Cefpiramide-containing medicine used for injection

Abstract

The invention relates to a cefpiramide-containing medicine used for injection, which is used for an injection used for treating diseases. The invention discloses the medicine used for the injection, which comprises a component A of cefpiramide and a component B of a solvent which contains organic base and is exclusively used for the cefpiramide used for the injection, wherein the cefpiramide and the solvent are separately packaged, and the weight ratio of the component A to the component B is 1:5 to 20. The invention is easy to dissolve, is simple and convenient to operate and is safe during injection.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to cefpiramide (Cefpiramide) specially used for injection containing an organic base, that is, 7-[2-[(4-hydroxyl-6-methylpyridine-3-carbonyl)-amino]-2- (4-Hydroxyphenyl)-acetylamino]-3-(1-methyl-1H-tetrazole-5-thiomethyl)-8-oxo-5-thia-1-azabicyclo[4.2 .0] Vehicle combinations of oct-2-ene-2-carboxylic acid and process for their preparation. technical background [0002] This product is a semi-synthetic third-generation cephalosporin antibiotic, characterized by broad antibacterial spectrum and bactericidal power, strong antibacterial activity against Gram-positive bacteria, negative bacteria and anaerobic bacteria, and β-lactamase quite stable. It is mainly used clinically for pharyngitis, tonsillitis, acute and chronic bronchitis, pneumonia, pulmonary suppurative disease, pyelonephritis, cystitis, prostatitis, meningitis and gynecological infections caused by sensitive bacterial i...

AI Technical Summary

Problems solved by technology

This kind of composition generally has the problem of difficulty in dissolution. When dissolving, there are phenomena such as sticking to the wall, sticking to the bottom, and agglomeration. The dissolution is slow, the dissolution time is long, and the operation is difficult.

[0004] There are still many problems in the use of this composition. For example, during clinical application, the injection site will cause pain, or cause blood vessels, muscle irritation symptoms and thrombophlebitis. The main symptom is the appearance of cords along the veins. red line, local tissue redness, swelling, burning, pain, sometimes accompanied by chills, fever, etc.

[0005] In addition, because this composition exists in the form of sodium salt, after a large amount of sodium ions enter the human body, it is very risky for people with diabetic bacterial infections, neurosurgery patients, patients with heart and kidney insufficiency, or patients with high blood pressure. Hypernatremia, causing adverse reactions

Therefore, bring very big inconvenience to clinical medication, make its popularization and application subject to certain restriction