The invention discloses a preparation method of an anti-climacteric health care product. According to the method, an excipient, Maca, Salvia miltiorrhiza, antelope horn powder, Tribulus terrestris, longan, Schisandra chinensis, ginger, ophiopogon japonicus, cistanche, polygala tenuifolia, cortex albiziae, radix paeoniae alba, hawthorn and a lubricant are weighed. With reasonable compatibility, the health care product follows the principle of treatment based on differentiation of syndromes in traditional Chinese medicine, various drugs in the formula supplement each other, the health care product has obvious anti-climacteric efficacy, is non-toxic and harmless to the human body, has the health care effect of improving immunity, and has high safety. By a totally closed form, the capsule realizes isolation of the content from air, prevents the content effective components from being oxidized and losing effectiveness or being polluted, at the same time covers up the bad taste of raw materials, is easily absorbable, enhances the stability, guarantees the efficacy, does not generate worm internally, is convenient for carrying and taking, and is conducive to treating senile dementia, mental retardation, poor memory, poor metabolism and other diseases.