894 results about "Stannous octoate" patented technology

A method of forming a three-dimensional object by bottom-up three-dimensional fabrication by irradiating a polymerizable liquid to produce the three-dimensional object, is described. In the method: (i) a Lewis acid or an oxidizable tin salt (e.g., stannous octoate) is included in said polymerizable liquid in an amount effective to accelerate the formation of said three-dimensional object during said fabrication; and / or (i) the three-dimensional object is irradiated after forming to further polymerize unpolymerized material remaining in the three-dimensional object.

The invention discloses an injectable type fast curing medical polyurethane compound and a preparation method thereof. The compound comprises the basic components of a polyurethane component (A) and a curing agent (B) which can be cured after being mixed, wherein the polyurethane component comprises aliphatic series diisocyanate and polymer of polyhydric alcohol, a molar ratio of NCO (isocyanate) and OH (oxyhydrogen) in polyhydric alcohol is (0.5-4):1; and polyhydric alcohol is composed of macromolecule linear-chain polyhydric alcohol polymer and C1-4 micromolecule polyhydric alcohol together, and the molar ratio between macromolecule linear-chain polyhydric alcohol polymer and C1-4 micromolecule polyhydric alcohol is (4.0-0.5):1. The curing agent (B) is composed of micromolecule polyhydric alcohol, stannous octoate and / or tertiary amine compound catalysts. The compound can be quickly cured after being mixed at the normal temperature, particularly can be quickly cured in the containing water environment, and has an excellent mechanical property and a micro-expanding characteristic after being completely cured. The curing of the polyurethane component has a high conversion rate above 90%, and the polyurethane component has a good biocompatibility and a wide application prospect in various biomedical fields where the polyurethane component can be preferentially applied and not only limited to dentistry filling seal.

A graphene oxide modified silicone rubber composite material of the present invention, calculated in parts by weight, consists of 100 parts of phenyl silicone rubber, 0.01-0.2 parts of graphene oxide modified by silane coupling agent or graphene oxide modified by isocyanate , 1-3 parts of stannous octoate, 1-10 parts of tetraethyl orthosilicate. The present invention also provides a preparation method for the above-mentioned graphene oxide modified silicone rubber composite material, wherein the modified graphene oxide is ultrasonically dispersed, and added to the silicone rubber to form a uniform mixed solution by ultrasound, and the solvent is removed in a vacuum oven , add a catalyst and a curing agent, pour into a mold for vacuum defoaming, and cure at room temperature to obtain a graphene oxide-modified nanocomposite material. The invention utilizes silane coupling agent and isocyanate to improve the compatibility of graphene oxide, significantly improves the dispersion of graphene in phenyl silicone rubber, and the prepared phenyl silicone rubber material has excellent dielectric properties and thermal conductivity properties and mechanical properties.

The invention discloses an amphiphilic triblock copolymer with acid sensitivity and a preparation method and an application thereof. The preparation method comprises the following steps of: modifying polyethylene glycol with a hydroxyl group at the end to enable the structure of polyethylene glycol to contain a diazido ethyl diacetal end group, namely polyethylene glycol contains the diazido ethyl diacetal group at the end; carrying out ring-opening polymerization on cyclic ester monomers by utilizing propargyl alcohol as an initiator and stannous caprylate as a catalyst to obtain biodegradable polyester with alkynyl at the single end; and finally, under the action of a 'click' chemical catalyst and ligand, carrying out 'click' chemical reaction on polyethylene glycol containing the diazido ethyl diacetal group at the end and the biodegradable polyester with alkynyl at the end to obtain the biodegradable amphiphilic triblock copolymer with acid sensitivity. The biodegradable amphiphilic triblock copolymer with acid sensitivity has good biocompatibility, biodegradability and acid sensitivity, and can be used as a drug carrier.

The invention discloses a preparation method for anode material of tin-cobalt alloy / carbon nanofiber film lithium ion battery. The method process comprises a first step of preparing a polymer nanofiber film via electrostatic spinning with proper electrostatic spinning parameters by a uniform electrostatic spinning solution which is formed by employing stannous octoate as a tin precursor, cobalt acetate as a cobalt precursor, polyacrylonitrile as a carbon nanofiber precursor and an organic solvent; and a second step of preparing the tin-cobalt alloy / carbon nanofiber film by using a pre-oxidation treatment and a carbonization treatment. The tin-cobalt alloy / carbon nanofiber composite film prepared by the method effectively improves specific capacity and cycle performance of the anode material of the lithium ion battery, because tin-cobalt alloy particles are uniformly dispersed in the carbon nanofibers with uniform diameters; cobalt metal component increases conductivity of the material and can buffer volume change to a certain degree when the tin metal is charged and discharged; and simultaneously the carbon fibers can further play a role for buffering the volume change of the materials.

