849results about How to "Good analgesic effect" patented technology

Patients are treated with 24-hour oral sustained release opioid formulations which, upon administration, provide an initially rapid opioid absorption such that the minimum effective analgesic concentration of the opioid is more quickly achieved. These sustained release opioid formulations include an effective amount of at least one retardant material to cause said opioid analgesic to be released at a such a rate as to provide an analgesic effect after oral administration to a human patient for at least about 24 hours, and are characterized by providing an absorption half-life from 1 to about 8 hours. A method of titrating a human patient utilizing these sustained release opioid formulations is also disclosed.

Disclosed is a pharmaceutical composition, comprising a combination of a dose of meloxicam or a pharmaceutically acceptable salt thereof and a dose of oxycodone or a pharmaceutically acceptable salt thereof, said combination in an amount sufficient to provide an analgesic effect in a human patient. Also disclosed is a method of effectively treating pain in humans or other mammals, comprising administering to the patient a combination of a dose of meloxicam or a pharmaceutically acceptable salt thereof and a dose of oxycodone or a pharmaceutically acceptable salt thereof such that the dosing interval of the meloxicam overlaps with the dosing interval of the oxycodone, said combination in an amount sufficient to provide an analgesic effect in a human patient.

An object of the present invention is to provide a novel fused-ring compound which has a FAAH inhibitory effect and is useful as an analgesic.The present invention relates to a compound represented by formula (I):wherein symbols are as defined in the specification, or salt thereof.

Apparatus for providing transcutaneous electrical nerve stimulation (TENS) therapy to a user, the apparatus comprising: a housing; an application unit for providing mechanical coupling between the housing and the user's body; a stimulation unit for electrically stimulating at least one nerve of the user; a sensing unit for sensing the user's body movement and body orientation; and a reporting unit for providing the user with feedback based on the user's sensed body movement and body orientation.

The invention relates to a medicinal composition and a preparation method and application thereof. The medicinal composition is prepared from ibuprofen and arginine serving as medicinal active ingredients in a molar ratio of 1:1 and pharmaceutically acceptable auxiliary materials. The composition can be prepared into an oral preparation and an injection preparation for treating related symptoms such as fever, inflammation, pain and the like.

The invention relates to a quadruple long-acting medicine composition and application thereof to pain treatment, in particular to the quadruple long-acting medicine composition. The medicine composition contains lappaconitine, tetrahydropalmatine, fumaric acid and succinic acid of the treatment and / or effective quantity as active ingredients. Compared with a composition formed by single ingredients or two ingredients or three ingredients, the quadruple long-acting medicine composition has the characteristics of good water solubility, good curative effect, low toxic and side effects and the like. The quadruple long-acting medicine composition can be used for preventing and / or treating diseases relevant to the pain; the pain includes tumor pain, pain of cancer patients after chemotherapy, joint pain, trauma pain, postoperative pain, inflammatory pain, pain caused by drug detoxification or drug addicition and intractable pain due to unknown reasons. The quadruple long-acting medicine composition can also be used for sedation, hypnosis, collaborative anesthesia, antiarrhythmia and the like.

A kind of tetrahydro isoquinoline derivatives (I), their preparation methods, medicine compositions and medicinal uses thereof, especially their uses as κ-opioid receptor excitant in pain relieving, which belongs to the medicine chemistry. The substituents R1, R2, R3, R4 of general formula (I) are defined as the description.

In consideration of physical and chemical properties that the cobratoxin is complex in component and cobratide is basic polypeptide, has molecular weight of about 7000 Dalton ad is relatively resistant to acid and alkali, and by considering the separating mechanism, the application characteristic, the long-term use stability, the cost controllability and the achievement of an extracting goal of each chromatographic column packing, the invention provides an extracting method of high-purity cobratoxin. The extracting method disclosed by the invention is stable in process, easily available in chromatography packing, low in comprehensive cost, good in operation condition adaptability and high in yield of neurotoxin. The invention further provides high-purity cobratoxin obtained by the method provided by the invention. An injection cobratide preparation prepared by the high-purity cobratoxin is less in impurities irrelevant with the treatment effect, quick to become effective in treatment effect and stable in curative effect. The invention further provides several pharmaceutical compositions taking the high-purity cobratoxin as an effective constituent formulated with preparation auxiliary materials needed for preparing a preparation as well as cobratide preparations with different dosage forms, which are suitable for being orally taken, absorbed by an oral cavity or rectal administration.

