180results about "Alkaloids chemistry" patented technology

The invention relates to a complex extraction process for mulberry leaf flavonoid, polysaccharide and alkaloid through cogeneration, which is characterized by having the following extraction steps: raw material processing, extraction, and separation. The complex extraction process adopting a complex extraction method for the mulberry leaf flavonoid, the polysaccharide and the alkaloid obtained through the cogeneration has the advantages of mild condition, low energy consumption, small environment pollution; macroporous absorbent resin and chloroform used in the complex extraction process can be reused through regeneration; the economic value of the obtained effective ingredients is very high; the mulberry leaf resource is greatly saved; a new utilization approach of the agricultural product mulberry leaf is opened up; and the medicinal utilization value and the economic added value of the mulberry leaf are improved.

The invention discloses a technique to use supercritical fluid technology to separate Zantho- xylum bungeanumí»s tingling-taste component. It crushes Zantho- xylum bungeanumí»s peel into powder, places in supercritical extraction pot and adds carrier, alcohol, to extract the component; and adjusts the separation pot to control parameters, to separate the component. It adopts CO2 as extraction solvent, has not pollution and can be used as raw material of food and drug.

The present invention discloses a Rhizoma Corydalis Decumbentis total alkaloids extract, its preparation method, pharmaceutical composition containing same. The total alkaloids mainly comprise : macleyine, tetrahydropalmatine, bicucalline, palmatine hydrochloride, 'xiawuning' alkaloid, corydaline harmine, other alkaloid and extract. The preparation method is : using Rhizoma Corydalis Decumbentis as material, adding right amount of polar solvent for leaching, merging the leachate, carrying out large pore adsorption resin chromatography, eluting impurity with diluted acid and alkaline aqueous solution orderly, eluting using polar organic solvent, collecting elution liquor, eliminating impurity further by alumina column adsorption, Collecting after-column liquid, concentrating liquor to obtain the Rhizoma Corydalis Decumbentis total alkaloids extract. The present invention also discloses a pharmaceutical composition containing the total alkaloids extract and uses of the pharmaceutical composition in preparing tablet, capsule, soft capsule, suppository, granula, transdermal absorption agent, drop pills, oral disintegrating agent, slow release agent, freeze-drying powder injection etc.

The invention discloses an anticancer and antalgic Chinese medicinal Gelsmium elegans total alkaloid and drug combination containing it as well as its preparing method, where the Gelsmium elegans total alkaloid is extracted from the raw material Chinese medicinal Gelsmium elegans and the Gelsmium elegans total alkaloid and acceptable carrier or excipient in any pharmacy are made into drug combination whose drug form can be oral preparation and also injection, concretely speaking tablet, capsule, soft capsule, oral solution, injection solution, transfusion, powder injection and freeze-dried powder injection. The drug combination has good anticancer effect and high-quality ntalgic function and the drug combination's antalgic strength is inferior to morphia's and superior to other clinical antalgics'.

The invention discloses a total alkaloid extract and making method of eye drip, which comprises the following parts: opium alkaline, tetrahydropalmatine, cumic acid, alcaine palmatine, corydaline, summer alkaline and other biological alkalines. The preparing method comprises the following steps: adopting summer non as raw material; optimizing hypercritical CO2 flow to extract; collecting extract; drying; obtaining the total alkalilne extract; fitting for tablet, pill, suppository, percutaneous absorption agent, oral rapid-breaking agent, release-control agent and freeze dried.

The invention discloses a method for synchronously separating, extracting and purifying flavone, alkaloid and polyoses in lotus leaves. The method is characterized in that the lotus leaves are pretreated, added with different organic solvents and continuously leached for three times to obtain three kinds of leaching liquors of the flavone, the alkaloid and the polyoses respectively, and the three kinds of the leaching liquors are subjected to concentration, decoloration and drying treatment to obtain three kinds of products of the flavone, the alkaloid and the polyoses. The method overcomes the defects that the prior art can only extract a single component, destroys other components during the process of extracting the single component, has low extraction rate for the other components, high impurity content of extractives, and so on, gives attention to chemical properties of the flavone, the alkaloid and the polyoses, sufficiently considers mutual influence, activity and extraction rate of the extracting processes of various components and has the characteristics of high extraction rate, high purity and high utilization rate of lotus leaf resource.

The invention relates to a lotus leaf extract, a monomer component and application thereof. An active monomer component of the extract is aporphine alkaloid and comprises 2-hydroxy-1-methoxy-aporphine, nuciferine and N-nornuciferine. The lotus leaf extract and the monomer component have good inhibition to acetylcholinesterase, and can be developed into medicaments for treating the diseases such as Alzheimer's disease, glaucoma, asthenic bulbar paralysis, intestinal obstruction and the like.

