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537 results about "Phthalimide" patented technology

Phthalimide is the organic compound with the formula C₆H₄(CO)₂NH. It is the imide derivative of phthalic anhydride. It is a sublimable white solid that is slightly soluble in water but more so upon addition of base. It is used as a precursor to other organic compounds as a masked source of ammonia.

Pharmaceutical compositions of 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline

Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNFα in a mammal. Typical embodiments are 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafuoroisoindoline and 1,3-dioxo-2-(2,6-dioxo-3 -methylpiperidin-3-yl)-4-aminoisoindoline.
Owner:CELGENE CORP

Phthalimide compounds useful as protein kinase inhibitors

The present invention provides compounds as inhibitors of protein kinase, particularly inhibitors of AKT, PDK1, p70S6K, or ROCK kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides processes for preparing the compounds of the invention, pharmaceutical compositions comprising the compounds, and methods of utilizing those compounds and compositions in the treatment of various disorders.
Owner:GREEN JEREMY +1

Process for preparing monodisperse anion exchangers

The present invention relates to a process for preparing novel, monodisperse anion exchangers by(a) reacting monomer droplets made from monovinylaromatic compounds and polyvinylaromatic compounds, and optional porogens and / or initiators,(b) amidomethylating the resultant monodisperse, crosslinked bead polymers with phthalimide derivatives,(c) converting the amidomethylated bead polymers to aminomethylated bead polymers, and(d) alkylating the aminomethylated bead polymers.
Owner:LANXESS DEUTDCHLAND GMBH

Pyrimidine nucleoside compounds and oligonucleoside compounds containing same

Novel 2- and 4-substituted pyrimidine nucleosides and oligonucleosides are provided, as are methods and intermediates useful in preparing same. In preferred embodiments, one of the 2- and 4-substituents is =O, =NH, or =NH2+ and the other is Q, =C (RA)-Q, C(RA)(RB)-C(RC)(RD)-Q, C (RA)=C(RC)-Q or C 3BOND C-Q, where RA, RB, RC and RD independently are H, SH, OH, NH2, or C1-C20 alkyl, or one of (RA)(RB) or (RC)(RD) is =O, and Q is halogen, hydrogen, C1-C20 alkyl, C1-C20 alkylamine, C1-C20 alkyl-N-phthalimide, C1-C20 alkylimidazole, C1-C20 alkylbis-imidazole, imidazole, bis-imidazole, amine, N-phthalimide, C2-C20 alkenyl, C2-C20 alkynyl, hydroxyl, thiol, keto, carboxyl, nitrates, nitro, nitroso, nitrile, trifluoromethyl, trifluoromethoxy, O-alkyl, S-alkyl, NH-alkyl, N-dialkyl, O-aralkyl, S-aralkyl, NH-aralkyl, azido, hydrazino, hydroxylamino, isocyanato, sulfoxide, sulfone, sulfide, disulfide, silyl, O-(hydroxyl protecting group), a leaving group, a heterocycle, an intercalator, a reporter molecule, a conjugate, a polyamine, a polyamide, a polyethylene glycol, a polyether, or a depurination enhancing group.
Owner:IONIS PHARMA INC

(R) and (S) isomers of substituted 2-(2,6-dioxopiperidin-3-yl) phthalimides and 1-oxoisoindolines and methods of using the same

Substituted 2-(2,6-dioxopiperidin-3-yl) phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl) isoindolines reduce the levels of TNFα in a mammal. Typical embodiments are 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline and 1,3-dioxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4-aminoisoindoline.
Owner:CELGENE CORP

Thifluzamide-containing sterilization composition

The invention discloses a thifluzamide-containing sterilization composition, and belongs to the technical field of pesticides. The sterilization composition comprises a raw pesticide prepared by compounding a bactericide A and a bactericide B with a ratio of 1-80:1-80; the bactericide A is thifluzamide; and the bactericide B is any one of the following bactericides: a copper preparation, methoxy acrylates, triazoles, amides, benzimidazoles, thiocarbamates, substituted benzenes, pyrroles, dicarboximides, phthalimides, imidazoles, morpholines, carbamates, oxazoles, antibiotics, and the like. The sterilization composition comprises the raw pesticide prepared by compounding a bactericide A and a bactericide B, the sterilization spectrum is expanded, the pesticide resistance of pathogens is alleviated, and the sterilization composition has obvious continuous synergic effect.
Owner:王学权

