40 results about "Methyl gallate" patented technology

A synergistic flame retardant composition comprising a phenolic compound comprising condensed tannin, hydrolysable tannin, lignin, cardanol, quercetin, catechin, epicatechin, anthocyanidin, catechol, dopamine, hydroxytyrosol, adrenaline, 4-hydroxyphenylacetic acid, gallic acid, digallic acid, methyl gallate, ellagic acid, phloroglucinol, hexahydroxydiphenic acid, luteic acid, casuarictin, or a combination thereof; and a phosphorus-containing compound comprising a C5-7 carbocyclic polyol substituted with at least one phosphate group.

Provided are a multicomponent crystalline system (co-crystal), use thereof, as well as a process for obtaining the same. The said multicomponent crystalline system (co-crystal) comprises Dasatinib and a second compound selected from methyM-hydrobenzoate, nicotinamide, ethyl gallate, methyl gallate, propyl gallate, ethyl maltol, vanillin, menthol, or (1R,2S,5R)-(−)-menthol.

The invention relates to an application of active parts of gallnut in preparing an anti-ulcerative colitis medicine, wherein the active parts of the gallnut are obtained by water extraction and then organic solvent extraction and mainly comprise a tannin type; and then the active parts are subject to extraction separation through a gel chromatography to obtain a monomeric compound, gallic acid, m-digallic acid, methyl gallate, 1,2,3,6-4-O-galloyl group-Beta-D-glucose and 1,2,3,4,6-5-O-galloyl group-Beta-D-glucose. Clinical outcomes show that the active parts of the gallnut have obvious therapeutic action on ulcerative colitis with the total effective rate up to 91.7%, the short-term cure rate up to 66.7%, effective rate of 25% and inefficiency of 8.3%. Pharmacologic research shows that the active parts of the gallnut can obviously increase SOD content and lower MPO content of an ulcer tissue, and has obvious therapeutic action on rat ulcerative colitis, obvious anti-inflammatory and analgesic action and bacteriostatic action on the common pathogenic bacteria related to ulcerative colitis.

The invention discloses an inhibitor of fatty acid synthase and application thereof, comprising the following active ingredients: 5 galloyl group gluconic acid, methyl gallate and quercetin-3-O-L-rhamnoside. The mass of three active ingredients in per gram of the inhibitor of fatty acid synthase are sequentially as follows: 18-20mug, 2-3mug, 1-2mug. The inhibitor of fatty acid synthase not only can be applied to preparation of weight loss drugs, preparation of anti-cancer drugs, but also can be widely applied to additives for foods, health products, as well as daily chemicals.

The invention relates to a method for synthesizing methyl (ethyl) gallate through catalysis of Cu-mordenite. The method comprises the step: by taking gallic acid and dimethyl carbonate or diethyl carbonate as raw materials and Cu-mordenite as a catalyst, performing transesterification reaction under pressurization to obtain methyl gallate or ethyl gallate. As the green and environment-friendly dimethyl carbonate or diethyl carbonate are a methylating (ethylating) agent, the method is low in cost and environment-friendly, the yield of the synthesized technical products can achieve more than 98%, and the purity of the ethyl gallate product is greater than 99%.

The invention discloses an organic rust conversion agent. The organic rust conversion agent comprises the following components in parts by weight: 5-10 parts of ethanol, 15-20 parts of tannic acid, 0.5-1.5 parts of acetylacetone, 35-65 parts of phosphoric acid, 1-3 parts of methyl gallate, 8-10 parts of sodium benzenesulfonate, and 10-18 parts of water. The rust conversion agent has the advantages of: easiness in taking of raw materials, low cost, capability of increasing the film forming rate and capability of prolonging the service life of equipment. A preparation method is simple; the adopted charging sequence and mixing step are not reported by documents so far; and the preparation method is an innovation, and can increase the film forming rate. An application method of the organic rust conversion agent is simple and convenient.

