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Medicinal chewing tablet used for antipyretic analgesic and its preparation method

A chewable tablet and drug technology, applied in the directions of antipyretics, drug combinations, pharmaceutical formulations, etc., can solve the problems of patients who do not want to take ibuprofen orally, and achieve the effects of improved solubility, fast absorption, and stable quality

Inactive Publication Date: 2006-09-13
GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It solves the problem that ibuprofen has a spicy taste and patients are unwilling to take it orally; the inclusion powder is directly prepared into chewable tablets or lozenges, which not only tastes good and is convenient to take, but also improves the solubility of ibuprofen so that it can quickly reach the solution. The effect of thermal analgesia improves the quality stability and formability of chewable tablets. The drug is chewed or contained, and its active ingredients are quickly absorbed through the oral mucosa or sublingual mucosa, with fast absorption and high bioavailability. The problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] 1. Prescription: Ibuprofen 50g

[0074] Beta cyclodextrin 125g

[0075] Mannitol 150g

[0076] Lactose 30

[0077] Citric acid 12g

[0078] Aspartan 7.2g

[0079] Potassium hydrogen tartrate 24g

[0080] Xanthan Gum 12g

[0081] Cyclamate 5g

[0082] Orange flavor 1.8g

[0083] Sunset yellow 0.12g

[0084] Carmine 0.12g

[0085] Magnesium stearate 1.2g

[0086] 20g of 10% polyvinylpyrrolidone 80% ethanol solution.

[0087] 2. Preparation method:

[0088] A. Crush mannitol, lactose, citric acid, potassium hydrogen tartrate, and sodium cyclamate first, pass through an 80 mesh sieve, and set aside;

[0089] B. Take the prescription amount of ibuprofen, add proper amount of ethanol to dissolve it at low temperature, and weigh the prescription amount of beta cyclodextrin, add water to make a saturated solution in a constant temperature water bath at 80°C. Slowly add...

Embodiment 2

[0094] 1. Prescription: Ibuprofen 10g

[0095] Betacyclodextrin 10g

[0096] Mannitol 10g

[0097] 10g lactose

[0098] Citric acid 2g

[0099] Rebaudioside 1g

[0100] Potassium hydrogen tartrate 1g

[0101] Propolis 10g

[0102] Cyclamate 1g

[0103] Banyan flavor 1g

[0104] Lemon yellow 0.05g

[0105] Micronized silica gel 1g

[0106] 20g of 20% ethyl cellulose ethanol solution.

[0107] 2. Preparation method:

[0108] 1. Crush mannitol, lactose, citric acid, potassium hydrogen tartrate, and sodium cyclamate first, pass through an 80 mesh sieve, and set aside;

[0109] 2. Take the prescription amount of ibuprofen, add proper amount of ethanol to dissolve it at low temperature, and weigh the prescription amount of beta cyclodextrin, add water to make a saturated solution in a constant temperature water bath at 80°C. Slowly add the ibuprofen ethanol solution to the beta cy...

Embodiment 3

[0114] 1. Prescription: Ibuprofen 100g

[0115] γ-Cyclodextrin 500g

[0116] Mannitol 100g

[0117] Lactose 100g

[0118] Malic acid 50g

[0119] Glycyrrhizin 20g

[0120] Potassium hydrogen tartrate 20g

[0121] Peach gum 50g

[0122] Cyclamate 10g

[0123] Apple flavor 10g

[0124] Corn yellow 1.5g

[0125] Apple green 3.5g

[0126] Talcum powder 20g

[0127] 10% polyethylene glycol ethanol solution 100g.

[0128] 2. Preparation method:

[0129] 1. Crush mannitol, lactose, malic acid, potassium hydrogen tartrate, and sodium cyclamate, pass through an 80-mesh sieve, and set aside;

[0130] 2. Take the prescription amount of ibuprofen, add proper amount of ethanol to dissolve it at low temperature, and weigh the prescription amount of γ-cyclodextrin, add water to make a saturated solution in a constant temperature water bath at 80°C. Slowly add the ibuprofen ethanol...

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PUM

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Abstract

A medicine in the form of chewing tablet for antipyresis and anodyne is prepared from ibuprofen through including it in cyclodextrin, mixing with filler and flavouring, granulating and die pressing.

Description

Technical field [0001] The invention relates to a medicine chewable tablet for antipyretic and pain relief and a preparation method thereof. The medicine contained is ibuprofen, which belongs to the technical field of medicines. Background technique: [0002] Ibuprofen is an anti-inflammatory, antipyretic and analgesic product. It is one of the most commonly used non-steroidal anti-inflammatory drugs in clinical use. Its chemical name is α-methyl-4-(2-methylphenyl)phenylacetic acid. Prescription drugs and over-the-counter drugs are widely used by physicians to treat rheumatism or rheumatoid diseases, as well as joint and muscle pain, headaches, dysmenorrhea and other pains; ibuprofen has long been used in adults, and was approved by the US Food and Drug Administration in 1989. Profen is used as a prescription drug for children; in 1995, the ibuprofen suspension under the trade name Motrin was approved by the FDA as an antipyretic and analgesic OTC drug for children aged 2 to 11 y...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K9/20A61K47/40A61K47/26A61P29/00
Inventor 张观福李德琨
Owner GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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