Sterilization compound containing chloroisobromine cyanuric acid

The invention discloses a sterilization compound containing chloroisobromine cyanuric acid, comprising a raw medicine formed by compounding a sterilizing agent A and a sterilizing agent B, wherein the proportion of the sterilizing agent A to the sterilizing agent B is (1-80):(1-80); the sterilizing agent A is the chloroisobromine cyanuric acid; and the sterilizing agent B is any one of the following types of the sterilizing agents: copper preparations, methoxy acrylic esters, triazoles, amides, benzimidazoles, thiocarbamates, substituted benzenes, dicarboximides, phthalimides, imidazoles, morpholines, carbamates, oxazoles and the like. The sterilization compound is formed by compounding the sterilizing agent A and the sterilizing agent B so that not only a sterilization spectrum is enlarged, but also the drug resistance of bacteria is slowed; and the sterilization compound has an obvious lasting synergistic effect.
Owner:王学权

Imazalil-containing sterilization composition

The invention discloses an imazalil-containing sterilization composition, and belongs to the technical field of pesticides. The sterilization composition comprises a raw pesticide prepared by compounding a bactericide A and a bactericide B with a ratio of 1-80:1-80; the bactericide A is imazalil or efficient imazalil; and the bactericide B is any one of the following bactericides: a copper preparation, methoxy acrylates, triazoles, amides, benzimidazoles, thiocarbamates, substituted benzenes, pyrroles, dicarboximides, phthalimides, imidazoles, morpholines, carbamates, oxazoles, antibiotics, and the like. The sterilization composition comprises the raw pesticide prepared by compounding imazalil or efficient imazalil and a bactericide B, the sterilization spectrum is expanded, the pesticide resistance of pathogens is alleviated, and the sterilization composition has obvious continuous synergic effect.
Owner:王学权

Mixed n-butyl and iso-propyl phthalimide compounds as sunscreen solubilizers

The present invention is directed to a high active sunscreen composition for topical application to human skin to protect the skin against UV radiation damage. The composition is particularly suitable for over-coating with make-up or other cosmetic compositions. More particularly, the present invention is directed to the use of a specific eutectic mixture of lower alkyl phthalamide that is surprisingly effective in solubilizing 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane (PARSOL.RTM. 1789). Such concentrates solutions of PARSOL.RTM. 1789 can be used to formulate a more effective sunscreen, having a surprisingly increased sunscreen protection factor (SPF) and such that the PARSOL.RTM. 1789 is more effective over a longer period of time so that the sunscreen composition need not be applied to the skin as frequently.
Owner:PHOENIX RES

Antimicrobial polycarbonate plastic and preparation method thereof

The invention discloses an antimicrobial polycarbonate plastic and a preparation method thereof. The antimicrobial polycarbonate plastic comprises the following components in parts by weight: 100 parts of polycarbonate, 0.3-0.5 part of antimicrobial agent and 0.2-0.4 part of dispersant. The antimicrobial agent is one or mixture of nano titanium dioxide, nano silver oxide, polyhexamethyleneguanidine phosphate and N-(trichloromethylthio)phthalimide. The antimicrobial polycarbonate plastic disclosed by the invention can be easily processed into various shapes of interior ornaments of automobiles by an injection molding technique. The antimicrobial polycarbonate plastic disclosed by the invention has strong effects of bacterium control and killing and mold resistance.
Owner:SHANGHAI HAN MOLDING SHAPE CO LTD

Environment-friendly type terylene low temperature dyeing assistant with alkyl phthalic imide as vector and preparation thereof

