37 results about "Male reproductive system" patented technology

The present invention relates to methods of identifying a disease treatable with PARP modulators by identifying a level of PARP in a sample of a subject, making a decision regarding identifying the disease treatable by the PARP modulators wherein the decision is made based on the level of PARP. The method further comprises of treating the disease in the subject with the PARP modulators. The methods relate to identifying up-regulated PARP in a disease and making a decision regarding the treatment of the disease with PARP inhibitors. The extent of PARP up-regulation in a disease can also help in determining the efficacy of the treatment with PARP inhibitors. The present invention discloses various diseases that have up-regulated or down-regulated PARP and can be treated with PARP inhibitors or PARP activators, respectively. The examples of the diseases include cancer, inflammation, metabolic disease, CVS disease, CNS disease, disorder of hematolymphoid system, disorder of endocrine and neuroendocrine, disorder of urinary tract, disorder of respiratory system, disorder of female reproductive system, and disorder of male reproductive system.

In a new pharmaceutical combination, the herb, Vitex agnus-castus (chasteberry), enhances hormone balance by increasing progesterone release and, therefore, ovulation frequency. The antioxidants, green tea, vitamin E, and selenium, improve overall reproductive health. L-arginine, an amino acid, stimulates the reproductive organs by improving circulation. Folic acid, vitamins B6 and B12, iron, zinc and magnesium help promote womens' fertility. Sperms are highly susceptible to free radical or oxidative damage from environmental toxicants and natural aging. Vitamins C and E, coenzyme Q10 and selenium are all potent antioxidants that help improve sperm counts and quality. Ferulic acid, an antioxidant found in Dong quai, also improves sperm quality. Zinc and B vitamins (B6, B12 and folate) are critical nutrients in male reproductive systems for hormone metabolism, sperm formation and motility. The amino acid, L-carnitine, promotes formation of healthy sperm.

The present invention relates to methods of identifying a disease treatable with PARP modulators by identifying a level of PARP in a plurality of samples from a population, making a decision regarding identifying the disease treatable by the PARP modulators wherein the decision is made based on the level of PARP. The method further comprises of treating the disease in a subject population with the PARP modulators. The methods relate to identifying up-regulated PARP in a disease and making a decision regarding the treatment of the disease with PARP inhibitors. The extent of PARP up-regulation in a disease can also help in determining the efficacy of the treatment with PARP inhibitors.The present invention discloses various diseases that have up-regulated or down-regulated PARP and can be treated with PARP inhibitors or PARP activators, respectively. The examples of the diseases include cancer, inflammation, metabolic disease, CVS disease, CNS disease, disorder of hematolymphoid system, disorder of endocrine and neuroendocrine, disorder of urinary tract, disorder of respiratory system, disorder of female reproductive system, and disorder of male reproductive system.

An energy delivery probe is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply energy to tissue, such as a duct, to shrink, damage, or occlude the duct. In some embodiments, the energy can be applied with a vapor media. In some embodiments, the duct can be a ductus deferens or an ejaculatory duct of the male reproductive system. Another feature of the energy delivery probe is that it can utilize an inflatable member to form a seal to contain the vapor media. Methods associated with use of the energy delivery probe are also covered.

An energy delivery probe is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply energy to tissue, such as a duct, to shrink, damage, or occlude the duct. In some embodiments, the energy can be applied with a vapor media. In some embodiments, the duct can be a ductus deferens or an ejaculatory duct of the male reproductive system. Another feature of the energy delivery probe is that it can utilize an inflatable member to form a seal to contain the vapor media. Methods associated with use of the energy delivery probe are also covered.

The present invention discloses a sweet dried oyster with iodine-tea taste, which belongs to instant dried food ingredients and the making method. The main raw material of the present invention is fresh oyster, and the supplemental materials are slat, white sugar, malt sugar, honey, edible oil and so on. The product is made after the materials being treated, cooked, immersed, dried, fried, roasted (for dehydration), coated with instant black tea powder, baked, cooled, packed, disinfected with microwave and stored in case, and processed cold storage process or procedure. The produced instant dried oyster has original flavor and taste, and has taste of Chinese herbal preparation honey-peppery oil tea camellia. The present invention has oyster and Chinese herbal preparation, and so the dried oyster has the function of enhancing the male reproductive system, preventing male sexual function from decreasing and prostatic hypertrophy. The present invention also can protect heart and liver, benefit for gallbladder, adjust blood lipid, make the skin soft, improve appearance, and is good for mental and brain, and so on.

