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Application of cortex lycii radicis extract in preparation of product for repairing reproductive system injury

A technology of reproductive system and ground bone skin, which is applied in the field of phytochemistry, and can solve the problems such as the lack of relevant research on drugs for diseases related to the reproductive system.

Pending Publication Date: 2022-08-09
NINGXIA MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there is currently no relevant research on the use of Digupi extracts to prepare medicines for treating diseases related to the reproductive system

Method used

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  • Application of cortex lycii radicis extract in preparation of product for repairing reproductive system injury
  • Application of cortex lycii radicis extract in preparation of product for repairing reproductive system injury
  • Application of cortex lycii radicis extract in preparation of product for repairing reproductive system injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Preparation of ground bone skin extract

[0038] The ground bone skin extract in this application is prepared by the following preparation methods:

[0039] S1: Water extraction:

[0040] (1) Called 5g ground bone leather powder, and add pure water to mix in pure water to 1: 8;

[0041] (2) After full stirring for 30 minutes, fry 3 times, cook for 1-1.5h each time, filter and merge the filter liquid obtained by frying 3 times, and condense to thick cream. , Get ground bone skin extract, store in a refrigerator 4 ° C for later use.

[0042] S2: Alcohol extraction:

[0043] (1) Called 5g of pink powder for the ground bone skin, placed in a cone -shaped bottle, add 100ml of ethanol aqueous solution with a concentration of 60 %, soak and stir for 2h;

[0044] (2) In the pre -set ultrasonic cleaning device with a temperature of 60 ° C for 50 minutes;

[0045] (3) Condense the soaked solution to 20ml, then filter, add 12ml acetate, extract 2h, set the filtrate stratifi...

Embodiment 2

[0049] Example 2: Preparation of experimental model

[0050] 1) Ovarian injury and repair grouping:

[0051] Choose 60 healthy and mature female SD rats with 80 weeks of age, weighing 220-250g, normal breeding management, free water intake, and adaptive breeding before the experiment for three days. The random number table is used to randomly group the 60 rats, and the specific grouping and testing are as follows:

[0052] Blank control group: 1 % alkar carbocarcanic cellulose sodium spray for 28 days;

[0053]Ovarian injury model group: daily abdominal cavity injection VCD (oxygenylinylene cytotene) (80mg / kg / d), induces the ovarian functional failure, each rats are adjusted according to weight, and the medicine is used for 15 days. After the amount of 1 % carboxymethyl cellulose sodium spray for 28 days;

[0054] Ground bone skin extract treatment group: daily injection of VCD (80 mg / kg / d) of abdominal cavity per day, each rats are adjusted for 15 days in a row for 15 days, and t...

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PUM

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Abstract

The invention discloses an application of a cortex lycii radicis extract in preparation of a product for repairing reproductive system injury. The reproductive system injury comprises decline of sex hormone level, abnormal counting of sperms and follicles, and abnormal farrowing and pregnancy. The medicine prepared by using the cortex lycii radicis extract can play a role in repairing female and male reproductive system injuries, not only can remarkably improve the hormone endocrine level and basic metabolism function, but also can improve sperm motility and follicle development capability and improve testis and ovary morphological structures, so that the reproductive system injuries are effectively repaired, and the curative effect is good. The farrowing and pregnancy functions are improved.

Description

Technical field [0001] The invention involves the application of plant chemical technology, and the application of ground bone skin extracts in the product that is damaged to repair the reproductive system is involved. Background technique [0002] Chemotherapy, radiotherapy, poison and diseases, and other durable or non -persistent biological cumulative chemical chemicals, pesticides, medicines and nursing products, organic metal chemicals and plant estrogen and other interference factors A series of complex damage and influence causes the function of male or female reproductive systems to be disturbed, causing disorders of basic metabolic levels and hormone endocrine levels, reducing testicles and ovarian functions, and even affecting their growth and development and morphological structure. Infertility or male infertility in women. [0003] Cortex Lycii Radicis is the dry root of Lycium Chinese CHINENSE MIl or Lycium Barbarum L ·. Dig the roots at the beginning of the spring o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P15/00A61P5/24A61P15/08
CPCA61K36/815A61P15/00A61P5/24A61P15/08A61K2236/331A61K2236/333
Inventor 马会明陈冬梅虎娜刘自钰陈苗马文欣刘畅
Owner NINGXIA MEDICAL UNIV
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