The invention belongs to the filed of biopolymer material synthesis, relates to a preparation method of a polyethylene glycol monomethyl ether-dl-polylactic acid block copolymer. The method includes the following steps of: adding a solvent with volume more than 3-6 times of total weight of reagents into a dried reactor, adding stannous octoate as a catalyst, and polyethylene glycol monomethyl ether and dl-lactide whose weight ratio is in the range of 65:35 to 20:80, introducing nitrogen, removing air, then heating and reacting, pouring a product into a compound of petroleum ether-carbon dioxide dry ice, simultaneously, violently stirring, obtaining the needed product after drying a white filtered solid in a vacuum drying oven. The new-type solvent is used in the invention, and a novel purification processing method is provided and is simple and easily controlled, the copolymer with a certain amount of molecular weight can be synthesized according to the specified requirement, and the requirement of further producing a pharmaceutical preparation is met.

The invention discloses a graphene oxide-polyurethane compound foam as well as preparation method and application thereof. Specifically, the preparation method comprises the following steps: under the condition of room temperature, synthesizing polyurethane foam with porous framework by adopting foaming technology and taking the raw materials as polyether polyol, polyisocyanates, foam stabilizer, triethylene diamine, stannous octoate, water, nano calcium carbonate and graphene oxide, immersing the obtained polyurethane foam with porous framework in the graphene oxide solution, adding the cross-linking agent and performing cross-linking reaction, washing with the water and drying to obtain the graphene oxide-polyurethane compound foam. Compared with the common polyurethane, the graphene oxide-polyurethane compound foam has higher adsorption efficiency, stronger hydrophobic lipophilic and mechanical property, has advantages in the aspects of oil storage transportation and water surface / underwater oily waste treatment and has no secondary pollution to the environment; the raw materials are easy to obtain and the preparation is convenient for large-scale industrial production.

A process for preparing lactic acid graft modified starch and starch grafted aliphatic polyester copolymer includes such steps as adding starch and lactic acid to organic solvent, heating while stirring for dewatering-polycondensating reaction, dewatering it toluene or xylene while graft reaction between the hydroxy on the surface of starch and lactic acid to obtain starch lactate (or oligolactate), and open-loop copolymerizing between said product, stannous octoate as trigger and epsilon-caprolactone or lactide. Its advantages are full biodegradability, high plasticity and machinability and high resistance to acid, alkali, and water.

The invention provides a polyurethane potting sealant, which is composed of a component A and a component B. The polyurethane potting sealant includes a diluting agent containing fatty acid methyl ester or dioctyl phthalate and a catalyst containing dibutyltin laurate or stannous octoate. The component A contains (by weight percentage) hydroxyl-terminated polybutadiene (HTPB) 60% to 80%, the diluting agent 10% to 25%, and carbon black 5% to 15%. The component B contains (by weight percentage) liquefied diphenylmethane-diisocyanate (DMI) 80% to 95% and the catalyst 5% to 20%. The polyurethane potting sealant of the invention has the advantages of low potting viscosity, good leveling property and less formation of air vents.

The invention discloses a hydroxylapatite / biodegradable polyester composite material and a preparation method thereof. The preparation method includes the following steps: under conditions of no water, no oxygen, and argon protection, the composite material is obtained by carrying out an in-situ polymerization reaction of hydroxyapatite and an aliphatic cyclic monomer under catalysis of stannous octoate; the aliphatic cyclic monomer is selected form at least one of lactide, epsilon-caprolactone and glycolide; and the composite material provided by the invention comprises hydroxylapatite and a biodegradable polyester. The composite material provided by the invention has the surface enriched with a hydroxylapatite layer having a biological activity, and has an excellent biological compatibility and the biological activity; an biological activity interface can rapidly induce calcium ion deposition in a physiological environment so as to induce nucleation and growth of apatite, and imitates inorganic / organic components of a natural bone matrix in composition; based on the above characteristics, the modified hydroxylapatite / biodegradable polyester composite material is a good support material for repairing bone defects, and has good application prospects in the fields of cell expansion and bone tissue engineering.

