832 results about "Propylamine" patented technology

The invention belongs to the technical field of preparation of a carbon nano material, and particularly relates to a method for preparing a carbon dot having a high fluorescent quantum yield from citric acid and different nitrogen-containing molecules. The method comprises the following steps: weighing 1-10 mmol of solid citric acid, and dissolving in 10 ml of deionized water; weighing 1-10 mmol of ethylenediamine, ethylamine, propylamine, butanediamine, n-hexylamine, p-phenylene diamine or urea, adding into the citric acid solution, and uniformly stirring; transferring the solution into a hydrothermal or high-pressure microwave reaction kettle, reacting under hydrothermal or microwave conditions, and naturally cooling the reaction kettle to room temperature, thus obtaining a yellow or brown carbon dot water solution; and finally, purifying the carbon dot water solution, evaporating, and drying to obtain pure carbon dot solid powder. The carbon dot solution can send out bright blue fluorescence under the irradiation of a handheld ultraviolet lamp. The invention has wide application prospects in the fields of biological imaging, fluorescent printing and the like.

The invention provides a tulathromycin intermediate, a preparation method of the tulathromycin intermediate, and a preparation method of the tulathromycin. The preparation method of the tulathromycin has the advantages of mild condition, convenience for operation, and low cost. The preparation method of the tulathromycin comprises the following steps of: using azithromycin A as a raw material; protecting 2'-hydroxy and 6'-amino in the azithromycin A through di-tert-butyl dicarbonate so as to obtain double-protective azithromycin A; carrying out Swern oxidation to 4''-hydroxy to the double-protective azithromycin A; salifying along with trifluoroacetic acid; and synchronously removing boc t-butyloxycarbonyl to obtain the azithromycin A bitrifluoroacetic acid salt of 4''-carbonyl; and then reacting with trimethylsulfonium bromide to obtain 4''-epoxy compound; and finally carrying out nucleophilic addition on the 4''-epoxy compound by n-propylamine so as to obtain the phosphate of tulathromycin; and further neutralizing via alkaline to obtain the target compound tulathromycin; and synchronously obtaining the tulathromycin intermediate of azithromycin A bitrifluoroacetic acid salt of 4''-carbonyl.

Relating to an enzyme capable of efficiently converting a ketone compound to an optically active amino compound by transamination, and a process for preparing an optically active amino compound using the enzyme. An (S)-alpha-phenethylamine:pyruvate transaminase, which acts on (S)-alpha-phenethylamine and a ketone compound, thereby catalyzing transamination for forming acetophenone and an amino compound corresponding to the ketone compound; a process for preparing an optically active amino compound using the transaminase; and a method for culturing a microorganism for producing the above transaminase, comprising adding to a medium one or more compounds selected from the group consisting of propylamine, 1-butylamine, 2-butylamine, 2-pentylamine, isopropylamine and isobutylamine as an inducer for the enzyme when a microorganism for producing (S)-alpha-phenethylamine:pyruvate transaminase is cultured.

The invention provides a Cu-SAPO-34 molecular sieve catalyst and a preparation method and application thereof. The method includes the steps of adding pseudo-boehmite to deionized water, stirring, adding fumed silica or silica sol and orthophosphoric acid, uniformly mixing, adding copper sulfate and tetraethylenepentamine, fully stirring, and adding diethylamine, triethylamine or n-propylamine; placing fully stirred gel in a hydrothermal reaction kettle for crystallization, cooling at room temperature, separating a solid crystalline product from the mother liquor, washing to be in neutral, drying, and calcinating in air at the temperature of 600 DEG C to 850 DEG C to obtain the Cu-SAPO-34 molecular sieve catalyst. The Cu-SAPO-34 molecular sieve catalyst prepared through a one-step hydrothermal synthesis method. And the molecular sieve catalyst of good NH3-SCR catalytic activity and hydrothermal stability is obtained by controlling the using amount of copper sulfate, tetraethylenepentamine and fumed silica or silica sol and the calcination temperature.

The present invention relates to an improved process for preparing chiral N-substituted N-methyl-3-hydroxy-3-(2-thienyl)-propylamine on an industrial scale using an asymmetric hydrogenation as a key step and optionally a special sequence of subsequent steps, using a catalyst system consisting of rhodium and (2R, 4R)-4-(dicyclohexylphosphino)-2-(diphenyl-phosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine.

