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97 results about "Benzyl chloroformate" patented technology

Benzyl chloroformate is the benzyl ester of chloroformic acid. Also known as benzyl chlorocarbonate it is an oily colorless liquid although impure samples appear yellow. It is also known for its pungent odor. In contact with water it degrades.

Aliphatic polyester-polyamino acid Y-type three-arm block copolymers and synthetic method thereof

The invention relates to a Y-shaped three-arm segmented copolymer of aliphatic polyester namely polyamino acid and a process for synthesis, which belongs to the high-polymer biological medicine material field. And the process for synthesis comprises protecting amidogens of 2-amidocyanogen-1 and 3-propylene glycol with benzyl chloroformate, ringopening and polymerizing 2-amidocyanogen-1 and 3-propylene glycol with aliphatic cyclic esters monomer in benzene or toluene dissolvent under the condition of warming up and stirring and without water and oxygen through utilizing stannous octoate as catalyst, utilizing amidogens to be macromolecule initiating agent after de-protecting, triggering alpha- amino acid-N-carboxylic acid anhydrides to ring-open and polymerize, getting Y-shaped segmented copolymer of carboxy group which is protected by benzyl group, forming relative polymer with free carboxy group through dewatering hydrogen bromide or catalyzing hydrogenating and deacidizing palladium-charcoal, and then getting the Y-shaped segmented copolymer which can be biodegraded and can have biology functionalization. The invention can be widely applied in the filed such as internal fixation of bone fracture, medicinal carrier, tissue engineering scaffold and the like.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI

Estrogen amino-acid ester compound with antitumor activity as well as synthetic method thereof

The invention relates to an estrogen amino-acid ester compound with antitumor activity as well as a synthetic method thereof, effectively solving the preparation problems of the estrogen amino-acid ester compound with the antitumor activity. The synthetic method comprises the following steps of: dissolving amino acids or small molecule peptides to an aqueous solution of sodium hydroxide or a saturated solution of sodium bicarbonate, dripping carbobenzoxy chloride, making the solution react until the solution is not purple by developing with ninhydrin or carrying out film detection; washing with aether, removing aether, adjusting the pH value of the water phase with hydrochloric acid until milky white solid occurs and extracting with ethyl acetate; washing mixed solution with distilled water and saturated common salt solution, drying with anhydrous magnesium sulfate, carrying out suction filtration, concentrating and purifying; and then, mixing the mixed solution with sterides nucleus and dissolving the mixture to a reaction solvent, adding a condensing agent and a catalyst, supplementing an additional condensing agent, carrying out film detection, filtering, concentrating and purifying, dissolving in a dissolving solvent, adding palladium carbon for catalytic hydrogenation, detecting the film, filtering, concentrating and purifying. The estrogen amino-acid ester compound withantitumor activity, provided by the invention, has favorable water solubility and is superior to 2-methoxyestradiol in the tumor cell resistance action.
Owner:ZHENGZHOU UNIV

Intermediate compound for use in preparation of androst amino acid ester and synthesis method thereof

The invention relates to an intermediate compound for use in the preparation of androst amino acid ester and a synthesis method thereof, and solves the problem of the preparation of the intermediate compound that is used in the preparation of androst amino acid ester, which is a novel antitumor compound, for keeping or increasing the antitumor activity of androst amino acid ester and increasing the water solubility of androst amino acid ester. The method comprises: dissolving amino acid or small peptides in aqueous solution of sodium hydroxide or saturated solution of sodium bicarbonate; dripping benzyl chloroformate, adding ninhydrin for color developing till no purple color or performing lamina detection; washing with diethyl ether; removing diethyl ether; regulating the pH value of water phase with hydrochloric acid till milky solid appears, extracting with ethyl acetate, washing mixed extract with distilled water and saturated table salt solution, drying by anhydrous magnesium sulfate, performing suction filtration, concentrating and purifying; and dissolving a mixture of a compound A and the mother nucleus of a steride in a reaction solvent, adding a condensing agent and a catalyst, supplying extra condensing agent, performing lamina detection, filtering, concentrating and purifying. In the invention, the method is simple and the operation is convenient.
Owner:ZHENGZHOU UNIV