The invention provides a rapidly degradable PVC material as well as a preparation method and an application thereof. The rapidly degradable PVC material comprises the following components: 100 parts of PVC resin, 20-80 parts of a plasticizer, 1-10 parts of an auxiliary plasticizer, 1-5 parts of a heat stabilizer, 0.1-3 parts of lubricant, 10-60 parts of an auxiliary agent A for accelerating degradation, and 10-30 parts of a preparation B for accelerating degradation; the auxiliary agent A for accelerating degradation is polyglycolic acid, and the preparation B for accelerating degradation is polylactic acid. The rapidly degradable PVC material satisfies physical properties, chemical properties and biological compatibility needed by the PVC material of disposable medical consumables, and is rapidly degradable in a burying treatment process. Irritation, carcinogenicity, and harm to male reproductive system which may exist in traditional PVC materials are removed, and disadvantages of long burying degradation period time, environment pollution, and the like of disposable medical consumable wastes are overcome.

The invention aims to provide a method for sex induction of hermaphrodite shrimps. According to the method, a target gene in macrobrachium is silenced by using an RNA interference technology to realize sex induction of macrobrachium rosenbergii, wherein the nucleotide sequence of the target gene is SEQ ID NO:1. By virtue of the induction technology provided by the invention, a macrobrachium individual has sex reversion and becomes hermaphrodite macrobrachium rosenbergii, and the developments of a female reproductive system and a male reproductive system are realized in the body of the hermaphrodite macrobrachium rosenbergii, so that a set of effective macrobrachium rosenbergii sex induction technology is established. Meanwhile, by using the hermaphrodite shrimps cultured by the method provided by the invention, a good scientific research material and an animal sample can be provided for sex determination, sex differentiation and researches on reproduction and fertilization of shrimps and crabs.

In a new pharmaceutical combination, the herb, Vitex agnus-castus (chasteberry), enhances hormone balance by increasing progesterone release and, therefore, ovulation frequency. The antioxidants, green tea, vitamin E, and selenium, improve overall reproductive health. L-arginine, an amino acid, stimulates the reproductive organs by improving circulation. Folic acid, vitamins B6 and B12, iron, zinc and magnesium help promote womens' fertility. Sperms are highly susceptible to free radical or oxidative damage from environmental toxicants and natural aging. Vitamins C and E, coenzyme Q10 and selenium are all potent antioxidants that help improve sperm counts and quality. Ferulic acid, an antioxidant found in Dong quai, also improves sperm quality. Zinc and B vitamins (B6, B12 and folate) are critical nutrients in male reproductive systems for hormone metabolism, sperm formation and motility. The amino acid, L-carnitine, promotes formation of healthy sperm.

The invention aims at providing a ribonucleic acid (RNA) molecule used for interfering macrobrachium rosenbergii male reproduction, and a preparation method thereof. The double-stranded ribonucleic acid molecule used for interfering macrobrachium rosenbergii male reproduction has a nucleotide sequence of SEQ ID NO:1 or 3. With the method provided by the invention, a large amount of double-stranded RNAs can be rapidly prepared with low cost and high efficiency. The preparation method is simple to operate. Also, with the nucleotide fragment screened by the invention, good interference efficiency can be achieved, and macrobrachium rosenbergii male reproductive system development can be effectively interfered. With the double strand provided by the invention, long-term and high-efficiency gene silencing can be realized in shrimp animals, such that good technical means and method are provided for the researches of shrimp functional genes.

L-carnitine, an amino acid, improves sperm quality and motility. Ferulic acid, an antioxidant found in Dong quai, also improves sperm quality. Sperm are highly susceptible to free radical or oxidative damage from environmental toxicants and natural aging. Vitamins C and E, green tea, and selenium are all potent antioxidants that help improve overall reproductive health. Zinc and B vitamins (B6, B 12 and folate) are critical nutrients in male reproductive systems for hormone metabolism, sperm formation and motility.

