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90 results about "Anodyne" patented technology
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An anodyne is a drug used to lessen pain through reducing the sensitivity of the brain or nervous system. The term was common in medicine before the 20th century, but such drugs are now more often known as analgesics or painkillers.
Sulfonamide and carboxamide derivatives and drugs containing the same as the active ingredient
InactiveUS6448290B1Low toxicityEasy to useBiocideOrganic chemistryBULK ACTIVE INGREDIENTAnalgesic agents
The sulfonamide or carboamide derivatives of the formula (I) and a pharmaceutical composition which comprise them as an active ingredient:(wherein A ring, B ring is carbocyclic ring, heterocyclic ring; Z1 is -COR1, -CH=CH-COR1 etc.; Z2 is H, alkyl etc.; Z3 is single bond, alkylene; Z4 is SO2, CO; Z5 is alkyl, phenyl, heterocyclic ring etc.; R2 is CONR8, O, S, NZ6, Z7-alkylene, alkylene etc.; R3 is H, alkyl, halogen, CF3 etc.; R4 is H, (substituted) alkyl etc.; n, t is 1-4).The compounds of the formula (I) can bind to receptors of PGE2 and show antagonistic activity against the action thereof or agonistic activity. Therefore, they are considered to be useful as medicine for inhibition of uterine contraction, analgesics, antidiarrheals, sleep inducers, medicine for increase of vesical capacity or medicine for uterine contraction, cathartic, suppression of gastric acid secretion, antihypertensive or diuretic agents.
Owner:ONO PHARMA CO LTD
Method and compositions for the treatment of gastrointestinal disorders
ActiveUS20060094658A1Reduce accumulationIncrease gastrointestinal motilityPeptide/protein ingredientsMetabolism disorderGastroparesisInflammatory Bowel Diseases
Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.
Owner:IRONWOOD PHARMA
Methods and compositions for the treatment of gastrointestinal disorders
InactiveUS20070010450A1Increase gastrointestinal motilityReduce inflammationPeptide/protein ingredientsMetabolism disorderIntestinal tract diseasesGastroparesis
Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.
Owner:IRONWOOD PHARMA
Medicinal wine compsn and its prepn. method
InactiveCN1480522AHave impotence and premature ejaculationPossesses yang anxiety and coldnessAntipyreticDigestive systemPharmacologyBiotechnology
Owner:蔡玉堂
Skin Penetration Composition
InactiveUS20120034320A1Avoid systemic side effectsDecreasing nerve painAntibacterial agentsBiocideAntidoteAntioxidant
The present invention comprises an all-natural composition of matter and methods of delivering nutrients, medicines, pain relievers, antioxidants, antidotes, antibiotics and various active ingredients and supplements directly to the affected area of the body. The all-natural carrier composition consists essentially of the combination of a natural oil, water, salt(s), natural emulsifier, natural sugar(s), plant extracts, natural acid(s), starch and natural flavor(s). The active substances that are mixed with the all-natural carrier composition, include, but are not limited to, drugs, vitamins, minerals, antibiotics anti fungal agents, antioxidants, diuretics, allergy medicines, anti-inflammatory agents, muscle relaxers, pain reducers, diabetic drugs, neuropathy drugs, chemotherapy agents, arthritis drugs, lotions for eczema, shingles, psoriasis, skin rash; herbal medicines, erectile dysfunction drugs, hormones, cholesterol drugs, essential fatty acids, and the like. The all-natural carrier composition facilitates the penetration of active substances into the dermal layer of the skin.
Owner:DOMINION RESOURCES UNLTD
Compound preparation of berberine hydrochloride
InactiveCN101467999AAvoid stabilityEasy to useOrganic active ingredientsAntiinfectivesEscherichia coliAntioxidant
The invention relates to a berberine hydrochloride compound preparation made from the following components in terms of weight percentage: 0.5-1% of berberine hydrochloride, 2-5% of antibacterial medicament, 0-0.1% of antiviral medicament, 1-1.5% of antibacterial synergist, 0-15% of stabilizer, 0-30% of cosolvent, 0-5% of local anodyne, 0-2% of antioxidant and balance of disperse medium. The inventive compound preparation has the following advantages: (1) the compound preparation solves the instability problem of berberine injection by making the berberine into orally taken liquid; (2) the berberine hydrochloride when used with enrofloxacin and TMP together can be used as the preferable medicament for intestinal infections, is more advantageous in treating intestinal infections caused by escherichia coli and salmonella than other single antibiotics sold in the market, especially good for drug resistant strains, is applied two times a day for three constant days, and prevention and treatment rate is up to 100%; (3) the berberine hydrochloride when used with enrofloxacin, gentamicin sulphate and TMP together is used to treat septicaemia, respiratory tract infections and intestinal infections caused by sensitive bacteria.
