222 results about "Postoperative pain" patented technology

The present invention provides capsaicinoid gel formulations and methods for relieving pre- and post-surgical pain at a site in a human or animal by administering at a surgical site in a human or animal in need thereof a dose of capsaicinoid gel in an amount effective to attenuate post-surgical pain at the surgical site, the dose of capsaicin ranging from 100 μg to 10,000 μg.

This invention relates to a porous bone implant (10, 110, and 210), a method of manufacturing the implant and a method of orthopedic treatment. The mesh implant can be manufactured using extrusion techniques and a variety of cutting and machining processes to provide the implant with the desired structural features and in the required dimensions to be matingly received within the bone defect or cavity. The implant can be used to strengthen bone structures and support bone tissue adjacent to a defect of cavity. Thus, the implant can be used to provide improved treatment of patients having bone defects or diseases with decreased postoperative pain and a shorter recovery time.

The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.

A medicament which contains a urea derivative or a salt thereof as an active ingredient is disclosed. The medicament has an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, incontinence and / or inflammatory disorders.

A surgical thoracic retractor has retraction members that grip the anterior and posterior surfaces of the ribs between vice-like jaws to prevent a crushing or other force being applied to the intercostal nerves, thus minimizing the patient's post-operative pain.

The invention features methods and compositions for preventing or treating post-surgical pain by administering an anti-NGF antagonist antibody.

The present invention relates to a compound of the formula [1′]wherein R2 is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the like, E is a single bond, —O—, —S— and the like, ring G is aryl, heterocyclic group and the like, R5 is halogen atom, hydroxy, lower alkyl optionally substituted by halogen atom etc., and the like, t is 0 or an integer of 1 to 5, when t is an integer of 2 to 5, each R5 may be the same or different, m is 0 or an integer of 1 to 8, and n is 0 or an integer of 1 to 4, and a nociceptin antagonist containing compound [1′] as an active ingredient. The compound [1′] shows, due to nociceptin antagonistic action, analgesic effect against sharp pain such as postoperative pain and the like. The present invention also relates to the use of certain amide derivative inclusive of compound [1′] as a nociceptin antagonist or analgesic.

Use of (S,S)- or racemic reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of a pain condition selected from neuropathic pain, nociceptive pain, cancer pain, back pain, inflammatory pain, musculo-skeletal disorders, visceral pain, pain from strains / sprains, post-operative pain, posttraumatic pain, burns, renal colic, acute pain, central nervous system trauma, head pain, and orofacial pain, is disclosed. Use of (S,S)-reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of pain in a patient refractory to an alpha-2-delta ligand, and use of (S,S)- or racemic reboxetine or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use as a mental performance or mood enhancer, are also disclosed.

A method, apparatus and kit for preparing and performing a surgical procedure includes providing a medicinal composition having an autologous tissue medium and a therapeutic agent. the medicinal composition is then delivered to a surgical site in a patient before closing to reduce postoperative pain, provide an interpositional membrane to prevent or inhibit the formation of scar tissue, and / or promote hemostasis. The medicinal composition is suitable for use in a variety of types of surgery, and has particular application in bone or tissue grating and orthopaedic surgery, expecially spine surgery.

The invention relates to a quadruple long-acting medicine composition and application thereof to pain treatment, in particular to the quadruple long-acting medicine composition. The medicine composition contains lappaconitine, tetrahydropalmatine, fumaric acid and succinic acid of the treatment and / or effective quantity as active ingredients. Compared with a composition formed by single ingredients or two ingredients or three ingredients, the quadruple long-acting medicine composition has the characteristics of good water solubility, good curative effect, low toxic and side effects and the like. The quadruple long-acting medicine composition can be used for preventing and / or treating diseases relevant to the pain; the pain includes tumor pain, pain of cancer patients after chemotherapy, joint pain, trauma pain, postoperative pain, inflammatory pain, pain caused by drug detoxification or drug addicition and intractable pain due to unknown reasons. The quadruple long-acting medicine composition can also be used for sedation, hypnosis, collaborative anesthesia, antiarrhythmia and the like.

The invention discloses a multifunctional catheter. The part, contacting the urethra of a human body, of catheter forms a urethral section; the rest part out of the human body is an external section; the urethral section is provided with a metal coil; at least two miniature vibration motors are connected with the metal coil in parallel; the miniature vibration motors are fixedly arranged in the catheter wall of the urethral section and is connected with an external control circuit and a power supply through the metal coil; a permanent magnet is also arranged in the catheter wall of the urethral section ; and a magnetic field can be generated in the human body by arranging the permanent magnet in the catheter wall of the urethral section so as to improve microcirculation of the human body and accelerate absorption of inflammation exudates. The miniature vibration motor can massage the urethra, and has the effects of relieving postoperative pain and expanding the urethra. The catheter is favorable for preventing and curing adhesion and infection, promoting early repair, dispersing swelling and relieving pains. The multifunctional catheter can effectively relieve pain and complication of ordinary patients caused by implanting the catheter, and is convenient for urethral postoperative recovery of the patients.

