510results about How to "The reaction is easy to operate" patented technology

The invention discloses a nitrogen doped carbon quantum dot as well as a preparation method and an application thereof, belonging to the technical field of material science. The preparation method comprises the steps: after mixing organic acid and organic amine, directly performing a hydrothermal reaction to prepare a nitrogen doped carbon quantum dot water dispersion solution, and extracting and drying the nitrogen doped carbon quantum dot water dispersion solution to obtain a nitrogen doped carbon quantum dot solid. The size of the nitrogen doped carbon quantum dot is not more than 10 nm, the nitrogen content is not more than 50 percent, the surface of the nitrogen doped carbon quantum dot contains amino, carboxyl and hydroxyl; and the quantum efficiency is 39.8-50 percent. The preparation method is simple to operate, environment-friendly, low in equipment requirement; and the prepared nitrogen doped carbon quantum dot has excellent light emitting property, and can be widely applied to fields such as photoelectric materials, biological imaging and fluorescence probe.

The invention discloses a phenyl bistriazole compound, and a preparation method and application thereof, and particularly relates to a 1-[4-(1H-1,2,4-triazole-1-yl)phenyl]-1H-1,2,4-triazole single crystal and a preparation method of 1-[4-(1H-1,2,4-triazole-1-yl)phenyl]-1H-1,2,4-triazole. The organic compound is prepared by heating ethylenediamine, 1H-1,2,4-triazole, potassium carbonate, 1,4-diiodobenzene and cuprous iodide through a one-pot method. The preparation method disclosed by the invention has the characteristics simple process operation, low production cost and less environmental pollution, and is suitable for large-scale industrial production. The 1-[4-(1H-1,2,4-triazole-1-yl)phenyl]-1H-1,2,4-triazole single crystal prepared by the invention can be used in the aspect of photoelectric materials, especially dye and luminescent agents.

The invention relates to a carbon-aerogel-carried bimetal organic framework electro-Fenton cathode and a preparation method thereof. The preparation method comprises the following steps: by using a block carbon aerogel as a substrate electrode, carrying out hydrothermal reaction to load a bimetal organic framework onto the substrate electrode, filtering, washing, and carrying out vacuum drying to obtain the carbon-aerogel-carried bimetal organic framework electro-Fenton cathode, wherein the bimetal organic framework is a Fe / Co bimetal organic framework. Compared with the prior art, by combining the photocatalytic technique and electro-Fenton, the carbon-aerogel-carried bimetal organic framework electro-Fenton cathode can degrade organic pollutants by using the higher-efficiency low-energy-consumption advanced oxidation technique, thereby providing a new way for using the electro-Fenton cathode in the photocatalytic / electro-Fenton combined technique for treating nondegradable organic pollutants. The carbon-aerogel-carried bimetal organic framework electro-Fenton cathode has the advantages of simple technical operation, energy saving and high efficiency, and has very wide application range in the field of actual water treatment.

The invention provides a high temperature resistant Gemini cationic viscoelastic surfactant (VES) and a synthetic method thereof, relating to the field of oil recovery technology and engineering in the petroleum industry. The synthetic method is characterized by reacting unsaturated long-chain fatty acid with N,N-dimethyl propanediamine to synthesize a fatty acid amide intermediate; reacting methylamine with epichlorohydrin to synthesize a chloramine intermediate; reacting the intermediates synthesized in the two above steps respectively to synthesize the high temperature resistant Gemini cationic VES. The VES and the synthetic method have the beneficial effects that a high temperature surface active diverting acid system reacts with rocks at 160 DEG C, so that the liquid obviously diverts to become viscous and is subjected to automatic gel breaking under the condition that the hydrochloric acid concentration is below 5%, thus achieving rapid flowback; the VES has good temperature resistance, is relatively low in price and is beneficial for popularization and application.

The invention discloses a method for preparing azithromycin. The method comprises the following steps of: in acid aqueous solution and under an action of potassium borohydride, performing the reduction reaction of erythromycinA6, 9-imine ether represented by a formula II, then performing methylation reaction, and putting the reaction products in a mixed solvent of water and halogenated hydrocarbons for hydrolysis reaction so as to obtain the azithromycin represented by a formula I. In the method, the reducer is properly consumed, the yield is high, and the cost of the preparation of the azithromycin is obviously reduced. The invention also relates to a method for preparing the erythromycinA6, 9-imine ether and erythromycinA9-oxime.