The invention has supplied a method to prepare aliphatic polyester compound material of biological ceramic and biological degradation. Biological ceramic nm / mm particle reacts with glycolic acid in the dehydrating condition of boiling with toluene, or with biological ceramic and glycolic acid in inorganic solvent. By graft on the surface of the biological ceramic particle, acquire the chemical strycture of -biological ceramic, then without water and oxygen, with stannous octoate as initiator, initiate hydroxyl group of glycolic acid loaded with caprolactone, lactide, diglycolide and cyclic ester, acquiring the product of them and nm / mm compound material of copolymer. The biological ceramic modified by glycolic acid and loaded with polyester of surface graft can be used for polyester material directly.

The invention discloses an anti-pollution flashover coating and a preparation method thereof. The anti-pollution flashover coating consists of the following compositions in part by weight: 20 to 40 parts of hydroxyl-terminated polyorganosiloxane, 4 to 8 parts of modified silicon fluorine resin, 1 to 3 parts of small molecular siloxane, 3 to 6 parts of nanometre silicon dioxide, 1 to 3 parts of decabromdiphenylethane (DBDPE), 1 to 3 parts of wollastonite, 4 to 8 parts of aluminium hydroxide, 1 to 2 parts of pigment, 1 to 6 parts of crosslinker, 0.02 to 1 part of catalyst and 30 to 60 parts of solvent, wherein the small molecular siloxane is trimethyl end-capped polydimethylsiloxane; the catalyst is dibutyltin dilaurate or stannous octoate; and the solvent is a mixed solvent of dimethylbenzene and butyl acetate in a weight ratio of 3:1-5:1. The prepared coating has the advantages of high flame retardant grade and good anti-pollution effect.

The invention relates to a preparation method of sulfonate amphoteric polyurethane emulsion, comprising the following steps: adding oligomer polyalcohol subject to vacuum dehydration and isocyanate into a reactor under the protection of dry nitrogen, mechanically stirring the oligomer polyalcohol and the isocyanate to react for 2h at 85-100 DEG C, reducing the system temperature to 40-60 DEG C, adding a micro-molecule chain extender, a solvent, a catalyst stannous octoate (T-9) and dibutyltin dilaurate (T-12), and maintaining the temperature to react for 2h at 55-75 DEG C; reducing the systemtemperature below 60 DEG C, and adding a positive ion chain extender and the solvent to control the temperature between 40 DEG C and 60 DEG C to react for 1h; adding the sulfonate and the solvent; adding water to carry out emulsion dispersion until the content of an isocyanate group can not change in a generated prepolymer to be reacted; and decompressing, distilling and desolventizing to obtain the sulfonate amphoteric polyurethane emulsion. The prepared sulfonate amphoteric polyurethane emulsion has a certain acidity-alkalinity resistance and can be used as an excellent carrier of a biological macromolecule and a more ideal protein model compound.

The invention discloses high-purity lactide and a preparation method thereof. The preparation method comprises the steps of raw material addition, free water removal, polycondensation, depolymerization, distillation and secondary distillation. The raw material addition step refers to that a catalyst is added into L-lactic acid or D-lactic acid, wherein the catalyst is one or more of zinc oxide, stannous oxide and stannous octoate. In the preparation process, the use of an organic solvent, N2 and inert gas and environmental pollution are avoided, the vacuum degree is moderate, purification loss is reduced, the production cost is reduced, and the method is suitable for industrial production. The L-lactide or D-lactide product prepared by the method is high in yield, optical purity and quality, the yield is more than or equal to 97 percent, and the optical purity of the purified lactide is 99.45 percent or above.

The invention relates to the technical field of chemical adhesives and aims at providing a preparation method of a dual-component solvent-free type polyurethane adhesive for composite flexible packaging. The preparation method comprises the following steps: (1) preparing an A component: sequentially adding polyether polyol with -OH end, castor oil, natural polysaccharides and a catalyst into a reaction kettle, stirring, heating to 60-80 DEG C, and performing vacuum dehydration; and cooling to room temperature, discharging, sealing and packaging; (2) preparing a B component: adding castor oil and polyisocyanate into the reaction kettle, stirring, and performing vacuum dehydration; adding stannous octoate and triethylene diamine under nitrogen production conditions, and heating to 60-80 DEG C; stopping the reaction when the content of NCO is constant, cooling to room temperature, discharging, sealing and packaging; and mixing the two components according to an OH / NCO functional group. According to the preparation method disclosed by the invention, an organic solvent is not used, the pollution is avoided, and the safety is high; raw materials are green, environment-friendly, degradable, easy to obtain and low in cost; the dual-component solvent-free type polyurethane adhesive further has the advantages of water (hydrolysis) resistance, flexibility and low temperature resistance; and a natural polysaccharide is used as a cross-linking agent, so that the cross-linking density and the bonding strength are improved.

