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418 results about "Isopropylamine" patented technology

Isopropylamine (monoisopropyl amine, MIPA, 2-Propylamine) is an organic compound, an amine. It is a hygroscopic colorless liquid with ammonia-like odor. It is miscible with water and flammable. It is a valuable intermediate in chemical industry.

Ultra-high loading glyphosate concentrate

ActiveUS20090318294A1Much cycle timeMuch efficient productionBiocideDead animal preservationHigh concentrationActive agent
This invention relates to a storage stable, aqueous, herbicidal formulation containing an ultra-high concentration of glyphosate in the isopropylamine, potassium or mixed salt form in combination with a surfactant system, to a method of making the formulation, and to a method of treating unwanted vegetation employing the formulation. The surfactant system employed in the concentrate comprises dialkoxylated alkylamine, water miscible solubilizer and amine oxide. The surfactant system unexpectedly permits the formulation of storage stable, ultra-high loaded aqueous glyphosate salt concentrates possessing high or no cloud points.
Owner:STEPAN COMPANY

Aminotransferase, mutant and application to Sitagliptin preparation

The invention discloses aminotransferase, a mutant and application to Sitagliptin preparation. According to the application, wet thalli obtained by performing fermentation culture on recombinant escherichia coli containing aminotransferase encoding genes are used as biocatalysts; Sitagliptin precursor ketone is used as a substrate; dimethyl sulfoxide is used as a latent solvent; phosphopyridoxal is used as a coenzyme; isopropylamine is used as an auxiliary substrate; a trolamine buffer solution with the pH being 8 to 9 is used as a reaction medium; a reaction system is formed; the biocatalytic reaction is performed under the conditions of the temperature being 30 to 45 DEG C and the stirring speed being 100 to 250 r / min; after the reaction is completed, the reaction liquid is separated and purified; the Sitagliptin is obtained. The aminotransferase and the mutant are used as biocatalysts; the latent carbonyl compound of Sitagliptin precursor ketone is directly used as the substrate; meanwhile, biocatalytic reaction is performed by using isopropylamine as the auxiliary substrate and using the pyridoxal phosphate as the coenzyme; the separation and purification is performed; Sitagliptin with high optical purity is prepared. The method has the advantages that the total yield is 76 percent; the product e.e. value reaches 99 percent.
Owner:ZHEJIANG UNIV OF TECH +2

Synthesis of nano-ZSM-5 molecular sieve

The invention discloses a method for synthesizing nanometer ZSM-5 molecular sieve, which belongs to the technical field of inorganic chemosynthesis. The method comprises steps as follows: sodium metaaluminate or aluminium sulphate, silica sol or water glass, sodium hydroxide and isopropylamine are prepared into reaction mixer; the reaction mixer is subjected to hydrothermal crystallization; and the reaction mixer after the hydrothermal crystallization is filtered, washed, dried and baked conventionally to obtain nanometer ZSM-5 molecular sieve. The synthesized ZSM-5 molecular sieve has the advantages of higher specific surface, short production flow and low cost, and the section of the synthesized ZSM-5 molecular sieve crystal grain has an average diameter not larger than 100 nm, thereby facilitating industrialization production and application.
Owner:EAST CHINA NORMAL UNIVERSITY

Herbicide consisting of a glyphosate formulation containing as a surfactant an alkylamine polyethoxylated where the alkyl group is branched in order to reduce substancially the surface tension and improve efficacy

Linear Alkyl amine polyethoxylated containing in the alkyl chain 16 to 20 carbon atoms are well known surfactants for glyphosate formulations, which have synergistic effects, besides the reduction of surface tension.Concerns on environment and health negative effects of these surfactants forced the search to new compounds.Branched alkyl alcohol polyethoxylated with alkyl chains with less carbon atoms like 10-12 have been earlier used together with the linear alkylamine polyethoxylated in order to reduce the micelle formation and therefore the surface tension. In this way the content of the classical long chain alkylamines polyethoxylated could be reduced.Branches in the alkyl chain create steric hindrance to micelle formation. Micelles consisting of surfactant molecules reduce the amount of surfactant available to decrease the surface tension.Because of miscibility limitations, the content of the branched alcohol polyethoxylated is limited.We found that a branched alkyl amine polyethoxylated mixed or not with a branched alkyl alcohol polyethoxylated makes possible a reduction of isopropylamine, which is a co-formulant, and avoids the micelle formation, which is the most important. The speed of penetration of the solution in water of the glyphosate formulation through the membranes of the leaves of the weeds is therefore strongly improved, therefore improving the efficacy as an herbicide.
Owner:CORREIA PEDRO BRITO

Glyphosate isopropylamine salt water solution and preparation method thereof

The invention provides a glyphosate isopropylamine salt water solution and a preparation method thereof. The glyphosate isopropylamine salt water solution comprises 30.3 percent of glyphosate, 11.5 to 13 percent of isopropamide, 8 to 12 percent of tallowamine polyoxyethylene ether, 3 to 6 percent of alkyl polyglucoside and the balance of deionized water. The formula cost is reduced greatly, and the medicine effect of the glyphosate isopropylamine salt water solution is the same as that of glyphosate isopropylamine salt water solution pesticide with an expensive aid.
Owner:SICHUAN LESHAN FUHUA TONGDA AGRO-CHEM TECH CO LTD