Method for preparing docetaxel

The invention relates to a new method for preparing Docetaxel which includes a new synthesizing method for forming 10-deacetyl baccatin III(II) for protecting C-7, C-10-carbobenzoxy by using the 10-deacetyl baccatin III(I) for reacting with a benzyl chloroformate compound, and a new method for forming a new compound of 2'-(1-ethoxyethyl)-N-debenzoyl-N-(boc)-C-7, C-10-II-X-CBZ-10-deacetyl paclitaxel(IV) by the reaction of (II) with 1-boc-(3R,4S)-4-phenyl azetidine-2-ketone(III) as well as the new compound. Simultaneously, the invention also provides a new method for preparing a new compound of 2'- (1-ethoxyethyl)-N-debenzoyl-N-(boc)-10-deacetyl paclitaxel(V) and a new method for removing the 1-ethoxyethyl from the (IV) to form the Docetaxel.
Owner:重庆医科大学医药研究所

Linezolid preparation method

ActiveCN103420933AReduce the refining processMild conditionsOrganic chemistryMorpholineBenzyl chloroformate
The invention relates to a linezolid (1) preparation method. The method comprises the following steps: reacting a raw material 3,4-difluoronitrobenzene with morpholine, reducing, reacting with benzyl chloroformate to obtain N-benzyloxycarbonyl-3-fluoro-4-morpholinylaniline, carrying out a ring closure reaction of N-benzyloxycarbonyl-3-fluoro-4-morpholinylaniline and (S)-N-(2,3-epoxypropyl)phthalimide, ammonolyzing, and acetylating to obtain linezolid (1).
Owner:LUNAN PHARMA GROUP CORPORATION

Method for synthesizing ticagrelor intermediate by micro-channel reactor

The invention discloses a method for synthesizing a ticagrelor intermediate through a micro-channel reactor, and belongs to the technical field of cardiovascular and cerebrovascular drug synthesis. The invention aims to solve the problems of low yield, low purity, uncontrollable heat release and the like in the synthesis of an intermediate in a traditional stirring reaction kettle. The method forsynthesizing the ticagrelor intermediate comprises the following steps of: mixing a precursor (3aR, 4S, 6R, 6aS)-6-aminotetrahydro-2, 2-dimethyl-4H-cyclopentene-1, 3-dioxolane-4-ol with an organic solvent to obtain a material I; dissolving alkali required by the reaction in water to obtain a material II; and dissolving benzyl chloroformate in an organic solvent to obtain a material III, preheatingthe materials, conveying the preheated materials to the reaction module group of a micro-channel reactor, carrying out a reaction, and carrying out post-treatment on a reaction product to obtain theticagrelor intermediate. The method has the advantages of short reaction time and greatly improved safety, and is suitable for industrial production of the ticagrelor intermediate.
Owner:HEILONGJIANG XINCHUANG BIOLOGICAL TECH DEV CO LTD

Preparation method of flame-retardant material for wires and cables

The invention provides a preparation method of a flame-retardant material for wires and cables. The preparation method comprises steps as follows: benzyl chloroformate modified levodopa as a monomer is subjected to a polymerization reaction, and a modified dopa polymer is prepared; the modified dopa polymer is dissolved in acetone, and a modified dopa polymer solution is prepared; sodium-based montmorillonite is placed in an ethanol solution, a sodium-based montmorillonite dispersion liquid is prepared, and the pH value of the sodium-based montmorillonite dispersion liquid is adjusted to 9.5-10 with an alkaline solution; the sodium-based montmorillonite dispersion liquid treated with a sonifier cell disrupter for 7-9 min; polyimide fibers are soaked in a hydrochloric acid water solution for 1.2-1.5 h and squeezed to be dewatered for later use, and a polyimide fiber substrate is prepared; the sodium-based montmorillonite dispersion liquid and the modified dopa polymer solution are applied to the surface of the polyimide fiber substrate alternately, the surface is dried once every time when the surface is coated, and the flame retardant material for the wires and cables is prepared finally after being dried. The flame-retardant material has the flame retardance, mechanical property and environmental protection property.
Owner:JIANGXI CHENGDA ENG CONSULTING & SUPERVISION +1
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