides means for controlling for the thirty or more known CONS species in assessing SA samples, especially those CONS species that may carry antibiotic resistance genes, such as SCCmec.

Spreadable pharmaceutical compositions containing hard fat and Mupirocin, an improved process of preparing same and methods of using same are provided.

The invention relates to a composite ointment used for rapid wound heal and a preparation method thereof. The composite ointment is prepared from following raw materials by weight: 5-20% of resina draconis, 20-60% of a traditional Chinese medicine mixture extraction product, 1-10% of mupirocin, 1-7% of borneol, 10-30% of aloe gel and 5-15% of polyethylene glycol. The traditional Chinese medicine mixture extraction product is prepared by mixing 4-10 parts by weight of pangolin scale, 4-10 parts by weight of garden burnet, 3-7 parts by weight of Chinese angelica, 3-7 parts by weight of radix angelicae, 4-10 parts by weight of arnebia root, 4-10 parts by weight of frankincense, 3-7 parts by weight of myrrh, 4-10 parts by weight of rhizoma picrorhizae, 4-10 parts by weight of sophora flower bud, 4-10 parts by weight of resina draconis, 3-7 parts by weight of cape jasmine fruit and 3-7 parts by weight of rheum officinale, extracting, and concentrating. The composite ointment has functions of promoting blood circulation to remove stasis, arresting pain, stopping bleeding, healing sore, promoting tissue regeneration, expelling the putrefied materials, diminishing inflammation, expelling swell, detoxicating, and the like, is capable of promoting rapid wound heal, and is suitable for pressure sores, diabrosis, erosion, slough, friction burn, eczema, burn, and other symptoms.

The invention discloses a method for preparing a nano-fiber dressing by virtue of an electrospinning method. The preparing method comprises the following steps: preparing a 0.1g / mL type I collagen solution by taking hexafluoroisopropanol as a solvent, and adding lidocaine, so that outer spinning liquid is obtained; preparing a 0.2g / mL polycaprolactone solution by taking dichloromethane as a solvent, and adding mupirocin, so that inner spinning liquid is obtained; and adding the outer spinning liquid and the inner spinning liquid into two injectors, connecting the two injectors by virtue of a coaxial needle, so that a coaxial structure is formed for conducting high-pressure electrostatic spinning, drying an obtained dressing in a vacuum environment and soaking the dried dressing in an ethanol solution of genipin, washing the dressing with ethanol and drying the dressing, so that the nano-fiber dressing is obtained. The prepared nano-fiber dressing is higher in swelling rate and mechanical strength; the nano-fiber dressing is more suitable to be used as a wet dressing and for absorbing exudation; and the nano-fiber dressing is excellent in long-term use resistance, antibacterial performance and the like.

Methods and compositions, including diagnostic kits, for the detection of Staphylococcus Aureus (SA) and clinically important antibiotic resistant forms thereof, such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Staphylococcus aureus (VRSA), mupirocin-resistant Staphylococcus aureus (mupSA), and the like, from individuals in a sample population are disclosed Also disclosed are cost effective methods and kits for bacterial sampling and analysis via inherent and expeditious SA cell disruption methods followed by Direct PCR, circumventing the need, expense and contamination πsks associated with DNA isolation methods These improved methods in conjunction with SA prevalence analysis are applied so as to eliminate the approximately 70% of samples in the human population which do not carry SA (SA negative), followed by a second more costly test for antibiotic resistant forms thereof, such as amplification to confirm for presence of MRSA or other target disease

The invention discloses a fermentation culture medium and a method for preparing mupirocin by virtue of the fermentation culture medium. The method comprises the following steps: breeding pseudomonasfluorescence with good growth state, vigorous vitality and strong metabolic capability, blending a culture medium, carrying out strain activation on pseudomonas fluorescence, and selecting optimal strains for later use; and inoculating the strains to a special seed culture medium so as to increase the quantity of excellent pseudomonas fluorescence, carrying out culturing to a logarithmic phase soas to obtain a seed bacteria solution, and finally, inoculating the seed bacteria solution to the special fermentation culture medium. According to the fermentation culture medium, sufficient nutrients can be provided for pseudomonas fluorescence, the growth and metabolism speeds of pseudomonas fluorescence can be increased, a fermentation liquid containing mupirocin is obtained, and the content of mupirocin in the fermentation liquid is over 6000ug / mL.