The invention provides a method for industrially producing an industrial, cell-grade or high-purity lithium hydroxide monohydrate, which comprises the following steps of: (1) grinding; (2) removing impurities by a thermal precipitation method; (3) causticizing; and (4) removing impurities, crystallizing, washing, separating and drying. The invention also provides a method for preparing high-purity lithium carbonate. After causticizing reaction equipment and a reaction method which are provided by the invention are utilized, the feeding amount of the single causticizing production can be greatly improved and the large-scale industrial continuous production of the industrial and cell-grade lithium hydroxide monohydrate and the high-purity lithium carbonate is implemented; the consumption of water resources and energy can be effectively reduced and in the reaction, only a cheap precipitating agent or a cheap complexing agent needs to be used, so that the production cost is reduced; and the reaction is simple and convenient to operate and, the environment pollution is small, the obtained product has high quality and yield, the quality of the obtained product is stable and the product has wide industrial application prospect.

The invention discloses a linaclotide solid-phase synthesis method, and belongs to the biochemical technical field. The method includes the following steps: (1) preparation of linaclotide resin; (2) cutting the linaclotide linear peptide resin obtained in the step (1), to obtain a protection group linear peptide containing Cys(Acm) and Cys(tBu); (3) oxidizing to form a first disulfide bond, to obtain a monodisulfide cyclopeptide; (4) removing an Acm protection group in the monodisulfide cyclopeptide, to obtain a dual disulfide cyclopeptide; (5) removing a tBu protection group of the dual disulfide cyclopeptide, to obtain a trisdisulfide cyclopeptide; and (6) purifying the trisdisulfide cyclopeptide by HPLC, and freeze-drying to obtain linaclotide. The process has the characteristics of simple reaction operation, easy post-processing, low cost, high yield, and considerable economic and practical values, and besides, has wide application prospect in the polypeptide drug design and synthesis field.

The invention discloses a method for preparing an organic ternary polycarboxylic acid dustless antirust additive 2,4,6-tri(amino caproyl)-1,3,5-triazine by adopting a one-pot method, which comprises the following steps of: ring-opening caprolactam with alkali to generate carboxylate of aminocaproic acid first; then performing a substitution reaction by the carboxylate of aminocaproic acid and cyanuric chloride; and finally, acidizing with hydrochloric acid to prepare derivatives of organic ternary polycarboxylic acid. The preparation method is free from a toxic organic solvent and employs common water as a solvent for reaction. The preparation method ha the advantages of simple process operation, low production cost and low environmental pollution and is more suitable for large scale industrial production.

The invention relates to a method for preparing aromatic-aliphatic copolyester. In the method, aromatic binary acid, dihydric alcohol and aliphatic hydroxy acid are used as a copolymerization system to prepare the aromatic-aliphatic copolyester by direct melt polycondensation under the action of a catalyst, wherein the dihydric alcohol is one or both of aliphatic dihydric alcohol and cyclized aliphatic dihydric alcohol. The method overcomes the defect of the generation of poisonous methanol in the prior ester exchange process. By the random copolymerization, a polylactic acid chain segment can be introduced to an aromatic polyester chain segment, and the sequence length of an aromatic component is reduced, thereby improving the degradation property of the copolyester and keeping better mechanical behavior; moreover, the method also has the advantages of simple synthesis process, easy reaction operation and low-priced and easily obtained materials, and the obtained copolyester has certain degradation property.

A benzimidazole ester compound, 2-ethoxy-1-(p-halophenyl) methyl-1H-benzimidazole-7-carboxylate-1-[[(cyclohexoxy)carbonyl] oxy] ethylester, its preparing process, and its application in preparing medicinal compound candesartan ester are disclosed.

