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Pharmaceutical use of medicine composition containing zedoary turmeric oil

A technology of zedoary oil and composition, which is applied in the field of pharmaceutical use of pharmaceutical compositions containing zedoary oil, and can solve problems such as no preventive and therapeutic effects, complex components, and limitations in drug development for the prevention or treatment of HPV infection

Active Publication Date: 2009-05-06
HAINAN BIKAI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Humans are the only host of HPV, so it is impossible to carry out culture and expansion experiments in vitro and in animal models, and can only be judged by clinical efficacy, which greatly limits the development of drugs for the prevention or treatment of HPV infection, resulting in the worldwide There is no effective drug for preventing and treating HPV infection; although foreign countries have developed vaccines that can prevent HPV16 and 18 subtype infections, they have the following defects: they can only be used for asexual women aged 9-24 who are not infected with HPV16 and 18, but It has no prophylactic and therapeutic effect on subtype infections other than 16 and 18 subtypes
[0008] In the past ten years, Chinese medicine has achieved certain results in the treatment of female reproductive tract HPV infection, but most of them use multi-flavored Chinese medicines to form compound prescriptions with complex ingredients; therefore, it is still necessary to develop pharmaceutical compositions with simple ingredients and exact curative effects to prevent or treat cervical cancer. HPV infection and its induced benign or malignant lesions, especially for high-risk HPV infection causing cervical cancer, is urgently needed to develop clinical drugs with definite curative effect

Method used

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  • Pharmaceutical use of medicine composition containing zedoary turmeric oil
  • Pharmaceutical use of medicine composition containing zedoary turmeric oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: suppository

[0033] In addition to the above-mentioned main components and weight percentages, the contents also include:

[0034] Suppository base (water-soluble) appropriate amount to 100%

[0035] Preparation method:

[0036] (1) Put the matrix in a chemical tank, heat, stir until the matrix is ​​completely dissolved, add a penetration enhancer, and stir evenly;

[0037] (2) Take turmeric oil, borneol, and mix well.

[0038] (3) Transfer and combine the products obtained in the two steps of (1) and (2) into a blending tank, mix well, fill, and freeze to obtain the product.

Embodiment 2

[0039] Embodiment 2: foaming agent

[0040] In addition to the above-mentioned main components and weight percentages, the contents also include:

[0041] Excipients such as cosolvents, humectants, emulsifiers, diluents, propellants, etc. in appropriate amount to 100%

[0042] Wherein the co-solvent is selected from one or more of Spans or Tweens commonly used in pharmacy.

[0043] The humectant is selected from one or more of commonly used pharmaceutical glycerin, sorbose, propylene glycol, and polyethylene glycol; the emulsifier is selected from commonly used pharmaceutical soybean lecithin, lecithin, sodium lauryl sulfate, monohard One or more of fatty acid glycerides and polyoxyethylene stearates; the diluent is selected from purified water or water for injection; the propellant is selected from at least one of propane, n-butane, and isobutane.

[0044] The preparation method comprises the following steps:

[0045] (1) Mix and stir turmeric oil, borneol, cosolvent, hume...

Embodiment 3

[0048] Embodiment 3: capsule (soft capsule, hard capsule)

[0049] 1. Soft capsules

[0050] In addition to the above-mentioned main components and weight percentages, the contents also include:

[0051] Thinner Appropriate amount to 100.0%

[0052] The diluent is selected from one or more of polyethylene glycols and polyoxyethylene stearates.

[0053] (1) Preparation method of capsule skin contents:

[0054] Mix the main drug zedoary oil, borneol and diluent, heat and stir to dissolve completely, homogenize and set aside.

[0055] (2) The composition of the capsule skin

[0056] The capsule skin is generally made of glue, plasticizer, additive and water, and its composition ratio is:

[0057] Rubber material 30~50%

[0058] Plasticizer 8~20%

[0059] Water 30~50%

[0060] Additive 0.1~3%

[0061] The rubber material is selected from hide glue, bone glue, etc., because the quality of bone glue is better than hide glue, and meets the medicinal standard, so this case ch...

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Abstract

The invention relates to the pharmaceutical application of a medicament combination containing oil of zedoary turmeric. The medicament combination has new pharmaceutical application for preventing and treating various diseases, such as various HPV virus subtype infections, intraepithelial lesion(isl), papilloma and cervical carcinoma, and the like, in particular to high-risk HPV subtype infections. The medicament is prepared into various conventional formulations in the category of pharmaceutics, and the medicament combination can significantly prevent and treat multiple related diseases of HPV infection by clinical verification.

Description

(1) Technical field [0001] The present invention relates to the pharmaceutical use of a pharmaceutical composition containing zedoary oil, in particular to a pharmaceutical preparation containing zedoary oil, borneol, a transdermal absorption accelerator, etc. in the treatment of high-risk human papillomavirus (HR-HPV) common in Chinese women—— Infection with 11 subtypes of HPV16, 18, 31, 33, 39, 45, 51, 52, 56, 58, 68, etc. Low-risk human papillomavirus (LR-HPV)—HPV11, 53, 66, CP8304, etc. 4 subtypes of infection, mild and moderate "cervical squamous intraepithelial neoplasia" - CINI, CINII, prevention of cervical cancer, treatment of benign lesions such as papilloma, new medical applications such as genital tract (acute) condyloma, etc. (2) Background technology [0002] Human papillomavirus (HPV) infection is a sexually transmitted disease with an increasing incidence in recent years. High-risk HPV (HR-HPV) infection is associated with cervical squamous intraepithelial ne...

Claims

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Application Information

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IPC IPC(8): A61K36/906A61P31/20A61P35/00A61K31/045
CPCA61K31/12A61K31/045A61K36/906A61P15/00A61P31/12A61P31/20A61P35/00
Inventor 陈容康晓飞潘路殷栋二冯仲异
Owner HAINAN BIKAI PHARM CO LTD
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