The invention relates to a Y-shaped three-arm segmented copolymer of aliphatic polyester namely polyamino acid and a process for synthesis, which belongs to the high-polymer biological medicine material field. And the process for synthesis comprises protecting amidogens of 2-amidocyanogen-1 and 3-propylene glycol with benzyl chloroformate, ringopening and polymerizing 2-amidocyanogen-1 and 3-propylene glycol with aliphatic cyclic esters monomer in benzene or toluene dissolvent under the condition of warming up and stirring and without water and oxygen through utilizing stannous octoate as catalyst, utilizing amidogens to be macromolecule initiating agent after de-protecting, triggering alpha- amino acid-N-carboxylic acid anhydrides to ring-open and polymerize, getting Y-shaped segmented copolymer of carboxy group which is protected by benzyl group, forming relative polymer with free carboxy group through dewatering hydrogen bromide or catalyzing hydrogenating and deacidizing palladium-charcoal, and then getting the Y-shaped segmented copolymer which can be biodegraded and can have biology functionalization. The invention can be widely applied in the filed such as internal fixation of bone fracture, medicinal carrier, tissue engineering scaffold and the like.

The invention discloses a nano-antibacterial low-surface energy organosilicon luminescence anti-fouling paint, which comprises the following components by weight: 25-35 parts of component A, 2-5 parts of component B and 1 part of component C; the component A comprises 25.0-50.0 parts of nano fluorescence pre-dispersion, 5-25.0 parts of organosilicon quaternary ammonium salt and 0.5-5.0 parts of silicone oil; the component B comprises 3.0-50.0 parts of crosslinking curing agent and 1.0-10.0 parts of silane coupling agent; The component C comprises 0.1-3.0 parts of catalyst; and the catalyst is at least one of stannous octoate, dibutyl tin diacetate and dibutyltin dilaurate. The paint has long persistence luminescent performance, has can prevent pollution by depending on fluorescence and enables contact sterilization, and has advantages of excellent antifouling performance, high strength and high adhesive force, can be used for various ships, sea petroleum platforms, marine structure and facility, marine aquaculture nets.

The invention discloses a terminal amidocyanogen star-shaped lactic and glycolic acid / polyethyleneglycol segmented copolymer, a preparation method, drug-loaded nano-micelle and application thereof. The preparation method of the terminal amidocyanogen star-shaped lactic and glycolic acid / polyethyleneglycol segmented copolymer: (1) glycolide, polyhydroxy activator, stannous octoate and lactide are added into a polymerized tube sealing for vacuumized nitrogen permutation and reaction, and terminal hydroxyl star-shaped lactic and glycolic acid can be obtained; (2) butanedioic anhydride is added for reaction to prepare terminal carboxyl group star-shapedl actic and glycolic acid; (3) the terminal carboxyl group star-shaped lactic and glycolic acid is dissolved in anhydrous toluene, then doublepointed amidocyanogen polyethyleneglycol, N and N'- dicyclohexylcarbodiimide are added for reaction, solvent is evaporated to dryness and aether is added for sedimentation to prepare the terminal amidocyanogen star-shaped lactic and glycolic acid / polyethyleneglycol segmented copolymer which can form about 100nm of micelle automatically in water solution. Hydrophobic nature drugs can be loaded in the caryon of the micelle and putamen surface of the micelle is rich of high activity and freedom terminal amidocyanogen arms that can couple with various bioactivators to achieve the effect of targeted release.

The invention discloses a preparation method of polyurethane foam materials based on liquefied lignin calcium sulfonate polyalcohol. The preparation method is characterized in that through being metered in parts by weight, 100 parts of polyether polyol is added into a reaction kettle, 5 to 100 parts of lignin calcium sulfonate is added, the reaction lasts 1 to 5 hours at the temperature being 150 to 190 DEG C and the pressure being 1 to 3 MPa, and liquefied lignin polyalcohol is obtained; 100 parts of liquefied lignin polyalcohol is respectively mixed and stirred with 2.5 to 5 parts of foaming agent water, 0.8 to 1.2 parts of foam stabilizers, 0.2 to 0.6 part of triethylene diamine, then, 0.3 to 0.5 part of stannous octoate is added, the stirring is carried out, and ingredients A are obtained; and crude diphenylmethane-4,4'-diisocyanate is taken as ingredients B, the ingredients A and the ingredients B are mixed according to a weight ratio being (0.95-1.1):1 and take reaction for foaming and curing by a high-pressure foaming machine, and the polyurethane foam materials are prepared. The preparation method has the advantages that the process is simple, green and clean effects are realized, and good market prospects are realized.

