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1931results about How to "Fast dissolution" patented technology

Porous drug matrices and methods of manufacture thereof

Drugs, especially low aqueous solubility drugs, are provided in a porous matrix form, preferably microparticles, which enhances dissolution of the drug in aqueous media. The drug matrices preferably are made using a process that includes (i) dissolving a drug, preferably a drug having low aqueous solubility, in a volatile solvent to form a drug solution, (ii) combining at least one pore forming agent with the drug solution to form an emulsion, suspension, or second solution and hydrophilic or hydrophobic excipients that stabilize the drug and inhibit crystallization, and (iii) removing the volatile solvent and pore forming agent from the emulsion, suspension, or second solution to yield the porous matrix of drug. Hydrophobic or hydrophilic excipients may be selected to stabilize the drug in crystalline form by inhibiting crystal growth or to stabilize the drug in amorphous form by preventing crystallization. The pore forming agent can be either a volatile liquid that is immiscible with the drug solvent or a volatile solid-compound, preferably a volatile salt. In a preferred embodiment, spray drying is used to remove the solvents and the pore forming agent. The resulting porous matrix has a faster rate of dissolution following administration to a patient, as compared to non-porous matrix forms of the drug. In a preferred embodiment, microparticles of the porous drug matrix are reconstituted with an aqueous medium and administered parenterally, or processed using standard techniques into tablets or capsules for oral administration.
Owner:ACUSPHERE INC

Porous drug matrices and methods of manufacture thereof

Drugs, especially low aqueous solubility drugs, are provided in a porous matrix form, preferably microparticles, which enhances dissolution of the drug in aqueous media. The drug matrices preferably are made using a process that includes (i) dissolving a drug, preferably a drug having low aqueous solubility, in a volatile solvent to form a drug solution, (ii) combining at least one pore forming agent with the drug solution to form an emulsion, suspension, or second solution and hydrophilic or hydrophobic excipients that stabilize the drug and inhibit crystallization, and (iii) removing the volatile solvent and pore forming agent from the emulsion, suspension, or second solution to yield the porous matrix of drug. Hydrophobic or hydrophilic excipients may be selected to stabilize the drug in crystalline form by inhibiting crystal growth or to stabilize the drug in amorphous form by preventing crystallization. The pore forming agent can be either a volatile liquid that is immiscible with the drug solvent or a volatile solid compound, preferably a volatile salt. In a preferred embodiment, spray drying is used to remove the solvents and the pore forming agent. The resulting porous matrix has a faster rate of dissolution following administration to a patient, as compared to non-porous matrix forms of the drug. In a preferred embodiment, microparticles of the porous drug matrix are reconstituted with an aqueous medium and administered parenterally, or processed using standard techniques into tablets or capsules for oral administration.
Owner:ACUSPHERE INC

Gelling compositions and methods

A method for the administration of a composition that augments the acidity of gastric fluid such that intra-gastric gelation of the polysaccharide:acid soluble multivalent cation formulation is initiated independent of endogenous acid secretion. The composition includes:(a) at least one of a polysaccharide, modified polysaccharide, or polysaccharide salt, each capable of ionotropic gelation, (b) at least one source of multivalent cations capable of solubilization at an acidic pH, and (c) at least one acid component capable of providing a controlled release of protons sufficient to solubilize the multivalent cations. The composition is capable of hydrating in aqueous media and subsequently forming a gel in a stomach when ingested, which gel resists peristaltic forces and remains in the stomach for an extended time. Also disclosed are edible compositions including this composition, as well as methods of inducing a satiety effect and providing controlled release of various components employing the composition of the invention.
Owner:FMC BIOPOLYMER AS

Concentrated film delivery systems

A water soluble strip that includes a carrier film that include water soluble polymer, one or more actives and one or more agents such as heat forming agent and / or degrading accelerator. The water soluble strip can optionally include other additives. The actives includes antimicrobial agent, cleaning agent and / or surfactant. The water soluble strip can include other materials. The heat forming agent and / or degrading accelerator, when used, are designed facilitate in degrading or dissolving the water soluble strip and / or increase the activity of the one or more actives. The water soluble film can be used for a variety of applications such as a hard surface cleaning strip, dishwashing strip, laundry cleaning strip, stop removing strip, drain unclogging strip, toilet bowl cleaning strip and the like. The water soluble strip eliminates the need to purchase and store numerous containers and / or heavy containers of cleaner that take up large amounts of shelf space.
Owner:THE CLOROX CO

Water-solubility acidity temporary plugging agent for press cracking

The invention relates to a water-soluble fracturing-acidifying temporary-stopping agent, used in temporary- stopping bed of oil water well in the course of selecting fracturing and multi-crack fracturing. It is comprised of bone glue, sulfonated pitch and guargum in the weight ratio of 5.5-6.5 to 1.5-3.5 to 1-2. Its preparing method is taking a certain amount of water to heat and keep the temperature at 70-80 deg.C, adding in bone glue and stirring, dissolving; when the temperature is lowered to 40-50 deg.C, adding in sulfonated pitch and stirring uniformly; adding in guargum and strongly stirring uniformly; pouring into a special container, spreading out into an about 3mm-thick cake in shape, and naturally drying; crushing and then screening, and selecting the particles with 3-6 mm diameter as the finished product. It is fast to dissolve, low-cost and strongly-stopping.
Owner:北京卓辰基业技术开发有限公司

