The invention discloses a compound Chinese herbal medicine preparation preventing freshwater fish bacterial diseases and a production method of the compound Chinese herbal medicine preparation, and belongs to the technical field of fishery. The compound Chinese herbal medicine preparation preventing the freshwater fish bacterial diseases is prepared by the following raw materials: Chinese rhubarb, herba andrographitis, scutellaria baicalensis, oriental wormwood, cape jasmine, wrinkled giant hyssop, radix isatidis, mint, cortex phellodendri, abrotani herba, herba schizonepetae, radix curcuma, radix curcumae, fructus mume, fructus forsythiae, white paeony root, moutan bark, radix bupleuri, folium isatidis, melia toosendan, glycyrrhiza and aquatic product multivitamins. The compound Chinese herbal medicine preparation preventing the freshwater fish bacterial diseases is obtained by the raw materials after a procedure of step-by-step boiling, filtering, vacuum concentration and sterile filling. The compound Chinese herbal medicine preparation preventing the freshwater fish bacterial diseases adopts assistant and guide, combines prevention and treatment, is synchronously beneficial for a drug effect, strengthens immunity of freshwater fishes, and is prominent in prevention and treatment effects to the freshwater fish bacterial diseases, low in production cost, long in drug effect time, free of residual, and free of a toxic and side effect on the freshwater fishes and the environment.