The invention discloses a process of preparing Dehydroandrographolide Succinate
Sodium and
Potassium salts with
Potassium Dehydroandrograpolide Succinate. The process comprises the steps of: weighing right amount of
Potassium Dehydroandrograpolide Succinate, adding absolute ethyl
alcohol about 3 to 6 times to make suspension; weighting mole
Sodium bicarbonate in equal weight, adding water to dissolve, dripping slowly
Sodium bicarbonate solution in
potassium dehydroandrograpolide succinate suspension in a water bath at a temperature of between 40 and 60 DEG C, mixing into liquid
medicine and defecating, dissolving
impurity and filtering, putting on a 0.22 mu m filter membrane, adding absolute ethyl
alcohol about 7 to 12 times while mixing, after 10 to 30 minutes of mixing, natural
crystallization seeds out after 13 to 18 hours standing in
room temperature; filtering and washing 2 to 3 times with right amount of absolute ethyl
alcohol; filtering and
drying with less pressure. The invention provides a process
route of preparing
potassium sodium dehydroandroan drographolide succinate for injection with high purity, which is high in process yields, high in product purity, good in
solubility, less in
impurity and complete in combination of Potassium and Sodium; no obvious toxic and
side effect in clinic application, the preparation is more stable compared with the similar and can be prepared into various preparations.