Owner:ZHENGZHOU HOUYI PHARMA
Medical dust cloud agent or granular agent and its use
ActiveCN1899265AQuality improvementLow costOrganic active ingredientsAerosol deliveryWound healingSurgical operation
The medical atomized agent consists of chitin derivative and macromolecular isolator in the weight ratio of 100 to 0.1-99.9; or consists of chitin derivative and anti-phlogistic anodyne or spasm inhibitor in the weight ratio of 100 to 0.001-10. The medical atomized agent is used in surgical operation for preventing tissue adhesion and relieving pain and in clinical treatment for promoting wound healing and relieving pain.
Owner:青岛博益特生物材料股份有限公司
Lappaconitine hydrochoric acid, its production method and its uses in preparing analgetic
InactiveCN1962639ANo teratogenic effectNo mutagenic effectOrganic chemistryAntipyreticAlcoholSolvent
The invention discloses a manufacturing method of alcaine high-sinomontanine and application in the anodyne, which comprises the following steps: dissolving high-sinomontanine through alcohol or carbinol; dripping alcaine solution; stewing; eluting; crystallizing; filtering; washing crystallization through little solvent; drying.
Owner:韦璧瑜 +1
Novel postoperative-analgesia hemostasis device for anus and intestine surgery
InactiveCN107951526ADoes not interfere with normal activitiesEasy to replaceSurgeryMedical devicesIntestine surgeryEngineering
The invention discloses a novel postoperative-analgesia hemostasis device for anus and intestine surgery. The novel postoperative-analgesia hemostasis device comprises a mounting block. A mounting groove is formed in the upper surface of the mounting block. Styptic cotton is placed into the mounting groove. Connection ropes are arranged on two side surfaces of the mounting block and connected withtwo fixing ropes. Straps are arranged at the ends of the two fixing ropes. The novel postoperative-analgesia hemostasis device has the advantages that the device can be fixed to a wound part of a patient to relieve pain and stop bleeding, so that normal movement of the patient is not affected, and frequent medication is avoided, the device is simple to operate and convenient to use, the styptic cotton can stop bleeding, sterile gauze can avoid infection, acesodyne can be sprayed onto the sterile gauze to relieve the pain of the patient, the fixing ropes are connected with the connection ropesthrough hanging rings and fixing blocks, so that the mounting block can be replaced conveniently, convenience in use is achieved, and the first strap and the second strap can be adhered through maleand female surfaces of a hook-and-loop fastener and can be fixed to the waist of the patient, so that convenience in fixation and simplicity in operation are realized.
Owner:刘冰
Tibetan medicine composition and use of the Tibetan medicine composition in preparation of inflammation-diminishing and pain-relieving drugs and sanitary products
InactiveCN102716277APreparation method is simple and easy to controlThe preparation method is simple and easy to controlAntibacterial agentsCosmetic preparationsCrocus sativusSaussurea medusa
Owner:TIBET ZHENGYUAN BIO TECH
Insoluble polysaccharide compound with hemostatic function and preparation method thereof
ActiveCN104208096AHigh coagulation efficiencyEvenly dispersedAerosol deliveryOintment deliveryAntibiotic YBlood plasma
The invention provides an insoluble polysaccharide compound with a hemostatic function. The compound includes insoluble polysaccharide and a blood component. The blood component is whole blood or plasma, and the insoluble polysaccharide is macromolecular polysaccharide insoluble in whole blood or plasma. According to the invention, by mixing the blood component with the insoluble polysaccharide, the blood component undergoes clotting reaction evenly and dispersedly on the surface of the insoluble polysaccharide, so that clotting factors generated in the clotting process can be adsorbed by the insoluble polysaccharide surface, and high clotting activity can be maintained, thereby obtaining a composite hemostatic material with an excellent clotting effect. The preparation method of the insoluble polysaccharide compound provided by the invention is simple, and is convenient and safe to use, thus being widely applicable to trauma and surgical hemostasis. The insoluble polysaccharide compound can be combined with other medical materials and medical instruments so as to be prepared into band aids, infusion bands, self-adhesive dressings, tablets and capsule core materials, operation packages and first-aid packets, etc. At the same time, the adsorption performance and other characteristics of the insoluble polysaccharide compound are utilized to adsorb antibiotics, painkillers and the like thereinto, thus achieving better curative effect.
