166 results about "Tetrahydropalmatine" patented technology

The present invention discloses a Rhizoma Corydalis Decumbentis total alkaloids extract, its preparation method, pharmaceutical composition containing same. The total alkaloids mainly comprise : macleyine, tetrahydropalmatine, bicucalline, palmatine hydrochloride, 'xiawuning' alkaloid, corydaline harmine, other alkaloid and extract. The preparation method is : using Rhizoma Corydalis Decumbentis as material, adding right amount of polar solvent for leaching, merging the leachate, carrying out large pore adsorption resin chromatography, eluting impurity with diluted acid and alkaline aqueous solution orderly, eluting using polar organic solvent, collecting elution liquor, eliminating impurity further by alumina column adsorption, Collecting after-column liquid, concentrating liquor to obtain the Rhizoma Corydalis Decumbentis total alkaloids extract. The present invention also discloses a pharmaceutical composition containing the total alkaloids extract and uses of the pharmaceutical composition in preparing tablet, capsule, soft capsule, suppository, granula, transdermal absorption agent, drop pills, oral disintegrating agent, slow release agent, freeze-drying powder injection etc.

The invention discloses a total alkaloid extract and making method of eye drip, which comprises the following parts: opium alkaline, tetrahydropalmatine, cumic acid, alcaine palmatine, corydaline, summer alkaline and other biological alkalines. The preparing method comprises the following steps: adopting summer non as raw material; optimizing hypercritical CO2 flow to extract; collecting extract; drying; obtaining the total alkalilne extract; fitting for tablet, pill, suppository, percutaneous absorption agent, oral rapid-breaking agent, release-control agent and freeze dried.

The invention belongs to the technical field of pharmacy, and particularly discloses a stephania hainanensis total alkaloid extract extracted from stephania hainanensis tubers and a preparation method thereof. The preparation process is as follows: material (stephania hainanensis dry tubers); grinding; soaking in a moderate amount of 0.01 to 10 percent of hydrochloric acid or sulfuric acid; 1 to 4 times of ultrasonic extraction; filtration; storng-acid cation exchange resin purification; solvent recovery for drying; and stephania hainanensis total alkaloid extract. The extract mainly comprises L-tetrahydropalmatine, palmatine, fangchinoline, hanfangchin and other active ingredients, the percentage by weight of stephania hainanensis total alkaloid is greater than or equal to 70 percent, the percentage by weight of the palmatine is greater than or equal to 20 percent, and the percentage by weight of the fangchinoline is greater than or equal to 40 percent. Reports on the stephania hainanensis total alkaloid extraction process are not found in related literatures so far, the operation flow of the method is simple, the purity of the product is high, the efficacy is remarkable, and the method disclosed by the invention is applicable to industrial production and the exploitation and utilization of local stephania hainanensis resources.

The invention discloses a total alkaloid of Stephania delavayi Diels, the content of which is measured by tetrahydropalmatine. Tetrahydropalmatine occupies 55-95 percent of the total alkaloid extract of Stephania delavayi Diels, wherein the weight percentage of tetrahydropalmatine contained is no less than 2 percent, while the weight percentage of palmatine hydrochloride contained is no less than 0.8 percent. The invention also discloses a preparation method of the total alkaloid of Stephania delavayi Diels, which relates to the steps as follows: adding the Stephania delavayi Diels meal into ethanol for diacolation or reflux to acquire alcohol extract, decompressing and recycling the ethanol and concentrating into a condensed ointment for dissolving and filtrating with acid to acquire a filtrate, passing the filtrate through a macroporous resin column or a strong acid cation exchange resin column for adsorption, washing with water to remove the impurities and extracting with a eluent, collecting the eluent and decompressing and recycling the extract and then concentrating and drying, thus acquiring the total alkaloid of Stephania delavayi Diels; the steps can also be decompressing a percolating liquid to recycle the ethanol, concentrating, dissolving with acid and then filtrating, adjusting the pH value of the filtrate with weak base to produce deposition, filtrating the deposition to acquire a filter residue, adding ethanol into the filter residue to resolve and decompress, recycle the ethanol and then drying, thus acquiring the total alkaloid. The results of a pharmacological study on the acquired total alkaloid show that the total alkaloid of Stephania delavayi Diels has good effect on spasmolysis, pain relieving, antiphlogosis and antibiosis, blood activating and so on, and can combine with the acceptable components in pharmacy to prepare various sustained release or controlled release formulation or other formulations.