The invention discloses melamine cross-linked polyvinyl alcohol hydrogel dressing which is prepared from, by weight, 3-9 parts of water retention films, 1-8 parts of medical pressure-sensitive adhesive, 2-8 parts of acetylsalicylic acid, 2-12 parts of melamine cross-linked polyvinyl alcohol hydrogel, 1-6 parts of mupirocin, 4-12 parts of wood pulp cellulose, 2-6 parts of vitamin A, 4-12 parts of vitamin E, 4-8 parts of protein, 0.2-1 part of perfume essential oil, 0.2-0.8 part of lemon essence and 0.2-1.2 parts of mint essential oil. The melamine cross-linked polyvinyl alcohol hydrogel dressing has good water solubility and conglutination, and can better promote cell growth, acetylsalicylic acid has an antiinflammation effect, the high-performance hydroscopicity of wood pulp cellulose is far better than that of common gauze, vitamin A, vitamin B and protein accelerate blood circulation, skin ageing is relieved, and the essential oil can fade scars and can also make people pleasure. The dressing can promote cell growth and repair and heal wounds, meanwhile can fade scars and whiten and tender skin, is remarkable in treatment effect, has no side effect and is wide in prospect.

The invention discloses a mupirocin purification method and belongs to biotechnology. A high-purity mupirocin product is obtained by using structural characteristics of mupirocin, extracting by composite solvents and regulating the pH (potential of hydrogen) value to remove micromolecules in fermentation liquor and by means of nanofiltration, ion exchange, column chromatography and recrystallization, and the product purity is above 98% by testing so that the product can satisfy the demands of the pharmaceutical industry. The mupirocin purification method has the advantages of advanced technology, simple process, high yield, low cost, high mupirocin purity and the like, and is beneficial to improvement of production technology and industrialization level of the mupirocin in China.

The present application relates to compounded compositions, methods of making compounded compositions, and methods of using compounded compositions. For example, disclosed herein are compounded compositions and methods of making compounded compositions comprising one or more anti-infective agents such as mupirocin and doxcycline.

The invention relates to the field of biotechnology and pharmaceutics, in particular to cyclic gamma-polyglutamic acid (cyclo-gamma-PGA) modified poly-N-isopropylacrylamide (PNIPAM) hydrogel loaded with an antibacterial drug and a preparation method of the hydrogel. The cyclic gamma-polyglutamic acid modified poly-N-isopropylacrylamide hydrogel is loaded with the antibacterial drug to obtain the product. The hydrogel with the three-dimensional network structure prepared by the invention has high biocompatibility, can be used as a drug loading system to load various broad-spectrum antibacterialdrugs such as erythromycin, neomycin, tetracycline and mupirocin, and is applied to the fields of biological medicines, medical auxiliary materials and the like.

The invention discloses a western medicine ointment for eliminating abscess. The ointment is prepared from, by weight, 5-15 parts of erythromycin; 20-30 parts of ciprofloxacin; 10-20 parts of mupirocin; 8-15 parts of polyethylene glycol; 8-15 parts of benzalkonium chloride; 5-10 parts of triethanolamine; 10-15 parts of glycerin; 5-10 parts of laurocapram; 0.1-0.5 part of ethylparaben, 1-3 parts ofsodium lauryl sulfate, 5-15 parts of benzalkonium chloride; 5-10 parts of methyl salicylate; 2-10 parts of diphenhydramine hydrochloride; 5-15 parts of procaine hydrochloride; 100-150 parts of water.The ointment is simple in formula and has effects of promoting ulcer wound healing and eliminating abscess. The ointment has the advantages of exquisite appearance, easy application, moderate consistence, heat resistance, cold resistance, rapid effect and short treatment period and meets the current use requirements.

Disclosed is a cetirizine hydrochloride gelling agent, wherein each 1000g of the gelling agent comprises 100.0g of cetirizine hydrochloride, 0.5-2g of mupirocin, 5.0-10.0g of base, 60-100ml of glycerin propylene glycol, 5.0-10.0g of triethanolamine, right amount of PBS, and balancing distilled water.

An antibiotic inhalation or irrigation composition for the treatment of bacterial infections especially in the respiratory tract, is provided. The antibiotic inhalation or irrigation composition may include a mixture of mupirocin as active pharmaceutical ingredient (API), and a micronized poloxamer composition as excipient. Micronized poloxamer composition may be produced by mixing poloxamer 188 and poloxamer 407 in an apparatus where a low-frequency acoustic field is applied to facilitate mixing. Antibiotic inhalation or irrigation composition may be obtained in powder or solution form. In other embodiments, antibiotic inhalation or irrigation composition may be employed to produce a topical formulation for the treatment of traumatic skin lesions. In some embodiments, other suitable poloxamers or sugar alcohols may be employed as excipients. Due to the synergistic effect of micronized poloxamer composition, antibiotic inhalation or irrigation composition may provide improved solubility and bioavailability of mupirocin, thus decreasing side effects and time of treatment.