Owner:ZHEJIANG UNIV
Traditional Chinese medicine combination for treating bone injury and fracture and preparation method of traditional Chinese medicine combination
InactiveCN104435169ARelieve excruciating painPromote formationOintment deliverySkeletal disorderWolfiporia extensaRhizome
The invention provides a traditional Chinese medicine combination for treating bone injury and fracture. The traditional Chinese medicine combination for oral administration comprises the following crude drugs: Indian bread, red sage root, cornus officinalis, acanthopanax bark, rhizome of Sichuan lovage, large leaf gentian root, loranthus muberry mistletoe, achyranthes root, safflower, ground beetle, caulis spatholobi, rhizome of drynaria, giant knotweed, psoralea fruit, elderberry, buck grass, cassia twig, earthworm, red peony root, heroubill geranium, ledebouriella root and epimedium; the traditional Chinese medicine combination for external use comprises the following raw materials: anisetree bark, myrrh, frankincense, dipsacus root, notoginseng, safflower, dragon's blood, nux vomica, black catechu, radix aconiti preparata, cassia, caulis impatientis, dahurian angelica root, triperygium wilfordii, Chinese clematis, notopterygium root, earthworm and dried body of scorpion. The traditional Chinese medicine combination has the efficacies of promoting blood circulation to remove blood stasis, promoting reunion of fractured bones, removing stasis to relieve pain and promoting focus repair, and is applicable to the treatment of various types of bone injury and fracture, and is high in cure rate. The traditional Chinese medicine combination ensures that patients are free from the pain of bone fracture and are not required to take strong paregoric. The traditional Chinese medicine combination ensures that callus is rapidly formed and the physiological healing stage is obviously advanced, thereby achieving the purpose of treating bone injury and fracture. The traditional Chinese medicine combination for oral administration has the effects of relieving distension, relieving pain, eliminating stasis, engendering the new and promoting the callus growth, and the traditional Chinese medicine combination for external use can ensure that the callus is rapidly formed and the physiological healing stage is obviously advanced.
Owner:青岛申达高新技术开发有限公司
Chinese medicine preparation with effects on expelling wind, dispelling cold and dampness, promoting blood circulation, removing blood stasis, promoting qi circulation and relieving pain
InactiveCN102106988ASignificant effectFast onset and long lastingAnthropod material medical ingredientsAntipyreticMyrrhHomalomena
The invention relates to a Chinese medicine preparation with the effects on expelling wind, dispelling cold and dampness, promoting blood circulation, removing blood stasis,, promoting qi circulation and relieving pain. The Chinese medicine preparation is a plaster prepared from the following Chinese medicinal plants in parts by weight: 10-15 parts of radix angelicae pubescentis, 10-15 parts of garter snake, 10-15 parts of cinnamon, 10-15 parts of frank incense, 10-15 parts of myrrh, 10-15 parts of leech, 10-15 parts of notopterygium root, 10-15 parts of lumbricus, 10-15 parts of tortoise shell, 10-15 parts of cortex acanthopanacis, 10-15 parts of Chinese taxillus twig, 10-15 parts of east Asian tree fern rhizome, 10-15 parts of obscured homalomena rhizome, 10-15 parts of pine nodular branch, 10-15 parts of radix clematidis, 10-15 parts of kadsura pepper stem, 10-15 parts of ovientvine, 10-15 parts of szechuan lovage rhizome, 10-15 parts of rhizoma corydalis, 10-15 parts of radix curcumae and 10-15 parts of radix curcumae longae. The Chinese medicine preparation provided by the invention has the effects of expelling wind, dispelling cold and dampness, promoting blood circulation, removing blood stasis, promoting qi circulation and relieving pain. In the Chinese medicinal plants, the radix angelicae pubescentis, garter snake and cinnamon are taken as monarch drugs, the frank incense, myrrh, radix curcumae, radix curcumae longae, rhizoma corydalis, szechuan lovage rhizome, leech, notopterygium root, cortex acanthopanacis, Chinese taxillus twig, east Asian tree fern rhizome, pine nodular branch, radix clematidis, kadsura pepper stem and ovientvine are taken as ministerial drugs, and the lumbricus and tortoise shell are taken as adjuvant drugs; and all the Chinese medicinal plants play the effects on expelling wind, dispelling cold and dampness, promoting blood circulation, removing blood stasis, promoting qi circulation and relieving pain.
