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Injectable type fast curing medical polyurethane compound and preparation method thereof

A fast-curing, polyurethane technology, applied in pharmaceutical formulations, applications, dental preparations, etc., can solve problems such as conversion rate less than 70%, failure of root canal filling, and difficulty in light-curing effect, achieving moisture insensitivity and curing speed Fast, good biocompatibility results

Active Publication Date: 2013-04-03
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of light curing is difficult to act in the deep part of the root canal, and the polymerization conversion rate is low
At present, the research on polyurethane root canal filling materials has been reported, but the conversion rate is still less than 70% after 12 days of curing (Kuo-Huang Hsieb, ken-hsuan Liao, et al. J Endod, 2008, Vol.34, No. 3: 303-305), its residual monomers are likely to cause chemical irritation, stimulate cell inflammatory response, and easily lead to failure of root canal filling
[0010]Due to the stringent clinical needs, although there are many technical reports to realize the injectable curing of polyurethane, there is still a need for an improved polyurethane composition with a biological safety margin , and its high conversion rate and low biotoxicity will benefit the application of polyurethane materials in various biomedical fields including dentistry

Method used

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  • Injectable type fast curing medical polyurethane compound and preparation method thereof
  • Injectable type fast curing medical polyurethane compound and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Add polytetrahydrofuran ether glycol (PTMEG, molecular weight 2000) into a three-neck flask with a stirring device filled with nitrogen, and then add isophorone diisocyanate (IPDI) (the molar ratio of NCO of isocyanate to OH in polyol is 1.5 :1), react at 50~80°C for 5~6 hours, then add chain extender 1, 4 butanediol (the mass ratio of it to PTMEG is 1:45), and continue to stir in a nitrogen environment at a speed of about 60r / min The reaction is carried out to obtain the polyurethane polymer component A with a degree of polymerization of 8-9. Component B was prepared by mixing polyethylene glycol (molecular weight 600), triethanolamine (TEA), and stannous octoate at a mass ratio of 5:1:1. When using, mix A and B components according to the mass ratio of 5:1, stir well for about 1 minute to make it solidify.

[0039] The scanning electron micrographs of the polyurethane composition co-cultivated with mouse fibroblast L929 for three days and five days after being solidi...

Embodiment 2

[0042] Add polytetrahydrofuran ether glycol (PTMEG) (molecular weight 3000) into a three-necked flask with a stirring device filled with nitrogen, add nano-silver powder with a total amount of 3wt%, and then add lysine diisocyanate (NCO of isocyanate and poly The molar ratio of OH in the alcohol is 2:1), react at 50~80°C for 24 hours, then add the chain extender 1, 4 butanediol (the mass ratio of the macromolecule alcohol PTMEG is 1:30), continue to Reaction under a nitrogen environment and stirring at about 50 r / min to obtain a polyurethane polymer component A with a polymerization degree of 9-11. Component B was prepared by mixing polyethylene glycol (molecular weight 400), triethanolamine (TEA), and stannous octoate in a ratio of 2:1:1. When using, mix A and B components according to the mass ratio of 5:1, stir well for about 1 minute to make it solidify.

Embodiment 3

[0044] Add polyethylene glycol (PEG) (molecular weight 4000) into a three-neck flask with a stirring device filled with nitrogen, add nano-hydroxyapatite powder with a total amount of 20wt% (refer to the aforementioned literature for the preparation method), and then add isofor ketone diisocyanate (IPDI) (the molar ratio of NCO of isocyanate to OH in polyol is 1.5:1), react at 50~80°C for 30 hours, and then add chain extender 1,4 butanediol (which is compatible with macromolecule The mass ratio of alcohol PEG is 1:60), continue to react under nitrogen environment and 100r / min stirring, and obtain the polyurethane polymer component A with a polymerization degree of 7~9. Mix glycerol, triethylenediamine, and stannous octoate in a ratio of 4:1:1 to prepare component B. When using, mix A and B components according to the mass ratio of 3:1, stir fully for about 2 minutes to make it solidify.

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Abstract

The invention discloses an injectable type fast curing medical polyurethane compound and a preparation method thereof. The compound comprises the basic components of a polyurethane component (A) and a curing agent (B) which can be cured after being mixed, wherein the polyurethane component comprises aliphatic series diisocyanate and polymer of polyhydric alcohol, a molar ratio of NCO (isocyanate) and OH (oxyhydrogen) in polyhydric alcohol is (0.5-4):1; and polyhydric alcohol is composed of macromolecule linear-chain polyhydric alcohol polymer and C1-4 micromolecule polyhydric alcohol together, and the molar ratio between macromolecule linear-chain polyhydric alcohol polymer and C1-4 micromolecule polyhydric alcohol is (4.0-0.5):1. The curing agent (B) is composed of micromolecule polyhydric alcohol, stannous octoate and / or tertiary amine compound catalysts. The compound can be quickly cured after being mixed at the normal temperature, particularly can be quickly cured in the containing water environment, and has an excellent mechanical property and a micro-expanding characteristic after being completely cured. The curing of the polyurethane component has a high conversion rate above 90%, and the polyurethane component has a good biocompatibility and a wide application prospect in various biomedical fields where the polyurethane component can be preferentially applied and not only limited to dentistry filling seal.

Description

technical field [0001] The invention relates to an injectable fast-curing medical polyurethane composition which is preferentially applicable to but not limited to dental filling materials, and a preparation method of the composition. Background technique [0002] In the treatment of dental diseases, root canal therapy, also known as endodontic treatment, is to remove all the pulp and fill the root canal tightly with root canal filling materials to preserve the affected tooth. It is a medical treatment for pulp necrosis and root canal A type of surgery for infection. Because it preserves the tooth, it is the most effective treatment for endodontic and periapical diseases complementary to tooth extraction, where root canal filling is a key step in this treatment technique. [0003] The root canal system is not a single regular pipeline, but a complex combination of pipelines with many side branches. If these passages are not tightly sealed during treatment, bacteria will re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L75/08C08K5/17C08K5/053C08K9/12C08K3/32C08K3/08C08K3/22C08G18/75C08G18/73C08G18/66C08G18/48C08G18/32A61K6/09A61L24/04A61K6/893
Inventor 左奕李玉宝孙斌王立李吉东邹琴
Owner SICHUAN UNIV
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