The invention discloses a technology for producing
cytarabine through a
chemical synthesis method, relating to a synthesis technology of an
organic compound and aiming to provide a technology for producing the
cytarabine through the
chemical synthesis method, which has the advantages of cheap and available
raw material, simple reaction condition, low cost,
environmental protection and high yield. Based on the solving technical scheme, the technology for producing the
cytarabine through the
chemical synthesis method has a synthetic
route which comprises the following synthesis steps of: firstly, reacting the cytarabine (1) used as a starting
raw material with hexamethyldisilazane (HMDS) for 10-80h under the pressure of 5-20kg and at the temperature of 70-160 DEG C, cooling, stirring and vacuum concentrating a
reaction system, and removing and recovering redundant hexamethyldisilazane to obtain an intermediate (II), wherein the dosage of the hexamethyldisilazane is 2-10 times larger than the weight of the cytarabine; secondly, dissolving the intermediate (II) into a proper
solvent, and cooling or stirring to prepare crude cytarabine. The invention is used for preparing an
anticancer drug.