Owner:孙玉宝
An externally applied analgetic and preparation method thereof
Owner:YUNAN XITAO GREEN PHARMA
Production method of modified surgical catgut of point heeling-in therapy
The invention relates to a making method of a modified cat gut in a point-embedding therapy. Granular traditional Chinese medicines are selected, the traditional Chinese medicines are soaked medical alcohol to obtain herb liquor; another medical cat gut is soaked in the herb liquor to obtain the modified cat gut. The method is characterized in that in the traditional Chinese medicines, asarum is 0.25 parts, cortex moutan is 1 part, cornu bubali is 1 part, radix paeoniae rubra is 1 part, and paris rhizome is 1 part according to the weight proportion, and the concentration of the alcohol is themedical alcohol of 50 percent. The cat gut and the herb liquor are mixed to be integrated after the cat gut of the technical proposal is soaked in the herb liquor, and the asarum which is the traditional Chinese medicine is used as a warming meridian anodyne; the cortex moutan, the cornu bubali, the radix paeoniae rubra and the paris rhizome have the effects of cooling and activating blood, clearing heat and detoxifying, reducing the rejection reaction, and has the effects of diminishing inflammation and relieving pain after medicine compatibility, and effectively avoiding the form of the consequence such as suppuration. The modified cat gut has strong point reaction and lasting effects; in addition, the drug has chronic point-release and amplification effect, so that the curative effectsof meridian points are strengthened.
Owner:杨良机
System for providing therapy to a body
InactiveUS20060067994A1Efficient use ofEffective guidanceLight therapyTherapeutic coolingPhysical therapyPain medicine
Some embodiments of the present invention relate to a system, kit and method for providing therapy to a portion of a body. The system includes a holder and a therapeutic patch that is held by the holder. The therapeutic patch applies therapy to the portion of the body when the first patch is placed near the portion of the body. The system further includes an oral pain reliever that is held by the holder. The method includes selecting a therapeutic patch from a holder and applying the therapeutic patch near a portion of a body such that the therapeutic patch applies therapy to the portion of the body. The method further includes selecting an oral pain reliever from the holder and ingesting the oral pain reliever.
Owner:KIMBERLY-CLARK WORLDWIDE INC
Chinese south China sea signal taro snail nerve toxin gene 1t5.4 and uses thereof
InactiveCN101041691AHas an analgesic effectInhibit currentNervous disorderPeptide/protein ingredientsCDNA libraryNeural biology
The invention discloses a Chinese South China Sea signal Conidae neuropoison gene It 5.4 and coded peptide It5d as well as the application in the instrumental drug and anodyne, which constructs cDNA library to clone T-super of Conidae poison in the poisonous pipe of Chinese South China Sea signal Conidae.
Owner:SUN YAT SEN UNIV
Use of medicinal fatheadtree leaf in the preparation of antimicrobial anti-inflammation medicament
InactiveCN101138590AImprove permeabilityInhibition hasAntibacterial agentsAntipyreticAnti-inflammatoryDrug
The present invention relates to a new medicinal part of Chinese medicine, namely, the purpose of biliary konoha in preparing antibacterial, anti-inflammatory and analgesic drugs. Studies show that biliary konoha includes alkaloid and flavonoid similar to konoha and these two ingredients have similar antibacterial, anti-inflammatory and analgesic pharmacological activity. The biliary konoha is extracted by water or ethanol of appropriate concentration; the extracted liquid is merged and filtered; the ethanol is washed through a macroporous resin column and the eluate is decompressed, concentrated and dried to obtain the biliary konoha extract including alkaloid and glycoside compounds. The extract mixed with an appropriate number of pharmaceutical auxiliary materials can be manufactured into oral solid dosage such tablet, capsule, granule and pill according to the conventional preparation process; or injection dosage such as water injection and powder injection according to the conventional injection preparation process.