The invention relates to the technical field of microorganisms, and particularly discloses a pseudomonas fluorescens fermentation medium, a culture method and application. The pseudomonas fluorescensfermentation medium contains urea and sodium molybdate, and the mass ratio of the sodium molybdate to the urea is (1-5):(10-30). In addition, glucose, glycerin and soybean oil are used as carbon sources, corn steep liquor is used as a nitrogen source, and sodium chloride, leucine, calcium carbonate and a defoaming agent are included. When the culture medium is used for fermentation culture of pseudomonas fluorescens, the cell activity of pseudomonas fluorescens can be remarkably improved, and the fermentation yield of mupirocin is remarkably increased. In addition, the culture method is low incost, simple and convenient in culture and fermentation process, suitable for popularization and application and suitable for industrial production of mupirocin.

The invention discloses a method for purifying a pseudomonas acid A, which comprises the following steps: 1) absorption: absorbing solution containing the pseudomonas acid A with resin; 2) desorption: desorbing the pseudomonas acid A from the resin in the step 1) by using a solvent to obtain a desorption solution containing the pseudomonas acid A; and 3) processing the desorption solution containing the pseudomonas acid A obtained by the step 2) to obtain the pseudomonas acid A. The recovery rate and purity of pseudomonas acid A purified by the method provided by the invention reach 79 percent and over 98 percent respectively. The method for purifying the pseudomonas acid A (mupirocin) by using resin of the invention has obvious advantages in aspects of ecology, environmental protection, economy and industrial large-scale production.

The invention discloses a method for purifying mupirocin. The method comprises the following steps: filtering with a fermentation broth membrane; carrying out solid-liquid separation on a mupirocin fermentation broth through membrane filtration so as to obtain filtrate; carrying out membrane concentration on the filtrate, namely carrying out membrane concentration on the filtrate obtained in the step 1) till the content of mupirocin in the concentrated liquid is 40000-60000mu g / mL; further carrying out extraction, dehydration, concentration and crystallization, thereby obtaining the mupirocin.By adopting the method disclosed by the invention, large-scale industrial production of the mupirocin can be achieved, GMP (Good Manufacturing Practice) production requirements can be met, conventional production procedures can be simplified, the production efficiency can be improved, and environmental protection is realized and pollution can be reduced.

The invention discloses a method for purifying a pseudomonas acid A, which comprises the following steps: 1) absorption: absorbing solution containing the pseudomonas acid A with resin; 2) desorption: desorbing the pseudomonas acid A from the resin in the step 1) by using a solvent to obtain a desorption solution containing the pseudomonas acid A; and 3) processing the desorption solution containing the pseudomonas acid A obtained by the step 2) to obtain the pseudomonas acid A. The recovery rate and purity of pseudomonas acid A purified by the method provided by the invention reach 79 percent and over 98 percent respectively. The method for purifying the pseudomonas acid A (mupirocin) by using resin of the invention has obvious advantages in aspects of ecology, environmental protection, economy and industrial large-scale production.

Anhydrous topical gel composition of mupirocin or its salts comprising: a) a lipophilic base selected from the group consisting of petrolatum, medium-chain triglycerides, isopropyl myristate and mixtures thereof; b) a bioadhesive selected from the group comprising polyvinylpyrrolidone and polymethacrylates; and c) a solvent selected from the group comprising ethanol, propanol, and isopropanol; which is stable and shows an increased residence time of the active ingredient in the skin, resulting in an improved clinical effect in the treatment of bacterial skin infections while maintaining the safety profile of the commercial pharmaceutical product.

The invention discloses a preparation method for a mupirocin ointment. The mupirocin ointment is prepared from, by mass, 1-5 parts of a main drug mupirocin, 19-80 parts of polyethylene glycol 3350 and 19-80 parts of polyethylene glycol 400. The preparation method comprises the steps that the polyethylene glycol 3350 is dissolved at 80 DEG C until the solution is clear to obtain a polyethylene glycol 3350 solution; the main drug mupirocin is dispersed with the polyethylene glycol 400, the mixture is added into the polyethylene glycol 3350 solution, 80-DEG C heat preservation is performed for 30 min, low-speed stirring is performed, it is guaranteed that the main drug mupirocin is completely dissolved, and materials are obtained; cooling water is started, high-speed stirring is started at the speed of 600 r / min for 30 min in the cooling process until the materials are cooled to 55 DEG C, then a high-speed emulsification head is started, a 3000-r / min high-speed shearing state is kept until the materials are cooled to 38 DEG C, and the material is discharged and filled. According to the preparation method, the particle size of 95% of the prepared materials is smaller than 50 micrometers, and the problem that filling amount cannot be controlled in the filling process is solved.