The invention discloses an improved synthesis method for bicyclol (4,4'-dimethoxy-5,6,5',6'-methylenedioxy-2-hydroxymethyl-2'-methoxycarbonyl biphenyl). According to the method, methyl gallate is taken as a starting material, and the bicyclol is prepared by etherification, bromination, cyclization, reduction, hydrolysis, esterification, condensation, coupling reaction and alcoholysis. The invention has the characteristics that the method is easy to operate, practical and favorable for post-treatment; and the method is suitable for industrial production, and has considerable economic and practical value and broad application prospect in pharmaceutical synthesis.

The invention provides a simultaneous preparation and detection method of gallic acid and gallicin in toona sinensis leaves, belonging to the technical field of traditional Chinese medicine. Through the adopted preparation method, the gallic acid and the gallicin can be simultaneously obtained from the traditional Chinese medicine toona sinensis leaves by means of drawing, extracting and secondary column chromatography, so that the use of various column chromatography padding and repeated column chromatography can be avoided, and the simultaneous preparation method is easy and simple to operate, and low in time and reagent consumption; and in the adopted detection method, the high-efficiency liquid phase chromatographic instrument normally prepared in a laboratory is used, various methodology indexes, i.e., the separation degree, the veracity, the reproducibility, the stability and the like meet the content detecting requirement, the simultaneous preparation method is high in reliability, the method can be used for analyzing the content of the gallic acid and the gallicin in the toona sinensis leaves medicinal materials with different sources and batches, and the requirements of the pharmacological activity test and the normal quality control of the traditional Chinese medicine can be met.

The invention discloses a novel composite energy-saving heat-preservation material including the following substances by weight: 3-6 parts of brucite, 5-10 parts of sepiolite, 6-11 parts of perlite, 3-7 parts of sodium metasilicate, 4-8 parts of potassium silicate, 8-12 parts of montmorillonite, 3-7 parts of heavy calcium carbonate, 2-5 parts of a coal gangue powder, 10-15 parts of methyl gallate, 15-20 parts of triisopropanolamine cyclic borate, 5-9 parts of hydroxypropyl cellulose, and 15-20 parts of 2-fluoroanisole. The inorganic filler and the organic components are added in an original formula of an inorganic energy-saving heat-preservation material, and thus the novel composite energy-saving heat-preservation material has good heat preservation effect and flame retardancy and stability simultaneously.

The invention belongs to the technical field of medicines, and relates to a method for preparing 3,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate. Preferentially, 3,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate is 3 alpha,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate. According to the method, 3,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate, especially 3 alpha,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate, prepared through the method can be used for preparing obeticholic acid.

The invention discloses an extract of Rosa rosea. The rose fruit extract comprises any one or several combinations of saponins, rose fruit flavonoids and glucopyranosyl gallate, and these three substances account for 20% of the total weight of the rose fruit extract. -80%. The invention also discloses the preparation method and the application in cosmetics of the rose fruit extract. The Rosa rose fruit extract provided by the present invention, in addition to having significant anti-aging properties, can also significantly promote the secretion of type I collagen, and also has good moisturizing properties, whitening and anti-inflammatory properties, and can be used for cosmetics and / or skin care It is an ideal comprehensive cosmetic and / or skin care product additive.

The invention provides a preparation method for N,N'-ferrocenediacetyl-tri(dodecyloxy) benzamide, and belongs to the field of synthesis of functionally micromolecules. The method comprises the following steps: taking methyl gallate, bromododecane and ferrocene as reaction raw materials, firstly performing substitution and hydrazinolysis on methyl gallate to generate 3,4,5-tri(dodecyloxy)benzoyl hydrazine; performing acylation, acidification and acyl chlorination on ferrocene to generate 1,1'-ferrocenedicarbonylchloride; and finally reacting 3,4,5-tri(dodecyloxy)benzoyl hydrazine with 1,1'-ferrocenedicarbonylchloride, so as to obtain N,N'-ferrocenediacetyl-tri(dodecyloxy)benzamide. The method possesses the characteristics of being mild in reaction conditions, simple in operation, low in cost, high in yield and high in product purity. Additionally, the N,N'-ferrocenediacetyl-tri(dodecyloxy)benzamide possesses good gelling effect and possesses good market application prospect.

