147 results about "Advanced cancer" patented technology

The invention discloses an anti-cancer medicinal composition, which comprises 15-70 parts by weight of plant polysaccharide and mainly comprises the following medicinal crops or mainly comprises a Chinese medicinal composition prepared by the following medicinal crops in parts by weight: 18-22 parts of astragalus, 13-17 parts of ginseng, 22-26 parts of angelica, 13-17 parts of honeysuckle and 13-17 parts of root of straight ladybell, wherein the plant polysaccharide is selected from one more of ganoderma lucidum polysaccharide, lentinan polysaccharide, cordyceps sinensis polysaccharide, coriolus versciclor polysaccharide, agaricus blazei polysaccharide, hericium erinaceus polysaccharide, maitake polysaccharide, ginkgo polysaccharide and ginseng polysaccharide. The invention also disclosesthe Chinese medicinal composition in the anti-cancer medicinal composition. The anti-cancer medicinal composition provided by the invention is used for treating advanced cancer in the case that surgery and concurrent chemoradiotherapy are unsuitable or invalid, particularly has an obvious treatment effect on the advanced gastric cancer; the total effectiveness ratio reaches about 90 percent; the total cure rate reaches about 30 percent; the three-year survival rate reaches about 40 percent; and the five-year survival rate reaches about 25 percent.

The invention discloses a traditional Chinese patent medicine with the components of plant polysaccharide and bamboo extract for treating medium and terminal cancer, which has a formula as follow: 10 kg of whangee, 5 kg of CV.Ventricousinternode, 10 kg of moso bamboo, 5 kg of palm bamboo, 5 kg of phyllostachys glauca, 10 kg of fishscale bamboo and 5 kg of fortune paulownia bark. A method for preparing the traditional Chinese patent medicine comprises the following steps: adding 50 kg of water into the total 50 kg of the medical materials; decocting the mixture to obtain 200 ml to 400ml of concentrated material; adding mineral trace elements: 0.01 milligrams of calcium, 0.01 milligrams of ferrum, 0.01 milligrams of zinc, 0.01 milligrams of selenium, 0.01 milligrams of iodine and 0.01 milligrams of potassium which are essential to the body into the concentrated material after removing impurities and filtering; finally, fermenting the final mixture to obtain the medicine, and bottling the medicine for use. The traditional Chinese patent medicine has the beneficial effects of treating medium and terminal esophagus cancer, gastric cancer, intestinal cancer, liver cancer, cerebral cancer and other cancers and treating gastritis, gastric ulcer, hepatitis, rhinitis and other inflammation. In addition, the traditional Chinese patent medicine can be also used for treating skin cancer and various kinds of skin diseases by exterior spreading. The traditional Chinese patent medicine takes effect rapidly and has no toxic and side effect.

The invention relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for the treatment of cancer, including advanced cancer. Also, the present invention relates to novel adamantyl or adamantyl group derivatives containing retinoid compounds and their usage for treatment and / or prevention of cancer, keratinization disorders, dermatological conditions, and other therapies More specifically, it has been shown that such adamantyl compounds, e.g., 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid, 2-[3-(1-adamantyl)-4-methoxyphenyl]-5-benzimidazole carboxylic acid, and 6-[3-(1-adamantyl)-4,5-methylenedioxyphenyl]-2-naphthoic acid, can be used to treat or prevent cervical cancers and precancers such as cervical dysplasias, including high grade and low grade dysplasias.

The method for in vitro culture of lymphocytes involves incubating lymphocytes and cells with a particular gene expressed in a particular cancer cell line or cells, which are deficient or lowered in expression of a class 1 antigen and the particular gene has already been expressed, to amplify mainly NK cells or non-MHC-bound or MHC-bound killer T cells and then to amplify killer T cells specific to an antigen to a cancer. The in vitro culture of the lymphocytes can produce a group of lymphocytes composed mainly of killer cells. The group of the lymphocytes so produced can be used for immune therapy effective even for patients with cancer in the terminal stage to whom conventional cancer treatment and cancer curing agents.