The invention relates to a method for extracting cobratide, a medicine used to treat chronic pain, the cobratide extracted by the method and a preparation containing the cobratide. The method for extracting the cobratide comprises the following steps: firstly, a stock solution of snake poison of a cobra is pretreated with ammonium sulphate to remove partial other compositions in the snake poison,is subjected to desalination and concentration through ultrafiltration, dialysis or gel chromatography, and after the concentration, is purified by a cation column, and finally is subject to freeze-drying preservation after the concentration. The cobratide preparation comprises an enteric preparation, a rectal administration preparation, a colon-specific administration preparation and so on. Withcobratide extraction and purification processes provided by the method, the purity of the extracted cobratide is more than 95 percent, and the yield reaches 70 percent; and the method is simple and reliable, and saves cost and time.

The invention discloses an integration obstetric table system with monitoring and analgesia functions which includes a base, a lifting column, a table plate and a back supporting plate, wherein the lifting column is fixed on the base and is used for supporting the table plate and one end of the back supporting plate is flexibly connected with the table plate. The table plate is divided into a front half portion and a latter half portion through a flexible connection position of the back supporting plate and the table plate. A casing body is arranged on the front half portion of the table plate. A obstetric table workstation module which is connected with an ultrasonic image module, a maternal-fetal monitoring module, a labor analgesia module, a magnetic field tracking and locating module and an obstetric table control module respectively is arranged in the casing body. Holes placing interfaces produced by connections of probes and respective modules are formed on a lateral side of the table plate. Functions of the obstetric table system have the advantages that an organic combination of every functional module is achieved, more accurate, complete and detailed obstetric characteristic parameters are acquired and measure precision and analgesia effects are improved. A structure of the obstetric table system has the advantages that cables are reduced, medical treatment space of a delivery room is saved and system applicability is improved.

The invention discloses application of compound traditional Chinese medicine extract in preparation of oral care health products, and relates to the technical field of oral case. Five traditional Chinese medicine extracts, namely a radix rehmanniae extract, a radix angelicae extract, a mulberry teaf extract, a gallnut extract, a white pepper extract and a pepper extract used as auxiliary medicine raw materials having an abirritation function are added into the oral care health products in a process of preparing the oral care products, so that the five traditional Chinese medicine extracts can be safely used in oral care products, such as toothpastes, mouth wash water, tooth powder, throat lozenge, chewing gum and the like, and also can have an obvious abirritation function.

The presenting invention is directed to methods and compositions for the topical or transdermal treatment of neuropathy. More particularly, transdermal or topical compositions including a combination of ingredients that provide a surprising degree of effective relief from the symptoms of peripheral neuropathy and methods for administering the compositions to treat various neuropathies.

The invention provides an anti-inflammatory, antalgic and antibacterial extract which is extracted from rape bee-pollen according to lots of process researches. Strict tests prove that the extract has anti-inflammatory, antalgic and antibacterial functions and inhibition effect on human leukocyte elastase, excellent antalgic effect on visceral pain caused by ethylic acid and external pain caused by a hot plate in mice and excellent inhibition effect on Escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, bacillus subtilis and other bacterial. The extract can be used in the development of plant-source anti-inflammatory agents, antalgics and bacteriostatic agents. In addition, China's rape pollen productivity is huge, so the rape pollen can be used as the raw material for the plant-source anti-inflammatory agents, antalgics and bacteriostatic agents; and the extract has the advantages of low cost and simple process flow.

The invention relates to an external traditional Chinese medicine for treating burn, scald and various skin injuries; the medicines of raw materials of the external traditional Chinese medicine consist of rhubarb, scutellaria, phellodendron, burnet and coptis which have weight percentage of 1 to1 to1to1 to 1 to 1. The external traditional Chinese medicine belongs to a pure traditional Chinese medicine preparation, is safe, reliable and easy to obtain the medicines, has lower price, no toxic side effect, short treatment time and high curative effect and generally remains no scar after healing.