Copy-protected optical medium utilizing a composition comprising a transient optical state change security materials capable of changing optical state when exposed to a wavelength of about 630 nm to about 660 nm and an electron transfer agent.

A method for the treating septic shock in a patient comprises administering to the patient a therapeutically-effective amount of a composition comprising a compound having the formula (I): wherein R1 is hydrogen, hydroxyl, carboxyl, amino or C1-C8alkyl; R2 is hydrogen, hydroxyl, amino or C1-C8 alkyl; and R3 is hydrogen, hydroxyl, carboxyl, amino, C1-C8 alkyl, substituted or unsubstituted phenyl, amide, C3-C8 aminoalkyl, or C1-C8 aminoalkylcarbonyl; or a therapeutically-effective salt, ester or solvate thereof. Particularly preferred compounds for use in the present invention include butylamine, propylamine, diaminopropane, diaminobutanone, tyrosine, threonine, asparagine, and aspartate.

The invention relates to a selective flocculation reverse flotation desilication process of collophanite containing primary slime. The process comprises the following steps of: adding a modifier sodium hydroxide or sodium carbonate to the pulp obtained after the collophanite containing primary slime is subjected to the reverse flotation demagging till the pH value of the slurry is between 9.5 and10.5; then, adding a dispersant water glass or alkali metal phosphate, a flocculant anionic starch and a collector ethers propylamine or alkyl diaminopropane for roughing and obtaining concentrate ina roughing groove; and adding a collector to roughed foam, concentrating, using concentrated foam as tailing, returning middling in a concentrating groove for roughing or mixing with the concentrate in the roughing groove into mixed phosphor concentrate, wherein flotation machine impellers have the rotating speed of 1900-2400 rounds / min. In the process provided by the invention, the anti-flotation separation of siliceous gangue of quartz class is realized by adjusting the pH value of the slurry, adding various agents and selectively flocculating and inhibiting the collophanite according to the surface acting force of the various medicaments on the collophanite surface, and the optimal separation effect is achieved through adjusting the rotating speed of the flotation machine impellers.

The invention relates to a synthetic method using hetero atoms to replace the AEL framework structure of a phosphoaluminate molecular sieve, and the method uses the hetero atoms of chlorine, titanium, cobalt, calcium, palladium, zinc, cerium, etc. as the materials of the hetero atoms to replace the AEL framework structure of the phosphoaluminate molecular sieve. In the synthesis process, aluminum isopropoxide or pseudo-boehmite is used as aluminum resources, and hexacosanoic propylamine and isopropylamine or the mixture of both are used as templates, thereby realizing the purposes of single feeding adoption, relatively mild crystallization condition, suitable water-solid ratio and great template dosage reduction. Once crystallization in the process can improve the crystallization efficiency, greatly improve the synthesis efficiency and control the formation of mixed crystal, having obvious advantages.

Objects of the invention are to provide a method in which coated metal fine particles are smoothly manufactured when the coated metal fine particles are manufactured using a metal amine complex decomposition method, and, particularly, to provide coated metal fine particles that can be smoothly sintered even at a low temperature. The manufacturing method of coated metal fine particles includes a first step of mixing an amine liquid mixture of an alylamine having 6 or more carbon atoms and an alkylamine having 5 or less carbon atoms with a metal compound including one or more metal atoms, thereby generating a complex compound including the metal compound and amines; and a second step of heating and decomposing the complex compound, thereby generating coated metal fine particles.

The invention discloses an omega-aminotransferase mutant gene and an application thereof, and belongs to the field of the molecular biological technology. The nucleotide sequence of the omega-aminotransferase mutant gene is shown as SEQ ID NO.1. The omega-aminotransferase amino acid sequence embodied by the code of the omega-aminotransferase mutant gene is shown as SEQ ID NO.2. The omega-aminotransferase mutant gene is firstly provided, and the omega- aminotransferase corresponding to the code of the omega-aminotransferase mutant gene has a high enzyme amount, so that the biological catalysis and conversion efficiency is improved in industrial production. The invention further provides the application of the omega-aminotransferase embodied by the code of the omega-aminotransferase mutant gene in preparation of trifluoro-propylamine. The trifluoro-propylamine is added to a buffer solution to serve as the substrate for the reaction, and then products of trifluoromethyl amine compounds are collected from the reaction liquid. The method for preparing the trifluoro-propylamine has the obvious advantages that the reaction conditions are mild, no pollution is caused, and the process is simple.