Owner:邓世明
Clot-dispersing pain-relieving medicinal composition and preparation method and application thereof
Owner:JIANGSU KANION PHARMA CO LTD
Method for activation of transient receptor potential cation channel, subfamily a, member 1 using acetaldehyde
ActiveUS20090269280A1Improve isolationEasy to useMicrobiological testing/measurementTissue cultureSensory potentialSensory neuron
The present invention relates to a method for activation of TRPA1 (transient receptor potential cation channel, subfamily A, member 1) using acetaldehyde, more precisely a method for selecting a candidate for TRPA1 activation blocker from neurons activated by acetaldehyde. Acetaldehyde of the present invention works on TRPA1 specifically so that it facilitates the isolation of sensory neurons expressing TRPA1. Therefore, acetaldehyde of the invention can be effectively used for the studies on TRPA1 mechanisms and the development of a TRPA1 based anodyne.
Owner:HANBAT NAT UNIV IND ACADEMIC COOPERATION FOUND
Medicine provided with the functions of promoting blood circulation and stopping pain and used for treating chronic rheumatic disease, as well as preparation process and application of medicine
ActiveCN102552607AGood curative effectHas the effect of promoting blood circulation and relieving painAntipyreticAnalgesicsJoint arthralgiaLycopodium clavatum
The invention relates to a capsule provided with the functions of promoting blood circulation and stopping pain and used for treating chronic rheumatic disease, as well as a preparation process and an application of the medicine. The medicine is prepared by the crude medicines according to parts by weight: 12-18 parts of lycopodium clavatum, 12-18 parts of teasel root, 8-12 parts of ligusticum wallichii, 4-6 parts of frankincense, 12-18 parts of rhizoma cibotii, 12-18 parts of caulis spatholobi, 8-12 parts of medicinal cyathula root, 8-12 parts of angelica sinensis, 12-18 parts of parasitism, 4-6 parts of sangusis draconis, 12-18 parts of fried eucommia bark, 4-6 parts of pseudo-ginseng, 12-18 parts of fried radix paeoniae alba, 3-5 parts of borneol and 4-12 parts of ground beeltle. The sangusis draconis, pseudo-ginseng and ground beeltle are grinded into fine powder; the 3-5 parts of borneol is grinded; the other medicines are in alcohol extraction to obtain alcohol extraction fine powder; and the obtained medicines are uniformly mixed. The medicines are used together so as to dispel the wind, invigorate the circulation of blood, stretch the muscles and smooth the vein. The medicine provided by the invention is used for treating chronic rheumatic arthralgia, lumbago and the like. The total effective rate is 91.3%.
Owner:曾爱荣
Traditional Chinese medicine for treating osteoarticular diseases, and preparation method thereof
The invention relates to a traditional Chinese medicine for treating osteoarticular diseases, and a preparation method thereof. The traditional Chinese medicine for treating osteoarticular diseases is prepared through using the following raw medicines, by weight, 20-45 parts of Sevenlobed Yam Rhizome, 20-40 parts of Atractylodes lancea, 20-40 parts of white peony root, 20-40 parts of Chinese angelica, 20-40 parts of pawpaw, 20-40 parts of Millettia dielsiana, 20-40 parts of Himalayan Teasel Root, 20-40 parts of Rhizoma Corydalis, 20-40 parts of dried Rehmannia glutinosa Libosch, 20-40 parts of Chinese Taxillus Twig, 20-40 parts of Rhizoma Drynariae, 20-40 parts of Divaricate Saposhnikovia Root, 20-40 parts of Radix Stephaniae Tetrandrae, 20-40 parts of Eucommia ulmoides, 20-40 parts of Fructus Liquidambaris, 20-40 parts of Rhizoma Cibotii, 10-30 parts of Boswellia carteri, 10-30 parts of myrrh, 10-30 parts of Radix Clematidis, 5-25 parts of prepared Aconitum kusnezoffii, 5-25 parts of prepared Radix Aconiti, 10-30 parts of Ligusticum wallichii, 20-40 parts of dahurian angelica root, 20-40 parts of centipede and 20-40 parts of pangolin. The traditional Chinese medicine a beneficial effect that the traditional Chinese medicine has good treatment effects on the osteoarticular diseases, especially hydrarthrosis pains comprising pains in muscles and bones, ankylosing spondylitis, femur head necrosis and the like through the screening and the scientific matching of muscle and bone strengthening, swelling diminishing and pain relieving medicines.
