40 results about "Methyl gallate" patented technology

The invention relates to an application of active parts of gallnut in preparing an anti-ulcerative colitis medicine, wherein the active parts of the gallnut are obtained by water extraction and then organic solvent extraction and mainly comprise a tannin type; and then the active parts are subject to extraction separation through a gel chromatography to obtain a monomeric compound, gallic acid, m-digallic acid, methyl gallate, 1,2,3,6-4-O-galloyl group-Beta-D-glucose and 1,2,3,4,6-5-O-galloyl group-Beta-D-glucose. Clinical outcomes show that the active parts of the gallnut have obvious therapeutic action on ulcerative colitis with the total effective rate up to 91.7%, the short-term cure rate up to 66.7%, effective rate of 25% and inefficiency of 8.3%. Pharmacologic research shows that the active parts of the gallnut can obviously increase SOD content and lower MPO content of an ulcer tissue, and has obvious therapeutic action on rat ulcerative colitis, obvious anti-inflammatory and analgesic action and bacteriostatic action on the common pathogenic bacteria related to ulcerative colitis.

The invention discloses an improved synthesis method for bicyclol (4,4'-dimethoxy-5,6,5',6'-methylenedioxy-2-hydroxymethyl-2'-methoxycarbonyl biphenyl). According to the method, methyl gallate is taken as a starting material, and the bicyclol is prepared by etherification, bromination, cyclization, reduction, hydrolysis, esterification, condensation, coupling reaction and alcoholysis. The invention has the characteristics that the method is easy to operate, practical and favorable for post-treatment; and the method is suitable for industrial production, and has considerable economic and practical value and broad application prospect in pharmaceutical synthesis.

The invention provides a method for simultaneously detecting nine chemical components in quisqualis indica, and relates to the technical field of analysis and detection. The method comprises the following steps: extracting quisqualis indica by adopting an alcohol-water solution to obtain a to-be-detected sample solution; and then performing UPLC-MS/MS. According to the invention, a to-be-detectedquisqualis indica sample is pretreated through a UPLC MS/MS method, qualitative identification can be rapidly achieved while gradient elution conditions are controlled, nine chemicals (trigonelline, vanillic acid, ferulic acid, syringic acid, catechinic acid, ellagic acid, malic acid, gallic acid and methyl gallate) in the quisqualis indica medicinal material are quantitatively detected, and reliable experimental data are provided for development and utilization and quality evaluation of the quisqualis indica medicinal material. The detection method provided by the invention has the advantagesof simple operation, fast analysis time of only 8min, fast separation speed and high sensitivity, makes up the blank of nine chemical detection methods in quisqualis indica at present, and is worthyof popularization and application.

The invention discloses a methyl gallate analogue containing an amide structure and application. The structure of the methyl gallate analogue is shown as a formula (I); in the formula (I), R1 is independently selected from various alkoxy, hydroxyl, various halogens and aromatic heterocycles. The invention does a lot of experiment researches aiming at the technical field of a methyl gallate analogue which takes a hydrolyzed methyl gallate ester bond as a parent nucleus structure, and a lot of design, synthesis and pharmacological activity screening of the methyl gallate analogue which takes thehydrolyzed methyl gallate ester bond as the parent nucleus structure are carried out to obtain one type of the methyl gallate analogue which takes the hydrolyzed methyl gallate ester bond as the parent nucleus structure; the methyl gallate analogue provided by the invention has high-efficiency and broad-spectrum anti-inflammatory application. The formula I is shown in the description.