The invention discloses tetrahydropalmatine derivatives and a preparation method and application thereof. The structural formula of the tetrahydropalmatine derivatives is shown as a formula II, wherein R is octyl, isopropyl or 3-methybutyl. The provided application is the application of the tetrahydropalmatine derivatives shown as the formula II or pharmaceutically acceptable salts thereof in the preparation of eukaryotic tumor cell antiblastics and medicaments for preventing and/or treating tumors. The results of in-vitro anti-tumor activity experiments prove that each tetrahydropalmatine derivative has the effect of inhibiting human lung cancer cells A-549, KB human nasopharyngeal carcinoma cells, and HL-60 leukemia cell strains to a certain extent. The results show that the tetrahydropalmatine derivatives shown as the formula II can be applied to preparing the medicaments for treating the tumors, and the pharmaceutical application of the tetrahydropalmatine derivatives is widened.

The invention relates to a lubricant with paresis used in enteron endoscope and respiratory tract endoscope. Components of said lubricant for realizing paresis comprises: phosphate methylmorphine and levogyration tetrahydropalmatine; the components of said lubricant for realizing lubricate effect comprises: disilyloxy, methyl ethylene glycol, chloromycetin in glycerin and ammonium bithiolicum glycerin; and other components of said lubricant comprises: adhesion promoter of Kapo 934, preservative agent of gluconic acid chlorhexidine and pH value adjuster of triethanolamine. And the weight proportion of said lubricant comprises: 1-10% phosphate methylmorphine, 1-10% levogyration tetrahydropalmatine, 20-50% disilyloxy, 5-35% methyl ethylene glycol, 3-30% chloromycetin in glycerin, 3-30% ammonium bithiolicum glycerin, 1-10% adhesion promoter of Kapo 934, 1-10% preservative agent of gluconic acid chlorhexidine, and 1-10% pH value adjuster of triethanolamine.

The invention discloses an analgesic anti-inflammatory composite medicament made from lappaconitine and tetrahydropalmatine, a patch made from the composite medicament and a method for preparing the patch. The patch comprises a back lining layer, a medicament storage layer and a protection layer, wherein the medicament storage layer is made from raw materials including the lappaconitine, the tetrahydropalmatine and pressure-sensitive adhesive; and the patch is made by adding a proper amount of transdermal enhancerfrom in to the same three raw materials. Experiments and clinical research prove that the composite medicament made from raw medicament materials of lappaconitine and tetrahydropalmatine according to a certain proportion can reduce the toxicity of the lappaconitine and improve the median lethal dose (LD 50). Due to the use of the patch made from the composite medicament, the blood concentration can be kept stable for a long time, the first-pass effect on liver and the damage to gastrointestinal tracts are avoided, the toxicity and the side effect of the composite medicament are reduced, and the bioavailability and the safe curative effect of the composite medicament are improved. The composite medicament is convenient to use without causing patients to be afflicted by pain and is very effective in relieving pain and diminishing inflammation.

The invention discloses new applications f tetrahydropalmatine. The new application is an application that tetrahydropalmatine shown in formula I or salts thereof which are acceptable in pharmacy are used to prepare medicines used for inhibiting the proliferation of tumor cells and an application for preparing medicines used for preventing and/or curing tumors. The result of the in vivo experiment using nude mice shows that tetrahydropalmatine can effectively inhibit the growth of tumors, and the tumor volume is much smaller than the volume of the negative control group. Therefore, tetrahydropalmatine which is widely used for analgesia has good antitumor activity, and the result shows that tetrahydropalmatine can be used to prepare medicines for curing cancers, in particular to prepare medicines for curing the lung cancer. The invention broadens the medical application field of tetrahydropalmatine.