The invention discloses an extraction method for high-purity tetrodotoxin, which is mainly used for extracting tetrodotoxin from animal feed puffer fish seeds and livers by jointly utilizing the methods of ultrasonic fast dissolving out, organic solvent derosination, plate frame multi-level filtration, positive ion exchange resin, small film filtration, high-performance liquid preparation and the like and obtaining high-purity high-stability tetrodotoxin crystals. Tetrodotoxin has the effect of blocking a sodium ion channel is obvious in analgesic effect and free of dependency and is widely used in advanced cancer, postoperative pain relieving, de-addiction curing of drug abuse and the like. Extraction and preparation of high-purity tetrodotoxin can provide the possibility of developing a novel high-efficiency pain killer free of dependency.

The present invention relates to methods of treating patients with advanced forms of cancer, such as metastatic melanoma and non-small cell lung cancer, in which X4P-001 is administered as monotherapy or in combination with immune checkpoint inhibitors, such as pembrolizumab. The methods demonstrate surprising results, including regression of disease, with comparatively little toxicity.

The disclosed invention is a composition of matter, a process of production thereof, and a method for the treatment of chronic pain, especially to the treatment of heretofore intractable pain as associated with advanced cancer, neurological conditions and rheumatoid arthritis. The treatment of pain associated with viral infections and lesions are also within the contemplation of the present invention. The composition of matter comprises modified alpha-neurotoxins or modified venoms known to contain alpha-neurotoxins in an acceptable carrier for either parenteral, oral or topical administration.

The invention discloses a pharmaceutical composition with effects of resisting cancer and alleviating pain, which is prepared from 40 traditional Chinese medicines: toad venom, pangolin scales, centipede, scorpion, honeycomb, leech, szechuan aconite, wild aconite, arisaema tuber, tuber pinellia, euphorbia kansui, knoxia corymbosa, rhizoma sparganii, rhizoma zedoariae, polyporus umbellatus, rhubarb, amur corktree bark, baikal skullcap root and the like. The pharmaceutical composition of the invention has obvious curative effects on various cancers of early, middle and late stages, and has the efficacies of resisting cancer and inhibiting tumor, promoting blood circulation and removing stasis, removing the necrotic tissue and promoting granulation, and promoting circulation of qi and relieving pain. The pharmaceutical composition of the invention controls cancer pain by resisting cancer and inhibiting tumor, draws out cancer poison, enables the tumor to shrink and disappear to achieve the purposes of improving living quality and prolonging life, and has convenient and safe use and no toxic and side effect. The efficacies are better by pasting the pharmaceutical composition of the invention on corresponding points of a human body.

A composition of matter for an analgesia and its method of use is disclosed. The method of use is for the treatment of chronic pain, especially to the treatment of heretofore intractable pain as associated with advanced cancer. The pain associated with neurological conditions, rheumatoid arthritis, viral infections and lesions is also contemplated. The method includes administering to a host an alpha-neurotoxin that is characterized by its ability to blocking of the action of acetylcholine at nicotinic acetylcholine receptors.

A drug of treating cancers, its preparation method and application. The drug comprises 26 chinese medicines, including red sage root,gecko, cordate houttuynia,medicated leaven and so on. The detailedformulation and preparation method are seen in the specification. The drug could be used to treat liver cancer, lung cancer and so on.

The invention discloses a pharmaceutical for treating cancer and a preparation method thereof. The pharmaceutical is prepared from taxus, reed root, shinyleaf pricklyash root, cicada slough, medicinai changium root, manyprickle acathopanax root, isatis leaves, polygala root, umbrella polyporus, hirtellous clover-shrub root, tortoise shell, poria, snakegourd fruit, alpine yarrow herb, common portulaca, arisaema tuber, zedoary turmeric rhizome, spatholobus stem, natural indigo, self-heal, long-noded pit viper, rhubarb, subprostrate soplhor root, dandelion, polyphylla, kosam seed, wild glossy ganoderma, centipede, giant knotweed, airpotato yam, Sichuan clematis stem, sun spurge, ricepaper plant pith, medlar, largehead atractylodes rhizome, garden burnet root, schisandra fruit, oldenlandia,daxie, pilose asiabell root, grassleaved sweetflag, lycoris, ledebouriella root, brown lily and TAXEL by mixing proportionally. The pharmaceutical can be used for treating various cancers, especially for treating advanced cancers such as leukaemia with high leucocyte content and cancer metastasis to bones.