The invention belongs to the technical field of medicines and relates to two novel compounds in paeonia anomala subsp.anomala and antioxidant activity parts of the two novel compounds. The chemical structural formulas of the two novel compounds are shown in formulas (I) and (II). According to a 80% ethyl alcohol extract of the paeonia anomala subsp.anomala, petroleum ether, ethyl acetate and water-saturated n-butyl alcohol are used for extraction to obtain all parts, the n-butyl alcohol part is separated through macroporous resin to obtain all flow components, a water part is subjected to multiple separation methods such as silica gel column chromatography, MCI column chromatography, reverse-phase ODS column chromatography and Sephadex LH-20, and the two novel compounds shown in (I) and (II) are separated. The invention further relates to a method for simultaneously measuring the content of nine compounds, including albiflorin R1, paeoniflorin, nutgall acyl paeoniflorin, oxypaeoniflorin, isovanillic acid, benzoic acid, gallic acid, methyl gallate and 1,2,3,4,6-pentagalloylglucose, in the paeonia anomala subsp.anomala. It is proved through a DPPH test that the paeonia anomala subsp.anomala has application prospects in the antioxidation aspect.

The invention belongs to the technical field of biological medicines, and particularly relates to application of methyl gallate (MG) in the preparation of an NLRP3 pathway inhibitor for hyperuricemia nephropathy and/or gouty arthritis. The methyl gallate can specifically inhibit the activation of NLRP3 inflammasomes in BMDMs and PBMCs, and has no influence on the activation of NLRC4 or AIM2 inflammasomes; and the methyl gallate is a wide inhibitor for NLRP3 inflammasome activation, and can inhibit the activation of the NLRP3 inflammasome stimulated by agonists such as LPS/MSU, alum, ATP, nigericin and the like. In addition, the methyl gallate is widely distributed in various edible plants and is wide in source. Therefore, the methyl gallate as an effective component is expected to be developed into the NLRP3 pathway inhibitor for treating hyperuricemia nephropathy and/or gouty arthritis diseases.

The invention provides application of carbonized sanguisorba roots in prevention and treatment of tinea corporis and cruris and tinea manus and pedis, and application in preparation of medicines or daily necessities. Meanwhile, the invention provides application of one or more of gallic acid, pyrogallic acid, methyl gallate, ethyl gallate and protocatechuic aldehyde in prevention and treatment oftinea corporis and cruris and tinea manus and pedis, and application in preparation of medicines or daily necessities. Trichophyton rubrum is a main pathogenic bacterium of tinea corporis and cruris and tinea manus and pedis. The invention shows that the carbonized sanguisorba roots can significantly inhibit the growth of the trichophyton rubrum, and the effect is equivalent to that of common traditional Chinese medicines sophora flavescens and golden larch bark for skin tinea. After the carbonized sanguisorba roots are administrated, the growth of the trichophyton rubrum is remarkably inhibited through ocular lens observation. Clinical curative effect observation shows that after carbonized sanguisorba root gel with the content of 0.5% is used for treating for 4 weeks, the cure rate of patients reaches 96.15%, and half of the patients are cured. Meanwhile, the main components including the gallic acid, the pyrogallic acid, the methyl gallate, the ethyl gallate and the protocatechuic aldehyde in sanguisorba roots all have a remarkable effect of resisting the trichophyton rubrum, and the content is not reported.

The invention discloses a preparation method of a high-temperature resisting and tensile-resisting insulating material. The preparation method comprises the following steps: respectively adding methylglycolate, tetraethyl orthosilicate, isoamyl salicylate, methyl gallate and a polyurethane elastomer into an internal mixer, raising the temperature to 120 to 130 DEG C and performing banburying for20 to 35 minutes; adding 2,6-ditertbutyl-p-cresol and phosphoric acid, and performing banburying at the temperature of 135 to 145 DEG C for 15 to 25 minutes; carrying out sufficient ball milling on magnesium oxide, silicon carbide and zirconium oxide and then adding a mixture into the internal mixer; mixing for 2 to 4 hours under the condition that the temperature is 160 to175 DEG C and the pressure is 20 to 25 KN; finally, carrying out hot melting and extruding on the mixture at high temperature of 200 to 250 DEG C to obtain a mixture, thus obtaining the high-temperature resisting and tensile-resisting insulating material.