Tadalafil orally disintegrating tablet and preparation method thereof

Abstract

The invention relates to a tadalafil orally disintegrating tablet and a preparation method thereof. Aiming to improve the deficiency of existing tadalafil oral dosage forms, the invention provides the tadalafil orally disintegrating tablet which is convenient to take, is quick in absorption, takes effect quickly and has high bioavailability for doctors and patients to help the patients achieve requirements for natural and satisfactory sexual lives. The tadalafil orally disintegrating tablet takes tadalafil or medicinal salts thereof as an active ingredient, contains pharmaceutically acceptable auxiliary materials such as filling agents, disintegrating agents, flavouring agents and lubricating agents, and when being taken, dispenses with water, can be quickly disintegrated or dissolved in oral cavities only in a few seconds and is ingested along with saliva.

Description

technical field [0001] The invention relates to a tadalafil preparation for treating male erectile dysfunction, in particular to a fast-release orally disintegrating tablet of tadalafil. Background technique [0002] Studies have shown that about half of men over the age of 40 suffer from erectile dysfunction (ED), which seriously affects their quality of life. For the pathogenesis of ED, experts and scholars at home and abroad have conducted in-depth research from multiple perspectives. Especially at the level of signal transduction pathway, significant research results have been obtained, and it has been confirmed that NO-cGMP signaling pathway is the key pathway for the pathogenesis of ED. The research results have also been applied clinically. As cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) selective inhibitors such as sildenafil and tadalafil have been used in the treatment of ED Significant clinical effect. [0003] Penile erection ...

AI Technical Summary

Problems solved by technology

[0005] Up to now, the marketed dosage form of tadalafil is only ordinary tablets, but ordinary tablets need to be taken with water, which is inconvenient to take, and will give patients a psychological hint that they are taking the medicine, which cannot meet the needs of a natural and satisfactory sexual life

Although CN101143145 discloses tadalafil chewing gum and a preparation method thereof, compared with tablets, chewing gum will give patients a better sensory experience and there is no obvious indication of taking medicine, but this product has not been commercially listed, which is beneficial to doctors and patients. Medication options are not helpful

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