800 results about "Phenylacetic acid" patented technology

The invention relates to the technical field of fruit growing and in particular relates to a growth regulator for improving the fruit setting rate of peaches and a regulating method. The growth regulator comprises the following components of gibberellin and auxin, wherein the auxin may be one of 1-Naphthalene acetic acid, sodium alpha-naphthyl acetate, indoleacetic acid, phenylacetic acid, indolebutyric acid, indoleacetic acid and 2,4-dichlorphenoxyacetic acid, and the growth regulator is sprayed after the peaches bloom. The growth regulator provided by the invention is easy to obtain and prepare and low in economic cost, and can effectively remedy deficiency of endogenous hormone caused by poor fertilization of peaches; the method for applying the growth regulator provided by the invention is simple and convenient and easy to operate and control, effectively solves the problem that in the growing of peaches, the fruit setting rate is influenced by abnormal weather in a flowering phase, shriveled flower buds, overly rapid warming and the like, improves the fruit setting rate by more than 34 times, and is obvious in effect and applicable to popularization and application in the production of peaches in common peach orchards, green houses and other facilities.

The present invention discloses a stability enhanced aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid or its pharmacologically acceptable salt or a hydrate thereof, an alkyl aryl polyether alcohol type polymer such as tyloxapol, or a polyethylene glycol fatty acid ester such as polyethylene glycol monostearate. The present invention further discloses new bromfenac ophthalmic compositions which can potentially treat a broader patient population, and have greater stability properties, and may require a lower concentration or less doses of bromfenac then previously known bromfenac compositions. The present invention further comprises a method for treating inflammation and / or pain of the eye in a patient which method comprises topical application to the eye of a patient in need thereof of a therapeutically effective amount of a topical ophthalmic composition comprising bromfenac at a concentration of about 0.05% w / v to about 0.24% w / v.

The present invention provides a compounds the formula (IV):and methods for producing an α-(phenoxy)phenylacetic acid compound of the formula:wherein R1 is a member selected from the group consisting of:each R2 is a member independently selected from the group consisting of (C1-C4)alkyl, halo, (C1-C4)haloalkyl, amino, (C1-C4)aminoalkyl, amido, (C1-C4)amidoalkyl, (C1-C4)sulfonylalkyl, (C1-C4)sulfamylalkyl, (C1-C4)alkoxy, (C1-C4)heteroalkyl, carboxy and nitro; the subscript n is 1 when R1 has the formula (a) or (b) and 2 when R1 has the formula (c) or (d); the subscript m is an integer of from 0 to 3; * indicates a carbon which is enriched in one stereoisomeric configuration; and the wavy line indicates the point of attachment of R1; and compounds.

The present invention relates to a compound of the formula: R-AR—O—Y—R′Wherein R represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid, —NO2, —NH2, —NHCOCH3, and —NH—Y—R′, which is attached directly to AR or attached through an aliphatic chain. The carboxylic acid moiety in R includes but is not limited to the following carboxylic acids: benzoic acids, cinnamic acids, ferulic acid, caffeic acid, syringic acid, salicylic acid, vanillic acid, phenylacetic acids, phenylpropionic acids, and sinapinic acid. -AR—O— is a biologically active phenolic moiety comprising 1 to 6 substituted or unsubstituted aryl rings that are directly bonded to each other, fused together, or joined through a linking group. Y represents a member selected from: —COCH2O— (glycolic ester moiety) —COCH(CH3)O— (lactic ester moiety) —COCH2OCH2CH2O— (dioxanone ester moiety) —COCH2CH2CH2CH2CH2O— (caprolactone ester moiety) —CO(CH2)mO— where m is an integer between 2-4 and 6-24 inclusive —COCH2O(CH2CH2O)n— where n is an integer between 2 and 24, inclusive; and R′ is either hydrogen or a benzyl or an alkyl group, the alkyl group being either straight-chained or branched. The resultant functionalized phenolic compounds, used singly or in combinations, and their polymers have controllable degradation profiles, releasing the active component over a desired time range. The polymers are useful for biomaterials and biomedical devices, wherein said biologically active phenolic moiety is a residue of a phenolic compound.