The invention relates to the field of separation and purification of capsaicin and paprika red pigment, and particularly discloses a method for preparing paprika red pigment and a capsaicin material. According to the method, capsicum oleoresin is subjected to three-level molecular distillation to respectively obtain the capsaicin material and the paprika red pigment, wherein the total content of capsaicin and dihydrocapsaicin in the capsaicin material is greater than 70%, and the color value of the paprika red pigment is higher than 200. The capsaicin material is recrystallized and purified, the total content of capsaicin and dihydrocapsaicin in crystallization is more than 85%, further capsaicin crystals and dihydrocapsaicin crystals are obtained through preparation and separation of high performance liquid chromatography, and the content of each of the capsaicin crystals and the dihydrocapsaicin crystals is more than 95%. The method is simple and convenient to operate and low in production cost, has a good separation effect and is suitable for industrial production; and the content of the products is high.

The invention discloses a preparing method and application of lotus leaf flavone and lotus leaf alkaloid, which comprises the following steps: adopting rough-extract of lotus leaf, film separating impurity-removing lotus leaf extract or resin separating purifying lotus leaf extract as raw material; adding water to stir into suspension; adsorbing lotus leaf flavone through polyamide; decompressing non-adorbed part to recycle; condensing solvent into lotus leaf alkaloid in the vacuum; washing lotus leaf flavone on the polyamide; removing polar impurity and pigment; eluting through polar organic solvent; decompressing eluent; recycling solvent; condensing into lotus leaf flavone in the vacuum; fitting for prepare fat-reducing, antihyperglycemic, antiviral or oxidation resistance oral agent.

The present invention relates to extraction process and medicinal application of sessile stemona alkaloid. Sessile stemona alkaloid is extracted through the following steps: 1. extracting with alcohol solution or acid aqua; and 2. purifying with cation exchange resin. The sessile stemona alkaloid product has the sessile stemona alkaloid content over 50 %. The extracting process uses alcohol, no toxic organic solvent and reusable cation exchange resin, and has high safety and low cost. The medicine composition with the sessile stemona alkaloid may be used in treating skin diseases and diseases of respiratory tract, and in preventing and controlling plant diseases and pests.

The invention discloses a method for separating total alkaloid of traditional Chinese medicines, in particular a method for separating the total alkaloid from the extraction solution of traditional Chinese medicines and belongs to the field of traditional Chinese medicines. The method includes the technical proposal as follows: the extraction solution of traditional Chinese medicines is taken; the pH value is adjusted between 1 and 7; the solution is filtered; the filtrate is added to a cation exchange resin column; firstly, water is used for elution and impurity removal; then the resin column is immersed with 0.5 to 20 percent of the salt solution; 0.5 to 20 percent of the salt solution with acid or ethanol is used for elution until no alkaloid is tested; and the eluate is collected; thealkali is added for neutralization and then the total alkaloid of traditional Chinese medicines is obtained after the concentration drying through the desalted treatment. The method overcomes the defects of the low extraction rate, a large amount of organic solvents, too high acid base concentration, complex process, no mass production, etc., in the prior art and can separate the highly purified total alkaloid from the extraction solution of traditional Chinese medicines with high efficiency.

The invention aims to solve the problems in the prior art, such as low degree of utilization of konjac resources and lack of clean and high-efficiency full-biomass utilization method, and provides a comprehensive utilization method for konjac. Based on steam explosion classification in combination with glucomannan wet-method preparation techniques and in consideration of physicochemical properties of individual components, the method achieves co-production eco-industrial development and comprises the following steps: extracting alkaloids from konjac skin, making konjac tuber powder by wet grinding, extracting ceramide from konjac fly powder, and producing biogas and ethanol by fermentation of a grinding waste liquid. The method can not only increase the utilization ratio of konjac resources and reduce environmental pollution but also achieve full-biomass utilization of konjac. The method is advantageous in having low energy consumption and high efficiency, increasing purity of the refined powder and achieving full-biomass clean high-value utilization of konjac.

The invention discloses a method for separating total alkaloid from traditional Chinese medicine, in particular a method for separating jamaicin total alkaloid from an extracting solution of the traditional Chinese medicine, and belongs to the field of traditional Chinese medicines. The method comprises the following technical proposal: taking the extracting solution of the traditional Chinese medicine; adjusting the pH value of the extracting solution to between 1 and 7; filtering the extracting solution; taking and adding the filtrate to a cation exchange resin column; rinsing the filtrate and removing the impurities; eluting the filtrate with 0.5 to 15 percent acid liquor; collecting eluent; adding alkali to the eluent for neutralization; performing desalting treatment on the mixed solution; and obtaining the jamaicin total alkaloid. The method overcomes the defects of low extracting rate, large using level of organic solvent, complicated process, inability of large-scale production, and the like in the prior art, and can efficiently separate high purity of the jamaicin total alkaloid from the extracting solution of the traditional Chinese medicine.

