1211 results about "Pharmaceutics" patented technology

The invention discloses detumescent and analgesic ointment for curing rheumatism and contusion and a preparation method thereof. The ointment is a pure herbal pharmaceutics, which is composed of monarch drugs, ministerial drugs, adjuvant drugs and conductant drugs. The preparation method comprises the following steps: placing 5kg of tung oil in a pan; grinding all traditional Chinese bug bulk pharmaceutical chemicals (BPC) into refined powder, wrapping the adjuvant drugs and the conductant drugs with gauzes, and placing into a frying pan for boiling; boiling with charcoal fire for 90min, putting the powder in to the frying pan after generating smokes, and boiling the mixture to obtain semi-creamy mixture; placing the ministerial drugs into the pan for even stirring to obtain semi-creamy mixture; taking the pan away from the fire and putting the monarch drugs into ointment for even stirring; placing 2.5kg of rosin into the ointment and evenly stirring to obtain the ointment, and pasting the ointment on kraft papers with 11 centimeters; and pressing the ointment on the kraft papers by a 6-centimeter iron module to obtain the ointment with diameter of 6 centimeters, and placing the obtained ointment on fixed patches. The detumescent and analgesic ointment for curing rheumatism and contusion can be used for stimulating the circulation of the blood and causing the muscles and joints to relax, relieving bruises and pains, and curing traumatic injuries and rheumatoid arthritis.

The invention provides a device for separating a first entity and a second entity by flowing them downwardly in an inclined settling chamber. Each entity has its own outlet located at approximately the lowest end of the inclined settling chamber. The device may be used in industrial fields such as pharmaceutics, biologics, and biofuels, for the purposes of large-scale growth and separation of algae biomass, bacteria and yeast cultures; algae metabolite production; and cell separation, among others. The invention exhibits technical merits such as effective particle separation or concentration capacity, robust structure, easy operation, cost-effective manufacturability, disposability, and high productivity in e.g. perfusion photobioreactor systems.

A hydrate of brain protein is prepared from pig's brain through adding purified water, homogenizing, heating, cooling, regulating pH=1.5-2.0, enzymolyzing, regulating pH=7.7-8.0, enzymolyzing, regulating pH=2.5-3.0 freezing, thawing, filter, regulating pH to become neutral, ultrafiltering, concentrating, sterilizing, adding amino acids, regulating peptide map, diluting, and steam sterilizing.

The invention relates to the technical field of pharmaceutical nanoemulsion drug delivery systems and transdermal absorption, in particular relates to ginseng-containing whitening and anti-aging nanoemulsion essence and a preparation method thereof, and belongs to a new pharmaceutical technology and the field of study on new formulations applied to cosmetics. The nanoemulsion essence is characterized in that a natural or food-grade emulsifier and an oil phase are selected, wherein double distilled water containing fruit juice, vegetable juice or honey is used as an oil phase. The nanoemulsion essence comprises the following components in percent: 10.30 to 80.60% of emulsifier / co-emulsifier, 1.0 to 40.80% of oil phase, 0.10 to 14.0% of ginseng, and the balance of the water phase. The confocal microscopy result shows that the transdermal absorption mechanism of the essence is the mechanism of majorly dispersing among cells of cutaneous appendages at the beginning and then dispersing and penetrating through cytomembrane. The nanoemulsion essence has high absorption, is innocuous, unpoisonous and pollution-free, does not damage the skin, and can completely realize the green, health, whitening, anti-aging and beautifying makeup concept.

The present invention relates to a process of producing Maillard flavor preparation, such as process flavors, comprising heating a combination of a carbohydrate source and a nitrogen source in a continuous liquid phase containing at least 10 wt % of an α-hydroxycarboxylic acid component selected from the group of α-hydroxycarboxylic acids according to the following formula (I): R1—CR2(OH)—COOH salts of these acids and combinations thereof. It was found that the flavor preparations so obtained exhibit unique flavor profiles, making them particularly suitable for use in foodstuffs, beverages, pharmaceutics, tobacco products and oral care products.

The invention provides a metformin hydrochloride controlled-release tablet, which comprises a metformin hydrochloride controlled-release tablet with effective dose and pharmaceutical accessories and is characterized in that the metformin hydrochloride controlled-release tablet uses the common tabletting, and the controlled-release effect is controlled by totally depending on the film coating technique. The coating adopted by the invention is a releasing system comprising the prescription which can cause the medicine to reach release degree standard in vitro. The preparation method in the invention is simple and convenient; the process conditions are easy to control and suitable for batch production, can use conventional production equipment in pharmaceutical industries for economically and conveniently producing the metformin hydrochloride controlled-release tablet on a large scale, can effectively and stably cause the release degree of the metformin hydrochloride controlled-release tablet in the second hour to be 10% to 35%, the release degree to be 40% to 70% in the sixth hour and the release degree to be more than 80% in the twelfth hour.