The invention relates to a method for synthesizing 6-methyl-17alpha-acetoxyl-19-norpregnane-4,6-diene-3,20-diketone. The method comprises the following steps: 1) reacting acetylene with estrone-3-methyl ether so as to obtain 17alpha-acetenyl estrone-3-methyl ether; 2) carrying out Birich reaction at a low temperature; 3) carrying out alkene etherification on the product obtained in the step 2); 4) carrying out a Vilsmeier reaction on the product obtained in the steps 3); 5) reacting the product obtained in the step 4) with benzene sulfenyl chloride; 6) reacting the product obtained in the step 5) with sodium methoxide and trimethyl phosphate; 7) reducing the formoxyl at the 6-position of the product obtained in the step 6); and 8) reacting the product obtained in the step 7) with Pd-C / cyclohexene, then reacting with acetic oxide so as to obtain the target product 6-methyl-17alpha-acetoxyl-19-norpregnane-4,6-diene-3,20-diketone. By using the method, the operation is simplified, and theproduction cost is reduced; and the reactions involved in the invention are simple to operate, and the yield is high.

A nano colloidal golf linked immunoassary for detecting carbofuran includes such steps as coupling the immunized semi-antigen of carbofuran with BSA, synthesizing artificial immunoantigen compound, immunizing animal to prepare specific high-valence BFNH antibody, separating and purifying, linking the nano-class colloidal golf to said specific antibody, solidifying said linked compound, carbofurancoupled by egg albumin and sheep's mouse IgG antibody on a carrier, and for semi-quantitative analysis. Its advantage is high sensitivity and speed.

The invention belongs to a test paper and a preparation method for quickly semi-quantitative testing the residual quantity of 2, 4-D in synthetic water samples, the invention relates to a GICA reaction which relies on a colloidal gold mark to show color, and the invention belongs to the immunochemistry measurement technical field. The theory of the invention is according to the reaction of 2, 4-D and the accurately quantitative gold mark antibody, and then the reactant has an emulous combination with the 2, 4-D-OVA which is cross-band-shaped distributed on the GICA film, and the content of the 2, 4-D of the sample is judged by the number of the stripe on the GICA film. The number is huge, the content of the 2, 4-D of the sample is high, the LOD of the 2, 4-D is 21ug / l, and the test can be finished in 10 minutes. The invention has practical character and remarkable progress, the traditional multi-step fussy detecting of the agricultural chemical is changed, and the method for quickly semi-quantitative testing the residual quantity of 2, 4-D in one-step is realized. The test paper stripe comprises a soleplate, an absorbent filter, a nitrocellulose membrane, a gold mark pad of anti-2, 4-D antibody and a sample adsorption pad, the nitrocellulose membrane in the middle of the soleplate is used for the experiment reacting region of a cellulose nitrate membrane, 4 detection lines and a quality control line are on the cellulose nitrate membrane, a sample area is on the far left, an absorbent filter is on the other end of the soleplate.

The invention discloses a method for preparing artemisinin through arteannuic acid. The method comprises the steps that first the arteannuic acid is processed to obtain a dihydroartemisinic acid under the effect of a reducing agent such as sodium borohydride / nickel chloride or a hydrogen / metal catalyst, and then the dihydroartemisinic acid is oxidized into a peroxided dihydroartemisinic acid through peroxide in the presence of the catalyst, and finally the target product artemisinin can be obtained with high yield under the catalyzing of the acid and the effect of oxygen; or a dihydroartemisinic acid derivative can be obtained from the dihydroartemisinic acid based on the protection on carboxyl, and the dihydroartemisinic acid derivative is oxidized into a relevant peroxided dihydroartemisinic acid derivative through the peroxide in the presence of the catalyst, and then the target product artemisinin can be obtained with high yield under the catalyzing of the acid and the effect of the oxygen. Compared with the prior art, the method for preparing the artemisinin through the arteannuic acid has the advantages as follows: the used agent has low cost, and is easy to obtain; the synthetic route is short; the reaction selectivity is high; the preparation process is environmental-friendly; the operation and post-processing are simple; the total yield is high; and the method for preparing artemisinin through the arteannuic acid is applied to industrial production.