The invention provides a fluorescent monomer and a fluorescent acrylic acid polymer and a preparation method of the fluorescent monomer and the fluorescent acrylic acid polymer. The monomer and polymer are respectively shown in formulas (I) and (2), wherein m is 1 or 2, n is 10-120, R1 is H or -CH3, R2 is -CH3, -CH2CH3,-CH2CH2CH3 or -CH2CH2(OH)CH3. The preparation method is as follows: reacting 4-bromine-1,8-naphthalic anhydride with n-propylamine so as to obtain N-propyl-4-bromine-1,8-naphthalimide; reacting the N-propyl-4-bromine-1,8-naphthalimide with ethanolamine so as to obtain N-propyl-4-(2-ethoxyamino)-1,8-naphthalimide; reacting the N-propyl-4-(2-ethoxyamino)-1,8-naphthalimide with PBr3 so as to obtain N-propyl-4-(2-bromomethylamino)-1,8-naphthalimide, and dropwise adding unsaturated compound dimethylaminoethyl methacrylate so that the fluorescent monomer is obtained; and condensing the fluorescent monomer with at least one crylic acid monomer. The fluorescent polymer can be used as a special scale inhibitor for a sea water circulating cooling or sea water desalinization system, and has a good scale dispersion property and a good fluorescent trace characteristic.

A solution for treating a surface of an iron material includes (a) zirconium fluoride; (b) ion of a rare earth element and / or a compound containing a rare earth element; (c) a polyallylamine; (d) aluminum ion; and (e) free fluorine ion. Zirconium in the component (a) is at a weight concentration A of 10 to 1000 ppm. The ratio K of the weight concentration B of the rare earth element in the component (b) to the weight concentration A (B / A) is 0.1 to 30. The component (d) is at a weight concentration D of 50 to 250 ppm. The component (e) is at a weight concentration E of 0.5 to 30 ppm. A coating having excellent corrosion resistance before and after the subsequent coating can be deposited on the surface of an iron material by using the surface treating solution which does not contain environmentally harmful ingredients.

The invention relates to a preparation method of Iopromide. 3-methoxy acetamino-5-(2,3-dihydroxy n-propylamine formyl)-2,4,6-triiodide benzoic acid shown as a formula (9) is used as an intermediate to provide a cheaper and more reasonable method for synthesizing Iopromide with high yield and purity.

The invention relates to a method for synthesizing ZSM-5 / ZSM-5 core-shell type zeolite molecular sieve, mainly solving the technical problems of expensive used raw materials, great environment pollution of template agent, high difficulty of industrial amplification and synthesis, difficult industrial production and the like of the core-shell type zeolite molecular sieve in the prior art. The invention adopts the following technical scheme: the core-shell zeolite molecular sieve is prepared by adopting ZSM-5 core phase molecular sieve with a relatively low silica alumina ratio as a seed crystal, using at least one of soluble glass, silica solution, sodium silicate, white carbon black or atlapulgite which are cheap and easily obtained as a silicon source, and taking at least one organic amine from ethylamine, ethanediamine, propylamine and butylamine or the mixture of the organic amine and inorganic amine as a template agent so as to better solve the above technical problems. The invention can be used in industrialized synthetic production of core-shell type molecular sieve.

The invention discloses a cationic viscoelastic surfactant and preparation and application thereof. The preparation method of the cationic viscoelastic surfactant comprises the following steps: firstly, mixing long-chain fatty acid with dimethylaminopropylamine according to a certain proportion, adding a catalyst solution to obtain a required amide product intermediate A by a series of reaction; allowing reflux condensation reaction of epoxy chloropropane and water at a certain proportion to be carried out in oil bath of 100 DEG C to obtain colourless and transparent 3-chloro-1,2-propylene glycol aqueous solution, namely an intermediate B; heating the intermediate A in oil bath for melting, and dropwise adding an aqueous solution B to obtain the required viscoelastic surfactant by a series of reaction; the surfactant can be mixed with a potassium chloride solution according to a certain proportion to obtain clean fracturing fluid which is low in cost and excellent in performance, besides, the clean fracturing fluid has excellent high-temperature resistance, shearing resistance, and excellent solid-carrying performance, is automatic and thorough in gel breaking, causes little damage to the reservoir stratum and has the characteristic of wide application range.

