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Stable cephalosporin powder injection

A cephalosporin and powder injection technology, applied in the field of medicine, can solve the problems of instability and poor stability of cefpiramide sodium, and achieve the effects of long shelf life and high stability

Inactive Publication Date: 2005-12-14
北京盛世伟唐科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Because cefpiramide is insoluble in water, it needs to be made into a water-soluble sodium salt before it can be used clinically. So far, cefpiramide sodium is usually obtained by freeze-drying or crystallization, and it is necessary to add a class of antioxidants, etc. Stabilizers or buffers, such as sodium benzoate, etc., due to the instability of cefpiramide sodium itself, the stability of the current marketed preparations is not good, it needs to be stored at low temperature, and the related substances are high. ", the related substances reached 6-8%

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Mix 1 g of sterile cefpiramide with 0.3 g of sterile sodium carbonate, and operate according to the conventional powder injection production process.

Embodiment 2

[0011] Mix 1 g of sterile cefpiramide with 0.15 g of sterile sodium carbonate, and operate according to the conventional powder injection production process.

Embodiment 3

[0013] 1 g of sterile cefpiramide is mixed with 0.4 g of sterile arginine, and the operation is carried out according to the conventional powder injection production process.

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PUM

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Abstract

The stable cephalosporin powder for injection is mixture of bacteria-free cefpiramide and cosolvent in the weight ratio of 1 to 0.1-0.5. The cosolvent is sodium carbonate, arginine or sodium hydroxide. Compared with available cefpiramide injection, the cephalosporin powder for injection has the features of ever high stability, less impurity content and longer preservation period.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a stable cephalosporin powder injection. Background technique [0002] Cefpiramide (Cefpiramide) is a semi-synthetic third-generation cephalosporin antibiotic. Its chemical structure is characterized by a methylthiotetrazolyl group at the 3-position side chain of the cephem core, and a hydroxyphenyl group and a hydroxyl group at the 9-position side chain. picoline. This product has the characteristics of broad antibacterial spectrum, strong antibacterial activity and stability to lactamase. It is effective against many Gram-positive cocci, including Staphylococcus and Enterococcus; it is also effective against Gram-negative bacilli and anaerobic bacteria, and has good antibacterial activity against Pseudomonas aeruginosa, similar to cefoperazone. This product is suitable for sensitive Gram-negative and positive bacteria such as Escherichia coli, Proteus, Klebsiella pneumoniae, Ps...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/545
Inventor 孔庆文杨春玮
Owner 北京盛世伟唐科技有限公司
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