The invention discloses a triggering method of acrylamide through two-segment composite low-temperature and high-temperature system, which comprises the following steps: adding acrylamide monomer into water with density at 20-40% without removing oxygen; cooling to 0 deg.c; adding oxidant-reducer-catalyst and azo-compound into composite system; sealing the reactor; insulating to react for 4-6h to finish polymerizing; fetching gel-shaped material; purifying through anhydrous alcohol; drying in the vacuum under 50-60 deg.c to constant weight; obtaining the product with molecule at 20000000-28000000; simplifying the reaction without removing oxygen.

The invention relates to the field of pharmaceutical chemistry, in particular to a synthesis method of a minodronate midbody and synthesis of minodronate. The preparation method of minodronate includes the following steps: using organic solvent to dissolve 2-aminopyridine, adding 4-acetyl chloride ethyl acetoacetate for reaction, monitoring the reaction solution by TLC(Thin-Layer Chromatography) until spots of 4-acetyl chloride ethyl acetoacetate disappear, concentrating to a dry state, dissolving concentrate in water, washing a water layer to remove impurities, extracting the water layer with the organic solvent, washing extract liquor, separating out an organic layer, conducting filtration, and concentrating the concentrate to be in a dry state, thereby obtaining A1.

The present invention discloses a method for synthesis of acetal / ketal in presence of acidic ionic liquid as catalyst, including: taking aldehyde / ketone and alcohol as raw materials and cyclohexane as a dehydrating agent, and performing azeotropic dehydration condensation under the catalytic action of the acidic ionic liquid at 80-120 DEG C. The acetal / ketal is obtained by aftertreatment of the reaction liquid after the reaction is completed. The acidic ionic liquid is a 3-(3-sulfonic acid)propyl benzothiazole salt acidic ionic liquid. The alcohol is C2-C4 organic alcohol. The method for synthesis of acetal / ketal catalyzed by the acidic ionic liquid has the advantages that the reaction operation is simple and convenient; separation of the catalyst from the product is easy; product purity and yield are high; and the catalyst can be reused and the catalytic activity thereof is essentially same. Accordingly, the method has broad application prospects.

The present invention discloses skeleton nickel catalyzed 5-nitrobenzimidazole ketone reducing process for preparing 5-aminobenzimidazole ketone, and belongs to the field of 5-aminobenzimidazole ketone preparing technology. The process includes: adding Ni-Al alloy into NaOH solution at certain temperature and in certain concentration to react for certain time and washing with water and anhydrous alcohol for several times to obtain skeleton nickel maintained in anhydrous alcohol; setting skeleton nickel, 5-nitrobenzimidazole ketone and anhydrous alcohol in certain weight proportion into high pressure kettle to react at 80-120 deg.c and 1.0-6.0 MPa for 4-15 hr; filtering to eliminate catalyst, vacuum distilling, suction filtering, and vacuum drying the filter cake to obtain 5-aminobenzimidazole ketone. The present invention has the advantages of simple technological process, easy operation, low cost, product yield of 89.0-94.0 % and purity 97.0-99.8 %, and environment friendship.

The invention relates to a synthetic method of tetra(dimethylamino)hafnium, which comprises the following steps: in an argon atmosphere, adding dimethylamine and n-hexane into a three-necked bottle, evenly mixing, putting the reaction bottle at -40--80 DEG C, dropwisely adding an n-butyllithium solution into the reaction bottle, and mixing to react for 10 hours; adding hafnium tetrachloride into the reaction system, keeping the temperature of the reaction system at 20-60 DEG C, and after finishing adding the hafnium tetrachloride, mixing the reaction system under inert gas shielding to react for 24-30 hours; after the reaction finishes, removing the reaction solvent in one atmosphere; and after all the solvent n-hexane is removed, carrying out reduced pressure distillation to collect 80-85 DEG C / 2-5mmHg fraction which is the tetra(dimethylamino)hafnium compound. The dimethylamine, butyllithium and zirconium tetrachloride which are simple and accessible are used as the reaction raw materials; and thus, the invention is simple to operate and lowers the cost.

The invention discloses a continuous synthesizing method of indoor ion liquid, which comprises the following steps: adopting pyridine or N-alkyl imidazole and halogenated hydrocarbon under normal pressure; stirring; making hydrocarbyl pyridine ammonium halides or 1, 3-dialkyl imidazole ammonium halides; adding fluorine salt to stir to react; obtaining the ion liquid under normal temperature; avoiding pollution due to using organic solvent; temperating reacting condition; improving reacting receiving rate and product quality; fitting for large scale of industrial manufacturing.