Owner:陈建杰
Medicinal chewing tablet used for antipyretic analgesic and its preparation method
InactiveCN1830429AQuality improvementGreat tasteOrganic active ingredientsAntipyreticCurative effectCyclodextrin
A medicine in the form of chewing tablet for antipyresis and anodyne is prepared from ibuprofen through including it in cyclodextrin, mixing with filler and flavouring, granulating and die pressing.
Owner:GUIZHOU XINBANG PHARMACEUTICAL CO LTD
Medicine for swelling and relieving pain and its preparation method and application
InactiveCN101143166BHas anti-inflammatory and analgesic effectsHydroxy compound active ingredientsAntipyreticTurpentinePharmaceutical Substances
Owner:广东中大南海海洋生物技术工程中心有限公司
Vibrissa removal wax used for human bodies, and production method and use method thereof
ActiveCN106511107AExcellent adhesionReduce consistencyCosmetic preparationsHair removalWaxNasal cavity
The invention discloses a vibrissa removal wax used for human bodies, and a production method and a use method thereof. The vibrissa removal wax used for human bodies comprises a tackifier, a plasticizer, a flexibilizer, a stabilizer, an essence, a filler, a bacterial depressant, a thickener, an anodyne and a wax substance. The production method comprises the following steps: heating the wax substance to melt the wax substance, adding the tackifier, the plasticizer, the flexibilizer, the stabilizer, the essence, the filler, the bacterial depressant, the thickener and the anodyne into the molten wax substance, and uniformly stirring all above substances to obtain the vibrissa removal wax. The use method comprises the following steps: heating the vibrissa removal wax used for human bodies by using a microwave oven, rolling up the obtained wax ball by using a rod, placing the rod in the nasal cavity, and rapidly pulling out the rod. The vibrissa removal wax used for human bodies has the advantages of good removal effect, easiness in peeling, no contact with the nasal mucosa, and bacteriostasis and infection prevention effects; and the tackifier adopts hydrocarbon resin, and the thickener and the filler are added to improve the fluidity, so user's experiences are improved.
Owner:GUANGZHOU DEXIN WAX PROD
Methods for screening for inhibitors of TRPV2 activation
Owner:KOREA UNIV IND & ACADEMIC CALLABORATION FOUND
Lmiquimod cream and preparation method thereof
InactiveCN1864664APromote osmotic absorptionGood curative effectOrganic active ingredientsAerosol deliveryPreservativeCurative effect
The present invention relates to imiquimod cream containing imiquimod of grain size not greater than 100 micron in 1.0-10.0 wt%, oil phase, water and emulsifier. The preparation process of imiquimod cream includes the following steps: heating at 75-85 deg.c to smelt oil phase with added thickener and anodyne; mixing humectant and water to obtain water phase and heating to 75-85 deg.c; mixing imiquimod, emulsifier, preservative, oil phase and water phase via maintaining the temperature and stirring for 15-20 min; and regulating pH value to 4.0-7.0 to obtain the imiquimod cream. The medicine of the present invention has raised permeating absorption and raised curative effect, and is used in treating condyloma acuminatum around male's and female's external genitalia and anus.
Owner:湖北科益药业股份有限公司
Method for activation of transient receptor potential cation channel, subfamily A, member 1 using acetaldehyde
ActiveUS7960130B2Nervous system cellsBiological testingTransient receptor potential channelSensory potential
Owner:HANBAT NAT UNIV IND ACADEMIC COOPERATION FOUND
Arg-Tyr modified aliphatic amine/ alcohol derivatives and preparation method and application thereof
The invention discloses Arg-Tyr modified aliphatic amine / alcohol derivatives and a preparation method thereof and application thereof as anodynes and anti-inflammatory agents. The structure of the Arg-Tyr modified aliphatic amine / alcohol derivatives is shown as a general formula I, namely Arg-TyrXCH2(CH2)nCH3, wherein in the formula, X is NH or O; and n is 6, 8, 10, 12, 14 or 16. The pain relieving activity of the compounds in the general formula is evaluated by adopting a mouse heat thrilling process model, the anti-inflammatory activity of the compounds in the general formula I is evaluated by adopting a mouse ear swelling model, and experimental results show that the 12 compounds represented by the general formula I have excellent pain relieving effect and high anti-inflammatory activity under the same dose and can be applied to production of analgesics and anti-inflammatory medicaments.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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