Slickwater fracturing fluid drag reducer and preparation method thereof

ActiveCN103013488AImprove stabilityReduce system complexity indexDrilling compositionFunctional monomerFracturing fluid
The invention discloses drag reducer which can be applied to slickwater fracturing fluid and a method for preparing drag reducer. The method includes: adding organic salt into acrylamide and functional monomer aqueous solution to prepare an aqueous phase, adding the aqueous phase into an oil phase system consisting of surfactant and base oil under the condition of high-speed stirring to form a stable W/O (water in oil) type microemulsion system, feeding nitrogen for dispersing oxygen, and adding initiator for polymerization to form a branchless long chain structure. The polymer microemulsion is a transparent or semitransparent thermodynamic stable system, can be quickly swelled into water and is directly usable. Adding a small quantity of the drag reducer during fluid transport can improve flow quantity and reduce energy consumption to some extent, and the drag reduction effect can reach 30%-65% when the drag reducer is compared with clear water. The drag reducer has the advantages of high stability, dissolving speed and dissolving performance, convenience in use, remarkable drag reduction effects and the like and is applicable to the slickwater fracturing technology, and excellent yield increasing effects are obtained after the drag reducer is applied to field fracturing operations.
Owner:CHENGDU BAICHUN PETROLEUM TECH +1

Additive for smelting aluminium alloy and preparation method and application method thereof

The invention relates to an additive for smelting aluminium alloy and a preparation method and an application method thereof, relating to the technical field of nonferrous alloy manufacturing with a special additive. The additive is composed of metal powder, cosolvent, heat-generating agent, detonating agent and moisture proof agent. The preparation method comprises the following steps: raw materials comprising the following by mass percentage, 70-81.5% of metal powder, 15-20% of cosolvent, 2-5% of heat-generating agent, 1-3% of detonating agent and 0.5-2% of moisture proof agent, are fully mixed evenly into compound powder with a ball mill, and the mixture is put into a mould, and is performed with cold pressing by a hydraulic pressure machine so as to obtain the additive for smelting aluminium alloy. The application method of the invention comprises the following steps: a graphite crucible filled with a pure aluminium pig is arranged in a resistance furnace to be heated until the aluminium pig is melted into aluminium liquid, and then the additive is added to react with the aluminium liquid so as to obtain aluminium alloy. Under the condition that the quality of aluminium alloy is not lowered, the additive solves the problems of high dissolving temperature, low absorptivity and unstable absorptivity of the additive.
Owner:HEBEI UNIV OF TECH

Shale gas reservoir pre-fracture composite acid solution, preparation method and application thereof

InactiveCN105086989APrevent collapseCore dissolution rate maintenanceDrilling compositionAcetic acidHydrofluoric acid
The invention belongs to the field of petroleum engineering and relates to a shale gas reservoir pre-fracture composite acid solution and its preparation method and application. The composite acid solution comprises the following components: Component a) at least one component of hydrochloric acid, hydrofluoric acid, fluorboric acid, phosphoric acid, formic acid and acetic acid; and Component b) a corrosion inhibitor, a discharge aiding agent, a ferric iron stabilizer and a clay stabilizer. The composite acid solution containing different acids is selected for different reservoirs. Rock core corrosion ratio is 25-30%. A certain rock core corrosion ratio is maintained, and borehole wall collapse caused by too high corrosion ratio is also prevented. The corrosion inhibitor, the discharge aiding agent, the ferric iron stabilizer and the clay stabilizer which are used as additives have good compatibility with acid. The composite acid solution provided by the invention has advantages of fast dissolving speed, uniform mixing, high corrosion inhibition efficiency, high surface activity, good clay stabilizing effect and wide range. Applicable temperature of the composite acid solution is 20-180 DEG C. by the use of the composite acid solution, normal construction of large-scale fracturing of long horizontal-section shale gas wells can be guaranteed under the condition of existing equipment capacity.
Owner:CHINA PETROLEUM & CHEM CORP +1

Preparation of cationic polyacrylamide reverse microemulsion

InactiveCN101298488AFast aggregationPolymerization temperature is easy to controlChemical industryIndustrial water treatment
The invention relates to a preparation method for cationic-type polyacrylamide reverse micro emulsion. The appearance of the micro emulsion is transparent or translucent low-viscosity micro latex and the mean particle diameter is 50 to 80 nm. The micro emulsion can be placed for a long time without delaminating. After routine extraction with alcohol and acetone, the micro emulsion becomes white powdered solids with the intrinsic viscosity of 200-600 ml / g. The preparation method is to take acrylamide and diallyl dimethyl ammonium chloride as comonomer, apply compounded emulsifying agent and redox initiation system, add sodium formate as reagent and additive in polymerization, and then apply the method of stepwise polymerization to the reverse micro emulsion polymerization. The cationic-type polyacrylamide of the invention has the advantages of moderate molecular weight, stable emulsion, rapid dissolution and narrow particle size distribution, thus being able to be widely applied to fields such as oil exploitation, paper making, textile dying, daily chemical industry and industrial water treatment.
Owner:SHANDONG UNIV
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