Composition of cefpiramide and sodium glycinate or special solvent composition containing sodium glycinate

Abstract

The invention relates to a composition of cefpiramide and sodium glycinate or a special solvent composition containing sodium glycinate. The invention is used for pharmacy. The weight ratio of the cefpiramide to the sodium glycinate is 1:0.152-0.210 and the solvent composition is specially used for injection. A bottle of 0.5g of cefpiramide is mixed with 2-10ml of solvent, and a bottle of 1g of cefpiramide is mixed with 5-20ml of solvent. The cefpiramide is easy to dissolve, and the invention is safe to inject, can provide amino acid indispensible to human body and improve the immunity of the patients, and is simple and convenient to operate.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to cefpiramide (Cefpiramide), namely 7-[2-[(4-hydroxy-6-methylpyridine-3-carbonyl)-amino]-2-(4-hydroxyphenyl)- Acetylamino]-3-(1-methyl-1H-tetrazole-5-thiomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene -The composition of 2-carboxylic acid and sodium glycinate or the solvent combination specially used for injection cefpiramide containing sodium glycinate. technical background [0002] This strain is a semi-synthetic third-generation cephalosporin antibiotic. After the drug was launched in Japan in 1985, it has been widely used in the clinical treatment of bacterial infections, and achieved good curative effect, with rare and mild adverse reactions. This product is characterized by broad antibacterial spectrum and bactericidal power, strong antibacterial activity against Gram-positive bacteria, negative bacteria and anaerobic bacteria, and quite stable against β-lactamase. Clinic...

AI Technical Summary

Problems solved by technology

This composition generally has the problem of difficulty in dissolving. When dissolving, there are phenomena such as sticking to the wall, sticking to the bottom, and agglomeration. The dissolving is slow, the dissolving time is long, and the operation is difficult; Irritant symptoms of blood vessels and muscles and thrombophlebitis, such as cord-like red lines along the direction of veins, local tissue redness, swelling, burning, pain, sometimes accompanied by systemic symptoms such as chills and fever

Therefore, it brings great inconvenience to clinical medication, which limits its popularization and application, and has attracted great attention from manufacturers and medical staff.

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