239 results about "Ketoprofen" patented technology

Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the the urinary tract during urological diagnostic, interventional, surgical and other medical procedures. One disclosed composition comprises ketoprofen and nifedipine in a liquid irrigation carrier, and includes a solubilizing agent, stabilizing agents and a buffering agent.

The invention relates to medicinal fibre used for treating cutaneous inflammation and pain, which comprises the components of cellulose acetate nano fibre, a ketoprofen ester precursor medicine and a medicinal percutaneous sorbefacient, wherein the ketoprofen ester precursor medicine accounts for 0.1-30% of the total weight of the fibre, the medicinal percutaneous sorbefacient accounts for 0.1-10% of the total weight of the fibre, and the cellulose acetate nano fibre accounts for 1-99% of the total weight of the fibre; the preparation of the medicinal fibre comprises the following steps: dissolving the ketoprofen ester precursor medicine, the medicinal percutaneous sorbefacient and the cellulose acetate into an organic solvent to prepare spinning liquid and then spinning to prepare the required medicinal fibre. The medicinal fibre has the effect of treating cutaneous inflammation and pain, has simple preparation method, convenient source of the raw materials and low cost, is friendly to the environment and is suitable for industrialized production; the fibre can be prepared into medicine-carrying clothings or other fabrics which directly contact with the skin of a human body, and the percutaneous administration is safe and comfortable.

A controlled release ketoprofen patch for the topical application of ketoprofen is described, in addition to methods of treating inflammatory disorders and pain disorders by the administration of the controlled release ketoprofen patch.

The present invention provides a proprietary compositions and systems to modulate genetic and metabolomic contributing factors affecting disease diagnosis, stratification, and prognosis, as well as the metabolism, efficacy and / or toxicity associated with specific vitamins, minerals, herbal supplements, homeopathic ingredients, and other ingredients for the purposes of customizing a subject's nutritional supplement formulation to optimize specific health outcomes. Specific to this invention the utilization of certain known polymorphic genes associated with Substance Use Disorder (SUD) are analyzed to target certain genetic anomalies that lead to a high risk and predisposition to SUD. The genotypic patterns are then utilized to provide certain nutritional customized solutions especially related to the attenuation of aberrant abuse of physician prescribed narcotic pain medication across all pain conditions. A priority GENOPROFILE is measured and directs the customization of a subsequent nutraceutical to act as a therapeutic modality. Specifically the treatment includes slow attenuation of the pain medication by incorporating orals (shakes, liquid beverages, pills, tablets, troche, ointments etc.), Intramuscular, Intravenous, intra-rectal and any form necessary to deliver a sufficient amount of an anti-craving and anti-stress nutraceutical. Moreover, the invention includes examples of novel analgesic ointments coupling Synaptamine and such analgesic and other anesthetic compounds including but not limited to Gabapentin, Ketamine, Baclofen, Ketoprofen, Amitriptyline, Lidocaine, Cyclobenzapine, Diclofenac, Menthol, Camphor and Capsaicin. The GENOPROFILE will be used to determine pain sensitivity Intolerance.

The invention relates to a preparation method and application of a typical acidic drug multi-template molecularly imprinted polymer. The adopted template molecules are clofibric acid, diclofenac sodium, ibuprofen, naproxen and ketoprofen. The preparation method and the application of the molecularly imprinted polymer belong to the technical field of analysis, determination and removal of five typical acidic drugs in environmental samples. The preparation method is simple and reliable, and the prepared multi-template molecularly imprinted polymer has a uniform size, a large specific surface area and higher specific selectivity for acidic drugs. The five acidic drugs in the environmental samples can be separated and gathered rapidly and efficiently. The multi-template molecularly imprinted polymer can be directly applied in selective removal of the five acidic drugs in surface water and has better effects than other adsorption materials. The method is an effective method for specific separation of a series of substances with the same attributes and has broad application prospects.

The invention relates to a two-phase drug-release multilayer drug-loaded nanofiber mat and a preparation method thereof. The fiber mat is a multilayer drug-loaded nanofiber membrane which consists of a water-soluble polymer, a water-insoluble polymer and a drug. The nanofiber membrane has the following two structures: a shell layer is the drug-contained water-soluble polymer, and a core layer is the drug-contained water-insoluble polymer; the shell layer is the drug-contained water-insoluble polymer, and the core layer is the drug-contained water-insoluble polymer. A preparation method for a nano analgesic comprises the following steps of: (1) preparing spinning solution containing analgesic ketoprofen; (2) preparing a multilayer nanofiber membrane through performing coaxial electrostatic spinning on the prepared spinning solution, and drying to obtain the drug-loaded nano analgesic. The nano analgesic can be used for rapidly and durably easing pains, can be easily carried, is convenient in administration and can be used for administrating drugs into intestinal tracts in the manner of targeting. The invention has the advantages that the preparation method is simple and is low in cost, and has no special requirements on equipment; and the two-phase drug-release multilayer drug-loaded nanofiber mat can be produced on a large scale.