The invention discloses an environment-friendly terylen low-temperature dyeing auxiliary agent taking alkyl phthalimide as a carrier and a preparation method thereof. The compositions in percentage by weight of the dyeing auxiliary agent are: 70 to 90 percent of alkyl phthalimide compound, 8 to 15 percent of concentrated emulsion 8206, 1 to 7.5 percent of castor oil polyoxyethylene ether sulphonated matter and 1 to 7.5 percent of alkyl phenol polyoxyethylene ether, wherein the alkyl phthalimide is takes as the carrier; and the concentrated emulsion 8206, the castor oil polyoxyethylene ether sulphonated matter and the alkyl phenol polyoxyethylene ether are takes as an emulsifying agent. The environment-friendly terylen low-temperature dyeing auxiliary agent is used in low-temperature dyeing of terylen and terylen-containing textile fabrics; moreover, the dyeing auxiliary agent not only has the characteristics of nontoxicity, tastelessness, environmental protection and low cost, etc., but also has the advantages of high dye uptake, excellent level dyeing property, high dyeing fastness and wide application range, etc., thereby meeting the requirements of low-temperature dyeing production of terylen-containing textile fabrics.
Owner:ZHEJIANG SCI-TECH UNIV +1

Compounded synergia sterilizing composite

The invention relates to a compounded synergia sterilizing composite, belonging to the technical field of pesticide. The sterilizing composite comprises an original medicine compounded by a sterilizing agent A and a sterilizing agent B, wherein the ratio of the sterilizing agent A to the sterilizing agent B is (1-90):(90-1), the sterilizing agent A is ethirimol or bupirimate, and the sterilizing agent B is any one of the following sterilizing agents: copper agent, methoxy-acrylics, triazoles, amides, pyrilamine, benzimidazole, thiocarbamate, dicarboximide, imidazole, morpholine, oxazole, ureas, pyridines, miazines, pyrroles, phthalimide, carbamates, antibiotics and others. The sterilizing composite comprises the original medicine compounded by the ethirimol or bupirimate and the sterilizing agent B, thus not only enlarging the bacteriocidal spectrum, but also slowing down the drug resistance of germs, and having obvious continuous synergia effect.
Owner:王学权

Method for preparing 5(S)-aminomethyl-3-aryl-2-oxazolidinone

The invention discloses a method for preparing 5(S)-aminomethyl-3-aryl-2-oxazolidinone. The method comprises the following steps of: reacting (S)-glycidyl phthalimide and aryl aniline to prepare an addition compound; and finally preparing the 5(S)-aminomethyl-3-aryl-2-oxazolidinone through cyclization reaction and aminolysis reaction. The method has the advantages of high total yield and low cost; all intermediates and a product synthesis method have the characteristics of convenience in recovery and purification; and the purity of a final product of the method is at least over 99.9 percent.
Owner:OMEGA MEDICAL TAIWAN

Methods for the treatment of cachexia

Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNFα in a mammal.
Owner:CELGENE CORP

Pipecolinic acid derivatives, method of manufacturing the same and therapeutic agents containing these compounds

The present invention provides a compound of the general formula (I) or a pharmaceutical salt thereof, wherein, when R1 and R2 are the same they are represented by =O, =N, -OR9 (where R9 is hydrogen, lower alkyl or benzyl), when R1 and R2 are different and one of R1 and R2 is represented by hydrogen, the other is represented by -R5-R6-, (where R5 is -O-, -NH-, -NHCO-, or -NHSO2-, and where R6 is hydrogen, lower alkyl, -Ph-R7, -(CH2)n-O-Ph-R7, (where n=1-6, R7 is hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro, or pyridyloxy), indolyl, N-oxidepyridyl, phthalimide, thienyl, or pyridyl); R3 represents -COOH, -COOEt, -COOMe, -CH2N(OH)CHO, or -CONHOH; R4 represents lower alkyl, thienyl, -Ph-R8 (where R9 represents hydroxy, lower alkyl, lower alkoxy, nitro, halogen, pyridyloxy, or phenyl group substituted hydrogen, lower alkyl, lower alkoxy, hydroxy, and halogen), and methods of making compounds within the class of the general formula (I).
Owner:KOTOBUKI PHARMA CO LTD

Method for preparing tert-butyl hydrogen peroxide and tert-butyl alcohol by oxidating isobutane