The invention discloses use of radix morindae officinalis polysaccharide in preparation of medicines or health foods for preventing and treating male reproductive system diseases. The radix morindae officinalis polysaccharide has an average molecular weight of (1.0-1.5)*10<4>, and the dosage of the radix morindae officinalis polysaccharide is 200-300mg kg<-1>; after being directly used for preparing the medicines or the health foods for preventing and treating the male reproductive system diseases, the radix morindae officinalis polysaccharide can repair the injury to a male reproductive system, promote spermatogenic function, improve sexual behavior ability, enhance reproductive capacity and increase the testosterone level in a body, so that the technical problem that radix morindae officinalis has toxicity for liver and kidney when being directly eaten is avoided.

The present invention discloses a sweet dried oyster with iodine-tea taste, which belongs to instant dried food ingredients and the making method. The main raw material of the present invention is fresh oyster, and the supplemental materials are slat, white sugar, malt sugar, honey, edible oil and so on. The product is made after the materials being treated, cooked, immersed, dried, fried, roasted (for dehydration), coated with instant black tea powder, baked, cooled, packed, disinfected with microwave and stored in case, and processed cold storage process or procedure. The produced instant dried oyster has original flavor and taste, and has taste of Chinese herbal preparation honey-peppery oil tea camellia. The present invention has oyster and Chinese herbal preparation, and so the driedoyster has the function of enhancing the male reproductive system, preventing male sexual function from decreasing and prostatic hypertrophy. The present invention also can protect heart and liver, benefit for gallbladder, adjust blood lipid, make the skin soft, improve appearance, and is good for mental and brain, and so on.

The invention relates to further processing of aquatic products, specially to a protamine and a preparation method thereof. The protamine comprises, in percentage by weight, 0.75-1% of VE, 0.65-0.8% of VC, 0.7-1% of taurine, 1-3% of yeast zinc, 0.6-1% of rehmannia glutinosa extract, 0.3-0.6% of cistanche extract, 0.2-0.6% of wolfberry extract, 0.6-1% of Radix Astragali extract, 10-14% of Apostichopus japonicus enzyme-hydrolyzed powder, 20-29% of xylo oligosaccharide, 20-40% of soybean protein isolate, with the balance being protamine powder. The protamine in the invention possesses abundant nutrition, and is nutrition supplement food for male reproductive system.

The invention relates to a formula for treating prostatitis and other male reproductive system diseases. The invention discloses a main compound extracted from mangosteen: Garcinia Mangostana, wherein alpha-mangostin is taken as a main effective constituent and mixed with various commonly used fillers in the medicine industry to prepare various appropriate preparation formulations including tablets, capsules, powder, and suppository; and the various preparation formulations can be used for preventing and treating male reproductive system inflammations such as prostatitis, orchitis, deferentitis and urethritis by means of oral taking or external application. The content of the alpha-mangostin in the product is between 3 and 99.8 percent; and the prepared product can relieve various inflammations, has the function of relieving pain to certain degree, and can be independently used or mixed with other natural substances for use.

The invention discloses a male intelligent medical care and treatment system and method. The treatment effect of male reproductive system diseases through deep ultraviolet technology is obvious. At the same time, users can make full use of information, networks and various tools to participate more in self-medical management and health management decisions. You can look up disease-related knowledge anytime, anywhere through the Internet, and make preliminary or even further judgments based on your own situation. On the one hand, this is conducive to the communication between doctors and patients about the condition, and at the same time, it also puts forward higher requirements for doctors, and solves the problem that men's private body positions are difficult to observe and privately collect medical care information.

The present invention is directed to the production of male sterile plants by providing them with a recombinant DNA capable of specific expression in the male reproductive system of a plant of the enzyme trehalose phosphate phosphatase (TPP). Restoration of the fertility can be established either by providing said male sterile plants with a recombinant DNA capable of expression of trehalose phosphate synthase (TPS) under control of an inducible promoter or with a recombinant DNA capable of expression of a suppressor protein which suppresses expression of TPP under control of an inducible promoter. This inducible restoration possibilities enable the maintenance site-specific recombination system is provided, by inserting two site-specific recombination sites flanking the recombinant DNA coding for TPP and crossing the male sterile lines with lines expressing the corresponding recombinase. By crossing the recombinase will excise the gene coding for TPP and fertile hybrids are produced.