The present invention provides one kind of injection containing ketoproten and its preparation process, and features that the injection contains ketoproten, alkaline assistant and stuffing in the molar ratio between ketoproten and alkaline assistant of 1 to 1, and the weight ratio between ketoproten and stuffing of 1 to 0-10. The injection containing ketoproten is superior to traditional orally taken ketoproten preparation, and has new administration way, high product quality, high bioavailability and fast acting.

The present invention relates to medicine technology and is especially one kind of new preparation form. The transdermal plaster is noe kind of antiphlogistic containing Flubiprofen, Ketoprofen, Ibuprofen, Rosorolfen, Naproxan and other aryl propionic non-steroid. It has three parts including non-sticking layer, medicine layer and lining layer. The medicine layer incldues medicine dispersed in matrix, and the matrix consists of non-polar polymer and plasticizer and may contains tackifier, transdermal promoter and oxidant. It has accurate admistration amount, no stimulation to gastrointestinaltract, relatively higher local medicine density in the affected part and controllable medicine release.

The invention relates to a method for measuring 12 types of remaining medicine in a water environment through separation and enrichment at the same time, and belongs to the field of safety detection of a trace of organic pollutant residue in the water environment. The content of 12 types of frequently-used medicine in the water environment (drinking water, faucet water, river water and water discharged into and out of sewage treatment plants) is directly measured with an ultra performance liquid-chromatography-mass spectrometer (UPLC-MS / MS) as a detection tool after a water sample is subjected to solid phase extraction combined with ultrasonic-assisted dispersion liquid-liquid micro-extraction (UA-DLLME) separation and enrichment. The 12 types of antibiotic include ketoprofen, ciprofloxacin, tinidazole, tolfenamic acid, sulfadiazine, sulindac, naproxen, sulfamethoxazole, chloramphenicol, cefuroxime axetil, piroxicam and mefenamic acid. Inspection and optimization are conducted on a sample pretreatment method and instrument detection conditions of the water sample, and the optimal UA-DLLME method is established and is successfully applied to practical sample detection. Compared with a traditional method, the method has the advantages of being high in sensitivity, high in extraction and recycle rate, wide in suitable object, friendly to the environment, and the like.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a medicament microsphere and a preparation method thereof. The medicament microsphere comprises medicinal materials, a high polymer material and a surfactant, wherein the ratio of the medicament to the high polymer material is 1:(1-3); the medicament preferably is celecoxib, ketoprofen, dipyridamole and nimodipine. The medicament microsphere is prepared by adopting an O / W emulsified solvent diffusion-volatilization method. The O / W emulsified solvent diffusion-volatilization method comprises the following steps: respectively weighing the medicinal materials, the high polymer material and a release regulator according to the prescription amount, and then adding the weighted materials to an organic solvent; ultrasonically or mechanically stirring and dissolving as a disperse phase; taking a surfactant solution as a continuous phase; warming and stirring after low-temperature emulsification under an agitation state, so as to remove an organic solvent; and then carrying out solid separation, washing by distilled water, and drying, so as to obtain the medicament microsphere. Thus, the prepared microsphere is high in encapsulation efficiency and high in yield.

An edible oral film strip dosage form containing an unpalatable acidic active pharmaceutical ingredient, particularly ketoprofen, and an ion exchange resin as a primary taste masking agent, along with an optional alkaline agent and further optionally containing one or more secondary taste masking agents is provided. The edible oral film strip dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). The inventive dosages minimize or completely mask the bitterness, burning sensation and throat irritation associated with many acidic active pharmaceutical ingredients. Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration.

The present invention relates to, among other things, methods for treating trigeminal cephalgias such as migraine and migraine like headaches and other cerebrovascular conditions associated with pain and or inflammation. When non-steroidal anti inflammatory drugs (NSAIDs), such as ketoprofen, are applied locally using specific topical formulations immediate relief of pain is obtained. Intense pain is typically reduced to mild pain or no pain within 30 minutes of application of the topical formulation. The NSAID may be given in combination with other pharmacological agents, such as vasoconstrictors, opioids, decongestants and / or non-opioid migraine drugs, such as triptans and ergots and agents that affect serotonin receptors as agonists, antagonists or partial agonists.