The invention relates to a method for synthesizing glabridin. The method comprises the following steps: using acetophenone protected by phenol hydroxy as a raw material, carrying out a Willgerodt-Kindler reaction to obtain aryl phenylacetic acid, and carrying out a Friedel-Crafts reaction to obtain an isoflavones compound; causing the isoflavones compound to carry out Pd / C catalytic hydrogenation to obtain a isoflavanone compound; and causing the isoflavanone compound to carrying out a crclizationreaction, a conyl reduction reaction and a removing phenolic hydroxyl group protection group reaction to obtain the glabridin. The operation and the serparation of the steps of the method are simple, the yield is higher, the used reagents are common reagents, are cheap and are easily obtained, the path is shorter, and the tptal yield is not lower than 20 percent.

A synergistic flame retardant composition comprising a phenolic compound comprising condensed tannin, hydrolysable tannin, lignin, cardanol, quercetin, catechin, epicatechin, anthocyanidin, catechol, dopamine, hydroxytyrosol, adrenaline, 4-hydroxyphenylacetic acid, gallic acid, digallic acid, methyl gallate, ellagic acid, phloroglucinol, hexahydroxydiphenic acid, luteic acid, casuarictin, or a combination thereof; and a phosphorus-containing compound comprising a C5-7 carbocyclic polyol substituted with at least one phosphate group.

An aqueous liquid preparation of the present invention containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid or its pharmacologically acceptable salt or a hydrate thereof, an alkyl aryl polyether alcohol type polymer such as tyloxapol, or a polyethylene glycol fatty acid ester such as polyethylene glycol monostearate is stable. Since even in the case where a preservative is incorporated into said aqueous liquid preparation, the preservative exhibits a sufficient preservative effect for a long time, said aqueous liquid preparation in the form of an eye drop is useful for the treatment of blepharitis, conjunctivitis, scleritis, and postoperative inflammation. Also, the aqueous liquid preparation of the present invention in the form of a nasal drop is useful for the treatment of allergic rhinitis and inflammatory rhinitis (e.g. chronic rhinitis, hypertrophic rhinitis, nasal polyp, etc.).

This invention provides a method for preparing 2, 4, 5-trifluorophenylacetic acid. The method comprises: (1) reacting 1,2,4-trifluorobenzene and chlorinating agent in paraformaldehyde to obtain 2,4,5-trifluorobenzyl chloride; (2) performing carbonylation reaction with CO in the presence of catalyst to obtain 2,4,5-trifluorophenylacetic acid. The catalyst is alkali cobalt tetracarbonyl. The method has such advantages as few reaction procedures, and mild reaction conditions, and is suitable for industrial production of 2, 4, 5-trifluorophenylacetic acid.

The present invention provides a method for producing an enantiomerically enriched α-(phenoxy)phenylacetic acid compound of the formula (I):from its enantiomeric mixture, where R1 is alkyl or haloalkyl R7 is heteroalkyl and X is halide.

A fertilizer composition for improving stress resistance of land planted pear trees comprises arbuscular mycorrhizal fungi, betaine, salicylic acid, ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid) ferric-sodium complex (EDDHA-Fe), a chelate zinc fertilizer titanium zinc ethylenediaminetetraacetate, a promoter and fertilizers containing other elements. Contained arbuscular mycorrhizal fungi is capable of substantially improving stress resistance on drought, waterlogging disaster, salt and alkali, high temperature, heavy metal toxicity, toxic organics and the like of pear trees, and promoting absorption of soil mineral nutritional elements by soil. Betaine and salicylic acid are capable of inducing to improve crop resistance on adverse situations such as drought, freeze injury and the like.

The present invention provides a methods and compounds for producing an enantiomerically enriched α-(phenoxy)phenylacetic acid compound of the formula:from a mixture of its enantiomers, where R1 is alkyl or haloalkyl and X is halide.

PCT No. PCT / ES97 / 00066 Sec. 371 Date Feb. 25, 1998 Sec. 102(e) Date Feb. 25, 1998 PCT Filed Mar. 14, 1997 PCT Pub. No. WO97 / 35029 PCT Pub. Date Sep. 25, 1997Alternative process for obtaining 6-aminopenicillanic acid. The process comprises replacing the stages of extraction with organic solvents and isolation and separation of the intermediate penicillin salt as a solid by a process of ultrafiltration of the culture broth in at least 2 successive stages. The first stage has a cut-off for molecular weights of 20,000 Dalton and the second, 2000 Dalton. Subsequent to the enzyme conversion stage the products from that stage are subjected to a series of anionic exchange chromatography steps.