The invention provides temperature-regulating healthcare bath pants for men, which comprise a water-transferring temperature-regulating interlayer 1, a water inlet tube 2 and a water outlet tube 3. and are characterized in that a crotch is provided with the water-transferring temperature-regulating interlayer 1; and the water- transferring temperature-regulating interlayer 1 is provided with the water inlet tube 2 and the water outlet tube 3. When the bath pants are worn, the water inlet tube is connected with an external water valve; the external water enters the water-transferring temperature-regulating interlayer, and the temperature in the healthcare bath pants is reduced. The temperature in the temperature-regulating healthcare bath pants for men is regulated by water supply / discharge volume so that a male reproductive system is protected from a high-temperature state. The temperature-regulating healthcare bath pants provided by the invention are simple, easy, practical and convenient to popularize; by wearing the temperature-regulating healthcare bath pants, the demands of the men who like to sauna and take hot baths can be met, namely that sauna and hot bath can be realized while guaranteeing the heath of the reproductive system; the temperature-regulating healthcare bath pants can be used at home or in public places; and moreover, the inner surface of the water-transferring temperature-regulating interlayer is provided with a medicine bag which can be used for preventing and curing female diseases and fills up a gap in the bath industry.

The invention relates to male massage cream. The male massage cream is prepared from the following components in percentage by mass of 2%-7% of glycerol, 1%-5% of 1, 3-propylene glycol, 1%-2% of a flower oil mixture, 0.1%-1% of a kudzuvine root extract, 0.1%-1% of a centella asiatica extract, 0.1%-1% of a cistanche deserticola extract, 0.1%-1% of a morinda officinalis extract, 0.1%-1% of an abelmoschus esculentus fruit extract,0.1%-1% of a Chinese yam extract, 4ppm-20ppm of a polypeptide mixture, 0.05%-1% of hydrolyzing elastin, 0.1%-1% of acrylic acid / C10-30 alkyl acrylate cross polymers, 0.2%-0.8% of tocopheryl acetate, 0.2%-0.8% of PEG-40 hydrogenated castor oil, 0.5%-3% of an emulsifying agent, 0.2%-1.5% of laurocapram, 0.1%-1% of a preservative, 0.1%- 1% of a humectant, 0.1%-1% of anantibacterial agent, 0.1%-1% of an antioxidant, 0.1%-2% of an auxiliary agent and the balance water. The male massage cream regulates neuroendocrine of a male reproductive system, so that a sperm storage sac is filled to promote sexual desire, normal balance of testosterone in a body cannot be affected, and men keep lasting and stable sexual desire.

The invention discloses a radix morindae officinalis processed product oligosaccharide composition, and a preparation method and application thereof. The invention carries out separation on a radix morindae officinalis processed product to obtain a radix morindae officinalis processed product oligosaccharide composition.The oligosaccharide composition consists of Inulo type oligosaccharide and Inulin type oligosaccharide. According to the radix morindae officinalis processed product salt radix morindae officinalis oligosaccharide, the content of MDA can be remarkably reduced, and the activity of SOD, GSH-Px and CAT is enhanced to protect TM4 oxidative stress damage induced by H2O2. According to the radix morindae officinalis processed product radix morindae officinalis oligosaccharide, the content of MDA can be remarkably reduced, the activity of GSH-Px and CAT is enhanced, mouse germ cell oxidative damage caused by cyclophosphamide is protected, and reduction of the sperm malformation rate of male mice with spermatogenesis disorder caused by cyclophosphamide and improvement of sperm generation and sperm quality can be remarkably promoted. The radix morindae officinalis processed product oligosaccharide composition can be used for preparing health-care products or medicines for preventing or treating male reproductive system diseases.