The invention provides a method for simultaneously detecting nine chemical components in quisqualis indica, and relates to the technical field of analysis and detection. The method comprises the following steps: extracting quisqualis indica by adopting an alcohol-water solution to obtain a to-be-detected sample solution; and then performing UPLC-MS / MS. According to the invention, a to-be-detectedquisqualis indica sample is pretreated through a UPLC MS / MS method, qualitative identification can be rapidly achieved while gradient elution conditions are controlled, nine chemicals (trigonelline, vanillic acid, ferulic acid, syringic acid, catechinic acid, ellagic acid, malic acid, gallic acid and methyl gallate) in the quisqualis indica medicinal material are quantitatively detected, and reliable experimental data are provided for development and utilization and quality evaluation of the quisqualis indica medicinal material. The detection method provided by the invention has the advantagesof simple operation, fast analysis time of only 8min, fast separation speed and high sensitivity, makes up the blank of nine chemical detection methods in quisqualis indica at present, and is worthyof popularization and application.

The invention discloses a methyl gallate analogue containing an amide structure and application. The structure of the methyl gallate analogue is shown as a formula (I); in the formula (I), R1 is independently selected from various alkoxy, hydroxyl, various halogens and aromatic heterocycles. The invention does a lot of experiment researches aiming at the technical field of a methyl gallate analogue which takes a hydrolyzed methyl gallate ester bond as a parent nucleus structure, and a lot of design, synthesis and pharmacological activity screening of the methyl gallate analogue which takes thehydrolyzed methyl gallate ester bond as the parent nucleus structure are carried out to obtain one type of the methyl gallate analogue which takes the hydrolyzed methyl gallate ester bond as the parent nucleus structure; the methyl gallate analogue provided by the invention has high-efficiency and broad-spectrum anti-inflammatory application. The formula I is shown in the description.

The invention relates to an application of active parts of gallnut in preparing an anti-ulcerative colitis medicine, wherein the active parts of the gallnut are obtained by water extraction and then organic solvent extraction and mainly comprise a tannin type; and then the active parts are subject to extraction separation through a gel chromatography to obtain a monomeric compound, gallic acid, m-digallic acid, methyl gallate, 1,2,3,6-4-O-galloyl group-Beta-D-glucose and 1,2,3,4,6-5-O-galloyl group-Beta-D-glucose. Clinical outcomes show that the active parts of the gallnut have obvious therapeutic action on ulcerative colitis with the total effective rate up to 91.7%, the short-term cure rate up to 66.7%, effective rate of 25% and inefficiency of 8.3%. Pharmacologic research shows that the active parts of the gallnut can obviously increase SOD content and lower MPO content of an ulcer tissue, and has obvious therapeutic action on rat ulcerative colitis, obvious anti-inflammatory and analgesic action and bacteriostatic action on the common pathogenic bacteria related to ulcerative colitis.

The invention discloses a methyl gallate analogue and application thereof. The structure of the methyl gallate analogue is as shown in a formula (I), wherein R is selected from C1 to C6 alkyl groups,N-methyl piperazine substituted C1 to C6 alkyl groups and N-alkyl carbazolyl groups. The methyl gallate analogue disclosed by the invention is capable of better inhibiting the release of inflammatoryfactors of TNF (Tumor Necrosis Factor)-alpha and IL (Interleukin)-6, and particularly, the anti-inflammatory activity of a compound 4e is obviously superior to that of a primer-methyl gallate so thatthe compound has certain anti-inflammatory ability and can be used as a potential anti-inflammatory drug. The formula (I) is shown in the description.