Preparation method for metoprolol salt

The invention discloses a preparation method for metoprolol salt, which includes the steps of utilizing p-(2-methoxyethyl) phenol and epoxy chloropropane as raw materials and water or ethanol as dissolvent, and obtaining 3-[4-(2-methoxyethyl phenoxy)]-1,2-epoxypropane under the action of strong alkali; and utilizing water as dissolvent, carrying reaction between the 3-[4-(2-methoxyethyl phenoxy)]-1,2-epoxypropane and isopropylamine so that metoprolol alkali is obtained, and then carrying out reaction between the metoprolol alkali and saturated monohydric alcohol liquor of organic acid or saturated monohydric alcohol liquor of hydrochloric acid, so that the metoprolol salt is obtained. Clinically, hydrochloride, succinate, fumarate or tartrate of the compound is utilized as common medicinefor treating hypertensive disease, coronary disease, congestive heart failure and arrhythmia. The raw materials of the preparation method are cheap and easy to obtain, the water and the ethanol are utilized as the dissolvent so as to hardly cause pollution, the method is convenient in operation, high in purity of the prepared metoprolol salt, high in yield, lower in cost and extremely suitable for mass production.
Owner:SHANDONG JINHE DRUG RES DEV

A kind of method for preparing (s)-metoprolol succinate

Belonging to the field of pharmaceutical chemistry, the invention specifically relates to a method for preparing (S)-metoprolol succinate. The method comprises the steps of: pumping hydroxyphenylethyl methyl ether and (R)-chloropropylene oxide into a reaction vessel, and during the reaction process, pumping a reaction feed liquid into an external circulating dewatering system loaded with a dewatering agent for circulating dewatering, reacting the prepared (S)-3-[4-(2-methoxyethyl) phenoxyl]-1, 2-epoxypropane with isopropylamine so as to obtain an (S)-metoprolol base; mixing the (S)-metoprolol base with succinic acid, thus obtaining (S)-metoprolol succinate. During the first step of reaction in the invention, water generated in the reaction process can be effectively removed through the external circulating dewatering device, and the loss of (S)-3-[4-(2-methoxyethyl) phenoxyl]-1, 2-epoxypropane is reduced, thus realizing simple and fast production of low energy consumption. By the method of the invention, the conversion rate of the first step product (S)-3-[4-(2-methoxyethyl) phenoxyl]-1, 2-epoxypropane is over 90%, the final yield of (S)-metoprolol succinate is greater than 75%, and the utilization rate of the reaction substrate is obviously enhanced.
Owner:SHANDONG CHUANGXIN PHARMA RES & DEV

Transaminase mutant as well as application thereof to preparation of sitagliptin midbody

The invention discloses a transaminase mutant as well as application thereof to preparation of sitagliptin midbody. The application adopts a wet thallus obtained by fermenting and culturing recombinant escherichia coli comprising aminotransferase coded gene as a biological catalyst, adopts sitagliptin midbody precursor ketone as a substrate, adopts dimethyl sulfoxide as a co-solvent and , adopts phosphopyridoxal as co-enzyme, adopts isopropylamine as an auxiliary substrate, adopts a pH 8-9 triethanolamine buffering solution as a reaction medium to form a reaction system to perform the biological catalytic reaction under the conditions that the temperature is 30 to 45 DEG C, and the stirring rate is 100 to 250 r / min, after the reaction is ended, the reaction solution is separated and purified to obtain sitagliptin; and the total yield of the method is about 81 percent, and a e.e. value of the product reaches 99 percent.
Owner:ZHEJIANG UNIV OF TECH +2

Treating method of high-concentration heavy metal polluted building waste

The invention relates to a treating method of high-concentration heavy metal polluted building waste. The method includes: stripping surfaces of the building waste, smashing, washing, separating solid and liquid to obtain the cleaned building waste the water-soluble heavy metal of which is removed, adding an isopropylamine glyphosate solution into the cleaned building waste, eluting to remove the heavy metals, adjusting the pH value to be neutral, separating solid and liquid, washing the waste after elution with water and separating solid and liquid. The heavy metal contents in the building waste after air drying are lower than the three-level standard thresholds of the environmental quality standards (GB15618-1995). The building waste after air drying is subjected to a leaching test by utilization of an HJ/T229 leaching method, and the heavy metal contents in the leachate are lower than the thresholds of the standards for hazardous wastes (GB5085.3-2007). The building waste after air drying can be directly buried and stacked without pollution to the soil, and can be used as a regenerated roadbed material and a concrete aggregate. The method is simple in process and capable of completely eliminating the hazard of the polluted building waste, and has good environmental benefit, economic benefit and social benefit.
Owner:TONGJI UNIV