The invention relates to a compound cedrela sinensis hand washing liquid, which is prepared from the following components in parts by weight: 165 to 180 parts of cedrela sinensis bark, 320 to 345 parts of cedrela sinensis leaves and 0.5 to 1 part of mupirocin. According to the compound cedrela sinensis hand washing liquid which is provided by the invention, the cedrela sinensis bark and the cedrela sinensis leaves are mainly used as raw materials; the cost is low; moreover, the prepared hand washing liquid has a favorable fragrance, and is easily accepted by a person; an essence-kind additive is not added necessarily any more; the vegetative raw materials and a minute quantity of the mupirocin are used, and compared with the singly used vegetative raw materials or mupirocin, the compounded hand washing liquid is better in sterilizing effect; moreover, a sterilizing agent is lower in concentration and good in safety.

The invention discloses a swelling and pain relieving ointment, relates to the technical field of external ointment and aims to solve the problems that existing ointments have single components and cannot remove root causes. The ointment is prepared from raw materials as follows: Vaseline, erythromycin, mupirocin, borneol, iodine tincture, glycerin, laurocapram, procaine hydrochloride, diphenhydramine hydrochloride and traditional Chinese medicine composition. The invention also discloses a preparation method of the swelling and pain relieving ointment. The prepared ointment is fine in appearance, easy to coat, medium in thickness and resistant to cold and heat and has the functions of promoting healing of ulcer wounds and removing abscess, Vaseline is used as a matrix, borneol fully playsthe role in relieving pain and promoting granulation, iodine tincture and erythromycin inhibit bacteria and diminish inflammation, traditional Chinese medicines are added for matched use, so that theointment has effects of dredging collaterals, reducing phlegm, resolving masses, promoting blood circulation to remove blood stasis and relieving swelling and pain, western medicines and traditionalChinese medicines have a synergistic effect, the swelling and pain relieving effect is better, and the ointment has wide market prospects.

The invention discloses an anti-adhesion membrane having effects of diminishing inflammation and resisting bacteria. The anti-adhesion membrane comprises the following components in parts by weight: 40-50 parts of polyhydroxyalkanoate, 3-10 parts of lemon peel pectin, 3-8 parts of metronidazole, 5-15 parts of glycerol, 5-11 parts of mupirocin, 1-3 parts of pimaric acid, 2-8 parts of divinylsulfone, 3-8 parts of succinic acid, 2-5 parts of glutamic acid, 11-14 parts of radix sanguisorbae powder, 3-7 parts of aloin, and 10-20 parts of wrinkled gianthyssop herb powder. The anti-adhesion membrane having effects of diminishing inflammation and resisting bacteria disclosed by the invention has the effects of diminishing inflammation and resisting bacteria, and good biocompatibility, and is degradable, convenient to use, good in biodegradability, free of irritation to tissues, and non-toxic and harmless to the human body, and can be widely applied to the medical field.

The present invention relates to a topical pharmaceutical composition comprising mupirocin and beclomethasone, a process for its preparation, its use in the treatment of infected dermatoses caused by bacteria susceptible to mupirocin and in the treatment of secondary bacterial infections in patients of steroid responsive dermatoses.

The invention relates to a cannabidiol-tannic acid-polyvinyl alcohol hydrogel wound dressing and a preparation method thereof. The method comprises the steps of preparation of a hydrogel precursor, preparation of a drug-loaded hydrogel precursor and preparation of drug-loaded hydrogel. According to the cannabidiol-tannic acid-polyvinyl alcohol hydrogel wound dressing disclosed by the invention, cannabidiol and mupirocin are used as main medicinal components in the wound dressing, and hydrogel is prepared from tannic acid and polyvinyl alcohol through a freeze thawing method. The cannabidiol-tannic acid-polyvinyl alcohol hydrogel wound dressing prepared by the method has the characteristics of bacteriostasis and anti-inflammation, and can protect an affected part, prevent wound infection and promote wound healing.