The invention provides cytokine induced killer (CIK) cell populations and methods of using CIK cells to treat cellular proliferative disorders. CIK cells generated in vitro include both bulk cultures and clones. Individual CIK cell clones display distinct but overlapping lytic specificities for tumor cells and endothelial cells in vitro. When injected in vivo, bulk CIK cell cultures selectively attack tumor tissue. CIK cells can be used to treat a variety of cellular proliferative disorders, including early and late stage cancers as well as hematopoietic cell and solid tissue tumors.

The invention discloses an amine compound containing aromatic ring shown in the general formula I and salts thereof. In the formula, X represents CH or N atom; R1 represents H atom or F atom or chlorine atom or substituted alkyl or substituted alkoxy; R2 represents H atom or F atom or chlorine atom or substituted alkyl or substituted alkoxy; R3 represents phenyl or substituted alkyl or substituted phenyl or substituted pyridyl or substituted benzpyrole; Y represents substituted alkyl or substituted alkanoyl; and Y1 represents substituted alkyl or substituted alkanoyl. The invention also provides an application and preparation method of the compound in preparation of medicine for preventing and treating tumormetastasis, advanced cancer, non-entity cancer, and the like.

There is disclosed a method for treating advanced cancer in patients in need of such treating. Temozolomide and alpha interferon are administered in combination in amounts sufficient to achieve a clinical response.

The invention relates to a preparation for treating cancer and the preparation method thereof, which is formed by panax, astragalus, ganoderma lucidum, myrobalan, Chinese chive seed, hedyotis diffusa, scullcap, smilax glabra rhizome, subprostrate soplhor root, glycyrrhiza, indico naturalis and aloe, applicable for early, middle and terminal cancer patients, with effects of anticarcinogenesis and effective strengthening the physical fitness of patients. The said preparation has effects of adjusting incretion, assisting healthy energy, enhancing immunity of the patients; eliminating the sick tendency, direct killing cancer cells; regulating stomache qi to improve the function of spleen and stomach, cleaning up the turbid qi to eliminate the sick tendency in the viscera; clearing heat and detoxicating, activating blood circulation to dissipate blood stasis, softening and resolving hard masses to perish tumour, control tumour, improve surgical treatment and remote therapeutic effect; lessening side effect, improving symptom, enhancing quality of existence and prolonging the suvival time.

The present invention discloses a Chinese medicine for curing advanced cancers and chronic hbv hepatitis and a preparation method. The present invention is proportionally manufactured by a medicinal active component made of dry toad skin and a medicine-acceptable carrier; the medicine carrier contains sodium carboxymethylcellulose and starch. Compared with the prior dosage, the present invention with advanced process and high medicine content strengthens the curing effect, reduces the toxic side effect of the medicine and ensures safer and more convenient medicine taking for patients.

The present invention is directed to compounds having the structure (I) wherein R1, R2, R3, R4, R5 and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. In particular, the invention relates to compounds that induce apoptosis of cancer cells and therefore may be used for the treatment or prevention of cancer, including advanced cancers and pre-cancerous cells. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.

Methods for the treatment of patients with HER2-positive, HER2-amplified and / or HER2-mutated advanced cancer by administration of pertuzumab plus trastuzumab are disclosed. In one aspect, the cancer is advanced HER2-positive, HER2-amplified and / or HER2-mutated colorectal, biliary, bladder, urothelial, salivary, lung, pancreatic, ovarian, prostate, or skin cancer. In another aspect, the cancer is HER2-positive, HER2-amplified and / or HER2-mutated colorectal, biliary, bladder, urothelial, salivary, lung, pancreatic, ovarian, prostate, or skin cancer that is refractory to one or more other treatment regimens.

