111 results about "Neural biology" patented technology

The invention discloses a three-dimensional flexible neural microelectrode and a manufacturing method thereof. The microelectrode uses a flexible polymer as a base material, and performs progressive electroplating through a circular pattern design of a metal seed layer to form smooth three-dimensional convex features. The electrode site structure can not only ensure good contact between the electrode site and the nerve cells, but also avoid damage to the nerve tissue caused by the sharp edges and corners of the raised electrode sites in the existing three-dimensional neural microelectrode. In addition, through the composite electroplating process in the electroplating process, that is, nano-scale dispersants are added to the electroplating solution to form a submicron-scale microporous structure on the surface of the electrode, increasing the surface area of ​​the electrode site, thereby enhancing the current output capability of the electrode and ensuring the nerve. Effective stimulation of microelectrodes under the constraints of biosafety conditions. The three-dimensional flexible neural microelectrode provided by the invention can be widely used in the fields of neurological disease treatment, neurological rehabilitation, neurobiological basic research and the like.

A data acquisition system for use in conducting functional magnetic resonance imaging studies. fMRI studies can provide clues to the neurobiological basis of CNS disorders and reliable and quantifiable data relating to their symptoms. The data acquisition system includes a control station, a patient stimulus and response system and fMRI data acquisition software for controlling the operation of the system in response to operator input and acquiring fMRI data comprising MR images and associated behavioral response data. The stimulus and response system presents visual or auditory or other stimuli to the patient under direction of the control station while functional MRI scanning takes place. The MRI image data is collected from the MRI scanner and combined with the behavioral data generated as the patient responds to the stimuli and archived for later analysis and use. The system includes quality control measures for properly setting up the equipment and preparing and training the patient and for verifying data quality during the different steps in the process.

The invention provides a Conus lividus neurotoxin gene 1v1.3 and a polypeptide 1v1c coded thereby and use of the polypeptide 1v1c in the preparation of tool medicines for neurobiological study and analgesic medicines. In the invention, a process of constructing a cDNA library is adopted to clone the conotoxin gene 1v1.3 in the toxin canal of Conus lividus, and through analysis on a base sequence with a tool software SEQTOOL, the mature peptide amino acid sequence of the polypeptide 1v1c coded by the Conus lividus neurotoxin gene 1v1.3 is determined to be represented by a sequence 400(2) in a sequence table. The polypeptide 1v1c provided by the invention can block the transmission of a transmitter of neuromuscular junction, and according to a mouse hot-plate method, the polypeptide 1v1c has pain relieving effect and can be used for preparing the tool medicines for neurobiological study and analgesic medicines.

The present inventors have recognized that proper utilization of reconfigurable event driven hardware may achieve optimum power conservation in energy constrained environments including a low power general purpose primary processor and one or more electronic sensors. Aspects of neurobiology and neuroscience, for example, may be utilized to provide such reconfigurable event driven hardware, thereby achieving energy-efficient continuous sensing and signature reporting in conjunction with the one or more electronic sensors while the primary processor enters a low power consumption mode. Such hardware is event driven and operates with extremely low energy requirements.

The present invention is quick identification method of the addiction and dependence of opium drug addict, and belongs to the field of medicine and biotechnology. Naloxone eye drop in 2 or 3 drops is dripped into the eye of drug addict, and after 10-40 min, the pupil diameter is measured and compared with that before naloxone is dripped. The addiction and dependence on opium drug is judged based on the diameter difference, and the difference over 5 pixels shows the existing addiction, and the difference of 5-10, 11-20 and over 21 shows the slight, middle and serious dependence separately. The said method is efficient, accurate and reliable.

The invention provides insect specific polyamine micromolecular toxin (denoted as AVTX-623), wherein the relative molecular weight is 622.3971 and the molecular formula is C28H50N10O6. The AVTX-623 has the following properties: (1) the AVTX-623 can specifically act on an insect sodium ion channel, and the action dose of the AVTX-623 on the insect sodium channel is ten times lower than that of ArgTX-636; (2) the toxicity result on the insect living body indicates that the half effective anesthetic dosage of the AVTX-623 on the insect is 20 times lower than that of the ArgTX-636; (3) for vertebrate NMDA receptor activity, the action dosage of the AVTX-623 is slightly lower than that of the ArgTX-636; (4) the selectivity activity of the AVTX-623 on the insects is much higher than that of the ArgTX-636. The invention further discloses a purification method of the AVTX-623. Pure AVTX-623 can be completely purified from venom of araneus ventricosus through three steps of ultra-filtration, ion-exchange column chromatography and reversed phase high-performance liquid chromatography, the operation steps are simple, the loss rate is low, and the practicability is high. The invention further discloses application of the AVTX-623. The AVTX-623 can be applied to preparation of insecticide or / and a neurobiological reagent and medicines.

The invention relates to compounds that inhibit thyrotropin-releasing hormone (TRH) degrading ectoenzyme and / or enhance, and / or mimic the biological actions of TRH. The compounds find therapeutic application, particularly in conditions involving neuronal cell injury and disturbances in neurobiological function.