The invention belongs to the field of microbial pharmaceutics and pharmaceutical engineering, specifically relates to a production method of prednisone acetate by microbial transformation with Arthrobacter simplex as bacteria strain and hydrocortisone acetate as substrate. The method uses Arthrobacter simplex as bacteria strain and comprises the following steps of: performing primary seed culture, performing second fermentation culture, adding hydrocortisone acetate into the fermentation liquid of Arthrobacter simplex to transform hydrocortisone acetate into prednisone acetate, filtering, and collecting cake to obtain prednisone acetate. The bacteria can be prepared into double liquid phase, broken cells or protoplast, each of which has high transformation ratio. The inventive production method replaces cortisone acetate with hydrocortisone acetate as raw material, and has the advantages of high yield, simple process, good economical and practical performance, and less use of harmful reagents; and is important for steroids production with biotransformation method.

The invention discloses an anticancer and antalgic Chinese medicinal Gelsmium elegans total alkaloid and drug combination containing it as well as its preparing method, where the Gelsmium elegans total alkaloid is extracted from the raw material Chinese medicinal Gelsmium elegans and the Gelsmium elegans total alkaloid and acceptable carrier or excipient in any pharmacy are made into drug combination whose drug form can be oral preparation and also injection, concretely speaking tablet, capsule, soft capsule, oral solution, injection solution, transfusion, powder injection and freeze-dried powder injection. The drug combination has good anticancer effect and high-quality ntalgic function and the drug combination's antalgic strength is inferior to morphia's and superior to other clinical antalgics'.

The invention discloses an oral disintegration tablet of alcaine aminobromisuo, which contains alcaine aminobromisuo with effective dosage and pharmacological findings, wherein the alcaine aminobromisuo is processed by metarchon with rate of aminobromisuo and metarchon at 1: 0. 1-1. 5, which is blended with pharmacologically acceptable findings; the metarchon can be medically inorganic oxide or / and medicinal organic acid and salt; the acceptable findings is filler, corrigent, disintegration agent, adhesive and lubricant; the oral disintegration tablet of alcaine aminobromisuo hasn't bitterness and numb sense to disintegrate within one minute with stripping degree not less than 90%. The invention is convenient and simple to control with high yield and low energy consumption, which widens the resource of metarchon to save cost.

The purpose of this invention is:new selenohydroxy acid compounds and their derivatives;their process for the preparation;use of the new compounds as precursors of L(+)-selenomethionine and / or source of selenium in human or animal nutrition, in cosmetics and pharmaceutics;and nutritional, cosmetic and pharmaceutical compositions containing them.The new compounds that are the subject of this invention satisfy the general formula (I):in whichn=0, 1 or 2,R1=OH, OCOR3, OPO3H2, OPO(OR4)(OR5), or OR6,R2=OH, R3, or NHR7,R3=particularly alkoxyl (C1-C26), ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6a and 6b, S-cysteinyl, or S-glutathionyl, carnitoyl, lipids, polyols,OR4=OR5=particularly alkoxyl (C1-C26), ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6a and 6b, S-cysteinyl, or S-glutathionyl, carnitoyl, lipids, polyols,OR6=pyruvate, lactate, citrate, fumarate, maleate, myristate, palmitate, stearate, palmitoleate, oleate, linoleate, natural fatty acids, or 13-cis retinoate,R7=H, alkyl, natural amino acids, or natural amines.

The invention provides a preparation and synthesis method of basic amino acid medicine salt of a dextral optical isomer in ibuprofen that is the existing anti-inflammation antipyretic and analgesic, and a medicinal combination thereof. After being mixed with necessary auxiliary material, the medicine salt can be prepared into oral solid preparations such as oral liquid, granules, tablets, dispersible tablets, capsules, coated tablets, sustained release tablets, collocystis, etc. through necessary pharmaceutics operations, and can also be prepared into the preparations for intravenous injection such as hydro-acupuncture, freeze-dried powders, aseptic powders, high volume transfusions, etc.

The present invention relates to a Chinese Tibet medicine for mainly curing the diseases of acute and chronic sprain and contusion, rheumatism and rheumatoid disease and its preparation method. It is characterized by that said preparation method includes the following steps: utilizing the Chinese Tibet medicinal materials of lamiophlomis rotate, Jidou, turmeric, zanthoxylum husk, water buffalo horn and myricaria germanica as raw material, making them undergo the processes of decocting, vacuum freeze-drying, pulverizing and making them into any pharmaceutically-acceptable dosage form, including oral preparation or preparation for external application, in particular, it can be made into the adhesive plaster, ointment preparation, spray, gel preparation, film preparation and resin plaster, etc.