42 results about "Cefpiramide" patented technology

The present invention relates to a method of using a superfine pulverizing technology to prepare sterile powder for injection (powder injection) of chemical medicine and the prepared medicine powder injection. Invert sugar, clindamycin phosphate, cefpiramide sodium, cefepime hydrochloride, latamoxef sodium or cefmetazole sodium are preferable as the chemical medicine.

The invention discloses a method for refining cefpiramide acid, and belongs to the technical field of medicines. The method comprises the following steps: A, putting crude cefpiramide acid into a solvent 1, adding a transaminating agent, stirring and dissolving the mixture to clarification, so as to obtain a cefpiramide salt solution; B, adding a decolorizing agent into the cefpiramide salt solution, filtering and collecting filtrate; C, controlling the filtrate temperature to be 10-20 DEG C, adding a dissolution agent, filtering and collecting a solid crystal; D, putting the solid crystal into a solvent 2, controlling the temperature to be 10-15 DEG C, adding an acidic reagent to adjust the pH value to 2.0-3.0, adding a seed crystal, crystallizing, filtering and collecting the solid crystal of cefpiramide acid and mother liquor; and E, washing the solid crystal of cefpiramide acid and drying to obtain refined cefpiramide acid. The cefpiramide acid prepared with the method is high in purity, few in impurities and low in color grade; and the refining method provided by the invention has the advantages of being simple in process, environmentally friendly, and suitable for large-scaleindustrial production, saving energy, and the like.

The invention discloses a preparation method of cefpiramide sodium, which belongs to the field of chemical pharmacy, and comprises the steps of preparing cefpiramide salt by using cefpiramide as raw material, forming salt and crystallizing, drying, and using gas to drive the atomized cefpiramide before drying. Purging with water for injection; the invention can reduce the solvent residue in the product, and the prepared cefpiramide sodium has the advantages of high purity and good stability, the preparation method is simple, energy-saving and environment-friendly, and is suitable for large-scale industrial production.

The invention discloses a method for crystallizing and producing cefpiramide sodium crystals. The method comprises the steps that: (a) cefpiramide acid and an transamination agent are dissolved in a solvent I, wherein the transamination agent is any one selected from triethylamine, diisopropylamine, and isopropylamine; and a temperature is controlled, and the materials are stirred until completely dissolved; (b) a salt-forming agent is added into a solvent II, wherein when the salt-forming agent is sodium ethylhexanoate, the solvent II is an acetone solvent, and when the salt-forming agent is sodium hydroxide, the solvent II is any one or a mixture of two selected from methanol and tetrahydrofuran; and the materials are stirred until completely dissolved; (c) the salt-forming agent solution is uniformly added into the solution of cefpiramide amine salt; the temperature is controlled, and crystal seeds are added; curing crystallization is carried out; acetone is added into the crystallization system for regulating the pH value of the crystallization system and for carrying out solvent-out crystallization; and filtering, washing, and drying are carried out, such that the cefpiramide sodium crystals are obtained. The method provided by the invention has the advantages of simple operation, uniform crystals, high purity, low impurity content, good stability, easy storage, and the like.

The invention relates to a method for synthesizing an intermediate of cephalosporins antibiotics cefpiramide, D-alpha-(6-methyl-4-hydroxy nicotinamido)-p-hydroxyphenyl acetic acid. The method comprises the steps of: reacting carboxyl group protected D-p-hydroxyphenyl glycine and anhydride or acyl chloride of 4-hydroxy-6-methylnicotinic acid to obtain acylated product, and hydrolyzing to remove the protecting group to obtain the target product D-alpha-(6-methyl-4-hydroxy nicotinamido)-p-hydroxyphenyl acetic acid. The method has the advantages of easy and feasible operation, and applicability to large scale production.

The invention discloses cephalosporin nucleus derivative compound and cephaene onium salt compound prepared from the cephalosporin nucleus derivative compound, which are respectively intermediates for synthesizing cefpiramide sulfate, and a method for preparing the cefpiramide sulfate from the two intermediates, namely preparing 7beta-[2-(2-alkanol aminothiazol-5-yl)-2-methoxyimino acetamid]]-3-[3-alkanol amino-2-(2-alkanol oxy ethyl)-1-pyrazol onium]methyl-3-cephem-4-carboxylate (IV) by coupling 7beta-[2(2-alkanol aminothiazol-5-yl)-2-methoxyimino acetamid]]-3-(hydrocarbon sulfonate)-3-cephem-4-carboxylic acid (I) serving as a raw material with 5-alkanol amino-2-(2-alkanol oxy ethyl)-1-pyrazol, and then converting to obtain the cefpiramide sulfate. The method has the advantages of mild reaction conditions, short steps, cheap raw materials, industrial production, no special reagents, simple process and easy amplification.

The invention relates to a composite method for cefpiramide midbody D-alpha-(4-Hydroxy-6-methylnicotinamido) hydroxyphenylacetic acid, which includes the steps of using the acyl chloride of 4-hydroxy-6-methylnicotinic acid to directly acylate and esterify D-hydroxyphenylglycine, using water to remove the estersil of an acylation product and directly obtaining an objective product D-alpha-(4-Hydroxy-6-methylnicotinamido) hydroxyphenylacetic acid. Compared with the method of composing D-hydroxyphenylglycine into alkane ester or salt at first, the composite method for cefpiramide midbody D-alpha-(4-Hydroxy-6-methylnicotinamido) hydroxyphenylacetic acid simplifies the operation and is suitable for large-scale production.

The invention relates to a cefpiramide composite which is used for the cefpiramide powder-injection in the medicinal manufacture field. The invention discloses the following characteristic of the cefpiramide composite: the composite for the cefpiramide powder-injection which is prepare by the conventional production technology of powder-injection contains two or more of the following components: (a) sterile cefpiramide, (b) sterile sodium carbonate; and (c) sterile anhydrous glucose, dextrose monohydrate, sodium chloride, mannitol, sorbitol, anhydrous lactose or lactose monohydrate, wherein the weight ratio of the component (a) to the component (b) and the component (c) is 1:0.15-0.4:0.03-4.0. The invention has the advantages that the problem that the cefpiramide for injection on the market is difficult to dissolve, especially at a low temperature is solved; the operation of the nurse is easy; and the raw materials are accessible and the drug stability is good.