The invention relates to a hygienic protective sleeve for man health, and is characterized in that the hygienic protective sleeve for man health is of a sleeve-shaped structure, wherein the external surface layer is made of waterproof cast film, the internal layer is a rapid-permeation and liquid-receiving layer, cotton core bodies are arranged in the external surface layer and the rapid-permeation and liquid-receiving layer, and a single sided adhesive is arranged on the external surface layer. The rapid-permeation and liquid-receiving layer is made of soft and hyposensitive non-woven fabrics with high venting quality, and 8 percent of Jieeryin liquid medicines are sprayed on the surface of the rapid-permeation and liquid-receiving layer according to percentage concentration by weight. Each cotton core body is made of wood-pulp cotton or two to three layers of sterile absorbent paper. The hygienic protective sleeve for man health is designed according to the physiological structure characteristics of men, can alleviate prostatoplasia patients from dribbling urination and vesical tenesmus, can effectively prevent the long-term pubes moisture caused by the urine dropping on the underwear after urination, has the functions of sterilization, bacteriostasis and inflammation elimination, and can prevent and alleviate the prostatic disorders and various male reproductive system diseases and keep the pubes clean and dry to prevent the cross infection.

A pharmaceutical composition for improving male reproductive system functions. The composition is prepared using 4-6 parts by weight of fructus lycii, 2-4 parts by weight of semen cuscutae, 1.5-3.5 parts by weight of fructus rubi, 1-2 parts by weight of schisandra chinensis, 1-2 parts by weight of semen plantaginis, and 1.5-2.5 parts by weight of yohimbine.

The invention relates to a composition for increasing concentration and motility of human sperms. L-carnitine, acetyl L-carnitine, amino acids, taurine, levulose, a selenium source, a zinc source, folic acid, vitamin B12, vitamin E, astaxanthin and N-acetylneuraminic acid are used as raw materials, through an appropriate compounding ratio and synergistic reaction of components, the oxidation and oxidation-resistant dynamic equilibrium in a male reproductive system can be effectively regulated, sperm generation is facilitated, the condition that if the sperms are accumulated, movement is blocked, is avoided, the survival rate of the sperms is increased, the motility of the sperms is improved, and finally, the concentration and the motility of the human sperms are effectively increased. The medical composition can meet treatment requirements of complex illness states, is free from adverse reactions, durable in treatment effects, safe and reliable, and convenient to take, and is an effective drug for treating the symptoms that the sperms are poor in forward movement capacity, low in concentration and low in motility rate caused by various reasons. Data displays that through the composition for increasing concentration and motility of human sperms, the effective treatment rate is as high as 96%.

The invention relates to a double-chain siRNA and application thereof, in particular to a double-chain siRNA of DNA damage repair oggl gene, which is applied to mouse testicle microenvironment knockdown gene expression for improving the sensitivity of a male reproductive system to the damage effect of environmental chemicals so as to provide a method for quickly and sensitively detecting male reproductive toxicity of environmental chemicals. As a new method for detecting the reproductive toxicity of the environmental chemicals, the method can realize sensitive and quick reflection of male reproductive hazard caused by the chemicals, and is favorable for more accurately evaluating the safety of the chemicals, and for shortening the period of pre-clinical reproductive toxicity experiments of medicaments.

The invention relates to technology and a method for preparing biological raw liquor capable of improving the content of docosahexaenoic acid (DHA) in eggs. The method comprises the following steps of: soaking an appropriate amount of needles of pinus massoniana in June in washing water of rice serving as a substrate; and soaking Chinese medicinal materials such as ginkgo leaves, honeysuckle flower, winter mulberry leaves, medlar, marigold, oak leaves and the like in the washing water of rice at normal temperature for leaching to obtain raw liquor serving as mother liquor, and adding liquor obtained by leaching pine nuts which are picked according to an esoteric season into a certain amount of mother liquor. The raw liquor is used for feeding laying hens and has the advantages that: (1) the DHA of eggs laid by the laying hens is over 20 percent based on the total weight of egg yolk; (2) various biological elements which are necessary for human bodies, such as the DHA and the like are enriched in the eggs, and the content of the biological elements, particularly the DHA cannot be achieved by the common eggs; (3) after being eaten by humans, the eggs have the effects of softening blood vessels, tonifying the brain, and improving intelligence and eyesight, have health-care effect on a male reproductive system, particularly can supplement the DHA which needs to be supplemented urgently in a gestation period of females and have important effect on the brain and vision development of fetuses, and can greatly improve immunity level and enhance the disease resistance of the human bodies at the same time; and (4) pullorum disease is prevented, and epidemic prevention in the whole process can be avoided without any antibiotic and hormone.

