The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to topical medicinal liquor for treating a rheumatoid bone disease. The topical medicinal liquor is prepared from prepared monkshood, prepared radix aconiti agrestis, eucommia ulmoides, flowers carthami, cinnamon, radix cyathulae, scorpio, long-noded pit viper, radices sileris, angelica sinensis, homalomena occulta, schizonepeta, radix clematidis, as arum, dipsacus root, pseudo-ginseng and white spirit. The prescription disclosed by the invention is appropriate and rigorous in compatibility of medicines, and unique in preparation method, can rapidly cure hyperostosis by the topical medicinal liquor disclosed by the invention, and is rapid to become effective, short in treatment course, high in recovery rate and low in expense. The drug has unique curative effects for rheumatism, rheumatoid arthritis, pain in waist and lower extremities, scapulohumeral periarthritis, limbs anesthesia, ischioneuralgia, hyperostosis, lumbar disc herniation, cervical spondylosis, ankylosing spondylitis, hyperplasia of mammary glands, various pain killer diseases, fracture sequelae and femoral head necrosis.