A corydaline for preparing medicines to prevent and treat acute cerebral sichemia is prepared from the drived tuber of corydalis, and contains protopine, bicuculline, tetraphdropalmatine, palmatine, etc. Its preparing process and its composite medicine are also disclosed.

The invention belongs to the field of daily-use chemicals, and discloses an extraction method and applications of oat avenanthramides. The method comprises the following steps: crushing oats, adding ethanol, evenly mixing and then adding enzyme, adjusting the pH value to be 5.0-6.0, performing enzymatic hydrolysis reaction under the stirring condition, centrifugally separating a reaction solution obtained after reaction is over, conducting subcritical extraction on solids obtained from centrifugal separation, and then recycling a solvent to obtain the oat avenanthramides extract. The method is simple and easy, conditions are easily controlled, the utilization rate of raw materials is high, and the industrial product is easily realized. Before extracting the oat avenanthramides, enzyme is added to perform pretreatment on oats, and the subcritical technology is used for extraction, so that the extraction rate of the oat avenanthramides is increased, and the time needed by extraction is shortened.

Ergot alkaloids are isolated from ergot in high yields and purity by a process including extracting Claviceps purpurea, i.e., ergot, with a toluene / ethanol solvent mixture to obtain a primary extract. The primary extract can be further subjected to two steps of liquid-liquid extraction to purify the alkaloids resulting in a purified toluene extract. The toluene extract can be further partially evaporated and a crystalline product obtained by crystallization from the toluene or a mixture of toluene and an aliphatic hydrocarbon.

The invention discloses a method for synchronously separating lotus leaf flavone and chlorophyll from fresh lotus leaves. The method comprises the following steps: a, adding the fresh lotus leaves and ethanol with the concentration of 90-95% into an extraction tank, extracting for 2-4 times at the temperature of 30-80 DEG C, wherein each extraction time is 1-2 hours, and mixing the extracting solutions; b, adding ligarine into the extracting solutions, stirring and performing still standing to obtain an extraction liquid layer and a raffinate layer; c, performing concentration on an extraction liquid obtained in the step b in a pressure reduction condition to obtain a green oily liquid; d, allowing a raffinate obtained in the step b to pass an ultrafiltration membrane for ultrafiltration so as to obtain a concentrated solution processed by the ultrafiltration membrane; e, adding the concentrated solution obtained in the step d into purified water for dilution, allowing the diluted solution to pass a macroporous adsorption resin column to enable the lotus leaf flavone to be adsorbed on the macroporous adsorption resin column, and obtaining the lotus leaf flavone through leaching, concentrating and drying. The method can synchronously separate the lotus leaf flavone and the chlorophyll from the fresh lotus leaves, is simple and feasible and low in cost, and adapts to industrial application.

A process for extracting ephedra alkaloid including ephedrine, pseudoephedrine, methyl ephedrnie, demethyl ephedrine incldues such steps as pulverization fresh and drying ephedrine, soaking in solvent, releasing ephedrine alkaloid by outside field including microwave, ultrasonic wave, electromagnetic field etc, extracting, separating by solid mediator adsorbent, precipitation, crystallization and purifying.

The invention discloses a method for separating total alkaloid from sophora flavescens ait by using ion exchange resin, which belongs to the field of Chinese medicament. The method comprises the following technical schemes: taking Chinese medicament extract, adjusting the pH value to 1-7, carrying out filtration, passing the extract through a cation exchange resin column, washing the extract by using deionized water until the pH value reaches 5-7, soaking the resin column in saline solution at appropriate concentration; eluting the extract by using saline solution containing ethanol until no alkaloid is detected, collecting the eluent, adding alkali to the eluent for neutralization, and obtaining Chinese medicament total alkaloid after desalination, concentration and drying. The method overcomes the disadvantages of low extraction efficiency, large consumption of organic solvent, excessively high acid and alkali concentration, complicated technique, unavailable mass production and thelike in the prior art. Moreover, the method can efficiently separate high-purity Chinese medicament total alkaloid from the Chinese medicament extract.

A process for extracting volatile oil and liposoluble alkaloid from the core of lotus seed includes such steps as pulverizing, supercritical CO2 extraction of volatile oil at 30-60 deg. C under 20-40 MPa, mixing the dregs with alcohol, thermal reflux extracting, vacuum evaporation to recover solvent and obtain the alkaloid extract, acidifying, filter, heating while stirring and adding absorbent cotton to remove impurities including chlorophyll, adding organic solvent, and alkalizing to obtain said liposoluble alkaloid.