The invention discloses a method for preparing 4-hydroxyphenyl hydantoin from a glyoxylic acid, phenol and urea by condensation under acid condition, which is characterized in that: the 4-hydroxyphenyl hydantoin is prepared in the presence of a sulfamic acid, the production of polymerization impurities is inhibited and simultaneously a phenylglycine byproduct is produced. The mol ratio of the reaction raw materials of the glyoxylic acid to the phenol to the urea to the sulfamic acid is 1:1.0-1.1:1-1.5:0.2-0.5. The method comprises the following steps of: adding dropwise glyoxylic acid solution at the relatively lower temperature of 50 to 60 DEG C to form a 2-ureidobenzeneacetic acid intermediate, preparing the 4-hydroxyphenyl hydantoin at the relatively higher temperature of 80 or 105 DEG C by ring formation and simultaneously producing the p-hydroxyphenylglycine byproduct, wherein reaction solution is subjected to post-treatment to obtain white 4-hydroxyphenyl hydantoin crystals with the purity of 99.6 percent and the yield of 62.7 percent; and mother solution is further treated to obtain white p-hydroxyphenylglycine crystals with the purity of 99.2 percent ad the yield of 10.1 percent. In the method, the main byproduct is p-hydroxyphenylglycine, the utilization rate of the synthesis raw materials is increased and the problems of unstable quality of product and high treatment cost of the mother solution in the prior art are solved.

The invention provides a method for preparing 2, 4, 5-trifluoro-phenylacetic-acid. The method adopts 1, 2, 4-trifluoro-benzene to react with polyformaldehyde and chlorinating agent to obtain 2, 4, 5-trifluoro-benzyl chloride, and adopts the 2, 4, 5-trifluoro-benzyl chloride to react with cyaniding agent in ionic liquid to obtain 2, 4, 5-trifluoro-benzyl cyanide, and then the 2, 4, 5-trifluoro-benzyl cyanide is hydrolyzed in acid or alkalic conditions to obtain the 2, 4, 5-trifluoro-phenylacetic-acid. The preparation method for preparing 2, 4, 5-trifluoro-phenylacetic-acid requires cheap and available materials, and has moderate reaction conditions, less three-wastes and better safety; industrialized production can be easily realized, the product purity is high, and quality is stable, thuscompletely meeting the using requirement of 2, 4, 5-trifluoro-phenylacetic-acid as a pharmaceutical intermediate.

The invention discloses a peach essence. The peach essence consists of the following ingredients: propanediol, hexanol, hexenyl phenylacetate, benzaldehyde, ethyl acetate, phenylacetic acid cis-3-ester hexane, methyl acetate, hexyl acetate, hexyl trans-2-ester hexane, ethyl maltol, leaf alcohol, hexanal, acetic acid, linalool, gamma-caprylolactone, theta-decalactone, gama-decalactone, gamma-undecalactone, 8-mercaptomenthone, 2-isopropyl-4-methylthiazole, beta- damascenone, ethyl caprate and ethyl benzoate. The peach essence is moderate in fragrance, saturated, thick, stable in quality, natural in flavor and approximat to the natural fragrance of peach.

The invention relates to a preparation method of a benzothiostrobin antigen and antibody and an application thereof, belonging to the technical field of immunochemical analysis. The chemical name of benzothiostrobin is 2-[[(5-methoxy-2-benzothiazole)-thiomethyl]-alpha-(E)-methoxymethylene]methyl phenylacetate. Under an alkaline condition, carboxylic ester in the benzothiostrobin structure is hydrolyzed to synthesize an artificial hapten of which the chemical name is 2-[[(5-methoxy-2-benzothiazole)-thiomethyl]-alpha-(E)-methoxymethylene]phenylacetic acid; the artificial hapten is coupled with bovine serum albumin and ovalbumin respectively to prepared an artificial antigen. The BALB / c female mouse is immunized by the artificial antigen to obtain a specific monoclonal antibody of benzothiostrobin. The antibody does not experience a cross reaction with other compounds. An enzyme linked immunosorbent assay method established by use of the antibody can be applied to quick, sensitive, convenient and cheap detection of benzothiostrobin residues in environment and agricultural products.