In laparoscopic surgery, small (5-12 mm diameter) incisions are made in the abdominal wall through which instruments dissect and remove specimens that may be several centimeters in diameter. Removal of the sample typically requires either enlarging these incisions or morcellating the sample to pass through the sub-centimeter ports. The laparoscopic device permits extraction of the sample to be removed in a female using the vagina, which has sufficient elasticity to accommodate removal of large specimens. The posterior portion of the vagina communicates to the abdomen through a few tissue layers, and is distant from vital anatomic structures. Utilizing the vagina is optimal due to its ease of access to the abdomen and repair, minimal scarring and post-operative pain, and faster recovery following surgery. A deployable collection bag is housed in a sheath, which is deployed into the vagina or abdominal cavity to extract a large (multiple-centimeter) specimen(s) through the vagina. Optional insufflation system and inflatable balloon to maintain pneumoperiotoneum may be used to reduce the number of laparoscopic ports required.

The invention discloses an extraction method for high-purity tetrodotoxin, which is mainly used for extracting tetrodotoxin from animal feed puffer fish seeds and livers by jointly utilizing the methods of ultrasonic fast dissolving out, organic solvent derosination, plate frame multi-level filtration, positive ion exchange resin, small film filtration, high-performance liquid preparation and the like and obtaining high-purity high-stability tetrodotoxin crystals. Tetrodotoxin has the effect of blocking a sodium ion channel is obvious in analgesic effect and free of dependency and is widely used in advanced cancer, postoperative pain relieving, de-addiction curing of drug abuse and the like. Extraction and preparation of high-purity tetrodotoxin can provide the possibility of developing a novel high-efficiency pain killer free of dependency.

The invention discloses a tibia osteotomy positioning device for a knee joint replacement surgery. The tibia osteotomy positioning device comprises an osteotomy unit, a backward inclination angle adjuster and a first toe and second toe aligner, wherein an arc-shaped contact surface is arranged at the inner side of the osteotomy unit; an osteotomy groove penetrating through the osteotomy unit is arranged at the outer side of the osteotomy unit; a plurality of first positioning holes and a plurality of second positioning holes are respectively arranged at the upper end and the lower end of the osteotomy groove; the number of the first positioning holes is larger than the number of the second positioning holes; and fixators used for fixing the osteotomy unit to the outer surface of the tibiaare detachably arranged in the first positioning holes and the second positioning holes. When the fixators penetrates through the first positioning holes and the second positioning holes to fix the osteotomy unit on the tibia, a majority of the fixators are nailed into the bone of the spinous process of the tibia located above the osteotomy groove, while the bone of the spinous process of the tibia located above the osteotomy groove is cut off in a surgery, so the injury of the fixators to the tibia can be greatly reduced; postoperative pain is reduced; and the postoperative recovery effect ofa patient is improved.

The invention discloses an auxiliary incision-free anus cannula device, relates to a peritoneoscope surgical operation auxiliary instrument and provides an auxiliary incision-free anus cannula device which has the advantages that no scar is left on the abdomen, the postoperative pain is reduced to the greatest extent, the length of stay is shortened, the expense is reduced and the like. The auxiliary incision-free anus cannula device is provided with an outer cannula, a guide tube, a rear cover and an apparatus hole cover, wherein external threads are formed at the tail end of the outer cannula; the outer cannula sleeves the guide tube; internal threads which are formed at the rear cover are in threaded connection with the external threads at the tail end of the outer cannula; a conical part is arranged at the front end of the guide tube; a grip handle is arranged at the rear end of the guide tube; an apparatus hole is formed in the tail of the rear cover; internal threads at the apparatus hole cover are in threaded connection with external threads at the tail of the rear cover. A peritoneoscope lower left colon and rectum resection operation is completed without an abdomen wall auxiliary incision, the minimally invasive aim is achieved, an abdomen wound is more attractive, the occurrence of postoperative incisional hernia, incision infection, dehiscence, incision tumour abdomen wall plantation and the like is avoided, and the intestinal canal adhesion probability is reduced. The auxiliary incision-free anus cannula device has the advantages that tumour-free operation is realized, the operation is simple and convenient, and safety and reliability are realized.

A drug depot implantable at or near a target tissue site beneath the skin of a patient is provided, the drug depot comprising a therapeutically effective amount of a drug and at least one surface adapted to receive one or more anchoring members so as to limit movement of the drug depot at or near the target tissue site, wherein at least one region of the drug depot is capable of releasing the therapeutically effective amount of the drug over a period of at least one day. In some embodiments, the drug depot provided can include an effective amount of at least analgesic and at least one anti-inflammatory agent at or near a target site, and can reduce, prevent or treat inflammation and / or pain, particularly postoperative pain.

This invention relates to urea derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The urea derivatives of the present invention has an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, incontinence and / or inflammatory disorders.