The invention belongs to the technical field of medicines and relates to two novel compounds in paeonia anomala subsp.anomala and antioxidant activity parts of the two novel compounds. The chemical structural formulas of the two novel compounds are shown in formulas (I) and (II). According to a 80% ethyl alcohol extract of the paeonia anomala subsp.anomala, petroleum ether, ethyl acetate and water-saturated n-butyl alcohol are used for extraction to obtain all parts, the n-butyl alcohol part is separated through macroporous resin to obtain all flow components, a water part is subjected to multiple separation methods such as silica gel column chromatography, MCI column chromatography, reverse-phase ODS column chromatography and Sephadex LH-20, and the two novel compounds shown in (I) and (II) are separated. The invention further relates to a method for simultaneously measuring the content of nine compounds, including albiflorin R1, paeoniflorin, nutgall acyl paeoniflorin, oxypaeoniflorin, isovanillic acid, benzoic acid, gallic acid, methyl gallate and 1,2,3,4,6-pentagalloylglucose, in the paeonia anomala subsp.anomala. It is proved through a DPPH test that the paeonia anomala subsp.anomala has application prospects in the antioxidation aspect.

The invention relates to an effective part of a nutgall with an anti-inflammatory effect and a preparation method thereof. A compound in the effective part of the nutgall with the anti-inflammatory effect shall include: 1, nutgall acyl glucose, 2, nutgall acyl glucose, digallic acid, methyl gallate, 3, one or more of nutgall acyl glucose. The preparation method comprises the following steps: grinding the nutgall, mixing the nutgall with water and decocting, mixing filtrates, concentrating and drying for subsequent separation; carrying out effective part enrichment on the obtained sample by using a C18 chromatographic column, a polyamide chromatographic column or a macroporous adsorption resin column, removing impurities, eluting by using ethanol or methanol, collecting eluent, concentrating and drying to obtain a concentrated solution or dried solid which is a nutgall anti-inflammatory extract. According to the invention, the effective part of the nutgall is determined through in-vitroand in-vivo pharmacological study after chromatographic separation is carried out. According to the invention, the preparation method is simple in process, reasonable in design and has small environmental pollution.

The invention discloses a method for synthesizing methyl 3,4,5-trimethoxybenzoate from gallic acid. The method comprises the following steps: by using gallic acid as a raw material, carrying out esterification on the gallic acid and methanol under the catalytic action of sulfuric acid to generate methyl gallate, carrying out methylation reaction on the methyl gallate and methyl chloride gas at 20-60 DEG C, and preparing the methyl 3,4,5-trimethoxybenzoate by using N,N-dimethylformamide as a solvent and any one of sodium carbonate, sodium hydroxide, potassium carbonate, potassium hydroxide and inorganic alkaline compounds as an acid-binding agent. The method is convenient and feasible, is simple to operate, has the advantages of high efficiency and environmental protection, can be used for commercialized large-scale production, and satisfies the ever-growing market demands.

The invention belongs to the technical field of biological medicines, and particularly relates to application of methyl gallate (MG) in the preparation of an NLRP3 pathway inhibitor for hyperuricemia nephropathy and / or gouty arthritis. The methyl gallate can specifically inhibit the activation of NLRP3 inflammasomes in BMDMs and PBMCs, and has no influence on the activation of NLRC4 or AIM2 inflammasomes; and the methyl gallate is a wide inhibitor for NLRP3 inflammasome activation, and can inhibit the activation of the NLRP3 inflammasome stimulated by agonists such as LPS / MSU, alum, ATP, nigericin and the like. In addition, the methyl gallate is widely distributed in various edible plants and is wide in source. Therefore, the methyl gallate as an effective component is expected to be developed into the NLRP3 pathway inhibitor for treating hyperuricemia nephropathy and / or gouty arthritis diseases.