The invention relates to a stem cell composite preparation for improving male reproductive system and a preparation method thereof, and the preparation method comprises the following steps: S1, separating testicular tissue to obtain spermatogonial stem cells, and carrying out adherent purification treatment on the spermatogonial stem cells on a reaction kettle in a temperature control chamber; s2, the purified spermatogonial stem cells are placed in a temperature control room to be subjected to slow freezing and cooling treatment and then stored; s3, the control device obtains the activity standard value of the to-be-recovered spermatogonial stem cells according to the preservation time of the to-be-recovered spermatogonial stem cells, and the blowing and beating efficiency of the blowing and beating device in the step S1 and the cooling rate of the gradient cooling stage in the step S2 are adjusted. The control device is arranged, the control device compares the activity of the spermatogonial stem cells to be recovered with the activity standard value of the spermatogonial stem cells to be recovered, and the control device adjusts the cooling rate of slow freezing cooling treatment and the blowing and beating efficiency of the blowing and beating device so as to improve the activity of the next spermatogonial stem cells.

The invention discloses a biomarker group and application thereof, and belongs to the technical field of bioengineering. By applying an RNA-seq technology, the result shows that the mRNA expression level of an mt-Nd6 gene in a male reproductive system is lowered, and meanwhile the mRNA expression level of an Slc12a4 gene in the male reproductive system is raised; and therefore, the Slc12a4 gene and the mt-Nd6 gene can serve as the biomarker group for diagnosing male reproductive toxicity caused by prochloraz. By studying the mechanism that prochloraz affects the male reproductive system, the invention provides the biomarker group for diagnosing the male reproductive toxicity caused by prochloraz, the Slc12a4 gene and the mt-Nd6 gene can provide an important basis for preventing and treating male reproductive diseases caused by prochloraz for human, and the study has practical significance.

The present invention relates to a compound preparation for improving male reproductive system stem cells and a preparation method thereof, comprising: step S1, performing adherent purification on the spermatogonial stem cells obtained after testicular tissue separation; step S2, The purified spermatogonial stem cells are stored in a temperature-controlled chamber after slow freezing and cooling; step S3, the control device obtains the standard value of the activity of the spermatogonial stem cells to be recovered according to the storage time of the spermatogonial stem cells to be recovered, and the blowing efficiency of the blowing device in step S1 and the temperature drop rate in the gradient temperature drop stage of step S2 are adjusted. The present invention is equipped with a control device, and the control device adjusts the cooling rate of the slow freezing and cooling treatment and the blowing efficiency of the blowing device according to the comparison between the activity of the spermatogonial stem cells to be recovered and the standard value of the activity of the spermatogonial stem cells to be recovered, so as to improve the 1. Activity of spermatogonial stem cells.

The invention aims at providing a ribonucleic acid (RNA) molecule used for interfering macrobrachium rosenbergii male reproduction, and a preparation method thereof. The double-stranded ribonucleic acid molecule used for interfering macrobrachium rosenbergii male reproduction has a nucleotide sequence of SEQ ID NO:1 or 3. With the method provided by the invention, a large amount of double-stranded RNAs can be rapidly prepared with low cost and high efficiency. The preparation method is simple to operate. Also, with the nucleotide fragment screened by the invention, good interference efficiency can be achieved, and macrobrachium rosenbergii male reproductive system development can be effectively interfered. With the double strand provided by the invention, long-term and high-efficiency gene silencing can be realized in shrimp animals, such that good technical means and method are provided for the researches of shrimp functional genes.

The invention discloses an application of a cortex lycii radicis extract in preparation of a product for repairing reproductive system injury. The reproductive system injury comprises decline of sex hormone level, abnormal counting of sperms and follicles, and abnormal farrowing and pregnancy. The medicine prepared by using the cortex lycii radicis extract can play a role in repairing female and male reproductive system injuries, not only can remarkably improve the hormone endocrine level and basic metabolism function, but also can improve sperm motility and follicle development capability and improve testis and ovary morphological structures, so that the reproductive system injuries are effectively repaired, and the curative effect is good. The farrowing and pregnancy functions are improved.