The present invention provides a topical formulation containing NSAID, particularly diclofenac. The topical formulation is particularly useful for alleviating pain / inflammation associated with infection caused by herpes virus, especially herpes simplex virus (HSV) and varicella-zoster virus (VZV). Similar relief can be achieved where diclofenac is replaced with another non-steroidal anti-inflammatory drug (NSAID), which includes, without limitation, etodolac, ketorolac, bromfenac, diflunisal, ibuprofen, fenoprofen, ketoprofen, naproxen, suprofen, meclofenamate, mefenamic acid, piroxicam, meloxicam, indomethacin, sulindac, phenylbutazone, oxyphenbutazone, and tolmetin. The topical formulation is further characterized by its fast relief on pain and / or inflammation associated with infection caused by herpes virus, i.e., a complete relief in no more than seven (7) days after the application of the topical formulation on skins of patients.

The present invention belongs to the field of medicine technology, in particular, it relates to a ketoprofen cataplasma preparation and its preparation method. The experiments of initial adhesion, paste content, excipient property, external release and external percutaneous test show that the invented ketoprofen cataplasma preparation can meet the requirements related to pharmacopeia.

The present invention relates to a lipid microsphere injection containing ketoprofen or ketoprofen ester, its preparation process and prescription. It has good action for stopping pain, resisting inflammation and reducing fever. Said lipid microsphere includes ketoprofen or one ketoprofen ester, injection soybean oil, injection medium chain triglyceride, phospholipids, pure glycerin and injection water. Said invention can be used for preparing pain-stopping and inflammation-relieving medicine.

The invention discloses a method to resolve 2-aryl radical propanoic acid antimer with Serratieae lipase, which comprises the following steps: touching Serratieae lipase with racemic 2-aryl propionic ester; proceeding enzymatic reaction with temperature at 20-60 deg. c and pH value at 5-11; collecting (S)-2-aryl propionic acid and un-reacting (R)-2-aryl propionic acid; using the (R)-2-aryl propionic acid to enzymatic resolution repeatedly. This invention can leases labor strength and environmental contamination, which can be used to antiphlogistic anodyne firm.

The invention discloses a long-acting viscose dispersing type transdermal patch and a preparing process thereof and belongs to the medical technical field. The transdermal patch is mainly prepared from bulk pharmaceutical chemicals (such as non-steroid anti-inflammatory drug ibuprofen and salt form thereof, naproxen and salt form thereof, ketoprofen, indometacin and salt form thereof), a penetration enhancer (menthol, oleic acid, medium chain triglyceride, propylene glycol monolaurate, azone, propylene glycol and the like), a dispersing solvent (water, acetone, ethanol, carbinol, ethyl acetate and the like), a polyacrylate pressure-sensitive adhesive (crylic acid, butyl acrylate, crylic acid 2-ethylhexyl ester and the like), a backing layer and a release liner. The long-acting viscose dispersing type transdermal patch and the preparing process thereof have the advantages that drugs can be released from a matrix continuously for 12-48 h, the number of drug residues is low, transdermic absorption property is excellent, and dosing frequency and dosing amount can be reduced; skin irritation is avoided, and adhesion and compliance are high; main drugs and additives are stable in a viscose mechanism; preparing technology is simple, and pollution is avoided.

The present invention relates to the arginine-ketoprofen with antalgic and inflammation-relieving functions, relative isomers and its preparing process. Its solubility in water is solved to reduce its by-effect and it can provide a new application approach.

The invention relates to platinum complexes of the upper right formula and pharmaceutically acceptable salts or solvates, wherein R1 and R2 are respectively and independently selected from H or C1-C4 alkyls, or R1 and R2 are coupled as shown by the lower right formula. X is selected from a 3,4-dinicotinic acid radical or a cis form aconitic acid radical; and Y which has the same case with Z is selected from a cinnamic acid radical, a ketoprofen acid radical, a chlorogenic acid radical, a caffeic acid radical or a ferulic acid radical; or Y is different from Z, wherein Y can be 1-methyl-3-pyridine carboxylic acid, and Z can be a sulfate radical. The invention also relates to a preparation method for the platinum complexes and application of the platinum complexes to the preparation of anticancer drugs.