The invention belongs to the field of wet metallurgy and in particular discloses a compound leaching agent for preventing landslide in the process of leaching weathering crust deposit type rare earth ore in situ. The compound leaching agent consists of a mixed aqueous solution of an organic amine salt anti-swelling agent, a leaching agent and a pH regulator, wherein the concentration of the organic amine salt anti-swelling agent is 1-15g / L; the concentration of the leaching agent is 5-30g / L; the pH value of the mixed aqueous solution is regulated to be 4.0-6.0 by using the pH regulator. The compound leaching agent is preferably any one of dimethylamine hydrochloride, di-n-propylamine hydrochloride, diethylamine hydrochloride and triethylamine hydrochloride. Due to the addition of the anti-swelling agent, the compound leaching agent has the capacity of well preventing swelling of clay minerals, the rare earth leaching effect is not influenced, the leaching agent has the functions of leaching and preventing swelling, and landslide is effectively avoided in the process of leaching the weathering crust deposit type rare earth ore in situ.

The invention relates to a novel nano-composite double network hydrogel and a preparation method thereof. The preparation method of the hydrogel comprises the steps of: performing a condensation (polycondensation) reaction of amines and epichlorohydrin or polyalcohol and aldehydes in clay solution to obtain a condensate (polycondensate) / clay composite first; and adding a hydrophilic monomer under the action of an initiator and a cross-linking agent to obtain the nano-composite double network hydrogel through free radical crosslinking polymerization, wherein in the condensation (polycondensation) reaction, the amines are selected from dimethylamine, methylamine, ethylamine, propylamine, diethylamine, quadrol, propylene diamine, diethylenetriamine, triethylenetetamine and tetraethylenepentamine, the polyalcohol is selected from glycol, propanediol, glycerol, butanediol, neopentyl glycol, pentaerythritol, polyvinyl alcohol, polyethylene glycol, glucose, sucrose, sorbierite, soluble starch and chitosan, the aldehydes are selected from formaldehyde, malonaldehyde and glutaraldehyde, clay is selected from laponite, bentonite or hydrophilic modified bentonite, and the hydrophilic monomer is selected from acrylic acid, acrylamide, N-Isopropylacrylamide, methacrylic acid, acrylonitrile and propene sulfonic acid. The novel hydrogel has the excellent mechanical strength under the condition of high moisture content.

The invention relates to compounds of Formula (I): (A′)x-(A)-(B)—(Z)-(L)-C(═O)NH2 or pharmaceutically acceptable salts or solvates thereof, wherein: (A) is heteroaryl or aryl; each (A′), if present, is indepedently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (A′) is substituted with 0, 1, 2 or 3 substituents independently chosen from halo, haloalkyl, aryl, arylalkoxy, alkyl, alkoxy, cyano, sulfonyl, sulfinyl, and carboxamide; X is 0, 1, 2, or 3; (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B); (Z) is —NH—; and (L) is —(CH2)mCR1,R2—, wherein m is 0, 1, 2, 3, 4, 5, or 6, and wherein R1 and R2 are each independently hydrogen or C1-C6 alkyl; provided that, if (L) is —CH2— or —CH(CH3)—, then X is not 0. The compounds of the invention are useful in the treatment of diseases such as cancer and neurodegenerative diseases.

The invention discloses a preparation method for preparing intermediate body of Pramipexole dihydrochloride, which includes the following steps: in the dissolvent, under the exist of Zn(BH4)2, carrying out reduction reaction of (R, S) configuration, (R) configuration or (S) configuration 2-amino-6-propionamido-4, 5, 6, 7-tetrahydro benzopyrene, and then collecting (R, S) configuration, (R) configuration or (S) configuration 2-amino-6-propylamine-4, 5, 6, 7-tetrahydro benzopyrene from the reaction product. The method provided by the invention uses (R, S) configuration, (R) configuration or (S) configuration 2-amino-6-propionamido-4, 5, 6, 7-tetrahydro benzopyrene as raw material, and Zn(BH4)2 as reducing reagent, and has advantages of high reaction yield, easily obtained raw material and low production cost, and is suitable for industrial production.