The invention relates to a method for synthesizing 5-(alkylamide-)-9-(N, N-dialkylamide) benzo-phenoselenazine hydrochloride shown in a formula I by using nanometer copper oxide as a catalyst. A benzo-phenoselenazine derivant, namely the 5-(alkylamide-)-9-(N, N-dialkylamide) benzo-phenoselenazine hydrochloride is an excellent photosensitizer for a photodynamic therapy, has the absorption wavelength above 650 nanometers, good water solubility, larger absorption intensity, high tumor cell selectivity and short metabolic time and is easy for synthesis and structure modification, thereby being an ideal novel photosensitizer. The method comprises the following steps of: with 3-iodo-N,N-dialkylaniline and selenium powder as raw materials, preparing di-(3-N,N-dialkylaniline) diselenide shown in a formula II under the catalysis of copper oxide, carrying out a nitrosation reaction on the bi-(3-N,N-dialkylaniline) diselenide and sodium nitrite to generate a bi-(3-N, N-dialkylamide-6-nitrosobenzene) diselenide, and finally carrying out a cyclization reaction on the bi-(3-N,N-dialkylamide-6-nitrosobenzene) diselenide and N-alkyl-1-naphthylamine to prepare the benzo-phenoselenazine derivant shown in the formula I. The method for synthesizing the benzo-phenoselenazine derivant is mild in reaction conditions, simple to operate and high in yield; and the raw materials are available.

The invention relates to a method for preparing paraphthaloyl chloride. The method comprises the following steps: mixing thionyl chloride and terephthalic acid according to the mass ratio of 2:1 to 5:1; adding one or more of nitrogen-containing organic bases such as substituted pyrrolidine, substituted piperidine, substituted pyridine, (substituted) quinoline, (substituted) isoquinoline, (substituted) phenanthroline, substituted imidazole, substituted benzimidazole and the like as a catalyst, which are 0.5-2% of mass of terephthalic acid; reacting at 70-120 DEG C for 4-16 hours; distilling and recovering excessive thionyl chloride; distilling or rectifying in vacuum to recover the catalyst, so as to obtain the product paraphthaloyl chloride by vacuum rectification, wherein the yield can be up to 96%, and the purity is higher than 99%. The method has the advantages that the catalyst is low in price and available, and can be recycled, the product is high in yield and purity, the reaction operation is simple and convenient and the like.

The invention provides a preparation method of ilaprazole. According to the method, ilaprazole is prepared through a thioether intermediate; obtained ilaprazole is high in quality and has no overoxidation impurities; the method is simple and easy, high in yield, low in cost, environment-friendly, and suitable for industrial production, and has no need for special equipment; and no toxic chloroform solvent is used.

The invention discloses a polymer containing a cyclic azobenzene-dinaphthalene structure on a side chain as well as a preparation method and application of the polymer. Specifically, the polymer has a structure shown by a formula I, and is prepared by the method comprising the following steps: (1) obtaining two types of donors; (2) connecting the two types of donors and performing closed-loop reaction; (3) synthesizing a cyclic monomer; and (4) synthesizing the polymer. The polymer disclosed by the invention is relatively good in product processability and mechanical property, and relatively narrow in molecular weight distribution; meanwhile, a general free radical polymerization method is adopted to synthesize asymmetrical monomers into a chiral optical polymer, and the experimental operation is simple and feasible, so that a new idea is provided for designing and synthesizing polymer chiral optical switches; and moreover, the chemical reagents used in the method disclosed by the invention are stable in the air, and the method is simple and convenient to operate, is high in efficiency and is convenient for industrial production.

The invention relates to the field of synthesis of compounds, in particular to a new method for synthesizing 6- methyl-17alpha-acetoxyl-19-norpregna-4,6-dialkyl-3,20-diketone. According to the method provided by the invention, norethindrone is taken as starting material to prepare 6- methyl-17alpha-acetoxyl-19-norpregna-4,6-dialkyl-3,20-diketone, the method provided by the invention has the advantages that the defects in the prior art are overcome, operation is simplified and production cost is reduced, related reactions and operations are simple, yield is high, and the yield of each step is 80% or above.

