42 results about "Carbobenzoxy chloride" patented technology

There is provided methods for producing nateglinide crystals, which comprises the steps of adding an acid(s) to a reaction mixture containing nateglinide to make it acidic, the reaction mixture being obtained by reacting trans-4-isopropylcyclohexylcarbonyl chloride with D-phenylalanine in a mixed solvent of ketone solvent and water in the presence of an alkali; and then adjusting the temperature of the mixture to 58° C. to 72° C. and the concentration of ketone solvent to more than 8 wt % and less than 22 wt % to conduct precipitation of nateglinide crystals. This producing method is the industrially beneficial methods for crystallization of nateglinide.

The invention discloses a biomass-based slow-release pesticide and a preparation method thereof. The method comprises the following steps: (1) carrying out a first contact reaction on a biomass raw material, fatty alcohol and a first acidic catalyst, and separating the product obtained after the first contact reaction so as to obtain light oil and alcoholysis residue; and (2) carrying out a third contact reaction on the alcoholysis residue and a pesticide drug compound and an optional cross-linking agent in an organic solvent at the pH value of 7-9 and at 30-50 DEG C for 0.5-1 h. The fatty alcohol is C4-C13 aliphatic saturated monohydric alcohol. The cross-linking agent is one or more ingredients selected from a group consisting of carbonyl chloride, thionyl chloride, isocyanate, maleic anhydride and phthalic anhydride. Drug loading capacity of the prepared biomass-based slow-release pesticide reaches up to 25.47 wt%. The pesticide has high insect poisoning efficiency. After three months of the use, the highest inhibition rate of fruit fly eggs still reaches up to 80% and above.

The invention discloses a preparation method of an amino acid surfactant. The specific steps are as follows: (1) at room temperature, add a fatty acid and a catalyst into a four-necked flask, slowly raise the temperature to 50-70 degrees, drop thionyl chloride or pass through Add carbonyl chloride and react for 3-6 hours to obtain fatty acid chloride; (2) at room temperature, add amino acid and caustic alkali solution in a four-necked flask, control the pH range to 10-12, and the temperature is 10-20 degrees, and dropwise Fatty acid chloride and caustic alkali solution, keep the pH constant during the dropwise addition, react for 3-6 hours, and obtain the crude product of amino acid surfactant; (3) add inorganic acid to adjust the pH to 1-2, then add cold water, filter and dry to obtain The final amino acid surfactant product. The invention has low production cost, high efficiency and simple process, is suitable for industrialized production, and under the premise of ensuring high yield and excellent product appearance, the solvent is recovered, which is green and environment-friendly.

The present invention relates to the production process of N-benzyloxy carbonyl glutamic acid, and belongs to the field of medicine chemical technology. The production process includes the reaction of glutamic acid and carbobenzoxy chloride under alkali condition to produce N-benzyloxy carbonyl sodium glutamate solution with impurity; extraction to eliminate imipurity; and processing the solution to obtain the product. The production process features that the N-benzyloxy carbonyl sodium glutamate solution with impurity is processed through pH regulation to 3-4 with acid, organic solvent extraction of impurity, pH regulation to strong acidity for separating coarse product and re-crystallization of the coarse product to obtain product. The production process is simple, low in cost, high in product quality and suitable for industrial production.

The invention relates to an estrogen amino-acid ester compound with antitumor activity as well as a synthetic method thereof, effectively solving the preparation problems of the estrogen amino-acid ester compound with the antitumor activity. The synthetic method comprises the following steps of: dissolving amino acids or small molecule peptides to an aqueous solution of sodium hydroxide or a saturated solution of sodium bicarbonate, dripping carbobenzoxy chloride, making the solution react until the solution is not purple by developing with ninhydrin or carrying out film detection; washing with aether, removing aether, adjusting the pH value of the water phase with hydrochloric acid until milky white solid occurs and extracting with ethyl acetate; washing mixed solution with distilled water and saturated common salt solution, drying with anhydrous magnesium sulfate, carrying out suction filtration, concentrating and purifying; and then, mixing the mixed solution with sterides nucleus and dissolving the mixture to a reaction solvent, adding a condensing agent and a catalyst, supplementing an additional condensing agent, carrying out film detection, filtering, concentrating and purifying, dissolving in a dissolving solvent, adding palladium carbon for catalytic hydrogenation, detecting the film, filtering, concentrating and purifying. The estrogen amino-acid ester compound withantitumor activity, provided by the invention, has favorable water solubility and is superior to 2-methoxyestradiol in the tumor cell resistance action.

The invention discloses a method for the preparation of thiophene-2-carbonyl chlorides starting from thiophenes with oxalyl chloride at elevated temperature with short reaction time.

A tri-carbobenzoxy-arginine represented by the following formula (2):is produced by carbobenzoxylating the arginine or arginine derivative (1) represented by the following formula (1), or a salt thereof:by adding carbobenzoxy chloride and a base in a water / organic solvent bilayer system to an arginine or arginine derivative (1) represented by the formula (1), or a salt thereof.

The invention provides a new synthesis process of creatine ethyl ester hydrochloride, the synthesis steps are as follows: using creatine in absolute ethanol, using 4-dimethylaminopyridine (DMAP) as a catalyst, thionyl chloride or carbon Acyl chloride is a reactive dehydrating agent, which can be reacted at low temperature to produce creatine ethyl ester hydrochloride. The catalyst effectively improves the esterification reaction speed between creatine and ethanol, reduces the occurrence of creatinine side reactions, and improves the purity of creatine ethyl ester hydrochloride. The overall process basically belongs to normal temperature and pressure process, with low energy consumption, high creatine conversion rate and high product purity.