The present invention discloses water treating agent containing methoxy naphthalene as fluorescent marker. The water treating agent is prepared through the first reaction of 4-chloro-1, 8-naphthalic anhydride, glacial acetic acid and 3-dimethylamino propylamine to obtain 4-chloro-N-3-dimethylamino propyl-naphthyl imide; the subsequent reaction with sodium methoxide to introduce methoxy group and obtain 4, 4-methoxyl-N-3-dimethylamino propyl-naphthyl imide, which is reacted with allyl chloride to obtain quaternary ammonium salt of 4-methoxyl-N-3-dimethylamino propyl-naphthyl imide allyl chloride as fluorescent monomer with fluorescent characteristic and double bond; and the final polymerization with phosphorus containing compound, acrylic acid and other monomer to obtain the multifunctional water treating agent with corrosion retarding, scale inhibiting, dispersing and fluorescent tracing functions.

The invention discloses a visible-light catalytic activity BiOBr-based heterojunction material which is prepared from BiOBr and Bi24O31Br10 at a mass ratio of (28%-100%):(0%-72%). A preparation method of the BiOBr-based heterojunction material comprises the following steps: (1) mixing bismuth nitrate, urea, and one or more than one of tetramethyl ammonium bromide, tetraethyl ammonium bromide, 2-bromoethylamine hydrobromide and 3-bromopropylamine hydrobromide at a mass ratio of 1:(0.1-1.0):(0.1-1.0) to obtain a mixture, and heating the mixture until melting so as to obtain an ionic liquid; (2) heating the ionic liquid obtained in the step (1) until burning; and (3) collecting a solid generated after complete burning in the step (2), and cooling and grinding the solid to obtain the BiOBr-based heterojunction material. The preparation method is simple without requiring complicated equipment, and is short in time, high in yield, low in cost and suitable for industrial large-batched production.

The invention relates to a method for preparing a silane polycarboxylate water-reducing agent, relates to a water-reducing agent in a concrete admixture and belongs to the technical field of building materials. The silane polycarboxylate water-reducing agent is prepared from polyoxyethylene ether macromonomer, sodium acrylate or a derivative monomer thereof, chain transfer agents, initiators, a silane functional monomer, 2-acryloyl amino-2-methyl-1-propane sulfonic acid and deionized water. The chain transfer agents are thioglycolic acid, mercaptopropionic acid, sodium methallyl sulfonate and sodium allylsulfonate. The initiators are sodium persulfate and ammonium persulfate. Silane monomer maleic anhydride and triethoxy silane propylamine are prepared through amidation. The silane polycarboxylate water-reducing agent is novel in molecular structure design, high in sulfate resistance and good in concrete material adaptability. The product has an obvious sulfate resistance effect while having a high performance water-reducing effect.

The invention relates to a SAPO-34 molecular sieve microsphere catalyst preparation method, which comprises: adding an aluminum source into deionized water under a room temperature stirring state, adding a phosphorus source, uniformly stirring, slowly adding a silicon source, continuously and uniformly stirring, adding a tetraethyl ammonium hydroxide solution, continuously adding one and / or a plurality of materials selected from isopropylamine, diethylamine and triethylamine after uniformly stirring to form a uniform gel, crystallizing, unloading the synthesized product mother liquor from the autoclave after completing the crystallizing, carrying out spray drying, and calcining for 1.5-2.5 h to obtain the catalyst. According to the present invention, the synthesis yield is high, the separation and the washing on the molecular sieve synthetic product are not required, and the one-time catalyst molding granulation is achieved.