The present invention relates to an analgesic tramadol hydrochloride oral disintegrant tablet. It is made up by using main medicine tramadol hydrochloride and auxiliary material gelatin and / or mannitol and / or aspartame and / or glucose and / or microcrystal cellulose and / or crosslinked povidone and essence, etc. and adopting freeze-drying or coating, granulating and pressing processes. When it is taken in, it has no need of drinking water, it can be quickly disintegrated in oral cavity, and can be used for curing acute and chronic pain, moderate and light pain due to cancer, pain due to fracture and pain after various operations and toothache, and can obtain good therapeutic effect.

The invention provides an anti-inflammatory and pain-killing medical composition; chondroitin sulfate and a non-steroidal anti-inflammatory agent are used as active ingredients and mixed with a medical carrier to form the composition. Non-steroidal anti-inflammatory agent includes but not confines in diclofenac sodium (potassium), naprosyn and Lornoxicam; the composition exists in forms of squirt, freeze-dried powder and large-capacity transfusion for intravenous medication of a human body. The composition can be applied to symptomatic treatments of various febrile illnesses, various arthritises and inflammatory rheumatic diseases, soft tissue rheumatisms, neuralgia, arthralgia and pains, wounds relevant to degenerative diseases of spines, or postoperative pains.

The present invention provides for compositions and methods for accelerating the rate of delivery of ketorolac to the systemic circulation by sublingual spray administration under the tongue to provide a rapid response in the treatment of pain, especially acute pain associated with postoperative pain and migraine headache. Compositions of ketorolac formulated for sublingual delivery as liquid spray are provided. Also provided are methods of treatment and management of pain.

The invention discloses an integrated fixing device for an olecranal fracture. The integrated fixing device comprises a banded knitted part and a rope bolt, wherein one end of the banded knitted part is connected with the tail end of the rope bolt; the other end of the banded knitted part is connected with a traction needle; the rope bolt is arranged in an olecranal fracture part for connection; and the banded knitted part is pressed on the olecranal fracture part and is tightened and fixed. The integrated fixing device has excellent biocompatibility; stimulation of implants to the implanted part is avoided; the difficulty that the implants need to be taken out by a secondary operation is avoided; the banded knitted part has relatively low elasticity modulus; blood supply of the fixed part is effectively protected when efficient fixation is provided; the postoperative pain of a patient is reduced; the recovery cycle of the patient is shortened; the banded knitted part provides an effective fixing mode for the slight comminuted olecranal fracture; and in addition, 'minimally invasive idea' is introduced, so that the problems that a previous surgery is complicated in operation, large in wound, serious in post operational pain and local stimulation and the like are solved.

To provide an amorphous composition for nasal administration or for administration by adhering to oral mucosa in which absorption property and chemical and physical stabilities of (2R)—N-(1-benzylpiperidin-4-yl)-3-cyclohexylmethylthio-2-[(4R)-3-tert-butoxycarbonylthiazolidin-4-ylcarbonylamino]propanamide which is useful as an N type calcium channel inhibitor are improved. A preparation comprising the amorphous composition of the present invention has been found to be excellent in physical stability and chemical stability and to be useful as a nasal preparation or a preparation for adhering to the oral mucosa. As a result, the resulting preparation has a high BA value and is useful for prevention and / or the treatment of a disease mediated by the N type calcium channel including pain (such as neuropathic pain, cancerous pain, intractable pain, postoperative pain, acute pain, chronic pain, neuralgia and infectious pain).

Ketorolac tromethamine is a new type of non-steroidal analgesic and anti-inflammatory drug with strong analgesic effect, which can be administered orally or by injection. It is mainly used to relieve moderate to severe postoperative pain, and Acute renal colic related to trauma, visceral pain related to cancer, anti-inflammatory of local inflammation, etc., the present invention provides a preparation method of ketorolac tromethamine freeze-dried powder preparation, which greatly improves the stability of the main drug, It not only overcomes the shortcoming of slow onset of oral administration, but more importantly, overcomes the problems of unstable main drug of liquid injection and unstable process in actual production.

The invention discloses a circumcision postoperative protection device which comprises a wearing component, a lifting arm and a spraying device. A human body wears the wearing component, a protectivecover is arranged on the wearing component, fastened on a penis and provided with a cavity for containing the penis, the lifting arm is arranged in the protective cover and used for lifting the penis,and the spraying device is used for spraying disinfectants. The circumcision postoperative protection device provides an independent space for the penis, and exacerbation of postoperative complications such as postoperative pain, even wound dehiscence bleeding and wound extravasated blood infection caused by contact friction of the penis and underpants and thigh root skins is avoided. The protective cover can be rigid, has plasticity and can avoid deformation of the protective cover caused by external force, and secondary injury to wounds caused by the external force can be avoided.

A method of endovenous laser is for treating varicose veins located at a depth below the surface of the skin by the application of laser energy to a selected target region or site.The method minimizes invasive surgical treatments, causing less perivenous tissue destruction and also less postoperative pain for the patient.