A process for preparing the alkaloid from coptis root and evodia fruit, which can be used to prepare the analgesic for gastritis and gastric ulcer, includes such steps as pulverizing, mixing, reflux extraction in alcohol, recovering alcohol, extracting by ethyl acetate, recovering ethyl acetate to obtain extract A, decocting the dregs, filtering, concentrating, mixing, filter regulating pH=1-4, adding NaCl, stirring, laying aside, filtering, washing deposit by water to obtain extract B, mixing A with B, vacuum drying and pulverizing.

The present invention provides preparation process of toad skin total alkaloid. The toad skin total alkaloid contains indole total alkaloid 50-95 wt%, cinobufagin and lipo bufogenin 0.02-0.08 wt%, and toad thetine 20-50 wt%. The present invention provides also the method of measuring toad thetine content, and the injection, powder for injection, dripping pill, capsule, oral liquid, etc with the oad skin total alkaloid as effective component and their preparation process.

The invention discloses a method for separating total alkaloid from traditional Chinese medicine, in particular a method for separating belladonna total alkaloid from traditional Chinese medicine extract, which belongs to the field of traditional Chinese medicines. The method comprises the following technical proposal that the traditional Chinese medicine extract is taken and filtered; the pH value of the traditional Chinese medicine extract is adjusted to be between 1 and 7; filtrate is added to a cation exchange resin column, eluted with water to remove impurities and then eluted by use of 0.5 to 15 percent acid liquid; and eluent is collected, added with alkali for neutralization and desalted so as to prepare belladonna total alkaloid. The method overcomes the deficiency that the prior art is low in extraction ratio, large in the amount of organic solvents, complex in process, incapable of mass production, and the like, and can efficiently separate high-purity belladonna total alkaloid from traditional Chinese medicine extract.

The invention discloses a method for separating total alkaloid from traditional Chinese medicine, in particular a method for separating total alkaloid from an extracting solution of the traditional Chinese medicine, namely mulberry leaf, and belongs to the field of traditional Chinese medicines. The method comprises the following technical proposal: taking the extracting solution of the mulberry leaf; adjusting the pH value of the extracting solution to between 1 and 7; filtering the extracting solution; taking and adding the filtrate to a cation exchange resin column; rinsing the filtrate and removing the impurities; eluting the filtrate with 0.5 to 15 percent acid liquor; collecting eluent; adding alkali to the eluent for neutralization; performing desalting treatment on the mixed solution; and obtaining the mulberry leaf total alkaloid. The method overcomes the defects of low extracting rate, large using level of organic solvent, complicated process, inability of large-scale production, and the like in the prior art and can efficiently separate high purity of the mulberry leaf total alkaloid from the extracting solution of the mulberry leaf.

The invention provides a method for classifying and preparing tertiary amine alkaloid and quaternary ammonium alkaloid from corydalis extract. The method comprises the following steps of eluting different solvents according to a like component preparation method by adopting a C18 / WCX (Weak cation exchange) type separating material with the combination of the hydrophobic effect and a weak cation exchange function, removing impurities, and enriching tertiary amine alkaloid and quaternary ammonium alkaloid, which are completely different in functional activity, contained in the corydalis extract respectively, wherein the total alkali contents in two like components can reach more than 65% and more than 90% respectively through HPLC (High Performance Liquid Chromatography) analysis. The preparation method has simple process, and has high efficiency and high recovery rate, the used separating material can be used repeatedly, the production cost is low, and the method can provide a good technical scheme for developing safe, efficient and controllable Chinese herbal preparations with alkaloids components.

The invention discloses a method for separating total alkaloid of traditional Chinese medicines, in particular a method for separating the matrine type total alkaloid from the extraction solution of traditional Chinese medicines and belongs to the field of traditional Chinese medicines. The method includes the technical proposal as follows: the extraction solution of traditional Chinese medicines is taken; the pH value is adjusted between 1 and 7; the solution is filtered; the filtrate is added to a cation exchange resin column; firstly, water is used for elution and impurity removal; then the acid solution of 0.5 to 15 percent is used for elution; the eluate is collected; the alkali is added for neutralization and then the matrine type total alkaloid is obtained through desalted treatment. The method overcomes the defects of low extraction rate, a large amount of organic solvents, complex process and no mass production, etc., in the prior art and can separate the highly purified matrine type total alkaloid from the extraction solution of traditional Chinese medicines with high efficiency.

The invention relates to a process for separating and extracting lipids general alkaloid from aconites and wolfsbanes, wherein the long ester chain, small polarity and property of infusible to water for the lipid alkaloid are utilized for carry out the extraction, the process consists of ethanol cold soaking, acid water treatment, and performing chromatography with silica gel column.

The invention discloses a preparation method of a total alkaloid, which is characterized in that plant extracts are purified using weak acidic cation exchange resin, strong acidic cation exchange resin and neutral alumina to obtain the total alkaloids. According to the basic experiment, the general effective preparation method of total alkaloids has an advantage of effectively increasing the content of the total alkaloids.