54 results about "Protopine" patented technology

A corydaline for preparing medicines to prevent and treat acute cerebral sichemia is prepared from the drived tuber of corydalis, and contains protopine, bicuculline, tetraphdropalmatine, palmatine, etc. Its preparing process and its composite medicine are also disclosed.

The invention relates to a new application of benzo [C] phenanthridine as formula I and original tropine alkaloid for preparing anti-drug-resistant bacterial drug, wherein R1-R10, R12-R15 are hydrogen and hydroxyl groups, cycloalkyl or alkyl groups with 1-12 carbon atoms, alkox or acyloxy groups, benzyloxy, chlorine or other halide atoms, amido, methylol, aldehydo, aldehydo, acetonyl, carboxy group, mesyloxy, 4-methyl-benzene sulfonyl oxygen group, aryl sulfonyl oxygen group, biphenyl phosphine acyloxy and -OCONH2, R11 is hydrogen, methyl or oxygen atom, R5 and R6 (or R15 of the formula I), R14 and R15 are formed with double bonds, R12 or R13 and nearby N atoms are formed with double bonds, N atom can be tertiary or quaternary N type, the substituents of nearby carbons of R1-R10 can have dioxolane structure. The inventive alkaloid can effectively restrain and kill drug-resistant bacterials as MRSA and ESBLs.

An extract of greater celandine for anticancer and antalgic purposes has its active components containing chelidonine 0.5-10 wt. portions, protopine 0.1-8, and total alkaloid of greater celandine 0.6-200. Its preparing process is also disclosed.

The invention relates to a decumbent corydalis tuber eye drop and a preparation method thereof. According to the decumbent corydalis tuber eye drop, the pH value is 4.6 to 6.5, and the permeation pressure is between 0.24 and 0.360 smol / kg; each 1,000 milliliters of decumbent corydalis tuber eye drop is prepared from the following substances: a decumbent corydalis tuber extract containing 0.32 to 0.43 gram of protopine, 0.0036 to 0.0048 mol of diluted phosphoric acid solution, and 0.1 to 3.0 grams of sodium dihydrogen phosphate, 3 to 8 grams of solubilizer, 0.2 to 0.8 gram of disodium edentate, 0.1 to 0.8 gram of bacteriostatic agent, 0 to 2.0 grams of thickening agent, 0 to 4 grams of medicinal ethanol solution of freshener, disodium hydrogen phosphate and glycerol which serve as auxiliary materials and the balance of water for injection, wherein the concentration of the diluted phosphoric acid solution is less than or equal to 0.5 mol / L, and a mass ratio of the freshener to medicinalethanol is 1:(1-15); the amount of the disodium hydrogen phosphate is used for regulating the pH value of the decumbent corydalis tuber eye drop; and the amount of the glycerol is used for regulatingthe permeation pressure of the decumbent corydalis tuber eye drop. The decumbent corydalis tuber eye drop has a mild effect, and the compliance of patients is improved greatly, so the decumbent corydalis tuber eye drop is an eye drop which is small in irritation and high in stability.

The invention discloses a detection method of a corydalis impatiens medicinal material. The detection method comprises the following steps: measuring the content of total alkaloids of the corydalis impatiens medicinal material through an ultraviolet spectrophotometric method, preparing a protopine reference solution, preparing a standard solution, making a standard curve and preparing a sample solution, wherein the preparation method of the sample solution comprises the steps of: backflow extracting corydalis impatiens medicinal material fine powder by using ethanol, dissolving filtered residue by using a sulfuric acid solution to obtain the sample solution, measuring the absorbance of the sample solution at 410nm wavelength, and calculating the content of the total alkaloids in the medicinal material according to the standard curve. According to the detection method disclosed by the invention, the protopine is used as reference; in a preparation process of the test sample, interference factors are removed by means of heating backflow and sulfuric acid solution dissolution, a characteristic reaction is carried out on alkaloid, bromocresol green and a phosphate buffer solution, the product of the characteristic reaction is extracted by dichloromethane to be measured; and since the dichloromethane only extracts the product generated in the characteristic reaction, the interference of non-alkaloid components is avoided and the accuracy and scientificity of the result are increased.