The invention relates to a non-steroidal anti-inflammatory drug with nitrogen oxide donor and a method for preparing same, which can be used to eliminate inflammation, relieve fever and stop pain, and can decrease the frequently seen side effect thereof on the gastrointestinal tract. The structure of which is A-O(X)-CO-O(y)-B-ONO2,wherein, A is the non-steroidal anti-inflammatory group; B is the connection group, when x=0, y=1; when x=1 then y=0. The the non-steroidal anti-inflammatory groups includes aspirin, diclofenac, indometacin, lumiracoxib, brufen, ketoprofen, naproxen, piroxicam, and meloxicam. The preparation process are that the bromhydrin (or hydroxybenzene) reacts with silver nitrate into hydroxy nitrate, then reacts with bromo acid into the connection group of nitrogen oxide donor, then connects with the non-steroidal anti-inflammatory drug; or the non-steroidal anti-inflammatory drug condensates with bromo acid into a bromide intermediate, then reacts with silver nitrate into the non-steroidal anti-inflammatory drug with nitrogen oxide donor.

The invention belongs to the technical field of organic synthesis, and particularly relates to a method of utilizing a continuous flow microreactor to synthesize a benzophenone derivative. The methodincludes: using aryl Grignard reagent and acyl chloride as raw materials; at normal temperature, continuously synthesizing the benzophenone derivative in the microreactor; recycling a reaction solvent2-methyl tetrahydrofuran. Problems of environmental pollution and reaction operation safety caused by the fact that conventional Fridel-Crafts reaction is excessively dependent on reagents like aluminum trichloride, ferric trichloride and zinc dichloride are avoided, the defect that novel catalytic processes are expensive in catalytic reagent and harsh in operation condition is made up, and continuous synthesis of a medical intermediate ketoprofen nitrile is realized efficiently. The method has the advantages of high operation convenience, high reaction safety, high yield, high efficiency andreaction solvent reusability and is environment-friendly and efficient.

A lysine ketoprofen with antipyretic, analgesia and anti-inflammatory functions and its production are disclosed. The process is carried out by proportioning lysine with ketoprofen in 1:1mol to obtain the final product. Its advantages include higher pharmacodynamic strength, better solubility, safety and stability and low side effect.

A method for synthesizing ketoprofen from ethylbenzene relates to a preparation method of organic drug, in particular to a method for using ethylbenzene as raw material to synthesize ketoprofen. The inventive method comprises synthesizing o-nitro ethylbenzene and p-nitro ethylbenzene via ethyl benzene, directly processing carboxylation reaction, hydrogenation reduction reaction and benzoylation reaction on the mixture of o-nitro ethylbenzene and p-nitro ethylbenzene without separation, and processing deamination reaction to obtain crude product of ketoprofen, and purifying to obtain the ketoprofen product. The invention directly processes o-nitro ethylbenzene and p-nitro ethylbenzene with cheap carbon dioxide without separation, via carboxylation reaction, while the reaction is safe and environment friend and can save cost. Aminophenyl and benzoyl chloride are directly treated via friedel craft reaction, with less reaction process, low cost, little waste discharge. And the invention uses copper powder as catalyst and uses isopropanol as reducer, thereby saving cost and avoiding the treatment to phosphorus waste water.

A drug-delivery system is described which can serve as a platform for the topical delivery of a wide variety of therapeutic agents to the skin. Specifically, a topical external analgesic gel contains ketoprofen, a skin penetration enhancer / cosolvent, a thickening agent and a base to adjust pH. The formulation uses a relatively small number of safe components and is easy to prepare with a high yield of finished product. The chemical stability of ketoprofen in the gel and the physical stability of the gel itself ensure a satisfactory shelf-life for the product. The gel is aesthetically pleasing (i.e., easy water-washability, non-irritating to skin, non-staining of clothing, etc.) and has proven to provide rapid relief of musculoskeletal pain, thereby helping to ensure patient compliance.

The invention relates to a ketoprofen gel and a preparation method thereof. The ketoprofen gel is prepared from the following components: 2-5 % of ketoprofen, 0.5-2 % of matrix material, 2-4 % of a transdermal enhancer, 0.5-5 % of a neutralizer, 0.05-0.2 % of an anti-oxidant, 20-50 % of ethanol and the balance being water. The ketoprofen gel provided by the invention solves problems of stimulation of ketoprofen preparations on gastrointestinal tract in a background technology, is used externally, has advantages of good transdermal effect, quick effect and good analgesic and anti-inflammatory effects, and can play drug effects for a long time.