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Preparation method of cephapian aseptic mixed powder injection agent

A technology of cefpiramide and mixed powder, which is applied in the field of preparation of cefpiramide aseptic mixed powder for injection, can solve the problems of high production cost, long freeze-drying time, and decreased purity, and achieve less process loss and less degradation , the effect of high purity

Inactive Publication Date: 2006-08-30
张庆华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With this process, the main drug is easily degraded under alkaline conditions, the purity decreases, the yield is low, and the freeze-drying time is long, and the production cost is high

Method used

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Embodiment Construction

[0006] The present invention will be described below in conjunction with embodiments.

[0007] In a class 100 clean area, the relative humidity is less than 60%, and the sterile cefpiramide and sterile sodium carbonate are respectively crushed through a 100 mesh sieve; then in the class 100 clean area, the relative humidity is less than 60%. Piramide is aseptically dispensed into 20ml antibiotic control bottles, 1.0g per bottle based on anhydrous, and sodium carbonate is divided into the above control bottles, 0.2g per bottle based on anhydrous, plus butyl rubber The rubber stopper and the pressed aluminum plastic cover obtain the present invention.

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Abstract

An aseptic mixed powder injection of a cefpiramide is prepared through respectively pulverizing aseptic cefpiramide and aseptic sodium carbonate by 100 meshes in 100-class clean region, respectively loading them in antibiotic tubular bottles, adding butyl rubber plug to them and pressing aluminum-plastic covers to said bottles.

Description

Technical field [0001] The invention relates to a preparation method of a medicine for injection, in particular to a preparation method of a sterile mixed powder injection of cefpiramide for injection. technical background [0002] The current preparation method of cefpiramide sodium for injection is to first adjust the activated carbon with water into a charcoal paste for later use; dissolve sodium benzoate in the injection water, add the main drug cefpiramide, add sodium bicarbonate in portions under stirring, and add after dissolution. The charcoal paste is stirred, then finely filtered with a microporous membrane, and bottled. It is also necessary to place the sub-packaged liquid medicine in a freeze-drying box in a 100-level clean area, and pre-freeze the product at -45°C for 2-3 hours. By adopting this process, the main drug is easily degraded under alkaline conditions, the purity is decreased, the yield is low, and the freeze-drying time is long,...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K9/14A61P31/04
Inventor 张庆华
Owner 张庆华
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