Method for producing isopropylamine

The invention discloses a method for producing isopropylamine, which belongs to the technical field of amine. To solve the problem that the prior isopropylamine industrial production device cannot effectively convert diisopropylamine into the isopropylamine, a reactor for an acetone hydroamination reaction performs the sectional control of the reaction temperature, the reaction temperature of a first section positioned at an inlet of the reactor is between 110 and 150 DEG C, and the reaction temperature of a downstream section is 5 to 30 DEG C higher than that of an upstream section which is adjacent to the downstream section. Along with the gradual reduction of the concentration of acetone along a bed, the reaction temperature is improved section by section, which is favorable for converting the diisopropylamine and isopropanol into the isopropylamine, thereby reducing the circulation of the diisopropylamine and the isopropanol, reducing energy consumption, and preventing the diisopropylamine from being gradually accumulated in a system so as not to need operating a diisopropylamine rectification system with difficult operation. The method is simple, feasible and easy to realize,and has considerable industrial application value and economic benefit.
Owner:CHINA PETROLEUM & CHEM CORP +1

Diisopropylamine fenofibrate, preparation method of same, medicinal composition and use of same

The invention discloses a diisopropylamine fenofibrate, a preparation method of the same, a medicinal composition and use of the same, relating to the field of medicaments for lowering blood fat and treating fatty liver. The problems that fenofibric acid products is poor in water solubility, has toxic and side effects and the like in the prior art are solved. A product of the invention is obtained through the following steps of: adding a fenofibric acid and diisopropylamine into a solvent, heating to 35-70 DEG C, cooling, separating out a solid, pumping a filtrate, washing the solid with ether, and drying to obtain a white solid which is the diisopropylamine fenofibrate. A diisopropylamine part in the invention can overcome the side effect that the fenofibric acid is heated to be converted into ammonia enzyme and blood sugar and exerts a synergetic effect of lowering the blood fat together with fenofibrate.
Owner:曹桂英

Biological preparation method for R-3-aminopiperidine

The invention discloses a biological preparation method for R-3-aminopiperidine. The biological preparation method comprises the following steps: carrying out gene synthesis according to a sequence as shown in SEQ ID NO:1, cloning the gene into an expression vector pET22a to prepare a recombinant expression vector, and transferring the vector into escherichia coli to prepare a genetically engineered bacterium of recombinant D-transaminase; culturing the bacterium to prepare recombinant D-transaminase genetically engineered bacterium; adding 3-ketopiperidine with final concentration of 10-300mmol / L, 2-15wt% dimethyl sulfoxide or acetonitrile, phosphopyridoxal with final concentration of 0.1-1mmol / L, isopropylamine or D-alanine with final concentration of 0.02-1mol / L and 0.2-0.4wt% recombinant D-transaminase to form a reaction system to carry out reaction; and extracting the R-3-aminopiperidine in the reaction liquor after the reaction is ended. According to the biological preparation method, the cost is low, the conversion ratio is over 97%, the product yield is greater than 85% and byproducts are not produced, so that the biological preparation method is more suitable for industrial application.
Owner:洛阳华荣生物技术有限公司

Method for crystallizing and producing cefpiramide sodium crystals

The invention discloses a method for crystallizing and producing cefpiramide sodium crystals. The method comprises the steps that: (a) cefpiramide acid and an transamination agent are dissolved in a solvent I, wherein the transamination agent is any one selected from triethylamine, diisopropylamine, and isopropylamine; and a temperature is controlled, and the materials are stirred until completely dissolved; (b) a salt-forming agent is added into a solvent II, wherein when the salt-forming agent is sodium ethylhexanoate, the solvent II is an acetone solvent, and when the salt-forming agent is sodium hydroxide, the solvent II is any one or a mixture of two selected from methanol and tetrahydrofuran; and the materials are stirred until completely dissolved; (c) the salt-forming agent solution is uniformly added into the solution of cefpiramide amine salt; the temperature is controlled, and crystal seeds are added; curing crystallization is carried out; acetone is added into the crystallization system for regulating the pH value of the crystallization system and for carrying out solvent-out crystallization; and filtering, washing, and drying are carried out, such that the cefpiramide sodium crystals are obtained. The method provided by the invention has the advantages of simple operation, uniform crystals, high purity, low impurity content, good stability, easy storage, and the like.
Owner:NORTH CHINA PHARMA HEBEI HUAMIN PHARMA

Preparation method of metoprolol

The invention relates to a preparation method of metoprolol. Reaction of methoxy ethyl phenol and sodium hydroxide liquor is carried out at the temperature ranging from 30 DEG C to 80 DEG C to generate methoxy sodium ethyl phenate. When the temperature is reduced to a range between 0 DEG C and 40 DEG C, epichlorohydrin is added for reaction to obtain compound II. Due to isopropyl alcohol, the compound II is reacted with isopropyl amine to obtain metoprolol. Compared with the prior art, fewer by-products are generated during preparation of the compound II, reaction time is short, and the obtained product can be reacted with the isopropyl amine to prepare the metoprolol without being purified.
Owner:YANGTZE RIVER PHARMA GRP BEIJING HAIYAN PHARMA +1
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