The invention discloses a method for preparing starch sulphate with high degree of substitution. In the method, sulfur trioxide pyridine is taken as an esterifying agent, dimethylformamide is taken as a dissolvent, and the sulfur trioxide pyridine and the dimethylformamide are used for esterfying starch so as to obtain the starch sulphate with high degree of substitution being 0.2-0.9, wherein the mass ratio of the sulfur trioxide pyridine to the starch is (1:1)-(5:1). Solid sulfur trioxide pyridine is taken as a sulfonating agent, so that the method is easy to control, the reaction operation is convenient and the sulfonation reaction degree is higher; in addition, by utilizing the method, corrosion of strong acid liquids on equipment can be avoided; and the dissolvent is convenient to recycle, thus preferably avoiding pollution to environments.

The invention relates to a preparation method of avanafil and a new compound provided in a preparation process. According to the method, 5-uracil carboxylic acid or an ester thereof is taken as the raw material, and the avanafil meeting the clinical requirements can be synthesized at a relatively cost; besides, the preparation method is simple and convenient to operate, mild in reaction conditions, high in yield, low in cost, environmentally friendly and suitable for industrial large-scale production of the avanafil.

The invention provides a preparation method of 3,3'-methylenebis(1H-Indole). The preparation method comprises the following steps that 1, indole and p-toluenesulfonic acid are dissolved in a solvent comprising water and 95wt% of ethanol and a formaldehyde aqueous solution is added into the mixed solution in a nitrogen protective atmosphere; 2, the mixture obtained by the step 1 undergoes a reaction at a room temperature in dark for 20 to 30 hours, preferably, for 24 hours; 3, reaction products are filtered so that solids precipitated by the step 2 are obtained; and 4, the solids obtained by the step 3 are subjected to recrystallization purification. In addition, the invention also provides a use of the prepared 3,3'-methylenebis(1H-Indole) which is a high purity compound in preparation of drugs.

The invention discloses a preparation method of a bifunctional MOF (Metal Organic Framework) nano-catalyst for degrading p-nitrophenol and simultaneously fixing nitrogen at room temperature and application of the bifunctional MOF nano-catalyst based on bifunctional electrocatalysis of the catalyst, and belongs to the technical field of metal organic framework material technologies and nano-catalysis. The preparation method comprises the following main steps: blending an isophthalic acid ligand solution with a mixed solution of zinc nitrate and cobalt nitrate, and adding a triethanolamine solution and activated carbon cloth to prepare a carbon cloth loaded Zn-MOF and Co-MOF crystal composite material; and activating the composite material in a 250 W microwave oven for 3 min to obtain the bifunctional MOF nano-catalyst. The catalyst is prepared from low-cost raw materials, is low in reaction energy consumption and has a good industrial prospect. The catalyst is used for degrading p-nitrophenol and fixing nitrogen at room temperature, and has the advantages of simple equipment, high electrochemical stability and the like.

The invention discloses a preparation method of hydrophobic association type cationic polyacrylamide. The preparation method specifically comprises the following steps of under the condition of existence of a nonionic surfactant, adding a certain ratio of acrylamide monomer, cation monomer, low molecular weight anionic polymer and deionized water into a reaction device, and completely and uniformly stirring, so as to form a micelle copolymerizing system; adding a small amount of solubilizer and photo-sensitive initiator into the micelle copolymerizing system, and uniformly stirring; after theoxygen in the device is completely exhausted, sealing the device, placing into an ultraviolet reaction device, and performing photo-initiating micelle copolymerizing and reaction, so as to obtain a hydrophobic association type cationic polyacrylamide gel with a block structure; finally, purifying the gel, refining, drying and granulating, so as to obtain a final product. The prepared hydrophobic association type cationic polyacrylamide has the advantages of hydrophobic association property, centralized distribution of cationic groups, strong electron neutralizing ability, high molecular weightand the like, has good flocculation property, and can be widely applied to multiple types of sewage treatment and sludge dewatering technology.