The invention discloses a method for preparing tert-butyl hydrogen peroxide and tert-butyl alcohol by oxidating isobutene. Molecular oxygen is taken as an oxygen source; N-hydroxy phthalimide (NHPI) or a derivative thereof is taken as a catalyst; in the presence of a polar solvent, carrying out catalytic oxidation on the liquid phase of the isobutane to prepare the tert-butyl hydrogen peroxide and the tert-butyl alcohol; after finishing the reaction and rapidly cooling, the catalyst and the products are subjected to solid-liquid separation; and the catalyst is recycled through centrifugal sedimentation and washing. Compared with the existing process without catalytic optimization, the method disclosed by the invention has mild reaction conditions, the temperature and the pressure needed in the reaction can be remarkably lowered; and in addition, under the condition of having higher rate of conversion of the isobutane, the high selectivity of the tert-butyl hydrogen peroxide and the tert-butyl alcohol can be maintained.
Owner:XIANGTAN UNIV

Dyeing process for jacquard fluff top fabric

The invention discloses a dyeing process for a jacquard fluff top fabric. The dyeing process comprises the steps as follows: 1) adding the following components in parts by weight in a dye vat: 19 parts of water, 0.9 part of EDDHA-FeNa, 1.4 parts of alkyl phthalimide compounds, 2.1 parts of diphenyl ether tetracarboxylic dianhydride, 1.3 parts of benzyl naphthalene sulfonate, 5 parts of natural plant pigment, 0.9 part of hexyldecanol and 1.6 parts of dodecyl trimethyl ammonium chloride, and stirring the mixture to be uniform; 2) soaking wool tops in the dye vat for 70 minutes; 3) drying the soaked wool tops at 80 DEG C; 4) immersing the dried wool tops in clear water to be washed for 15 minutes; 5) taking the washed wool tops out of the water and naturally airing the wool tops. The dyeing process for the jacquard fluff top fabric is high in dyed wool top color fastness, good in dyeing uniformity, and free of dyeing defect.
Owner:常熟市新华源有色毛条厂

Polythioetherimide and preparation method thereof

InactiveCN101531758AReduce manufacturing costReduce synthesis reactionFiberAdhesive
The invention relates to polythioetherimide and a preparation method thereof. The method is characterized by comprising the following steps: mono-substituted phthalic anhydride isomer with structural formula II is adopted as a reaction material to react with organic diamine NH2RNH2 with half mol equivalent weight at the temperature of about 100 DEG C to about 350 DEG C to generate binary-substituted phthalimide; then binary-substituted phthalimide and sulfur with about equimolar equivalent weight are subjected to coupling polymerization reaction at the temperature of about 60 DEG C to about 260 DEG C under the existence of reducing agent, catalyst and reaction auxiliary agent to generate polythioetherimide resin with structural formula I; and the molecular weight of the resin can be adjusted by end capping agent. The preparation method can greatly reduce the preparation cost and reaction steps, the whole process is more reasonable and practical, and the obtained resin has superior comprehensive properties such as good heat resistance, mechanical properties, melting processing property and the like, can be widely applied in the related fields such as high-temperature resistant engineering plastics, films, adhesives, enameled wires, foamed plastics, fiber, advanced composite materials and the like; in the structural formula II, A substituent is chlorine atom or nitro at 3-bit or 4-bit; and in the structural formula I, R is substituted or unsubstituted organic group.
Owner:NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI +1

Technique for using methylbenzene to prepare benzaldehyde and benzene methanol by multistage oxidation and equipment

The invention discloses a technique for using methylbenzene to prepare benzaldehyde and benzene methanol by air oxidation and equipment. In a reaction separating system consisting of a multistage oxidation reactor as well as a gas-liquid separator, a lateral line fractionating column or a fractionating column system, 0.1 to 50ppm of monometallic porphyrin or u-oxygen bimetallic porphyrin is separately used as a catalyst, or metallic porphyrin and phthalimide (or salt) are used as a mixed catalyst according to the weight ratio of 1:20 to 100; when the reaction temperature is 80 to 200 DEG C, the methylbenzene is maintained in a multistage oxidizer for 60 to 180 minutes and prepared into the benzaldehyde and benzene methanol by catalytic oxidation; and the gas-liquid separation and purification are carried out. Compared with the prior art, the technique and equipment can obviously improve the conversion rate of the methylbenzene, and the conversion rate of the methylbenzene can reach to be more than 95% by experiments; in addition, the technique and equipment also can improve the selection of the benzaldehyde and benzene methanol, and the selection of the benzaldehyde and benzene methanol can reach to be more than 50%.
Owner:HUNAN UNIV