The invention provides a preparation method of a middle calming tablet. The middle calming tablet is prepared from 180g of cassia twig, 180g of vinegar-treated corydalis tuber, 180g of calcined oyster, 120g of common fennel, 120g of amomum fruit, 60g of Chinese ginger and 120g of liquoric root serving as bulk pharmaceuticals. The middle calming tablet is prepared through ultrafine extraction and microwave extraction, so that the convent of tetrahydropalmatine is increased greatly. The invention further provides an application of the middle calming tablet to preparation of a medicament for inhibiting cell proliferation of rat breast cancer cells SHZ-88.

The invention belongs to the technical field of Chinese medicaments, in particular relates to a method for preparing a Chinese medicinal stomach medicament preparation and a quality test method thereof. The conventional preparation method is fussy, needs to prepare particles in four different colours, and has complicated granulation process and inconvenient operation; and the conventional test method does not have very high accuracy and reliability, and cannot determine the source of contained tetrahydropalmatine. The method for preparing the Chinese medicinal stomach medicament and the quality test method thereof, the Chinese medicinal stomach medicament consists of rhizoma corydalis (vinegar processed), drift cuttlebone, elecampane, calcined alum, fried chicken eggshell and calcined nacre. The Chinese medicament treats ache, stops pain, and is used for treating gastric cavity ache, acid stomach, and noisy acid regurgitation caused by liver-stomach disharmony. The method for preparing the Chinese medicinal stomach medicament preparation of the invention is simple and easy to operate, simplifies preparation processes, and ensures the uniformity of a product better; and the quality test method has simple operation, and accurate and reliable testing result.

The invention provides application of tetrahydropalmatine enantiomers in preparation of P-glycoprotein inhibitor. The tetrahydropalmatine is one of main active ingredients of the Chinese herbal medicine rhizoma corydalis and comprises L-tetrahydropalmatine and D-tetrahydropalmatine. The research shows that the tetrahydropalmatine enantiomers can obviously inhibit the P-gp function, but the tetrahydropalmatine enantiomers are not the P-gp substrates; the tetrahydropalmatine enantiomers can obviously increase the concentration of anti-tumor medicine adriamycins in medicament-resistant tumor cells and reverse the multi-medicament resistance of tumor cells and do not have obvious effects of inhibiting and inducing main medicament metabolic enzymes of liver microsomes, so that the racemes, laevo isomers or dextro isomers of the tetrahydropalmatine enantiomers can be used as auxiliary medicaments for tumor chemotherapy, and the range of indications of the tetrahydropalmatine is expanded; and simultaneously, the invention provides the medicament for the assistant treatment for tumors, which alleviates pain, improves curative effect and is not addictive, for tumor patients.

The invention relates to the field of medicines, and particularly relates to a pharmaceutical composition for relieving pain. The pharmaceutical composition is prepared from the following components: rosmarinic acid, tetrahydropalmatine, mangiferin and diclofenac sodium in a weight ratio of (1-10):(1-10):(1-10):(1-10), preferably (2-4):(5-8):(3-6):(2-4), more preferably 3:6:5:3, or 4:7:4:2.

The invention relates to a detection method for a musk Xintongning preparation. The detection method comprises identification for artificial musk, identification for storax, ligusticum wallichii and borneol, identification for ginseng, identification for corydalis tuber, detection for tetrahydropalmatine, and analysis for characteristic fingerprints and mass spectrum of the musk Xintongning preparation. According to the invention, all the herbal medicines of the musk Xintongning preparation are identified, and the characteristic fingerprints of the musk Xintongning taking tetrahydropalmatine as the reference substance are determined. The detection method provided by the invention is good in stability, easy to operate, small in loss and high in accuracy; the shape of the chromatographic peak meets the detection requirements well, and is symmetrical; ligusticum wallichii, storax and borneol are identified by using the same thin layer plate, and are identified at the same time, so that the specificity is strong; the identification for ginseng can meet the conventional detection standard; meanwhile, the preparation time of a test sample is greatly shortened, and the detection efficiency is improved; the developing spots during identification for corydalis tuber are abundant, so that environment protection purpose is achieved; the mass spectrum identification adopted in the invention is special technology for the musk Xintongning preparation.