60 results about "CEFMETAZOLE SODIUM" patented technology

The invention relates to a method for preparing cefmetazole sodium, which comprises the following steps: (1) dissolving sodium hydroxide in water, adding mercaptoacetic acid and chloroacetonitrile into the mixture to perform the reaction, then adding sodium chloride and ethyl acetate into the reaction solution, stirring and dissolving the mixture, standing to separate phases and reserving a solvent phase for later use; (2) dissolving 7-MAC in methylene dichloride, adding organic base and side-chain solution into the mixture, stirring the mixed solution to perform the reaction to carry out phase separation, removing a water phase and carrying out secondary phase separation on the solvent phase to obtain cefmetazole benzyl ester; (3) dissolving ferric trichloride in aether, adding methylene dichloride in the mixture, dropwise adding the obtained product into cefmetazole acid to perform the reaction for 0.5 to 1 hour, then carrying out phase separation, removing the water phase, carrying out back extraction of alkali liquor on the solvent phase, then reserving the water phase, adding seed crystals, stirring the product and carrying out crystallization to obtain cefmetazole acid; and (4) dissolving the cefmetazole acid in alkali water and freezing out the mixture to obtain cefmetazole sodium. The preparation method of the invention has the advantages of 58 to 62 percent of yield, low cost, environment-friendly property, 92 percent of product purity, suitability for industrial production and the like.

The invention relates to a method for preparing cefmetazole sodium, comprising the following steps of: undergoing a reaction of cefmetazole acid and sodium isocaprylate, then purifying, crystallizing, filtering, washing and drying to obtain a finished product. The method for preparing the cefmetazole sodium, provided by the invention, is scientific and reasonable, simple and practicable; and the obtained product has the advantages of stable quality performance, high content, low impurity content, allergy avoidance, and the like.

The invention relates to the field of pharmaceutics, specifically to cefmetazole aseptic powder and its preparation method. The preparation method comprises: employing a mixed solvent to recrystallize cefmetazole, using a good solvent to dissolve the cefmetazole raw material, adding activated carbon for injection to remove a pyrogen, then adding a poor solvent for recrystallization, and conducting drying at a low temperature, thus obtaining the cefmetazole aseptic powder with no pyrogen and high purity. Characterized by simple operation and high yield, the preparation method of the invention can prepare cefmetazole aseptic powder with high purity, safe and reliable quality, thus being suitable for preparing cefmetazole aseptic powder injections and widely applicable in large scale production of cefmetazole aseptic powder injections.

The invention relates to cefmetazole sodium composition sterile powder for injection, which comprises 99.0 to 99.9 weight percent of cefmetazole sodium and 0.1 to 1.0 percent of sodium benzoate. The cefmetazole sodium is cefmetazole sodium crystal and the primary granularity of the cefmetazole sodium ranges from 80 to 120 mu m. The cefmetazole sodium composition sterile powder for injection provided by the invention contains the cefmetazole sodium crystal, and has the advantages of large crystal granularity, uniform granularity distribution, qualified quality, and high stability.

The invention provides a pharmaceutical composition containing a cefmetazole sodium compound. The pharmaceutical composition is prepared from cefmetazole acid, sodium carbonate and mannitol. The invention also provides a preparation method of the pharmaceutical composition containing the cefmetazole sodium compound. The preparation method comprises the following steps of: adding the active component cefmetazole acid sterile powder, the cosolvent sodium carbonate and the excipient mannitol to water for injection, adding active carbon and stirring, regulating the pH to be 6 by sodium hydroxide, filtering to remove the active carbon, finely filtering by a filter membrane, filling and lyophilizing. Because a proper amount of excipient mannitol is added to the pharmaceutical composition prepared by the method, the lyophilized powder is more stable in quality and can be stored for a long term. The cefmetazole acid and the sodium carbonate directly react to obtain the cefmetazole sodium, thereby shortening the process flow.

The invention relates to a novel pharmaceutic preparation composition, especially to an injection preparation of cefmetazole. The injection preparation comprises the following components: cefmetazole, mannitol, EDTA-Ca, vitamin C, sodium hydrogen citrate, a trisodium citrate buffer solution and water for injection.

The invention relates to a cephamycin intermediate compound and a preparation method thereof. The cephamycin intermediate compound has a structure of formula (I), and is prepared by directly reacting 7beta-chloroacetamide-7alpha-methoxy-3-(1-methyl-1H-tetrazole-5-thiomethyl)-3-cephem-4-carboxylic acid and dicyclohexylamine in a specific solvent to form a salt and crystallizing. The cephamycin intermediate compound has the characteristics of high purity, high stability and the like, is conductive to improving the purity of cephamycin final products such as cefminox sodium, cefmetazole sodium and cefotetan disodium, and is beneficial to large-scale production and application.

The invention provides an injection-use pharmaceutical composition comprising cefmetazole sodium and clavulanate potassium, and the pharmaceutical composition has a cooperatively antibacterial effect. The pharmaceutical composition comprises the following ingredients: in parts by weight, 1-4 parts of the cefmetazole sodium; 1-2 parts of the clavulanate potassium; 2-6 parts of polyalkylcyanoacrylate; 0.2-0.5 parts of L-arginine; 0.5-1 parts of PVP; 0.5-1 parts of mannitol; 0.5-1 parts of glycine; 1-2 parts of a tween. The pharmaceutical composition has the advantages of high stability, good redissolubility, simple preparation processes, a good inhibitory effect on ESBLs-producing escherichiacoli, klebsiellapeumoniae, and proteusmirabilis, and a definite curative effect, can reduce the dosage of a single prescription preparation and shorten the treatment cycle, and has broad market prospects.

The invention discloses a novel cefmetazole compound, which has the purity greater than 99.5%. The invention further discloses a medicine composition of the cefmetazole compound. The medicine composition comprises the following components in part by weight: 60 to 90 parts of cefmetazole, 0.5 to 2 parts of mannitol, 2 to 7 parts of citrulline, and 1 to 5 parts of sodium citrate. The mannitol, the citrulline, and the sodium citrate contained in the medicine composition can work together to greatly improve light stability and heat stability of cefmetazole medicine composition, the cefmetazole medicine composition is less susceptible to oxygenolysis, and the probability of side effect of cefmetazole is effectively reduced.

The invention relates to a preparation method for a cephamycin intermediate. A compound of the cephamycin intermediate can be seen in the formula (IV). The cephamycin intermediate is obtained by making 7-ACA react with dichloroacetyl chloride in specific solvent, making the obtained product react with MMT under catalysis of a sulfoacid catalyst and conducting crystallization. The cephamycin intermediate has the advantages of being high in purity and stability and the like, is beneficial for improving the purity of final cephamycin products such as cefminox sodium, cefmetazole and cefotetan disodium, and is beneficial to large-scale production and application.

The invention relates to a preparation method of cefmetazole. The preparation method comprises the steps of adopting a one-pot method containing 7-ACA, 1-methyl-5-tetrazole-thione and chloroacetyl chloride, obtaining 7-DCT, then using seven-position methoxy groups of sodium methylate and tert-butyl hypochlorite, and obtaining methoxy cephalosporin mother nuclei which are shared mother nuclei. The cefmetazole can serve as four methoxy cephalosporin products, namely cefminox, cefmetazole, cephalosporin and cefotetan disodium, three steps are omitted, the processing steps are greatly shortened, cost is lowered, and the overall yield is raised to 70%.