The invention discloses a soft tissue binder with effects of antibiosis and haemostasis. The soft tissue binder comprises, by weight, 65-75 parts of polymethyl methacrylate, 5-11 parts of chitin, 11-14 parts of cellulose, 4-6 parts of agar, 5-11 parts of mupirocin, 5-11 parts of ethyl acetate, 2-5 parts of defatted silkworm chrysalis powder, 5-15 parts of powder of cortex dictamni, 11-14 parts of radix sanguisorbae powder, 2-5 parts of glutamic acid, 3-5 parts of stannous octoate and 5-10 parts of sodium carboxymethylcellulose. The soft tissue binder with effects of antibiosis and haemostasis has high bonding strength and compressive strength and small irritation on organism tissue, does not contain any harmful reagents, has functions of antibiosis and haemostasis, is suitable for a surgical operation and is especially suitable for soft tissue bonding.

The invention discloses a preparation method for thermoset high temperature resistant methyl phenyl silicone resin, which relates to the technical field of resin preparation and comprises the steps of utilizing toluene or dimethylbenzene or mixed solution of the toluene and dimethylbenzene to serve as a solvent, utilizing methyl trichlorosilane, dichlorodimethylsilane and methylphenyldichloros as monomer raw materials, dropping mixed solution of acetone and water into the raw materials under the condition of ice-water bath, ensuring that the dropping is finished within 3-5 hours, obtaining a prepolymer of the methyl phenyl silicone resin, performing condensation and curing on the obtained prepolymer above 150 DEG C after pressure of the prepolymer is reduced and the prepolyme is concentrated, the adopted condensation catalyst is caprylate or naphthenate, particularly is stannous octoate, zinc isoocatanoate, cobalt naphthenate and dibutyltin dilaurate. The resin is semi-transparent hard or elastic solid, can not be dissolved or fused, and can be resistant to high temperature above 200 DEG C, and can be used as silicon rubber or a plastic filler.

The invention relates to a targeted polymer medicament carrier and a preparation method and application thereof. The targeted polymer medicament carrier has a molecular structural formula shown in the graph. The preparation method comprises the following steps of: a) feeding Pluronic and Biotin in a molar ratio of 1:1.1-1.5; dissolving the mixture in dichloromethane; adding 4-dimethylamino pyridine; dropwise adding 1,3-dicyclohexyl carbodiimide in an ice water bath; reacting at room temperature for 24 to 48 hours; extracting reactive fluid with 10 to 15 percent NaHCO3; freezing over night; filtering to remove undissolved substances; concentrating the reactive fluid; dropping the reactive fluid into cold absolute ethyl ether; filtering, and drying in vacuum; and b) dissolving a product with dry toluene, and distilling the product in the presence of argon gas; dehydrating by an azeotropy method; cooling to the room temperature; adding lactide according to 50 to 90 percent of the weight of the product in the presence of the argon gas, and adding stannous octoate according to 0.1 to 0.15 percent of the weight of the lactide; heating to the temperature of between 120 and 140 DEG C; reacting for 6 to 8 hours under stirring; immersing a reactant into the cold ethyl ether, and filtering; and dissolving polymer by using dichloromethane, immersing into methanol, and filtering and drying. The carrier can be used as carriers of medicaments for treating and diagnosing cancers.

A high-molecular mPEG-PLGA-mPEG (PELGE) used as the axcessory of injection, oral-applied medicine, and the water-soluble medicine or the medicine difficult to dissolve in water is an amphipathic three-block copolymer, which is prepared from stannous octoate as catalyst, diisocyanate as coupling agent, polyethene glycol with single terminated end, glycollide, and lactide or polylactic acid-glycollic acid copolymer.