Bismide compound, acid generator and resist composition each containing the same, and method of forming pattern from the composition

The present invention relates to a novel bisimide compound useful as an acid generator for a chemically amplified resist composition used in manufacturing of semiconductor element and the like or a raw material for synthesizing heat resistant polymers, an acid generator and a resist composition using said compound and a method for pattern formation using said composition, and further relates to a synthetic n intermediate for a bisimide compound and a bis(N-hydroxy)phthalimide compound useful as an intermediate for a functional compound such as a heat resistant polymer or photosensitive material, and provides a bisimide compound shown by the general formula [1]: (wherein R and A1 are as defined in claim 1.)
Owner:WAKO PURE CHEMICAL INDUSTRIES +1

Polyetherimides, methods of manufacture, and articles formed therefrom

Polyetherimide compositions of formula (1) are described wherein the polyetherimide compositions comprise a polyetherimide comprising a reacted combination of alkali metal salts comprising an alkali metal salt of a dihydroxy aromatic compound and an alkali metal salt of a monohydroxy aromatic compound with a bis(halophthalimide), wherein the alkali metal salt of the monohydroxy aromatic compound is included in an amount of more than 0 and less than 5 mole percent, based on the total moles of the alkali metal salts, and the polyetherimide has a weight average molecular weight greater than or equal to 43,000 Daltons. The polyetherimide exhibits lower levels of chlorine and chlorine end groups, lower levels of bis(halophthalimide) and bis(phthalimide), and low plate-out during manufacturing.
Owner:SHPP GLOBAL TECH BV

Active phthalimide epoxy solvent-free dripping impregnating varnish and preparation method thereof

The invention relates to an active phthalimide epoxy solvent-free dripping impregnating varnish and a preparation method thereof. The varnish has the following components: 10wt%-15wt% of active phthalimide, 35wt%-45wt% of epoxy resin, 5wt%-10wt% of active toughening agent, 5wt%-10wt% of curing agent, 20wt%-45wt% of active diluent. The preparation method comprises the preparation of the active phthalimide and the solvent-free dripping impregnating varnish. The preparation features simple process and low cost and contributes to the realization of industrialized production; in addition, the solvent-free dripping impregnating varnish enjoys excellent comprehensive property, fine manufacturability and cohesiveness, excellent heat resistance and hydrophobicity, thus enjoying bright application prospect in fields such as motors of electric tools, small electric machine and the like.
Owner:DONGHUA UNIV +1

PASSI terpolymer and preparation method thereof

The invention discloses a PASSI terpolymer and a preparation method thereof. The invention is characterized in that sulphur, disubstituted phthalimide, disubstituted sulphone, reducing agent and reaction aid in a reactor filled with solvent, heating for reaction for certain time, pouring reaction liquid into precipitating agent, stirring and filtering, desalting and filter cake and residual solvent to obtain the PASSI terpolymer. Compared with the prior art, the invention has the advantages that the obtained product has good thermal stability (e.g. fluidity, mechanical property and heat resistance), lower fusion viscosity, wider processing window and excellent processing performance; meanwhile, the introduction of sulphur and sulphone containing structure can further reduce preparation cost of polyimide polymer.
Owner:NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI

Non-aqueous electrolyte and non-aqueous electrolyte cell

In a non-aqueous electrolyte comprising an organic solvent and a solute dissolved in the organic solvent, a lithium salt containing at least one organic anion selected from phthalimide, a derivative of phthalimide, phthalimidine and a derivative of phthalimidine is used as the solute. Such non-aqueous electrolyte is not liable to react with the negative electrode in a primary battery and a secondary battery during a long-term storage at high temperatures. As a consequence, by using this non-aqueous electrolyte, a non-aqueous electrolyte battery having an excellent storage property can be obtained; and the charge / discharge cycle characteristics are improved in a secondary battery.< / PTEXT>
Owner:PANASONIC CORP