Embodiments of the invention provide methods, polyclonal antibodies, monoclonal antibodies, assays, and kits for detecting HPV infection, including infection by various HPV genotypes, early and / or late HPV-associated or HPV-specific proteins or antibodies. Mononoclonal antibodies are used to detect oncogenic high risk and low risk HPV types in a single assay, which is not limited to assay type or format. Useful tools for specific detection of invasive cervical cancer are provided. Cervical cancer biomarkers are identified and can be used in a detection method for early stage precancerous lesions as well as late stage cancer progression.

A composition of matter for an analgesia and its method of use is disclosed. The method of use is for the treatment of chronic pain, especially to the treatment of heretofore intractable pain as associated with advanced cancer. The pain associated with neurological conditions, rheumatoid arthritis, viral infections and lesions is also contemplated. The method includes administering to a host an alpha-neurotoxin that is characterized by its ability to blocking of the action of acetylcholine at nicotinic acetylcholine receptors.

The invention relates to a traditional Chinese medicine for treating respiratory tract cancer, which comprises the following bulk drugs by weight portion: 190 to 210 portions of croton, 40 to 60 portions of arsenic, 20 to 30 portions of black pepper, 450 to 550 portions of red date, 3 to 5 portions of onion, and 1 to 3 portions of ginger. The drug is the drug for the respiratory tract, so that active components are not absorbed by the gastrointestinal tract, but are directly delivered to lesion parts through 'qi and blood' without any side effects on each organ in a body. The traditional Chinese medicine is mainly used for treating the respiratory tract cancer, can prevent metastasis in early cancers, and relieve the pain of in the treatment of advanced cancers so as to greatly improve the life quality of patients. The traditional Chinese medicine has certain curative effect on respiratory tract cancers such as lung cancer, bronchial cancer, nasopharyngeal carcinoma and larynx cancer, and postoperative recurrence.

The invention relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for the treatment of cancer, including advanced cancer. Also, the present invention relates to novel adamantyl or adamantyl group derivatives containing retinoid compounds and their usage for treatment and / or prevention of cancer, keratinization disorders, dermatological conditions, and other therapies More specifically, it has been shown that such adamantyl compounds, e.g., 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoicacid, 2-[3-(1-adamantyl)-4-methoxyphenyl]-5-benzimidazole carboxylic acid, and 6-[3-(1-adamantyl)-4,5-methylenedioxyphenyl]-2-naphthoic acid, can be used to treat or prevent cervical cancers and precancers such as cervical dysplasias, including high grade and low grade dysplasias.

We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is age-dependent spontaneous regression of advanced cancers. This powerful resistance segregates as a single-locus dominant trait, is independent of tumor burden and is effective against cell lines from multiple types of cancer. During spontaneous regression or immediately following exposure, cancer cells provoke a massive infiltration of host leukocytes which form aggregates and rosettes with tumor cells. The cytolytic destruction of cancer cells by innate leukocytes is rapid and specific without apparent damage to normal cells. The mice are healthy, cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance that may have potential for therapy or prevention of cancer.

The present invention is directed to compounds having the structure Formula (I) wherein R1, R2, R3, R4, R5 and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. In particular, the invention relates to compounds that induce apoptosis of cancer cells and therefore may be used for the treatment or prevention of cancer, including advanced cancers and pre-cancerous cells. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.