The invention discloses a carboxymethyl cellulose grafted polylactic acid amphiphilic polymer, as well as a preparation method and an application thereof. The method comprises the following steps: dissolving carboxymethyl cellulose in an ionic liquid to form a homogeneous solution; adding grafting monomers, namely L-lactide monomers and a catalyst, namely stannous octoate into the homogeneous solution; controlling the temperature at 100 DEG C-130 DEG C, performing magnetic stirring, reacting for 18-24 hours in the presence of nitrogen, stopping the reaction and reducing the temperature of a system to room temperature; pouring the reaction system into ethanol to produce a precipitate, filtering and separating the precipitate, and washing with anhydrous ethanol; performing extraction on an obtained product in acetone, and performing vacuum drying to get the purified carboxymethyl cellulose grafted polylactic acid amphiphilic polymer. A dialysis method is utilized for forming self-assembled nanosphere-like micelles of the carboxymethyl cellulose grafted polylactic acid amphiphilic polymer, the particle size is 30-150nm, the critical micelle concentration is 0.01-0.1g / L and the anti-dilution stability is good.

The invention provides a hydrophilic soft sponge, and relates to the technical field of polymer materials. The hydrophilic soft sponge has a developed and interconnected pore structure and a polyurethane framework structure connecting the pore structure, and high-water-absorbent resin is combined in the polyurethane framework structure. The hydrophilic soft sponge is prepared from the following raw materials: polyether polyol, toluene diisocyanate, dichloromethane, silicone oil, water, dimethethanolamine, stannous octoate, cellulose, super absorbent polymer (SAP) resin, porous adsorption powder subjected to surface coupling coating treatment, and a non-ionic surfactant. The hydrophilic soft sponge provided by the invention has the characteristics of softness, slow rebound, high water absorption ratio, high water absorption speed and high water retention rate; the water absorption capacity is high; and when the hydrophilic soft sponge is impacted by an external force, dehydration does not occur easily, and the water retention is good.

The invention provides a method for preparing a water soluble polyethylene glycol / polylactic segmented polycarbonate resin with thermal reversible gel effect by using solid phosgene as a coupling agent, which belongs to the technical field of water soluble polymer synthesis and degradable medical application. The method comprises the following steps that: under the catalytic action of stannous octoate, L-lactide is initiated to open by polyethylene glycol to synthesize a polylactic acid-polyethylene glycol-polylactic triblock copolymer containing a terminal hydroxy group; the triblock copolymer is subjected to chain extension by the solid phosgene to obtain polyethylene glycol / polylactic segmented polycarbonate resin; and the polyethylene glycol / polylactic segmented polycarbonate resin is precipitated and dried through a mixed solution of absolute methanol and absolute aether to obtain a viscous solid product. The copolymer has good water solubility and prominent reversible gel effect, and has wide application prospect in medicine slow release, tissue engineering and other fields.

The invention relates to a biodegradable hydrogel controlled release preparation and a preparation and an application thereof, belonging to the technology field of medicines. The preparation method comprises the steps of: synthesizing poly(lactic acid)-polyethylene glycol-poly(lactic acid) (PLA-PEG-PLA) triblock copolymer by inducing L-lactide and D-lactide to respectively conduct ring-expansion polymerization by using zinc powder, zinc lactate or stannous octoate as catalyst and polyethylene glycol (PEG) 2,000-20,000; respectively dissolving poly-L-lactic acid-polyethylene glycol-poly-L-lactic acid and poly-D-lactic acid-polyethylene glycol-poly-D-lactic acid in water to obtain solutions with concentration of 0.05-0.5g / mL, swelling, mixing, and allowing gelatinization under constant temperature to obtain PLA-PEG-PLA triblock copolymer hydrogel for injection by complexing reaction. The hydrogel has good biological compatibility and biodegradability, can be used for embedding water-soluble drugs, and is an ideal drug controlled release carrier.

The invention discloses a modification method and application of hydroxyapatite. The modification method comprises the following steps of: dispersing hydroxyapatite powder in N,N-dimethylformamide, adding citric acid, and heating and stirring for reaction at 100-120 DEG C; filtering and then washing and drying; performing ultrasonic dispersion on the hydroxyapatite treated by use of the citric acid, then adding a xylene solution of lactide, and adding 0.05-0.2% of stannous octoate catalyst; heating to 120-140 DEG C under the protection of N2; continuously heating and stirring for a grafting reaction; and after the reaction, cooling to room temperature and washing and drying. By adopting the modification method disclosed by the invention, the grafting rate of the hydroxyapatite surface can be improved; by compounding the modified hydroxyapatite of high content with a polylactic acid high polymer, a better mechanical enhancement effect still can be realized; and the modified hydroxyapatite can be applied to a fracture fixing material.