Polyetherimides, methods of manufacture, and articles formed therefrom

Polyetherimide compositions are described wherein the polyetherimide composition comprises a polyetherimide comprising a reacted combination of alkali metal salts comprising an alkali metal salt of a dihydroxy aromatic compound and an alkali metal salt of a monohydroxy aromatic compound with a bis(halophthalimide), wherein the alkali metal salt of the monohydroxy aromatic compound is included in an amount of greater or equal to 5 mole percent based on the total moles of the alkali metal salts, and the polyetherimide has a weight average molecular weight less than 43,000 Daltons. The polyetherimide exhibits lower levels of chlorine and chlorine end groups, lower levels of bis(halophthalimide) and bis(phthalimide), and low plate-out during manufacturing.
Owner:SHPP GLOBAL TECH BV

Production method of n-(cyclohixylthio) phthalimide

One process of producing N-(cyclohexyl thio) phthalimide is provided, which uses hydrocarbon chloride and similar environment harming solvent and has high industrial yield and high production efficiency. The process of producing N-(cyclohexyl thio) phthalimide features the first synthesis of cyclohexyl sulfenyl chloride in the mixed solvent of aromatic hydrocarbon and saturated hydrocarbon and the subsequent reaction between the cyclohexyl sulfenyl chloride and phthalimide in the mixed solvent of aromatic hydrocarbon and saturated hydrocarbon.
Owner:TORAY FINE CHEMICALS CO LTD

Synthesis of Important intermediate for mosapride citrate

The present invention relates to the preparation process of important intermediates for Mosapride citrate, 2-oxethyl-4-actamino-5-chlorobenzoic acid and 4-(4-fluorobenzyl-2- aminomethyl morpholine. The intermediate 2-oxethyl-4-actamino-5-chlorobenzoic acid is prepared with amino salicylic acid as initial material and through acidification with hydrochloric acid, esterification with methol, acetylation with acetic anhydride, ethylation, NCS chlorination and alkali hydrolysis. The intermediate 4-(4-fluorobenzyl-2- aminomethyl morpholine is prepared with p-fluorobenzaldehyde and phthalimide as initial material and through dropping at 70-90 deg.c, maintaining at 125-145 deg.c, and post-treatment in ice bath in 2-10 deg.c while adding acetic anhydride through stirring for 10-20hr. The present invention can raise the yield of Mosapride citrate and lower its production cost.
Owner:LUNAN BETTER PHARMA

USE OF PHTHALIMIDE AND/OR SULPHONAMIDE DERIVATIVES IN THE TREATMENT OF DISEASES WHICH REQUIRE REDUCING THE TNF-alpha LEVELS AND AN EXOGENOUS SOURCE OF NITRIC OXIDE, PHTHALIMIDE DERIVATIVES, SULPHONAMIDE DERIVATIVES, AND A METHOD FOR OBTAINING A SULPHONAMIDE DERIVATIVE

The present invention refers to the use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, which have important activities in increasing the gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF-α levels and an exogenous source of nitric oxide. More particularly, the present invention describes the use of such phthalimide and/or sulphonamide derivatives for the treatment of sickle-cell disease. The invention also has as a novel characteristic the disclosure of new functionalized phthalimide derivatives designed from the prototypes thalidomide and hydroxyurea, and designed rationally through the strategy of molecular hybridization for the treatment of said diseases. The invention still discloses a new method for obtaining a specific sulphonamide derivative which can be used in the preparation of a drug for the treatment of diseases which require reducing the levels of the TNF-α factor and an exogenous source of nitric oxide.
Owner:UNIV ESTADUAL DE CAMPINAS UNICAMP +2

Use of phthalimide derivative in preparation of medicament for resisting angiogenesis

The invention relates to the action of phthalimide derivatives of formula I and II in the preparation of medicament against angiogenesis, wherein the definitions of each substituent group are described in the specification.
Owner:北京恩华医药研究院有限公司 +1
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