The invention discloses an intermediate-advanced stage cancer imaging detecting system and an intermediate-advanced stage cancer imaging detecting method based on the quantum superstring engine, mainly used for overcoming the defect that the traditional medical device can not efficiently, safely, rapidly and comprehensively detect the cancer cell spreading area of a cancer patient. The intermediate-advanced stage cancer imaging detecting system comprises a quantum light emission source, an optical splitter, a convex lens, a light filter group, a detection unit, an image processing unit and a display. The intermediate-advanced stage cancer imaging detecting method comprises the steps that orthogonal polarized photons generated by the quantum light emission source pass through the optical splitter, and then are transmitted in two paths; one path of the orthogonal polarized photons irradiates the body of the patient through the convex lens and light filters, penetrates through the body and then is received by a detector, and the other path of the orthogonal polarized photons directly passes through the light filters, and are received by another detector; the detection unit carries out combined measurement on the photons detected by the two detectors, and outputs a detection result to the image processing unit, the image processing unit draws a diffusion area imaging picture of cancer cells in the body of the patient, and the diffusion area imaging picture is displayed by the display. With the adoption of the intermediate-advanced stage cancer imaging detecting system and the intermediate-advanced stage cancer imaging detecting method, the diffusion area imaging picture of the cancer cells can be obtained, and thus a basis is provided for the treatment and research on the cancer patient.

Adenine nucleotides such as adenosine 5′-monophosphate (AMP), adenosine 5′-diphosphate (ADP) or adenosine 5′-triphosphate (ATP) and / or adenosine and inorganic phosphate are administered in the treatment of advanced cancer in an out-patient setting and without serious side effects. Administration of up to 100 micrograms / kilogram / minute of continuous intravenous infusions of ATP for 8-10 hours, can be performed on an out-patient basis to patients who do not otherwise require hospitalization. No serious side effects, defined as grades 3 or 4 toxicity are observed during such an infusion.

The invention discloses a pure natural plant extract, composed of alfalfa, raspberry, small areca and pine bark wherein the ratio is 1:1:1:1 by weight. The small areca is from Australia, and the pine bark is Chinese red pine bark. The pure natural plant extract can be made into oral powder, capsule or injection, wherein the powder concentration in injection is 1000 mg / 5ml distilled water and 2000mg / 15ml distilled water or 3000mg / 20ml distilled water. The extract can prevent cancer and effectively repair cancer cell or prevent cancer cell at early-stage of cancer and obviously prevent cancer cell transition and diffusion at late-stage of cancer.

An oncolytic virus is for use in a method of treating or preventing cutaneous squamous cell carcinoma (CSCC), renal cell carcinoma (RCC), non-small cell lung cancer (NSCLC), triple negative breast cancer (TNBC), small cell lung cancer (SCLC), advanced recurrent head and neck cancer, squamous cell carcinoma of the head and neck (SCCHN), nasopharyngeal carcinoma (NPC), hepatocellular carcinoma (HCC), anal cancer, colorectal cancer (CRC), basal cell carcinoma (BCC), Merkel cell carcinoma, appendiceal carcinoma, sarcoma of the skin, recurrent melanoma after surgery, advanced or metastatic urothelial carcinoma, liver metastases, microsatellite instability high cancer (MSI-H), mixed advanced solid tumors, virally caused cancer, locoregionally advanced cancer, pediatric cancer, cancer in patientswith no or minimal pre-existing anti-cancer immunity, cancer as first line therapy, cancer in previously treated patients, cancer in patients who have not received checkpoint blockade therapy, and / orcancer in patients who have received checkpoint blockade therapy, wherein the oncolytic virus is, or is derived from, a clinical isolate which has been selected by comparing the abilities of a panelof three or more clinical isolates of the same viral species to kill tumor cells of two or more tumor cell lines in vitro and selecting a clinical isolate which is capable of killing cells of two or more tumor cell lines more rapidly and / or at a lower dose in vitro than one or more of the other clinical isolates in the panel; comprises (i) a fusogenic protein-encoding gene; and (ii) an immune stimulatory molecule or an immune stimulatory molecule-encoding gene; comprises (i) a GM-CSF-encoding gene; and (ii) an immune co-stimulatory pathway activating molecule or an immune co-stimulatory pathway activating molecule-encoding gene; and / or comprises a gene encoding a CTLA-4 inhibitor.