The invention discloses a synthetic method of a floating agent of organophosphorous compound and the organophosphorous floating agent, belonging to the technical field of mineral separation. The synthetic method comprises the steps of: taking phosphorus trichloride as a phosphorus source, dissolving parahydroxyben-zaldehyde in ethanol, slowly dropping excess propylamine, reacting at room temperature, then obtaining product imine, using the mixture of the phosphorus trichloride and petroleum ether to prepare phosphite ester in a mixing liquid of the ethanol and the petroleum ether, then using the phosphite ester, the imine and anhydrous ether to prepare the mixture of phosphoramidic acid, imine, small amount of phosphite ester and solvent ether, and then conducting distillation, column chromatography and separation to obtain the organophosphorous floating agent phosphoramidic acid, therefore the method obtains 20 types of phosphoramidic acid compounds, and from which, 2-3 efficient and novel organophosphorous floating agents can be selected for use. The invention has simple synthetic method, easy operation and short period, and the obtained organophosphorous floating agent is widely applied to mineral dressing due to special structure thereof.

The present invention discloses one kind of silicon aluminum phosphate molecular sieve in AFO structure. It has molar composition in oxide form of Al2O3:yP2O5:zSiO2, where y is 0.60-1.20 and z is 0.05-1.3. It features that the molar composition before roasting to eliminate templating agent is (x1R1+x2R2):Al2O3:yP2O5:zSiO2, where R1 and R2 are templating agent in crystal pores of molecular sieve, R1 is diethylamine, R2 is di-n-propylamine, x1+x2 is 0.01-0.35, and neither x1 nor x2 is zero. The molecular sieve is synthesized with double templating agent and crystal seed and through high temperature synthesis.

The invention provides a preparation method of 2-(2', 2'-difluoroethoxyl)-6-trifluoromethyl phenyl propyl sulfide, having the following processes: reacting m-trifluoromethyl phenol with p-toluenesulfonyl chloride, trifluoromethanesulfonic anhydride or 3, 5-dinitrobenzol sulfonyl chloride in a solvent containing organic base or a solvent containing triethylamine hydrochloride and organic base, andthen, collecting a compound having a formula (III) from reaction products, dissolving the compound in butylene oxide, adding tetramethyl ethylene diamine and diisopropylamine, at a temperature range from -25 DEG C to -100 DEG C, adding butyl lithium cyclohexane solution for reaction, and then, adding dipropyldisulfide, and collecting a compound having a formula (II); reacting the compound having the formula (II) with 4-nitrogen, nitrogen-dimethyl pyridine and difluoroethanol for catalytic reaction in the solvent, and then, collecting a compound having a formula (I) from the reaction products.The invention simplifies reaction conditions, optimizes the technology, reduces production cost, and improves synthesis effects. The general formula of the reaction is as follows.

The invention discloses a carbonyl reductase expressed recombination engineering bacterium and application thereof. The engineering bacterium comprises a host cell and a recombinant vector transferred into the host cell, wherein the recombinant vector consists of an original vector and a target gene connected into the original vector, the host cell is Escherichiacoli Rosetta (DE3), the target gene is a carbonyl reductase gene, and the base sequence is shown in SEQ ID NO.1. According to the recombination engineering bacterium, the expression level of a carbonyl reductase is high, bacterial cells which are prepared through induced culture are used for converting N,N-dimethyl-3-oxy-3-(2-thienyl)-l-propylamine hydrochloride into (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)-l-propylamine or converting 4-chloroethyl acetoacetate into (S)-4-chloro-3-hydroxyethyl butyrate, and the two products are higher in both optical purity and conversion rate.

The invention relates to a preparation method of iopromide. The preparation method comprises the following steps of: on the basis of using 5-amino-3-(2,3-dyhydroxy propylamino formyl)-2,4,6-triiodo isophthalic acid shown in a formula II or 5-methoxyl acetamido-3-(2,3-dyhydroxy propylamino formyl)-2,4,6-triiodo isophthalic acid shown in a formula II-1 as a starting material, protecting amino in a position 5 of the formula II and two hydroxyls in (2,3-dyhydroxy propylamino formyl) in a position 3 or two hydroxyls in (2,3-dyhydroxy propylamino formyl) in a position 3 of the formula II-1 by using methoxyl acetyl, so as to generate a compound shown in a formula III; chloridizing by utilizing a chloridizing agent, so as to prepare a corresponding acyl chloride compound shown in a formula IV; then reacting with methylamino propylene glycol to generate a compound shown in a formula V; and hydrolyzing and purifying so as to prepare high-purity iopromide.