The invention discloses a photovoltaic inverter box. Heat dissipation coating layers are brushed on inner and outer walls of the photovoltaic inverter box; each heat dissipation coating layer is prepared from the following components: beta-(3,5-ditert-butyl-4-hydroxyphenyl)cellulose propionate, tetracosane, mucic acid dimethyl ester, tetraethylenepentamine, methyl gallate, hyperoside and polyisocyanurate; the contents of all the components are as follows in parts by weight: 45 to 55 parts of the beta-(3,5-ditert-butyl-4-hydroxyphenyl)cellulose propionate, 5 to 15 parts of the tetracosane, 30 to 40 parts of the mucic acid dimethyl ester, 2 to 10 parts of the tetraethylenepentamine, 25 to 40 parts of the methyl gallate, 3 to 15 parts of the hyperoside and 25 to 40 parts of the polyisocyanurate. The photovoltaic inverter box has a good heat dissipation property and has no influences on normal work of a photovoltaic inverter.

The invention provides application of carbonized sanguisorba roots in prevention and treatment of tinea corporis and cruris and tinea manus and pedis, and application in preparation of medicines or daily necessities. Meanwhile, the invention provides application of one or more of gallic acid, pyrogallic acid, methyl gallate, ethyl gallate and protocatechuic aldehyde in prevention and treatment oftinea corporis and cruris and tinea manus and pedis, and application in preparation of medicines or daily necessities. Trichophyton rubrum is a main pathogenic bacterium of tinea corporis and cruris and tinea manus and pedis. The invention shows that the carbonized sanguisorba roots can significantly inhibit the growth of the trichophyton rubrum, and the effect is equivalent to that of common traditional Chinese medicines sophora flavescens and golden larch bark for skin tinea. After the carbonized sanguisorba roots are administrated, the growth of the trichophyton rubrum is remarkably inhibited through ocular lens observation. Clinical curative effect observation shows that after carbonized sanguisorba root gel with the content of 0.5% is used for treating for 4 weeks, the cure rate of patients reaches 96.15%, and half of the patients are cured. Meanwhile, the main components including the gallic acid, the pyrogallic acid, the methyl gallate, the ethyl gallate and the protocatechuic aldehyde in sanguisorba roots all have a remarkable effect of resisting the trichophyton rubrum, and the content is not reported.

The invention discloses a methyl gallate analogue and application thereof. The structure of the methyl gallate analogue is as shown in a formula (I), wherein R is selected from C1 to C6 alkyl groups,N-methyl piperazine substituted C1 to C6 alkyl groups and N-alkyl carbazolyl groups. The methyl gallate analogue disclosed by the invention is capable of better inhibiting the release of inflammatoryfactors of TNF (Tumor Necrosis Factor)-alpha and IL (Interleukin)-6, and particularly, the anti-inflammatory activity of a compound 4e is obviously superior to that of a primer-methyl gallate so thatthe compound has certain anti-inflammatory ability and can be used as a potential anti-inflammatory drug. The formula (I) is shown in the description.

The invention discloses a preparation method of a high-temperature resisting and tensile-resisting insulating material. The preparation method comprises the following steps: respectively adding methylglycolate, tetraethyl orthosilicate, isoamyl salicylate, methyl gallate and a polyurethane elastomer into an internal mixer, raising the temperature to 120 to 130 DEG C and performing banburying for20 to 35 minutes; adding 2,6-ditertbutyl-p-cresol and phosphoric acid, and performing banburying at the temperature of 135 to 145 DEG C for 15 to 25 minutes; carrying out sufficient ball milling on magnesium oxide, silicon carbide and zirconium oxide and then adding a mixture into the internal mixer; mixing for 2 to 4 hours under the condition that the temperature is 160 to175 DEG C and the pressure is 20 to 25 KN; finally, carrying out hot melting and extruding on the mixture at high temperature of 200 to 250 DEG C to obtain a mixture, thus obtaining the high-temperature resisting and tensile-resisting insulating material.

The invention belongs to the technical field of medicines, and relates to a method for preparing 3,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate. Preferentially, 3,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate is 3 alpha,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate. According to the method, 3,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate, especially 3 alpha,7-bis(trimethylsilyl oxyl)-6-alkene-5 beta-cholane-24-methyl gallate, prepared through the method can be used for preparing obeticholic acid.