The present invention discloses a dicranostigma leptopodum (maxim) fedde alkaloid effective part preparation method, wherein the dicranostigma leptopodum (maxim) fedde alkaloid effective part obtained through chemical steps is a brownish-black powdery solid, and comprises aporphine alkaloid, morphinane alkaloid, protopine alkaloid, protoberberine alkaloid and isoquinoline alkaloid. According to the present invention, with the method, the concentration of the active compound can be effectively improved, the drug taking dose can be lowered, and the pharmacological activity of the dicranostigma leptopodum (maxim) fedde alkaloid can be significantly improved.

The invention relates to a decumbent corydalis tuber eye drop and a preparation method thereof. According to the decumbent corydalis tuber eye drop, the pH value is 4.6 to 6.5, and the permeation pressure is between 0.24 and 0.360 smol / kg; each 1,000 milliliters of decumbent corydalis tuber eye drop is prepared from the following substances: a decumbent corydalis tuber extract containing 0.32 to 0.43 gram of protopine, 0.0036 to 0.0048 mol of diluted phosphoric acid solution, and 0.1 to 3.0 grams of sodium dihydrogen phosphate, 3 to 8 grams of solubilizer, 0.2 to 0.8 gram of disodium edentate, 0.1 to 0.8 gram of bacteriostatic agent, 0 to 2.0 grams of thickening agent, 0 to 4 grams of medicinal ethanol solution of freshener, disodium hydrogen phosphate and glycerol which serve as auxiliary materials and the balance of water for injection, wherein the concentration of the diluted phosphoric acid solution is less than or equal to 0.5 mol / L, and a mass ratio of the freshener to medicinalethanol is 1:(1-15); the amount of the disodium hydrogen phosphate is used for regulating the pH value of the decumbent corydalis tuber eye drop; and the amount of the glycerol is used for regulatingthe permeation pressure of the decumbent corydalis tuber eye drop. The decumbent corydalis tuber eye drop has a mild effect, and the compliance of patients is improved greatly, so the decumbent corydalis tuber eye drop is an eye drop which is small in irritation and high in stability.

The invention discloses an extraction and enrichment technology for a protopine monomer in dactylicapnos roots. The extraction and enrichment technology comprises the following steps: taking a properamount of dried dactylicapnos root medicinal materials and crushing; putting into an extraction pot; adding a water solution which is 10 to 20 times of the weight of the dried dactylicapnos root medicinal materials; stirring and impregnating for one night; removing an impregnation solution on the next day; adding a 9 to 10 percent acid water solution which is 8 to 13 times of the weight of the dried dactylicapnos root medicinal materials; and carrying out hot refluxing and extracting for 2 to 5 times. The invention further discloses application of the protopine monomer in the dactylicapnos roots to cough and asthma relieving preparations, pain alleviating preparations, anti-arrhythmia preparations or anti-tumor preparations. The technology disclosed by the invention is suitable for extracting, enriching and purifying the protopine in the dactylicapnos roots and the purity of the protopine reaches 80 percent or more and can reach 95 percent or more after the protopine is further refined; and the whole technology has simple and feasible operation steps, high yield and low cost.

The invention relates to a new protopine alkaloid and a preparing method and application thereof, and belongs to the technical field of phytochemistry. The molecular formula of the new protopine alkaloid is C31H34N2O6, and the new protopine alkaloid is a new compound separated and extracted from active parts of rhizoma corydalis decumbentis; meanwhile, the new compound of the new protopine alkaloid has significant anti-depression activity, and an important theoretical foundation and an experiment basis are laid for China to develop anti-depression drugs with independent intellectual property from the rhizoma corydalis decumbentis.

An extract of greater celandine for anticancer and antalgic purposes has its active components containing chelidonine 0.5-10 wt. portions, protopine 0.1-8, and total alkaloid of greater celandine 0.6-200. Its preparing process is also disclosed.