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Ketoprofen cataplasm and its preparing method

A kind of technology of ketoprofen emulsion and ketoprofen, applied in the field of medicine

Inactive Publication Date: 2006-08-09
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with traditional plasters, cataplasms have the advantages of large drug-containing capacity, high transdermal absorption rate, convenient use (repeatable paste), low irritation, no allergenic ingredients, and no pollution. However, no ketones have been found so far. Profen cataplasm and related reports

Method used

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  • Ketoprofen cataplasm and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: prepare ketoprofen cataplasm, ketoprofen 0.5mg / cm 2

[0046] Components and ratio:

[0047] Ketoprofen 4g Carboxymethylcellulose Sodium 20g

[0048] Propylene glycol 100g Polyvinylpyrrolidone (PVP-K90) 30g

[0049] Kaolin 20g Sodium polyacrylate (NP-700) 10g

[0050]Gelatin 10g Sorbitol 200g

[0051] Ethylparaben 1g Ethanol 25g

[0052] Ca(OH) 2 2g Glycerin 50g

[0053] Distilled water 340g

[0054] Preparation:

[0055] 1. Prepare (I) phase solution:

[0056] Add ketoprofen into ethanol according to the above proportioning ratio, stir and dissolve, then add ethylparaben and continue to stir and dissolve completely to obtain the (I) phase solution.

[0057] 2. Preparation of (II) phase solution:

[0058] Take kaolin, Ca(OH) that have passed through a 100-mesh sieve according to the above ratio 2 After mixing, add 150 g of water and stir to form a uniformly mixed (II) phase solution.

[0059] 3. Preparation of (III) phase solution:

[0060] Ta...

Embodiment 2

[0063] Embodiment 2: prepare ketoprofen cataplasm, ketoprofen 1mg / cm 2

[0064] Components and ratio:

[0065] Ketoprofen 9g Carboxyethyl Cellulose Sodium 25g

[0066] Paraffin oil 100g Polyvinylpyrrolidone (PVP-K90) 30g

[0067] Kaolin 20g Sodium polyacrylate (NP-700) 10g

[0068] Gelatin 10g Sorbitol 200g

[0069] Ethylparaben 1g Azone 8g

[0070] Aluminum Potassium Sulfate 1g Ethanol 25g

[0071] Glycerin 50g Isopropyl myristate 15g

[0072] Tween-80 10g distilled water 380g

[0073] Preparation:

[0074] 1. Prepare (I) phase emulsion:

[0075] Add ketoprofen to isopropyl myristate according to the above proportion, heat to dissolve at 50° C., add 15 g of paraffin oil, and cool at room temperature to form an oil phase. Dissolve 10 g of Tween-80 in 60 g of distilled water, then pour into the above oil phase, and mix to form milk to obtain (I) phase emulsion.

[0076] 2. Preparation of (II) phase solution:

[0077] Take the kaolin and aluminum potassium sulfate th...

Embodiment 3

[0082] Embodiment 3: prepare ketoprofen cataplasm, ketoprofen 1.2mg / cm 2

[0083] Components and ratio:

[0084] Ketoprofen 10g Carboxymethyl starch 25g

[0085] Propylene glycol 100g Polyvinylpyrrolidone (PVP-K90) 30g

[0086] Kaolin 20g Sodium polyacrylate (NP-700) 10g

[0087] Gelatin 20g Sorbitol 200g

[0088] Propylparaben 1g Isopropyl myristate 8g

[0089] Aluminum hydroxide 2g N-methylpyrrolidone 5g

[0090] Glycerin 50g Distilled water 380g

[0091] Preparation:

[0092] 1. Prepare (I) phase solution:

[0093] Add ketoprofen into 30 g of propylene glycol according to the above proportioning ratio, fully stir and dissolve, then add propylparaben, N-methylpyrrolidone and isopropyl myristate and continue to stir and dissolve to obtain (I) phase solution.

[0094] 2. Preparation of (II) phase solution:

[0095] Take kaolin and aluminum hydroxide that have passed through a 100-mesh sieve according to the above proportioning ratio, add 150 g of water after mixing, ...

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Abstract

The present invention belongs to the field of medicine technology, in particular, it relates to a ketoprofen cataplasma preparation and its preparation method. The experiments of initial adhesion, paste content, excipient property, external release and external percutaneous test show that the invented ketoprofen cataplasma preparation can meet the requirements related to pharmacopeia.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a ketoprofen cataplasm and a preparation method thereof. Background technique [0002] Ketoprofen (Ketoprofen) is a non-steroidal antipyretic analgesic anti-inflammatory drug (NSAID), has anti-inflammatory, analgesic, antipyretic effects, and is widely used clinically in the treatment of diseases such as rheumatism and rheumatoid arthritis. Similar to the adverse reactions of other non-steroidal antipyretic analgesic and anti-inflammatory drugs, oral administration of ketoprofen is also more likely to cause gastrointestinal reactions such as stomach pain, nausea, ulcers, and bleeding. The ketoprofen transdermal preparation can improve the local drug concentration of ketoprofen at the pain site, enhance the anti-inflammatory effect, avoid the gastrointestinal adverse reactions caused by oral administration, and can control the dosage by adjusting the area ...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K9/70A61P29/00
Inventor 胡晋红李晋朱全刚
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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