Corydalis decumbens extract, and its preparing method and use
A technology of extract and sum, applied in the field of summer non-extract and its preparation
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Embodiment 1
[0033] Preparation of extract A: 10 kg of summer powder is percolated with 8 liters of 95% industrial alcohol, and the percolation solution is concentrated under reduced pressure to obtain a crude extract. Dissolve the crude extract in 1.5 liters of dilute hydrochloric acid with pH 2 under heating, extract three times with equal volume of ethyl acetate to remove the ester-soluble non-alkaloid part, adjust the pH of the aqueous layer to 8 with concentrated ammonia water, and extract three times with equal volume of chloroform , The chloroform extract was concentrated to dryness under reduced pressure to obtain 120 g of total alkali. The total base was purified on a vacuum liquid chromatography column. 2 kg of silica gel (100-200 mesh), 100 g of total alkali was dissolved in chloroform and sampled, eluted with 15 liters of acetone, and the eluent was evaporated to dryness to obtain 82.1 g of residue. Take 20 g of the residue, add 100 ml of 10% NaOH aqueous solution with stirrin...
Embodiment 2
[0035] Preparation of extract A: 10 kilograms of summer-free coarse powder was percolated and extracted with 10 times the amount of 1% sulfuric acid, the percolated liquid was passed through 731 type cation exchange resin (the amount of resin was equal to the amount of crude drug), washed with water until the effluent was neutral, and then washed with The ethanol solution of 1% ammonium hydroxide was eluted, and the eluent was collected with 5 times the amount of the crude drug, and the ethanol was recovered to dryness to obtain 122 grams of total alkali. Weigh 2 kg of silica gel (100-200 mesh) and pack it into a column, dissolve 100 g of total alkali in dichloromethane and load the sample, elute with 15 liters of acetone, evaporate the eluent to dryness, and obtain 80.4 g of residue. Take 20 g of the residue, add 100 ml of 10% NaOH aqueous solution with stirring, and react in a water bath at 80° C. for 0.5 hour. Allow to cool to room temperature, add water to a total volume o...
Embodiment 3
[0037] testing sample
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